High tumor cell expression of microRNA-21 in node positive non-small cell lung cancer predicts a favorable clinical outcome

BMC Clinical Pathology

Volumn 14, Issue 1, 2014, Pages

  Stenvold, Helge ^a,b   Donnem, Tom ^a,b   Andersen, Sigve ^a,b   Al Saad, Samer ^a,b   Valkov, Andrej ^a,b   Pedersen, Mona Irene ^a,b   Busund, Lill Tove ^a,b   Bremnes, Roy M ^a,b  

^a UNIVERSITY OF TROMSØ   (Norway)

^b UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

Author keywords

miR 21; miRNA; NSCLC; Prognostic impact; Stage I IIIA; Survival

Indexed keywords

ANGIOGENIC PROTEIN; HYPOXIA INDUCIBLE FACTOR 1; MICRORNA 21; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; VASCULOTROPIN A;

ADULT; AGED; ARTICLE; CANCER CELL; CANCER PATIENT; CANCER PROGNOSIS; CANCER SURVIVAL; ENDOTHELIUM CELL; FEMALE; FIBROBLAST; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INFLAMMATORY CELL; LARGE CELL CARCINOMA; LUNG ADENOCARCINOMA; LUNG ALVEOLUS CELL; LUNG ALVEOLUS CELL CARCINOMA; LUNG NON SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PROTEIN EXPRESSION; SMOKING; STROMA CELL; TISSUE MICROARRAY; TREATMENT OUTCOME; TUMOR DIFFERENTIATION; VERY ELDERLY;

EID: 84896736752     PISSN: None     EISSN: 14726890     Source Type: Journal    
DOI: 10.1186/1472-6890-14-9     Document Type: Article

References (25)

1. Cancer statistics, 2010. Jemal A, Siegel R, Xu J, Ward E, CA Cancer J Clin 2010 60 277 300 10.3322/caac.20073 20610543
2. Prognostic role of microRNA-21 in various carcinomas: a systematic review and Meta-analysis. Fu X, Han Y, Wu Y, Zhu X, Lu X, Mao F, et al. Eur J Clin Invest 2011 41 1245 53 10.1111/j.1365-2362.2011.02535.x 21521185
3. MicroRNAs in cancer: small molecules with a huge impact. Iorio MV, Croce CM, J Clin Oncol 2009 27 5848 5856 10.1200/JCO.2009.24.0317 19884536
4. Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Kasinski AL, Slack FJ, Nat Rev Cancer 2011 11 849 864 10.1038/nrc3166 22113163
5. miR-21: a small multi-faceted RNA. Krichevsky AM, Gabriely G, J Cell Mol Med 2009 13 39 53 19175699
6. MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer. Olson P, Lu J, Zhang H, Shai A, Chun MG, Wang Y, et al. Genes Dev 2009 23 2152 2165 10.1101/gad.1820109 19759263
7. MicroRNAs as novel regulators of angiogenesis. Suarez Y, Sessa WC, Circ Res 2009 104 442 454 10.1161/CIRCRESAHA.108.191270 19246688
8. MicroRNA Signatures in Tumor Tissue Related to Angiogenesis in Non-Small Cell Lung Cancer. Donnem T, Fenton CG, Lonvik K, Berg T, Eklo K, Andersen S, et al. PLoS One 2012 7 29671 10.1371/journal.pone.0029671 22295063
9. MiR-21 induced angiogenesis through AKT and ERK activation and HIF-1alpha expression. Liu LZ, Li C, Chen Q, Jing Y, Carpenter R, Jiang Y, et al. PLoS One 2011 6 19139 10.1371/journal.pone.0019139 21544242
10. MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells. Sabatel C, Malvaux L, Bovy N, Deroanne C, Lambert V, Gonzalez ML, et al. PLoS One 2011 6 16979 10.1371/journal.pone.0016979 21347332
11. Deregulated expression of miR-21, miR-143 and miR-181a in non small cell lung cancer is related to clinicopathologic characteristics or patient prognosis. Gao W, Yu Y, Cao H, Shen H, Li X, Pan S, et al. Biomed Pharmacother 2010 64 399 408 20363096
12. MicroRNA expression differentiates histology and predicts survival of lung cancer. Landi MT, Zhao Y, Rotunno M, Koshiol J, Liu H, Bergen AW, et al. Clin Cancer Res 2010 16 430 441 10.1158/1078-0432.CCR-09-1736 20068076
13. Prognostic value of mature microRNA-21 and microRNA-205 overexpression in non-small cell lung cancer by quantitative real-time RT-PCR. Markou A, Tsaroucha EG, Kaklamanis L, Fotinou M, Georgoulias V, Lianidou ES, Clin Chem 2008 54 1696 1704 10.1373/clinchem.2007.101741 18719201
14. The association of microRNA expression with prognosis and progression in early-stage, non-small cell lung adenocarcinoma: a retrospective analysis of three cohorts. Saito M, Schetter AJ, Mollerup S, Kohno T, Skaug V, Bowman ED, et al. Clin Cancer Res 2011 17 1875 1882 10.1158/1078-0432.CCR-10-2961 21350005
15. MicroRNA expression and clinical outcomes in patients treated with adjuvant chemotherapy after complete resection of non-small cell lung carcinoma. Voortman J, Goto A, Mendiboure J, Sohn JJ, Schetter AJ, Saito M, et al. Cancer Res 2010 70 8288 8298 10.1158/0008-5472.CAN-10-1348 20978195
16. MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survival. Dillhoff M, Liu J, Frankel W, Croce C, Bloomston M, J Gastrointest Surg 2008 12 2171 2176 10.1007/s11605-008-0584-x 18642050
17. High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients. Nielsen BS, Jorgensen S, Fog JU, Sokilde R, Christensen IJ, Hansen U, et al. Clin Exp Metastasis 2011 28 27 38 10.1007/s10585-010-9355-7 21069438
18. Diverging prognostic impacts of hypoxic markers according to NSCLC histology. Andersen S, Eilertsen M, Donnem T, Al-Shibli K, Al-Saad S, Busund LT, et al. Lung Cancer 2011 72 294 302 10.1016/j.lungcan.2010.10.006 21075472
19. Diverse prognostic roles of Akt isoforms, PTEN and PI3K in tumor epithelial cells and stromal compartment in non-small cell lung cancer. Al-Saad S, Donnem T, Al-Shibli K, Persson M, Bremnes RM, Busund LT, Anticancer Res 2009 29 4175 4183 19846969
20. Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer. Donnem T, Al-Saad S, Al-Shibli K, Delghandi MP, Persson M, Nilsen MN, et al. Clin Cancer Res 2007 13 6649 6657 10.1158/1078-0432.CCR-07-0414 18006765 (Pubitemid 350206800)
21. Updated lung cancer staging system. Rami-Porta R, Chansky K, Goldstraw P, Future Oncol 2009 5 1545 1553 10.2217/fon.09.131 20001795
22. Robust one-day in situ hybridization protocol for detection of microRNAs in paraffin samples using LNA probes. Jorgensen S, Baker A, Moller S, Nielsen BS, Methods 2010 52 375 381 10.1016/j.ymeth.2010.07.002 20621190
23. High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer. Yang M, Shen H, Qiu C, Ni Y, Wang L, Dong W, et al. Eur J Cancer 2012 49 604 15 23099007
24. Analysis of gene expression in prostate cancer epithelial and interstitial stromal cells using laser capture microdissection. Gregg JL, Brown KE, Mintz EM, Piontkivska H, Fraizer GC, BMC Cancer 2010 10 165 10.1186/1471-2407-10-165 20426842
25. Hallmarks of cancer: the next generation. Hanahan D, Weinberg RA, Cell 2011 144 646 674 10.1016/j.cell.2011.02.013 21376230