MicroRNA-146a inhibits cancer metastasis by downregulating VEGF through dual pathways in hepatocellular carcinoma

Molecular Cancer

Volumn 14, Issue 1, 2015, Pages

  Zhang, Zheng ^a   Zhang, Yang ^a   Sun, Xiu Xuan ^a   Ma, Xi ^a   Chen, Zhi Nan ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

HAb18G CD147; Hepatocellular carcinoma; Invasion; Metastasis; MicroRNA 146a; VEGF

Indexed keywords

APC PROTEIN; BETA CATENIN; GENOMIC DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA 146A; SYNAPTOTAGMIN I; VASCULOTROPIN; 3' UNTRANSLATED REGION; BSG PROTEIN, HUMAN; CD147 ANTIGEN; MICRORNA; MIRN146 MICRORNA, HUMAN;

ANIMAL EXPERIMENT; ARTICLE; BIOINFORMATICS; CANCER PROGNOSIS; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; EPITHELIUM CELL; GENE EXPRESSION; HEPATOMA CELL; HEPG2 CELL LINE; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; LIVER METASTASIS; LUCIFERASE ASSAY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR INVASION; 3' UNTRANSLATED REGION; ANIMAL; BINDING SITE; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETICS; LIVER TUMOR; METABOLISM; METASTASIS; MORTALITY; PATHOLOGY; PROMOTER REGION; RNA INTERFERENCE; TUMOR CELL LINE; XENOGRAFT;

3' UNTRANSLATED REGIONS; ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; ANTIGENS, CD147; BINDING SITES; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DNA METHYLATION; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HETEROGRAFTS; HUMANS; LIVER NEOPLASMS; MICRORNAS; NEOPLASM METASTASIS; PROMOTER REGIONS, GENETIC; RNA INTERFERENCE; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 84924415559     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-14-5     Document Type: Article

References (34)

1. Nordenstedt H, White DL, El-Serag HB: The changing pattern of epidemiology in hepatocellular carcinoma. Dig Liver Dis 2010,42(Suppl 3):S206-14.
2. Yuen MF, Hou JL, Chutaputti A, Asia Pacific Working Party on Prevention of Hepatocellular C: Hepatocellular carcinoma in the Asia pacific region. J Gastroenterol Hepatol 2009, 24:346-53. 10.1111/j.1440-1746.2009.05784.x
3. Gish R, Marrero JB, Tong MJ: Medical therapies to extend survival in hepatocellular carcinoma. Clin Adv Hematol Oncol 2008, 6:1-14. quiz 15
4. Wu F, Yang LY, Li YF, Ou DP, Chen DP, Fan C: Novel role for epidermal growth factor-like domain 7 in metastasis of human hepatocellular carcinoma. Hepatology 2009, 50:1839-50. 10.1002/hep.23197
5. Wong CC, Wong CM, Au SL, Ng IO: RhoGTPases and Rho-effectors in hepatocellular carcinoma metastasis: ROCK N'Rho move it. Liver Int 2010, 30:642-56. 10.1111/j.1478-3231.2010.02232.x
6. Li H, Ren Z, Kang X, Zhang L, Li X, Wang Y, et al.: Identification of tyrosine-phosphorylated proteins associated with metastasis and functional analysis of FER in human hepatocellular carcinoma cells. BMC Cancer 2009, 9:366. 10.1186/1471-2407-9-366
7. Yoshida T, Hisamoto T, Akiba J, Koga H, Nakamura K, Tokunaga Y, et al.: Spreds, inhibitors of the Ras/ERK signal transduction, are dysregulated in human hepatocellular carcinoma and linked to the malignant phenotype of tumors. Oncogene 2006, 25:6056-66. 10.1038/sj.onc.1209635
8. Calin GA, Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer 2006, 6:857-66. 10.1038/nrc1997
9. Esquela-Kerscher A, Slack FJ: Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006, 6:259-69. 10.1038/nrc1840
10. Varnholt H: The role of microRNAs in primary liver cancer. Ann Hepatol 2008, 7:104-13.
11. Shenouda SK, Alahari SK: MicroRNA function in cancer: oncogene or a tumor suppressor? Cancer Metastasis Rev 2009, 28:369-78. 10.1007/s10555-009-9188-5
12. Li S, Fu H, Wang Y, Tie Y, Xing R, Zhu J, et al.: MicroRNA-101 regulates expression of the v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS) oncogene in human hepatocellular carcinoma. Hepatology 2009, 49:1194-202. 10.1002/hep.22757
13. Saelee P, Wongkham S, Bhudhisawasdi V, Sripa B, Chariyalertsak S, Petmitr S: Allelic loss on chromosome 5q34 is associated with poor prognosis in hepatocellular carcinoma. J Cancer Res Clin Oncol 2008, 134:1135-41. 10.1007/s00432-008-0379-1
14. Bhaumik D, Scott GK, Schokrpur S, Patil CK, Campisi J, Benz CC: Expression of microRNA-146 suppresses NF-kappaB activity with reduction of metastatic potential in breast cancer cells. Oncogene 2008, 27:5643-7. 10.1038/onc.2008.171
15. Lin SL, Chiang A, Chang D, Ying SY: Loss of mir-146a function in hormone-refractory prostate cancer. RNA 2008, 14:417-24. 10.1261/rna.874808
16. Li Y, Vandenboom TG 2nd, Wang Z, Kong D, Ali S, Philip PA, et al.: miR-146a suppresses invasion of pancreatic cancer cells. Cancer Res 2010, 70:1486-95. 10.1158/0008-5472.CAN-09-2792
17. Cui JG, Li YY, Zhao Y, Bhattacharjee S, Lukiw WJ: Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kappaB in stressed human astroglial cells and in Alzheimer disease. J Biol Chem 2010, 285:38951-60. 10.1074/jbc. M110.178848
18. Chatzikyriakidou A, Voulgari PV, Georgiou I, Drosos AA: A polymorphism in the 3'-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility. Joint Bone Spine 2010, 77:411-3. 10.1016/j.jbspin.2010.05.013
19. Chatzikyriakidou A, Voulgari PV, Georgiou I, Drosos AA: The role of microRNA-146a (miR-146a) and its target IL-1R-associated kinase (IRAK1) in psoriatic arthritis susceptibility. Scand J Immunol 2010, 71:382-5. 10.1111/j.1365-3083.2010.02381.x
20. Burgemeister R: Nucleic acids extraction from laser microdissected FFPE tissue sections. Methods Mol Biol 2011, 724:117-29. 10.1007/978-1-61779-055-3_8
21. Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT, et al.: Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 2005, 33:e179. 10.1093/nar/gni178
22. Xu J, Xu HY, Zhang Q, Song F, Jiang JL, Yang XM, et al.: HAb18G/CD147 functions in invasion and metastasis of hepatocellular carcinoma. Mol Cancer Res 2007, 5:605-14. 10.1158/1541-7786.MCR-06-0286
23. Wu J, Ru NY, Zhang Y, Li Y, Wei D, Ren Z, et al.: HAb18G/CD147 promotes epithelial-mesenchymal transition through TGF-beta signaling and is transcriptionally regulated by Slug. Oncogene 2011, 30:4410-27. 10.1038/onc.2011.149
24. Li Y, Xu J, Chen L, Zhong WD, Zhang Z, Mi L, et al.: HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection. Histopathology 2009, 54:677-87. 10.1111/j.1365-2559.2009.03280.x
25. Van Es JH, Kirkpatrick C, van de Wetering M, Molenaar M, Miles A, Kuipers J, et al.: Identification of APC2, a homologue of the adenomatous polyposis coli tumour suppressor. Curr Biol 1999, 9:105-8. 10.1016/S0960-9822(99)80024-4
26. Bienz M: The subcellular destinations of APC proteins. Nat Rev Mol Cell Biol 2002, 3:328-38. 10.1038/nrm806
27. Easwaran V, Lee SH, Inge L, Guo L, Goldbeck C, Garrett E, et al.: beta-Catenin regulates vascular endothelial growth factor expression in colon cancer. Cancer Res 2003, 63:3145-53.
28. Shibata A, Nagaya T, Imai T, Funahashi H, Nakao A, Seo H: Inhibition of NF-kappaB activity decreases the VEGF mRNA expression in MDA-MB-231 breast cancer cells. Breast Cancer Res Treat 2002, 73:237-43. 10.1023/A:1015872531675
29. Yu HB, Zhang HF, Zhang X, Li DY, Xue HZ, Pan CE, et al.: Resveratrol inhibits VEGF expression of human hepatocellular carcinoma cells through a NF-kappa B-mediated mechanism. Hepato-Gastroenterology 2010, 57:1241-6.
30. Garcia AI, Buisson M, Bertrand P, Rimokh R, Rouleau E, Lopez BS, et al.: Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers. EMBO Mol Med 2011, 3:279-90. 10.1002/emmm.201100136
31. Zhou L, Zhao X, Han Y, Lu Y, Shang Y, Liu C, et al.: Regulation of UHRF1 by miR-146a/b modulates gastric cancer invasion and metastasis. FASEB J 2013, 27:4929-39. 10.1096/fj.13-233387
32. Liu X, Gao Q, Li P, Zhao Q, Zhang J, Li J, et al.: UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9. Nat Commun 2013, 4:1563.
33. Harris ES, Nelson WJ: Adenomatous polyposis coli regulates endothelial cell migration independent of roles in beta-catenin signaling and cell-cell adhesion. Mol Biol Cell 2010, 21:2611-23. 10.1091/mbc. E10-03-0235
34. Clevers H: Wnt/beta-catenin signaling in development and disease. Cell 2006, 127:469-80. 10.1016/j.cell.2006.10.018