메뉴 건너뛰기




Volumn 8, Issue 10, 2013, Pages

MicroRNA-17, 20a Regulates the Proangiogenic Function of Tumor-Associated Macrophages via Targeting Hypoxia-Inducible Factor 2α

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 2ALPHA; INTERLEUKIN 6; MICRORNA; PLATELET DERIVED GROWTH FACTOR B; PROTEIN MIR 17; PROTEIN MIR 20A; REGULATOR PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN A; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; MIRN17 MICRORNA, HUMAN; MIRN20 MICRORNA, HUMAN; OLIGONUCLEOTIDE;

EID: 84886031527     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077890     Document Type: Article
Times cited : (26)

References (54)
  • 1
    • 7244250405 scopus 로고    scopus 로고
    • Angiogenesis and hepatocellular carcinoma
    • Semela D, Dufour JF, (2004) Angiogenesis and hepatocellular carcinoma. J Hepatol 41: 864-880.
    • (2004) J Hepatol , vol.41 , pp. 864-880
    • Semela, D.1    Dufour, J.F.2
  • 2
    • 34347226359 scopus 로고    scopus 로고
    • Tumor-associated macrophages press the angiogenic switch in breast cancer
    • Lin EY, Pollard JW, (2007) Tumor-associated macrophages press the angiogenic switch in breast cancer. Cancer Res 67: 5064-5066.
    • (2007) Cancer Res , vol.67 , pp. 5064-5066
    • Lin, E.Y.1    Pollard, J.W.2
  • 3
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian BZ, Pollard JW, (2010) Macrophage diversity enhances tumor progression and metastasis. Cell 141: 39-51.
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 4
    • 34547113798 scopus 로고    scopus 로고
    • Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes
    • Kuang DM, Wu Y, Chen N, Cheng J, Zhuang SM, et al. (2007) Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes. Blood 110: 587-595.
    • (2007) Blood , vol.110 , pp. 587-595
    • Kuang, D.M.1    Wu, Y.2    Chen, N.3    Cheng, J.4    Zhuang, S.M.5
  • 5
    • 77956397098 scopus 로고    scopus 로고
    • Tumor-activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients
    • Kuang DM, Peng C, Zhao Q, Wu Y, Zhu LY, et al. (2010) Tumor-activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients. J Immunol 185: 1544-1549.
    • (2010) J Immunol , vol.185 , pp. 1544-1549
    • Kuang, D.M.1    Peng, C.2    Zhao, Q.3    Wu, Y.4    Zhu, L.Y.5
  • 6
    • 79954657385 scopus 로고    scopus 로고
    • Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma
    • Kuang DM, Zhao Q, Wu Y, Peng C, Wang J, et al. (2011) Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma. J Hepatol 54: 948-955.
    • (2011) J Hepatol , vol.54 , pp. 948-955
    • Kuang, D.M.1    Zhao, Q.2    Wu, Y.3    Peng, C.4    Wang, J.5
  • 7
    • 73449111925 scopus 로고    scopus 로고
    • Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells
    • Kuang DM, Peng C, Zhao Q, Wu Y, Chen MS, et al. (2010) Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory T helper 17 cells. Hepatology 51: 154-164.
    • (2010) Hepatology , vol.51 , pp. 154-164
    • Kuang, D.M.1    Peng, C.2    Zhao, Q.3    Wu, Y.4    Chen, M.S.5
  • 8
    • 64549108462 scopus 로고    scopus 로고
    • Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients
    • Zhang JP, Yan J, Xu J, Pang XH, Chen MS, et al. (2009) Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J Hepatol 50: 980-989.
    • (2009) J Hepatol , vol.50 , pp. 980-989
    • Zhang, J.P.1    Yan, J.2    Xu, J.3    Pang, X.H.4    Chen, M.S.5
  • 9
    • 77954229219 scopus 로고    scopus 로고
    • Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects
    • Zhang W, Zhu XD, Sun HC, Xiong YQ, Zhuang PY, et al. (2010) Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects. Clin Cancer Res 16: 3420-3430.
    • (2010) Clin Cancer Res , vol.16 , pp. 3420-3430
    • Zhang, W.1    Zhu, X.D.2    Sun, H.C.3    Xiong, Y.Q.4    Zhuang, P.Y.5
  • 10
    • 59049106749 scopus 로고    scopus 로고
    • High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection
    • Ding T, Xu J, Wang F, Shi M, Zhang Y, et al. (2009) High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection. Hum Pathol 40: 381-389.
    • (2009) Hum Pathol , vol.40 , pp. 381-389
    • Ding, T.1    Xu, J.2    Wang, F.3    Shi, M.4    Zhang, Y.5
  • 11
    • 84885955149 scopus 로고    scopus 로고
    • Dynamic education of macrophages in different areas of human tumors
    • Wu Y, Zheng L, (2012) Dynamic education of macrophages in different areas of human tumors. Cancer Microenviron 5: 195-201.
    • (2012) Cancer Microenviron , vol.5 , pp. 195-201
    • Wu, Y.1    Zheng, L.2
  • 12
    • 0141988698 scopus 로고    scopus 로고
    • Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia
    • Sowter HM, Raval RR, Moore JW, Ratcliffe PJ, Harris AL, (2003) Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia. Cancer Res 63: 6130-6134.
    • (2003) Cancer Res , vol.63 , pp. 6130-6134
    • Sowter, H.M.1    Raval, R.R.2    Moore, J.W.3    Ratcliffe, P.J.4    Harris, A.L.5
  • 13
    • 0345118952 scopus 로고    scopus 로고
    • Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis
    • White JR, Harris RA, Lee SR, Craigon MH, Binley K, et al. (2004) Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis. Genomics 83: 1-8.
    • (2004) Genomics , vol.83 , pp. 1-8
    • White, J.R.1    Harris, R.A.2    Lee, S.R.3    Craigon, M.H.4    Binley, K.5
  • 14
    • 68249140395 scopus 로고    scopus 로고
    • Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
    • Fang HY, Hughes R, Murdoch C, Coffelt SB, Biswas SK, et al. (2009) Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood 114: 844-859.
    • (2009) Blood , vol.114 , pp. 844-859
    • Fang, H.Y.1    Hughes, R.2    Murdoch, C.3    Coffelt, S.B.4    Biswas, S.K.5
  • 15
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, et al. (2000) The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 157: 411-421.
    • (2000) Am J Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3    Maxwell, P.H.4    Pugh, C.W.5
  • 16
    • 77955295091 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation
    • Imtiyaz HZ, Williams EP, Hickey MM, Patel SA, Durham AC, et al. (2010) Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J Clin Invest 120: 2699-2714.
    • (2010) J Clin Invest , vol.120 , pp. 2699-2714
    • Imtiyaz, H.Z.1    Williams, E.P.2    Hickey, M.M.3    Patel, S.A.4    Durham, A.C.5
  • 17
    • 54549113030 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer
    • Kaelin WG Jr, (2008) The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer. Nat Rev Cancer 8: 865-873.
    • (2008) Nat Rev Cancer , vol.8 , pp. 865-873
    • Kaelin Jr., W.G.1
  • 18
    • 78649364332 scopus 로고    scopus 로고
    • Hypoxia-inducible factors and the response to hypoxic stress
    • Majmundar AJ, Wong WJ, Simon MC, (2010) Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell 40: 294-309.
    • (2010) Mol Cell , vol.40 , pp. 294-309
    • Majmundar, A.J.1    Wong, W.J.2    Simon, M.C.3
  • 19
    • 0036493984 scopus 로고    scopus 로고
    • Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer
    • Leek RD, Talks KL, Pezzella F, Turley H, Campo L, et al. (2002) Relation of hypoxia-inducible factor-2 alpha (HIF-2 alpha) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer. Cancer Res 62: 1326-1329.
    • (2002) Cancer Res , vol.62 , pp. 1326-1329
    • Leek, R.D.1    Talks, K.L.2    Pezzella, F.3    Turley, H.4    Campo, L.5
  • 20
    • 12144287073 scopus 로고    scopus 로고
    • Prognostic significance of endothelial Per-Arnt-sim domain protein 1/hypoxia-inducible factor-2alpha expression in a subset of tumor associated macrophages in invasive bladder cancer
    • Koga F, Kageyama Y, Kawakami S, Fujii Y, Hyochi N, et al. (2004) Prognostic significance of endothelial Per-Arnt-sim domain protein 1/hypoxia-inducible factor-2alpha expression in a subset of tumor associated macrophages in invasive bladder cancer. J Urol 171: 1080-1084.
    • (2004) J Urol , vol.171 , pp. 1080-1084
    • Koga, F.1    Kageyama, Y.2    Kawakami, S.3    Fujii, Y.4    Hyochi, N.5
  • 22
    • 75649139134 scopus 로고    scopus 로고
    • Physiological and pathological roles for microRNAs in the immune system
    • O'Connell RM, Rao DS, Chaudhuri AA, Baltimore D, (2010) Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 10: 111-122.
    • (2010) Nat Rev Immunol , vol.10 , pp. 111-122
    • O'Connell, R.M.1    Rao, D.S.2    Chaudhuri, A.A.3    Baltimore, D.4
  • 23
    • 70350759666 scopus 로고    scopus 로고
    • MicroRNA-155 regulates inflammatory cytokine production in tumor-associated macrophages via targeting C/EBPbeta
    • He M, Xu Z, Ding T, Kuang DM, Zheng L, (2009) MicroRNA-155 regulates inflammatory cytokine production in tumor-associated macrophages via targeting C/EBPbeta. Cell Mol Immunol 6: 343-352.
    • (2009) Cell Mol Immunol , vol.6 , pp. 343-352
    • He, M.1    Xu, Z.2    Ding, T.3    Kuang, D.M.4    Zheng, L.5
  • 24
    • 39649120597 scopus 로고    scopus 로고
    • Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells
    • Duluc D, Delneste Y, Tan F, Moles MP, Grimaud L, et al. (2007) Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells. Blood 110: 4319-4330.
    • (2007) Blood , vol.110 , pp. 4319-4330
    • Duluc, D.1    Delneste, Y.2    Tan, F.3    Moles, M.P.4    Grimaud, L.5
  • 25
    • 80052692611 scopus 로고    scopus 로고
    • Association of intra-tumoral infiltrating macrophages and regulatory T cells is an independent prognostic factor in gastric cancer after radical resection
    • Wang B, Xu D, Yu X, Ding T, Rao H, et al. (2011) Association of intra-tumoral infiltrating macrophages and regulatory T cells is an independent prognostic factor in gastric cancer after radical resection. Ann Surg Oncol 18: 2585-2593.
    • (2011) Ann Surg Oncol , vol.18 , pp. 2585-2593
    • Wang, B.1    Xu, D.2    Yu, X.3    Ding, T.4    Rao, H.5
  • 26
    • 80054757504 scopus 로고    scopus 로고
    • Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop
    • Wu Y, Zhao Q, Peng C, Sun L, Li XF, et al. (2011) Neutrophils promote motility of cancer cells via a hyaluronan-mediated TLR4/PI3K activation loop. J Pathol 225: 438-447.
    • (2011) J Pathol , vol.225 , pp. 438-447
    • Wu, Y.1    Zhao, Q.2    Peng, C.3    Sun, L.4    Li, X.F.5
  • 27
    • 67449110979 scopus 로고    scopus 로고
    • Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1
    • Kuang DM, Zhao Q, Peng C, Xu J, Zhang JP, et al. (2009) Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J Exp Med 206: 1327-1337.
    • (2009) J Exp Med , vol.206 , pp. 1327-1337
    • Kuang, D.M.1    Zhao, Q.2    Peng, C.3    Xu, J.4    Zhang, J.P.5
  • 28
    • 84863012436 scopus 로고    scopus 로고
    • Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages
    • Zhao Q, Kuang DM, Wu Y, Xiao X, Li XF, et al. (2012) Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages. J Immunol 188: 1117-1124.
    • (2012) J Immunol , vol.188 , pp. 1117-1124
    • Zhao, Q.1    Kuang, D.M.2    Wu, Y.3    Xiao, X.4    Li, X.F.5
  • 29
    • 13944282215 scopus 로고    scopus 로고
    • Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    • Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, et al. (2005) Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 433: 769-773.
    • (2005) Nature , vol.433 , pp. 769-773
    • Lim, L.P.1    Lau, N.C.2    Garrett-Engele, P.3    Grimson, A.4    Schelter, J.M.5
  • 30
    • 80055047968 scopus 로고    scopus 로고
    • MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression
    • Fang JH, Zhou HC, Zeng C, Yang J, Liu Y, et al. (2011) MicroRNA-29b suppresses tumor angiogenesis, invasion, and metastasis by regulating matrix metalloproteinase 2 expression. Hepatology 54: 1729-1740.
    • (2011) Hepatology , vol.54 , pp. 1729-1740
    • Fang, J.H.1    Zhou, H.C.2    Zeng, C.3    Yang, J.4    Liu, Y.5
  • 31
    • 78049506983 scopus 로고    scopus 로고
    • A novel GSK-3 beta-C/EBP alpha-miR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma
    • Zeng C, Wang R, Li D, Lin XJ, Wei QK, et al. (2010) A novel GSK-3 beta-C/EBP alpha-miR-122-insulin-like growth factor 1 receptor regulatory circuitry in human hepatocellular carcinoma. Hepatology 52: 1702-1712.
    • (2010) Hepatology , vol.52 , pp. 1702-1712
    • Zeng, C.1    Wang, R.2    Li, D.3    Lin, X.J.4    Wei, Q.K.5
  • 32
    • 84861542135 scopus 로고    scopus 로고
    • MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein
    • Zhu Y, Lu Y, Zhang Q, Liu JJ, Li TJ, et al. (2012) MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein. Nucleic Acids Res 40: 4615-4625.
    • (2012) Nucleic Acids Res , vol.40 , pp. 4615-4625
    • Zhu, Y.1    Lu, Y.2    Zhang, Q.3    Liu, J.J.4    Li, T.J.5
  • 33
    • 24644457736 scopus 로고    scopus 로고
    • Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways
    • Xu Q, Briggs J, Park S, Niu G, Kortylewski M, et al. (2005) Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways. Oncogene 24: 5552-5560.
    • (2005) Oncogene , vol.24 , pp. 5552-5560
    • Xu, Q.1    Briggs, J.2    Park, S.3    Niu, G.4    Kortylewski, M.5
  • 35
    • 39849095077 scopus 로고    scopus 로고
    • E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer
    • Petrocca F, Visone R, Onelli MR, Shah MH, Nicoloso MS, et al. (2008) E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 13: 272-286.
    • (2008) Cancer Cell , vol.13 , pp. 272-286
    • Petrocca, F.1    Visone, R.2    Onelli, M.R.3    Shah, M.H.4    Nicoloso, M.S.5
  • 36
  • 37
    • 84858379476 scopus 로고    scopus 로고
    • MicroRNAs in stress signaling and human disease
    • Mendell JT, Olson EN, (2012) MicroRNAs in stress signaling and human disease. Cell 148: 1172-1187.
    • (2012) Cell , vol.148 , pp. 1172-1187
    • Mendell, J.T.1    Olson, E.N.2
  • 39
    • 34347383305 scopus 로고    scopus 로고
    • MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation
    • Fontana L, Pelosi E, Greco P, Racanicchi S, Testa U, et al. (2007) MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation. Nat Cell Biol 9: 775-787.
    • (2007) Nat Cell Biol , vol.9 , pp. 775-787
    • Fontana, L.1    Pelosi, E.2    Greco, P.3    Racanicchi, S.4    Testa, U.5
  • 40
    • 52749087157 scopus 로고    scopus 로고
    • Effects of hypoxia on transcription factor expression in human monocytes and macrophages
    • Elbarghati L, Murdoch C, Lewis CE, (2008) Effects of hypoxia on transcription factor expression in human monocytes and macrophages. Immunobiology 213: 899-908.
    • (2008) Immunobiology , vol.213 , pp. 899-908
    • Elbarghati, L.1    Murdoch, C.2    Lewis, C.E.3
  • 41
    • 33750630119 scopus 로고    scopus 로고
    • Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype
    • Holmquist-Mengelbier L, Fredlund E, Lofstedt T, Noguera R, Navarro S, et al. (2006) Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype. Cancer Cell 10: 413-423.
    • (2006) Cancer Cell , vol.10 , pp. 413-423
    • Holmquist-Mengelbier, L.1    Fredlund, E.2    Lofstedt, T.3    Noguera, R.4    Navarro, S.5
  • 43
    • 2142644409 scopus 로고    scopus 로고
    • Macrophage infiltration and angiogenesis in human malignancy
    • discussion 200-184, 259-169
    • Knowles H, Leek R, Harris AL (2004) Macrophage infiltration and angiogenesis in human malignancy. Novartis Found Symp 256: 189-200; discussion 200-184, 259-169.
    • (2004) Novartis Found Symp , vol.256 , pp. 189-200
    • Knowles, H.1    Leek, R.2    Harris, A.L.3
  • 44
    • 48649102010 scopus 로고    scopus 로고
    • Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster
    • Taguchi A, Yanagisawa K, Tanaka M, Cao K, Matsuyama Y, et al. (2008) Identification of hypoxia-inducible factor-1 alpha as a novel target for miR-17-92 microRNA cluster. Cancer Res 68: 5540-5545.
    • (2008) Cancer Res , vol.68 , pp. 5540-5545
    • Taguchi, A.1    Yanagisawa, K.2    Tanaka, M.3    Cao, K.4    Matsuyama, Y.5
  • 45
    • 77952360640 scopus 로고    scopus 로고
    • microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling
    • Yu Z, Willmarth NE, Zhou J, Katiyar S, Wang M, et al. (2010) microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling. Proc Natl Acad Sci U S A 107: 8231-8236.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 8231-8236
    • Yu, Z.1    Willmarth, N.E.2    Zhou, J.3    Katiyar, S.4    Wang, M.5
  • 46
    • 54949154476 scopus 로고    scopus 로고
    • MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia
    • Hua Z, Lv Q, Ye W, Wong CK, Cai G, et al. (2006) MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. PLoS One 1: e116.
    • (2006) PLoS One , vol.1
    • Hua, Z.1    Lv, Q.2    Ye, W.3    Wong, C.K.4    Cai, G.5
  • 47
    • 45849107663 scopus 로고    scopus 로고
    • The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation
    • Ye W, Lv Q, Wong CK, Hu S, Fu C, et al. (2008) The effect of central loops in miRNA:MRE duplexes on the efficiency of miRNA-mediated gene regulation. PLoS One 3: e1719.
    • (2008) PLoS One , vol.3
    • Ye, W.1    Lv, Q.2    Wong, C.K.3    Hu, S.4    Fu, C.5
  • 48
    • 0026019353 scopus 로고
    • Induction of cytokine messenger RNA and secretion in alveolar macrophages and blood monocytes from patients with lung cancer receiving granulocyte-macrophage colony-stimulating factor therapy
    • Thomassen MJ, Ahmad M, Barna BP, Antal J, Wiedemann HP, et al. (1991) Induction of cytokine messenger RNA and secretion in alveolar macrophages and blood monocytes from patients with lung cancer receiving granulocyte-macrophage colony-stimulating factor therapy. Cancer Res 51: 857-862.
    • (1991) Cancer Res , vol.51 , pp. 857-862
    • Thomassen, M.J.1    Ahmad, M.2    Barna, B.P.3    Antal, J.4    Wiedemann, H.P.5
  • 49
    • 0028046042 scopus 로고
    • The role of platelet-derived growth factor production by tumor-associated macrophages in tumor stroma formation in lung cancer
    • Vignaud JM, Marie B, Klein N, Plenat F, Pech M, et al. (1994) The role of platelet-derived growth factor production by tumor-associated macrophages in tumor stroma formation in lung cancer. Cancer Res 54: 5455-5463.
    • (1994) Cancer Res , vol.54 , pp. 5455-5463
    • Vignaud, J.M.1    Marie, B.2    Klein, N.3    Plenat, F.4    Pech, M.5
  • 50
    • 80053640221 scopus 로고    scopus 로고
    • Tumor-associated macrophages provide a suitable microenvironment for non-small lung cancer invasion and progression
    • Wang R, Zhang J, Chen S, Lu M, Luo X, et al. (2011) Tumor-associated macrophages provide a suitable microenvironment for non-small lung cancer invasion and progression. Lung Cancer 74: 188-196.
    • (2011) Lung Cancer , vol.74 , pp. 188-196
    • Wang, R.1    Zhang, J.2    Chen, S.3    Lu, M.4    Luo, X.5
  • 51
    • 84856292648 scopus 로고    scopus 로고
    • Microglia isolated from patients with glioma gain antitumor activities on poly (I:C) stimulation
    • Kees T, Lohr J, Noack J, Mora R, Gdynia G, et al. (2012) Microglia isolated from patients with glioma gain antitumor activities on poly (I:C) stimulation. Neuro Oncol 14: 64-78.
    • (2012) Neuro Oncol , vol.14 , pp. 64-78
    • Kees, T.1    Lohr, J.2    Noack, J.3    Mora, R.4    Gdynia, G.5
  • 52
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
    • Biswas SK, Mantovani A, (2010) Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol 11: 889-896.
    • (2010) Nat Immunol , vol.11 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 53
    • 79955856003 scopus 로고    scopus 로고
    • Antigen-presenting cell (APC) subsets in ovarian cancer
    • Wilke CM, Kryczek I, Zou W, (2011) Antigen-presenting cell (APC) subsets in ovarian cancer. Int Rev Immunol 30: 120-126.
    • (2011) Int Rev Immunol , vol.30 , pp. 120-126
    • Wilke, C.M.1    Kryczek, I.2    Zou, W.3
  • 54
    • 84871144194 scopus 로고    scopus 로고
    • The mechanism of the anticancer function of M1 macrophages and their use in the clinic
    • Pan XQ, (2012) The mechanism of the anticancer function of M1 macrophages and their use in the clinic. Chin J Cancer 31: 557-563.
    • (2012) Chin J Cancer , vol.31 , pp. 557-563
    • Pan, X.Q.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.