Colorectal cancer cell-derived microvesicles containing microRNA-1246 promote angiogenesis by activating Smad 1/5/8 signaling elicited by PML down-regulation in endothelial cells

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Volumn 1839, Issue 11, 2014, Pages 1256-1272

  Yamada, Nami ^a   Tsujimura, Nonoka ^a   Kumazaki, Minami ^a   Shinohara, Haruka ^a   Taniguchi, Kohei ^a   Nakagawa, Yoshihito ^b   Naoe, Tomoki ^c   Akao, Yukihiro ^a  

^a GIFU UNIVERSITY   (Japan)

^b FUJITA HEALTH UNIVERSITY   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiogenesis; Colorectal cancer; Microvesicles; MiR 1246; Smad signaling

Indexed keywords

MICRORNA; MICRORNA 1246; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; MIRN1246 MICRORNA, HUMAN; NUCLEAR PROTEIN; PML PROTEIN, HUMAN; SMAD1 PROTEIN, HUMAN; SMAD5 PROTEIN, HUMAN; SMAD8 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TUMOR SUPPRESSOR PROTEIN;

AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CELL MIGRATION; CELL ORGANELLE; CELL PROLIFERATION; CLINICAL ARTICLE; COLORECTAL CANCER; DOWN REGULATION; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; MALE; MICROVESICLE; MOUSE; NONHUMAN; TUMOR VASCULARIZATION; TUMOR XENOGRAFT; CELL CULTURE; COLORECTAL TUMOR; CYTOPLASM VESICLE; GENETICS; HELA CELL LINE; HEPG2 CELL LINE; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULARIZATION;

CELLS, CULTURED; COLORECTAL NEOPLASMS; CYTOPLASMIC VESICLES; DOWN-REGULATION; ENDOTHELIAL CELLS; HELA CELLS; HEP G2 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICRORNAS; NEOVASCULARIZATION, PATHOLOGIC; NUCLEAR PROTEINS; SIGNAL TRANSDUCTION; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 84907732356     PISSN: 18749399     EISSN: 18764320     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2014.09.002     Document Type: Article

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