Compulsivity in obsessive-compulsive disorder and addictions

European Neuropsychopharmacology

Volumn 26, Issue 5, 2016, Pages 856-868

  Figee, Martijn ^a   Pattij, Tommy ^b   Willuhn, Ingo ^a,c   Luigjes, Judy ^a   van den Brink, Wim ^a,d   Goudriaan, Anneke ^a,d   Potenza, Marc N ^e,g   Robbins, Trevor W ^f   Denys, Damiaan ^a,c  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^d AMSTERDAM INSTITUTE FOR ADDICTION RESEARCH   (Netherlands)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^g YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Addiction; Behavioral addiction; Frontostriatal network; Obsessive compulsive disorder; RDoC; Substance use

Indexed keywords

4 AMINOBUTYRIC ACID; DOPAMINE; DOPAMINE 2 RECEPTOR; GLUTAMIC ACID; PRAMIPEXOLE; SEROTONIN; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR;

ALCOHOLISM; AMYGDALA; ANXIETY; ANXIETY DISORDER; ARTICLE; ATTENUATION; BINGE EATING DISORDER; CANNABIS ADDICTION; COCAINE DEPENDENCE; COGNITION; COMPULSION; COMPULSIVE EATING DISORDER; COMPULSIVITY; CORPUS STRIATUM; DEPRESSION; DOPAMINE RELEASE; DRUG DEPENDENCE; DRUG SEEKING BEHAVIOR; EATING DISORDER; FRONTAL CORTEX; HABENULA; HABIT; HUMAN; HYPERACTIVITY; LEARNING; LIMBIC SYSTEM; MEDIAL PREFRONTAL CORTEX; MENTAL STRESS; NONHUMAN; OBSESSIVE COMPULSIVE DISORDER; OPIATE ADDICTION; PATHOLOGICAL GAMBLING; POLYDIPSIA; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PUNISHMENT; REINFORCEMENT; REWARD; SEROTONINERGIC SYSTEM; SKIN PICKING DISORDER; SUBSTANCE ABUSE; TOBACCO DEPENDENCE; TRANSCRANIAL MAGNETIC STIMULATION; TRICHOTILLOMANIA; VENTRAL STRIATUM; WITHDRAWAL SYNDROME; ADDICTION; ANIMAL; BIOLOGICAL MODEL; COMPARATIVE STUDY; COMPULSIVE PERSONALITY DISORDER; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; EVIDENCE BASED MEDICINE; FRONTAL LOBE; MULTIMODALITY CANCER THERAPY; NERVE CELL NETWORK; NOMENCLATURE; PATHOPHYSIOLOGY; PSYCHOLOGY;

ANIMALS; BEHAVIOR, ADDICTIVE; COMBINED MODALITY THERAPY; COMPULSIVE BEHAVIOR; COMPULSIVE PERSONALITY DISORDER; CORPUS STRIATUM; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; EVIDENCE-BASED MEDICINE; FRONTAL LOBE; HABITS; HUMANS; MODELS, NEUROLOGICAL; NERVE NET; OBSESSIVE-COMPULSIVE DISORDER; PUNISHMENT; REINFORCEMENT (PSYCHOLOGY); REWARD; SUBSTANCE-RELATED DISORDERS; TERMINOLOGY AS TOPIC;

EID: 84969651342     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2015.12.003     Document Type: Article

References (183)

1. Albelda N., Joel D. Animal models of obsessive-compulsive disorder: exploring pharmacology and neural substrates. Neurosci. Biobehav. Rev. 2012, 36:47-63.
2. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 2013, American Psychiatric Association, Washington, DC. fifth ed.
3. Andrews M.A., Meda S.A., Thomas A.D., Potenza M.N., Krystal J.H., Worhunsky P.D., Stevens M.C., O'Malley S.S., Book G.A., Pearlson G.D. Individuals family history positive for alcoholism show fmri abnormalities in reward sensitivity that are related to impulsivity Factors. Biol. Psychiatry 2011, 69:675-683..
4. Arnsten A.F., Wang M., Paspalas C.D. Dopamine's Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders. Pharmacol Rev. 2015, 67(3):681-696.
5. Baas J.M., Klumpers F., Mantione M.H., Figee M., Vulink N.C., Schuurman P.R., Mazaheri A., Denys D. No impact of deep brain stimulation on fear-potentiated startle in obsessive-compulsive disorder. Front Behav Neurosci. 2014, 8:305.
6. Balodis I.M., Kober H., Worhunsky P.D., Stevens M.C., Pearlson G.D., Potenza M.N. Diminished frontostriatal activity during processing of monetary rewards and losses in pathological gambling. Biol. psychiatry 2012, 71:749-757.
7. Balodis I.M., Kober H., Worhunsky P.D., White M.a, Stevens M.C., Pearlson G.D., Sinha R., et al. Monetary reward processing in obese individuals with and without binge eating disorder. Biol. psychiatry 2013, 73:877-886.
8. Balodis I.M., Potenza M.N. Anticipatory reward processing in addicted populations: a focus on the monetary incentive delay task. Biol. Psychiatry 2015, 77:434-444.
9. Barlow R.L., Alsiö J., Jupp B., Rabinovich R., Shrestha S., Roberts A.C., Robbins T.W., Dalley J.W. Markers of serotonergic function in the orbitofrontal cortex and dorsal raphé nucleus predict individual variation in spatial-discrimination serial reversal learning. Neuropsychopharmacology 2015, 40(7):1619-1630.
10. Bechara A., Damasio H., Damasio A.R. Emotion, decision-making and the orbitofrontal cortex. Cereb. Cortex 2000, 10:295-307.
11. Belin D., Everitt B.J. Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum. Neuron 2008, 57:432-441.
12. Berridge K.C. The debate over dopamine's role in reward: the case for incentive salience. Psychopharmacology (Berl.) 2007, 191:391-431.
13. Blanco C., Potenza M.N., Kim S.W., Ibáñez A., Zaninelli R., Saiz-Ruiz J., Grant J.E. A pilot study of impulsivity and compulsivity in pathological gambling. Psychiatry Res. 2009, 167:161-168.
14. Boileau I., et al. In vivo evidence for greater amphetamine-induced dopamine release in pathological gambling: a positron emission tomography study with [(11)C]-(+)-PHNO. Mol. Psychiatry 2014, 19(12):1305-1313.
15. Boog M., Hoppener P., Wetering BJ V.D., Goudriaan A.E., Boog M.C., Franken, I.H. Cognitive Inflexibility in Gamblers is Primarily Present in Reward-Related Decision Making. Front. Hum. Neurosci. 2014, 8:569.
16. Bossong M.G., Van Berckel B.,N., Boellaard R., Zuurman L., Schuit R.C., Windhorst A.D., Van Gerven J.M., Ramsey N.F., Lammertsma A.A., Kahn R.S. Delta 9-tetrahydrocannabinol induces dopamine release in the human striatum. Neuropsychopharmacology 2009, 34:759-766.
17. Brambilla F., Bellodi L., Perna G., Arancio C., Bertani A. Dopamine function in obsessive-compulsive disorder: growth hormone response to apomorphine stimulation. Biol. Psychiatry 1997, 42(10):889-897.
18. Britton J.C., Rauch S.L., Rosso I.M., Killgore W.D., Price L.M., Ragan J., Chosak A., Hezel D.M., Pine D.S., Leibenluft E., Pauls D.L., Jenike M.A., Stewart S.E. Cognitive inflexibility and frontal-cortical activation in pediatric obsessive-compulsive disorder. J. Am. Acad. Child Adolesc. Psychiatry 2010, 49:944-953.
19. Brody A.L., Mandelkern M.A., Olmstead R.E., Allen-Martinez Z., Scheibal D., Abrams A.L., Costello M.R., Farahi J., Saxena S., Monterosso J., London E.D. Ventral striatal dopamine release in response to smoking a regular vs a denicotinized cigarette. Neuropsychopharmacol. 2009, 34(2):282-289.
20. Buhler M., Vollstadt-Klein S., Kobiella A., Budde H., Reed L.J., Braus D.F., Buchel C., Smolka M.N. Nicotine dependence is characterized by disordered reward processing in a network driving motivation. Biol. Psychiatry 2009, 67:745-752.
21. Burguiere E., Monteiro P., Feng G., Graybiel a M. Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science 2013, 340:1243-1246.
22. Casey B.J., Craddock N., Cuthbert B.N., Hyman S.E., Lee F.S., Ressler K.J. DSM-5 and RDoC: progress in psychiatry research?. Nat. Rev. Neurosci. 2013, 14:810-814.
23. Chamberlain S.R., Fineberg N.A., Blackwell A.D., Robbins T.W., Sahakian B.J. Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. Am. J. Psychiatry 2006, 163:1282-1284.
24. Chamberlain S.R., Menzies L., Hampshire A., Suckling J., Fineberg N.A., del Campo N., Aitken M., Craig K., Owen A.M., Bullmore E.T., Robbins T.W., Sahakian B.J. Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives. Science 2008, 321:421-422.
25. Chen B.T., Yau H.J., Hatch C., Kusumoto-Yoshida I., Cho S.L., Hopf F.W., Bonci A. Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking. Nature 2013, 496:359-362.
26. Choi J.S., Shin Y.C., Jung W.H., Jang J.H., Kang D.H., Choi C.H., Choi S.W., Lee J.Y., Hwang J.Y., Kwon J.S. Altered brain activity during reward anticipation in pathological gambling and obsessive-compulsive disorder. PloS One 2012, 7:9.
27. Clarke H.F., Dalley J.W., Crofts H.S., Robbins T.W., Roberts A.C. Cognitive inflexibility after prefrontal serotonin depletion. Science 2004, 304:878-880.
28. Clarke H.F., Walker S.C., Crofts H.S., Dalley J.W., Robbins T.W., Roberts A.C. Prefrontal serotonin depletion affects reversal learning but not attentional set shifting. J. Neurosci. 2005, 25:532-538.
29. Clarke H.F., Walker S.C., Dalley J.W., Robbins T.W., Roberts A.C. Cognitive inflexibility after prefrontal serotonin depletion is behaviourally and neurochemically specific. Cereb. Cortex 2007, 17:18-27.
30. Clarke H.F., Robbins T.W., Roberts A.C. Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex. J. Neurosci. 2008, 28:10972-10982.
31. Clarke H.F., Hill G.J., Robbins T.W., Roberts A.C. Dopamine, but not serotonin, regulates reversal learning in the marmoset caudate nucleus. J. Neurosci. 2011, 31:4290-4297.
32. Crunelle C.L., Kaag A.M., van den Munkhof H.E., Reneman L., Homberg J.R., Sabbe B., van den Brink W., van Wingen G. Dysfunctional amygdala activation and connectivity with the prefrontal cortex in current cocaine users. Hum. Brain Mapp. 2015, 36(10):4222-4230.
33. Dager A.D., Anderson B.M., Rosen R., Khadka S., Sawyer B., Jiantonio-Kelly R.E., Austad C.S., Raskin S.A., Tennen H., Wood R.M., Fallahi C.R., Pearlson G.D. Functional magnetic resonance imaging (fMRI) response to alcohol pictures predicts subsequent transition to heavy drinking in college students. Addiction 2014, 109:585-595.
34. Daglish M.R.C., Williams T.M., Wilson S.J., Taylor L.G., Eap C.B., Augsburger M., et al. Brain dopamine response in human opioid addiction. Br. J. Psychiatry J. Ment. Sci. 2008, 193:65-72.
35. De Greck M., Enzi B., Prösch U., Gantman A., Tempelmann C., Northoff G. Decreased neuronal activity in reward circuitry of pathological gamblers during processing of personal relevant stimuli. Hum. Brain Mapp. 2010, 31:1802-1812.
36. De Ridder D., Vanneste S., Kovacs S., Sunaert S., Dom G. Transient alcohol craving suppression by rTMS of dorsal anterior cingulate: an fMRI and LORETA EEG study. Neurosci. Lett. 2011, 496:5-10.
37. Denys D., van der Wee N., Janssen J., de Geus F., Westenberg H.G. Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder. Biol. Psychiatry 2004, 55:1041-1045.
38. Denys D. Obsessionality & compulsivity: a phenomenology of obsessive-compulsive disorder. Philos. Ethics Humanit. Med. 2011, 6:3.
39. Denys D., de Vries F., Cath D., Figee M., Vulink N., Veltman D.J., van der Doef T.F., Boellaard R., Westenberg H., van Balkom A., Lammertsma A.A., van Berckel B.N. Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder. Eur. Neuropsychopharmacol. 2013, 23:1423-1431.
40. DDOCS: Denys et al., unpublished (under review PLoS One).
41. Derbyshire K.L., Chamberlain S.R., Odlaug B.L., Schreiber L.R., Grant J.E. Neurocognitive functioning in compulsive buying disorder. Ann. Clin. Psychiatry 2014, 26:57-63.
42. Deroche-Gamonet V., Belin D., Piazza P.V. Evidence for addiction-like behavior in the rat. Science 2004, 305:1014-1017.
43. de Ruiter M.B., Veltman D.J., Goudriaan A.E., Oosterlaan J., Sjoerds Z., van den Brink W. Response perseveration and ventral prefrontal sensitivity to reward and punishment in male problem gamblers and smokers. Neuropsychopharmacology 2009, 34:1027-1038.
44. DeVito E.E., Meda S.A., Jiantonio R., Potenza M.N., Krystal J.H., Pearlson G.D. Neural correlates of impulsivity in healthy males and females with family histories of alcoholism. Neuropsychopharmacology 2013, 38:1854-1863.
45. De Weijer B.A., van de Giessen E., van Amelsvoort T.A., Boot E., Braak B., Janssen I.M., van de Laar A., Fliers E., Serlie M.J., Booij J. Lower striatal dopamine D2/3 receptor availability in obese compared with non-obese subjects. EJNMMI Res. 2011, 16:37.
46. Diekhof E.K., Falkai P., Gruber O. Functional neuroimaging of reward processing and decision-making: a review of aberrant motivational and affective processing in addiction and mood disorders. Brain Res. Rev. 2008, 59:164-184.
47. Dunlop, K., Woodside, B., Olmsted, M., Colton, P., Giacobbe, P., Downar, J., 2015. Reductions in cortico-striatal hyperconnectivity accompany successful treatment of obsessive-compulsive disorder with dorsomedial prefrontal rTMS. Biological Psychiatry. Conference: 70th Annual Scientific Convention and Meeting of the Society of Biological Psychiatry, vol. 77 (9 Suppl. 1), 234S pp.
48. Dvorkin A., Silva C., McMurran T., Bisnaire L., Foster J., Szechtman H. Features of compulsive checking behavior mediated by nucleus accumbens and orbital frontal cortex. Eur. J. Neurosci. 2010, 32(9):1552-1563.
49. Eagle D.M., Noschang C., d'Angelo L.S., Noble C.A., Day J.O., Dongelmans M.L., Theobald D.E., Mar A.C., Urcelay G.P., Morein-Zamir S., Robbins T.W. The dopamine D2/D3 receptor agonist quinpirole increases checking-like behaviour in an operant observing response task with uncertain reinforcement: a novel possible model of OCD. Behav. Brain Res. 2014, 264:207-229.
50. Enoch M.-A. The influence of gene-environment interactions on the development of alcoholism and drug dependence. Curr. Psychiatry Rep. 2012, 14(2):150-158.
51. Ersche K.D., Roiser J.P., Robbins T.W., Sahakian B.J. Chronic cocaine but not chronic amphetamine use is associated with perseverative responding in humans. Psychopharmacology 2008, 197(3):421-431.
52. Ersche K.D., Roiser J.P., Abbott S., Craig K.J., Müller U., Suckling J., Ooi C., Shabbir S.S., Clark L., Sahakian B.J., Fineberg N.A., Merlo-Pich E.V., Robbins T.W., Bullmore E.T. Response perseveration in stimulant dependence is associated with striatal dysfunction and can be ameliorated by a D(2/3) receptor agonist. Biol. Psychiatry 2011, 70(8):754-762.
53. Everitt B.J., Robbins T.W. Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat. Neurosci. 2005, 8:1481-1489.
54. Everitt B.J., Belin D., Economidou D., Pelloux Y., Dalley J.W., Robbins T.W. Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2008, 363(1507):3125-3135.
55. Everitt B.J., Robbins T.W. From the ventral to the dorsal striatum: devolving views of their roles in drug addiction. Neurosci. Biobehav. Rev. 2013, 37:1946-1954.
56. Figee M., Booij J., Denys D. Molecular imaging of obsessive compulsive disorder. Understandig Neuropsychiatric Disorders: Insights from Neuroimaging. S.l 2010, Cambridge University Press. M.E. Shenton, B.I. Turetsky (Eds.).
57. Figee M., Vink M., de Geus F., Vulink N., Veltman D.J., Westenberg H., Denys D. Dysfunctional reward circuitry in obsessive-compulsive disorder. Biol. Psychiatry 2011, 69(9):867-874.
58. Figee M., Wielaard I., Mazaheri A., Denys D. Neurosurgical targets for compulsivity: what can we learn from acquired brain lesions?. Neurosci. Biobehav. Rev. 2013, 37(3):328-339.
59. Figee M., Luigjes J., Smolders R., Valencia-Alfonso C.E., van Wingen G., de Kwaasteniet B., Mantione M., Ooms P., de Koning P., Vulink N., Levar N., Droge L., van den Munckhof P., Schuurman P.R., Nederveen A., van den Brink W., Mazaheri A., Vink M., Denys D. Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. Nat. Neurosci. 2014, 17(9):1286.
60. Filip M., Frankowska M., Sadakierska-Chudy A., Suder A., Szumiec L., Mierzejewski P., Bienkowski P., Przegaliński E., Cryan J.F. GABA-B receptors as a therapeutic strategy in substance use disorders: focus on positive allosteric modulators. Neuropharmacology 2015, 88C:36-47.
61. Fineberg N.A., Brown A., Reghunandanan S., Pampaloni I. Evidence-based pharmacotherapy of obsessive-compulsive disorder. Int. J. Neuropsychopharmacol. 2012, 15:1173-1191.
62. Flaisher-Grinberg S., Klavir O., Joel D. The role of 5-HT2A and 5-HT2C receptors in the signal attenuation rat model of obsessive-compulsive disorder. Int. J. Neuropsychopharmacol. 2008, 11:811-825.
63. Franklin T.R., Acton P.D., Maldjian J.A., Gray J.D., Croft J.R., Dackis C.A., O'Brien C.P., Childress A.R. Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients. Biol. Psychiatry 2002, 51(2):134-142.
64. Freyer T., Klöppel S., Tüscher O., Kordon A., Zurowski B., Kuelz A.K., Speck O., Glauche V., Voderholzer U. Frontostriatal activation in patients with obsessive-compulsive disorder before and after cognitive behavioral therapy. Psychol. Med. 2011, 41(1):207-216.
65. Gillan C.M., Morein-Zamir S., Urcelay G.P., Sule A., Voon V., Apergis-Schoute A.M., Fineberg N.A., Sahakian B.J., Robbins T.W. Enhanced avoidance habits in obsessive-compulsive disorder. Biol. Psychiatry 2014, 75(8):631-638.
66. Gillan, C.M., Papmeyer, M., Morein-Zamir, S., Sahakian, B.J., Fineberg, N.A., Robbins, T.W., de Wit, S., 2011. Disruption in the balance between goal-directed behavior and habit learning in obsessive-compulsive disorder. Am. J. Psychiatry 168 (7), 718-726.
67. Ginley M.K., Whelan J.P., Meyers A.W., Relyea G.E., Pearlson G.D. Exploring a multidimensional approach to impulsivity in predicting college student gambling. J. Gambl. Stud. 2014, 30(2):521-536.
68. Goldsmith T.B., Shapira N.A., Keck P.E. Rapid remission of OCD with tramadol hydrochloride. Am. J. Psychiatry 1999, 156(4):660-661.
69. Goodman A. Neurobiology of addiction. An integrative review. Biochem. Pharmacol. 2008, 75(1):266-322.
70. Goudriaan A.E., Oosterlaan J., de Beurs E., van den Brink W. Neurocognitive functions in pathological gambling: a comparison with alcohol dependence, Tourette syndrome and normal controls. Addiction 2006, 101:534-547.
71. Goudriaan A.E., de Ruiter M.B., van den Brink W., Oosterlaan J., Veltman D.J. Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fMRI study. Addict. Biol. 2010, 15(4):491-503.
72. Grant J.E., Brewer J.A., Potenza M.N. The neurobiology of substance and behavioral addictions. CNS Spectr. 2006, 12:924-930.
73. Hampshire A., Owen A.M. Fractionating attentional control using event-related fMRI. Cereb. Cortex 2006, 16:1679-1689.
74. Harrison B.J., Soriano-Mas C., Pujol J., et al. Altered corticostriatal functional connectivity in obsessive-compulsive disorder. Arch. Gen. Psychiatry 2009, 66(11):1189-1200.
75. Harrison B.J., Pujol J., Cardoner N., Deus J., Alonso P., López-Solà M., Contreras-Rodríguez O., Real E., Segalàs C., Blanco-Hinojo L., Menchon J.M., Soriano-Mas C. Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder. Biol. Psychiatry 2013, 73(4):321-328.
76. Heilig M., Thorsell A., Sommer W.H., Hansson A.C., Ramchandani V.A., George D.T., et al. Translating the neuroscience of alcoholism into clinical treatments: from blocking the buzz to curing the blues. Neurosci. Biobehav. Rev. 2010, 35(2):334-344.
77. Holden, C., 2001. Behavioral addictions: do they exist? Science 294, 980-982.
78. Hollander E., Pallanti S., Baldini Rossi N., Sood E., Baker B.R., Buchsbaum M.S. Imaging monetary reward in pathological gamblers. World J. Biol. Psychiatry 2005, 6:113-120.
79. Hommer D.W., Bjork J.M., Gilman J.M. Imaging brain response to reward in addictive disorders. Ann. N .Y. Acad. Sci. 2011, 1216:50-61.
80. Hu, Y., Salmeron, B.J., Gu, H., Stein, E.A., Yang, Y. 2015. Impaired functional connectivity within and between frontostriatal circuits and its association with compulsive drug use and trait impulsivity in cocaine addiction. JAMA Psychiatry 72 (6), 584-592.
81. Hyatt C.J., Assaf M., Muska C., Rosen R.I., Thomas A.D., Potenza M.N., Johnson M.R., Hylton J.L., Andrews M.M., Reynolds B., Krystal J.H., Pearlson G.D. Reward-related dorsal striatal activity differences between former and current cocaine dependent subjects during an interactive competitive game. PloS One 2012, 7(5):e34917.
82. Insel T., Cuthbert B., Garvey M., Heinssen R., Pine D.S., Quinn K., Sanislow C., Wang P. Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am. J. Psychiatry 2010, 167(7):748-751.
83. Izquierdo A., Jentsch J.D. Reversal learning as a measure of impulsive and compulsive behavior in addictions. Psychopharmacology (Berl.) 2012, 219(2):607-620.
84. Joel D., Avisar A. Excessive lever pressing following post-training signal attenuation in rats: a possible animal model of obsessive compulsive disorder?. Behav. Brain Res. 2001, 123:77-87.
85. Joel D., Doljansky J. Selective alleviation of compulsive lever-pressing in rats by D1, but not D2, blockade: possible implications for the involvement of D1 receptors in obsessive-compulsive disorder. Neuropsychopharmacology 2003, 28:77-85.
86. Joel D., Ben-Amir E., Doljansky J., Flaisher S. 'Compulsive' lever-pressing in rats is attenuated by the serotonin re-uptake inhibitors paroxetine and fluvoxamine but not by the tricyclic antidepressant desipramine or the anxiolytic diazepam. Behav. Pharmacol. 2004, 15:241-252.
87. Jonkman S., Pelloux Y., Everitt B.J. Drug intake is sufficient, but conditioning is not necessary for the emergence of compulsive cocaine seeking after extended self-administration. Neuropsychopharmacology 2012, 37:1612-1619.
88. Jung W.H., Kang D.-H., Han J.Y., Jang J.H., Gu B.-M., Choi J.-S., Jung M.H., et al. Aberrant ventral striatal responses during incentive processing in unmedicated patients with obsessive-compulsive disorder. Acta Psychiatr. Scand. 2011, 123(5):376-386.
89. Kasanetz F., Deroche-Gamonet V., Berson N., Balado E., Lafourcade M., Manzoni O., Piazza P.V. Transition to addiction is associated with a persistent impairment in synaptic plasticity. Science 2010, 328:1709-1712.
90. Kaufmann C., Beucke J.C., Preuße F., Endrass T., Schlagenhauf F., Heinz A., Juckel G., Kathmann N. Medial prefrontal brain activation to anticipated reward and loss in obsessive-compulsive disorder. Neuroimage Clin. 2013, 2:212-220.
91. Kashyap H., Fontenelle L.F., Miguel E.C., Ferrão Y.A., Torres A.R., Shavitt R.G., Ferreira-Garcia R., Rosário D., C M, Yücel M. 'Impulsive compulsivity' in obsessive-compulsive disorder: a phenotypic marker of patients with poor clinical outcome. J. Psychiatr. Res. 2012, 46:1146-1152.
92. Kennett J., Matthews S., Snoek A. Pleasure and addiction. Front. Psychiatry 2013, 4:117.
93. Khazaal Y., Krenz S., Benmebarek M., Zullino D.F. Worsening of obsessive-compulsive symptoms under methadone tapering. Prog. Neuropsychopharmacol. Biol. Psychiatry 2006, 30(7):1350-1352.
94. Koran L.M., Aboujaoude E., Bullock K.D., Franz B., Gamel N., Elliott M. Double-blind treatment with oral morphine in treatment-resistant obsessive-compulsive disorder. J. Clin. Psychiatry 2005, 66(3):353-359.
95. Koob G.F. The dark side of emotion: the addiction perspective. Eur. J. Pharmacol. 2015, 753:73-87.
96. Koob G.F., Le Moal M. Plasticity of reward neurocircuitry and the "dark side" of drug addiction. Nat. Neurosci. 2005, 8(11):1442-1444.
97. Koob G.F., Volkow N.D. Neurocircuitry of addiction. Neuropsychopharmacology 2010, 35(1):217-238.
98. Kravitz A.V., Tomasi D., LeBlanc K.H., Baler R., Volkow N.D., Bonci A., Ferré S. Cortico-striatal circuits: novel therapeutic targets for substance use disorders. Brain Res. 1628 (Pt A) 2015, 186-198.
99. Kühn S., Gallinat J. Common biology of craving across legal and illegal drugs-a quantitative meta-analysis of cue-reactivity brain response. Eur. J. Neurosci. 2011, 33(7):1318-1326.
100. Kuepper, R., Ceccarini, J., Lataster, J., van Os, J., van Kroonenburgh, M., van Gerven, J.M., Marcelis, M., Van Laere, K., Henquet, C., 2013. Delta-9-tetrahydrocannabinol-induced dopamine release as a function of psychosis risk: 18F-fallypride positron emission tomography study. PLoS One 8 (7), e70378.
101. LeBeau R.T., Mischel E.R., Simpson H.B., Mataix-Cols D., Phillips K.A. Preliminary assessment of obsessive-compulsive spectrum disorder scales for DSM-5. J. Obsessive-Compuls. Relat. Disord. 2013, 2(2):114-118.
102. Limpens J.H., Damsteegt R., Broekhoven M.H., Voorn P., Vanderschuren L.J. Pharmacological inactivation of the prelimbic cortex emulates compulsive reward seeking in rats. Brain Res. 1628(Pt A) 2014, 210-218.
103. Martinez D., Saccone P.A., Liu F., Slifstein M., Orlowska D., Grassetti A., et al. Deficits in dopamine D(2) receptors and presynaptic dopamine in heroin dependence: commonalities and differences with other types of addiction. Biol. Psychiatry 2012, 71(3):192-198.
104. Martin-Soelch C., Missimer J., Leenders K.L., Schultz W. Neural activity related to the processing of increasing monetary reward in smokers and non-smokers. Eur. J. Neurosci. 2003, 18:680-688.
105. McCracken C.B., Grace A.A. High-frequency deep brain stimulation of the nucleus accumbens region suppresses neuronal activity and selectively modulates afferent drive in rat orbitofrontal cortex in vivo. J. Neurosci. 2007, 27:12601-12610.
106. Meda S.A., Stevens M.C., Potenza M.N., Pittman B., Gueorguieva R., Andrews M.A., Thomas A.D., Muska C., Hylton J.L., Pearlson G.D. Investigating the behavioral constructs of impulsivity domains using principal component analysis. Behav. Pharmacol. 2009, 20:390-399.
107. Menzies L., Achard S., Chamberlain S.R., Fineberg N.A., Chen C.-H., del Campo N., Sahakian B.J., Robbins T.W., Bullmore E.T. Neurocognitive endophenotypes of obsessive-compulsive disorder. Brain 2007, 130(Pt 12):3223-3236.
108. Meunier D., Ersche K.D., Craig K.J., Fornito A., Merlo-Pich E., Fineberg N.A., et al. Brain functional connectivity in stimulant drug dependence and obsessive-compulsive disorder. NeuroImage 2012, 59(2):1461-1468.
109. Müller C.P., Homberg J.R. The role of serotonin in drug use and addiction. Behav. Brain Res. 2015, 277:146-192.
110. Mundt, A, Klein, J., Joel, D., Heinz, A., 2009. Djodari-Irani A, Harnack D, Kupsch A, Orawa H, Juckel G, Morgenstern R, Winter C. High-frequency stimulation of the nucleus accumbens core and shell reduces quinpirole-induced compulsive checking in rats. Eur. J. Neurosci. 29 (12), 2401-2412.
111. Naqvi N.H., Rudrauf D., Damasio H., Bechara A. Damage to the insula disrupts addiction to cigarette smoking. Science 2007, 315(5811):531-534.
112. Nuttin B., Gielen F., van Kuyck K., Wu H., Luyten L., Welkenhuysen M., Brionne T.C., Gabriëls L. Targeting bed nucleus of the stria terminalis for severe obsessive-compulsive disorder: more unexpected lead placement in obsessive-compulsive disorder than in surgery for movement disorders. World Neurosurg. 2013, 80(3-4):S30.e11-S30.e16.
113. Odlaug B.L., Chamberlain S.R., Kim S.W., Schreiber L.R., Grant J.E. A neurocognitive comparison of cognitive flexibility and response inhibition in gamblers with varying degrees of clinical severity. Psychol. Med. 2011, 41:2111-2119.
114. Olver J.S., O' Doherty G., Jones G.R., Burrows G.D., Tochon-Danguy H.J., Ackermann U., Scott A., Norman T.R. Dopamine D1 receptor binding in the striatum of patients with obsessive-compulsive disorder. J. Affect. Disord. 2009, 114:321-326.
115. Ornstein T.J., Iddon J.L., Baldacchino A.M., Sahakian B.J., London M., Everitt B.J., Robbins T.W. Profiles of cognitive dysfunction in chronic amphetamine and heroin abusers. Neuropsychopharmacology 2000, 23:113-126.
116. Patel K.T., Stevens M.C., Meda S.A., Muska C., Thomas A.D., Potenza M.N., Pearlson G.D. Robust changes in reward circuitry during reward loss in current and former cocaine users during performance of a monetary incentive delay task. Biol. Psychiatry 2013, 72:529-537.
117. Pelloux Y., Dilleen R., Economidou D., Theobald D., Everitt B.J. Reduced forebrain serotonin transmission is causally involved in the development of compulsive cocaine seeking in rats. Neuropsychopharmacology 2012, 37(11):2505-2514.
118. Pelloux Y., Everitt B.J., Dickinson A. Compulsive drug seeking by rats under punishment: effects of drug taking history. Psychopharmacology 2007, 194:127-137.
119. Pelloux Y., Murray J.E., Everitt B.J. Differential roles of the prefrontal cortical subregions and basolateral amygdala in compulsive cocaine seeking and relapse after voluntary abstinence in rats. Eur. J. Neurosci. 2013, 38(7):3018-3026.
120. Perani D., Garibotto V., Gorini A., Moresco R.M., Henin M., Panzacchi A., Matarrese M., Carpinelli A., Bellodi L., Fazio F. In vivo PET study of 5HT(2a) serotonin and D(2) dopamine dysfunction in drug-naïve obsessive-compulsive disorder. Neuroimage 2008, 42:306-314.
121. Peters J., Kalivas P.W., Quirk G.J. Extinction circuits for fear and addiction overlap in prefrontal cortex. Learn. Mem. 2009, 16(5):279-288.
122. Pettorruso M., De Risio L., Martinotti G., Di Nicola M., Ruggeri F., Conte G., Di Giannantonio M., Janiri L. Targeting the glutamatergic system to treat pathological gambling: current evidence and future perspectives. BioMed Res. Int. 2014, 2014:109786.
123. Petry N.M. Should the scope of addictive behaviors be broadened to include pathological gambling?. Addiction 2006, 101(Suppl 1):S152-S160.
124. Pitchot W., Hansenne M., Moreno A.G., Ansseau M. Growth hormone response to apomorphine in obsessive-compulsive disorder. J. Psychiatry Neurosci. 1996, 21(5):343-345.
125. Potenza M.N., Steinberg M.A., Skudlarski P., Fulbright R.K., Lacadie C.M., Wilber M.K., Rounsaville B.J., Gore J.C., Wexler B.E. Gambling urges in pathological gamblers: an fMRI study. Arch. Gen. Psychiatry 2003, 60:828-836.
126. Potenza M.N. Should addictive disorders include non-substance-related conditions?. Addiction 2006, 101(s1):S142-S151.
127. Potenza M.N., Koran L.M., Pallanti S. The relationship between obsessive-compulsive and impulse control disorders: a current understanding and future research directions. Psychiatry Res. 2009, 170:22-31.
128. Protasio M.I., da Silva J.P., Arias-Carrion O., Nardi A.E., Machado S., Cruz M.S. Repetitive transcranial magnetic stimulation to treat substance use disorders and compulsive behavior. CNS Neurol. Disord. Drug Targets 2015, 14(3):331-340.
129. Rachman S., de Silva P., Roper G. The spontaneous decay of compulsive urges. Behav. Res. Ther. 1976, 14:445-453.
130. Radua J., van den Heuvel O.A., Surguladze S., Mataix-Cols D. Meta-analytical comparison of voxel-based morphometry studies in obsessive-compulsive disorder vs other anxiety disorders. Arch. Gen. Psychiatry. 2010, 67(7):701-711.
131. Remijnse P.L., Nielen M.M., van Balkom A.J., Cath D.C., van O.P., Uylings H.B., Veltman D.J. Reduced orbitofrontal-striatal activity on a reversal learning task in obsessive-compulsive disorder. Arch .Gen. Psychiatry 2006, 63(11):1225-1236.
132. Reuter J., Raedler T., Rose M., Hand I., Gläscher J., Büchel C. Pathological gambling is linked to reduced activation of the mesolimbic reward system. Nat. Neurosci. 2005, 8:147-148.
133. Robbins T.W., Gillan C.M., Smith D.G., Wit S.D., Ersche K.D. Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry. Trends Cogn. Sci. 2012, 16(1):81-91.
134. Robinson T.E., Berridge K.C. The incentive sensitization theory of addiction: some current issues. Philos. Trans. R. Soc. B Biol. Sci. 2008, 363(1507):3137-3146.
135. Rodriguez C.I., Kegeles L.S., Levinson A., Feng T., Marcus S.M., Vermes D., Flood P., Simpson H.B. Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: proof-of-concept. Neuropsychopharmacology 2013, 38(12):2475-2483.
136. Root D.H., Mejias-Aponte C.A., Qi J., Morales M. Role of glutamatergic projections from ventral tegmental area to lateral habenula in aversive conditioning. J. Neurosci. 2014, 34(42):13906-13910.
137. Rotge J., Guehl D., Dilharreguy B., Cuny E., Tignol J., Bioulac B., Allard M., et al. Provocation of obsessive-compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies. J. Psychiatry Neurosci. 2008, 33:405-412.
138. Rothkirch M., Schmack K., Schlagenhauf F., Sterzer P. Implicit motivational value and salience are processed in distinct areas of orbitofrontal cortex. NeuroImage 2012, 62(3):1717-1725.
139. Russo A.J., Pietsch S.C. Decreased hepatocyte growth factor (HGF) and gamma aminobutyric acid (GABA) in individuals with obsessive-compulsive disorder (OCD). Biomark. Insights 2013, 8:107-114.
140. Sakai Y., Narumoto J., Nishida S., et al. Corticostriatal functional connectivity in non-medicated patients with obsessive-compulsive disorder. Eur. Psychiatry 2011, 26(7):463-469.
141. Scherrer J.F., Xian H., Slutske W.S., Eisen S.A., Potenza M.N. Associations between obsessive-compulsive classes and pathological gambling in a national cohort of male twins. JAMA Psychiatry 2015, 72(4):342-349.
142. Schultz W. Predictive reward signal of dopamine neurons. J. Neurophysiol. 1998, 80:1-27.
143. Sesia T., Bizup B., Grace A.A. Evaluation of animal models of obsessive-compulsive disorder: correlation with phasic dopamine neuron activity. Int. J. Neuropsychopharmacol. 2013, 16(6):1295-1307.
144. Simpson H.B., Shungu D.C., Bender J., Mao X., Xu X., Slifstein M., Kegeles L.S. Investigation of cortical glutamate-glutamine and γ-aminobutyric acid in obsessive-compulsive disorder by proton magnetic resonance spectroscopy. Neuropsychopharmacology 2012, 37(12):2684-2692.
145. Sjoerds Z., de Wit S., van den Brink W., Beekman A.J., Penninx B.W.J.H., Veltman D.J. Behavioral and neuroimaging evidence for overreliance on habit learning in alcohol-dependent patients. Transl. Psychiatry 2013, 3:e337.
146. Stalnaker T.A., Takahashi Y., Roesch M.R., Schoenbaum G. Neural substrates of cognitive inflexibility after chronic cocaine exposure. Neuropharmacology 2009, 56(Suppl 1):S63-S72.
147. Stice E., Yokum S., Bohon C., Marti N., Smolen A. Reward circuitry responsivity to food predicts future increases in body mass: moderating effects of DRD2 and DRD4. Neuroimage 2010, 50:1618-1625.
148. Szechtman H., Sulis W., Eilam D. Quinpirole induces compulsive checking behavior in rats: a potential animal model of obsessive-compulsive disorder (OCD). Behav. Neurosci. 1998, 112:1475-1485.
149. Upadhyay J., Maleki N., Potter J., Elman I., Rudrauf D., Knudsen J., Wallin D., et al. Alterations in brain structure and functional connectivity in prescription opioid-dependent patients. Brain 2010, 133:2098-2114.
150. Valencia-Alfonso C.E., Luigjes J., Smolders R., Cohen M.X., Levar N., Mazaheri A., van den Munckhof P., Schuurman P.R., van den Brink W., Denys D. Effective deep brain stimulation in heroin addiction: a case report with complementary intracranial electroencephalogram. Biol. Psychiatry 2012, 71(8):e35-e37.
151. Vanderschuren L.J., Everitt B.J. Drug seeking becomes compulsive after prolonged cocaine self-administration. Science 2004, 305(5686):1017-1019.
152. Van de Giessen, E., Celik, F., Schweitzer, D.H., van den Brink, W., Booij, J., 2014. Dopamine D2/3 receptor availability and amphetamine-induced dopamine release in obesity. J. Psychopharmacol. 28 (9), 866-873.
153. Van Hell H.H., Vink M., Ossewaarde L., Jager G., Kahn R.S., Ramsey N.F. Chronic effects of cannabis use on the human reward system: an fMRI study. Eur. Neuropsychopharmacol. 2010, 20(3):153-163.
154. Van Holst R.J., van den Brink W., Veltman D.J., Goudriaan A.E. Why gamblers fail to win: a review of cognitive and neuroimaging findings in pathological gambling. Neurosci. Biobehav. Rev. 2010, 34(1):87-107.
155. Van Holst R.J., Schilt T. Drug-related decrease in neuropsychological functions of abstinent drug users. Curr. Drug. Abus. Rev. 2011, 4(1):42-56.
156. Van Holst R.J., Lemmens J.S., Valkenburg P.M., Peter J., Veltman D.J., Goudriaan A.E. Attentional bias and disinhibition toward gaming cues are related to problem gaming in male adolescents. J. Adolesc. Health 2012, 50:541-546.
157. van Holst R.J., Veltman D.J., Büchel C., van den Brink W., Goudriaan A.E. Distorted expectancy coding in problem gambling: is the addictive in the anticipation?. Biol. Psychiatry 2012, 71(8):741-748.
158. van Holst, R.J., Clark, L., Veltman, D.J., van den Brink, W., Goudriaan, A.E., 2014. Enhanced striatal responses during expectancy coding in alcohol dependence. Drug and Alcohol Dependence 142, 204-208.
159. Van Huijstee A.N., Mansvelder H.D. Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction. Front. Cell. Neurosci. 2015, 8:466.
160. Vanes L.D., van Holst R.J., Jansen J.M., van den Brink W., Oosterlaan J., Goudriaan A.E. Contingency learning in alcohol dependence and pathological gambling: learning and unlearning reward contingencies. Alcohol. Clin. Exp. Res. 2014, 38(6):1602-1610.
161. Vlachou S., Markou A. GABAB receptors in reward processes. Adv. Pharmacol. 2010, 58:315-371.
162. Vollstädt-Klein S., Wichert S., Rabinstein J., Bühler M., Klein O., Ende G., et al. Initial, habitual and compulsive alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum. Addiction 2010, 105(10):1741-1749.
163. Volkow N.D., Ding Y.S., Fowler J.S., Wang G.J., Logan J., Gatley J.S., et al. Is methylphenidate like cocaine? Studies on their pharmacokinetics and distribution in the human brain. Arch. Gen. Psychiatry 1995, 52(6):456-463.
164. Volkow, N.D., Fowler, J.S., Wang, G.J., Baler, R., Telang, F., 2009. Imaging dopamine's role in drug abuse and addiction. Neuropharmacol. 56 (Suppl. 1), 3-8.
165. Volkow N.D., Wang G.J., Fowler J.S., Logan J., Gatley S.J., Hitzemann R., Chen A.D., Dewey S.L., Pappas N. Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects. Nature 1997, 386(6627):830-833.
166. Volkow N.D., Wang G.J., Telang F., Fowler J.S., Thanos P.K., Logan J., Alexoff D., Ding Y.S., Wong C., Ma Y., Pradhan K. Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors. Neuroimage 2008, 42(4):1537-1543.
167. Volkow N.D., Wang G.-J., Fowler J.S., Tomasi D., Telang F. Addiction: beyond dopamine reward circuitry. Proc. Natl. Acad. Sci. USA 2011, 108(37):15037-15042.
168. Volkow N.D., Wang G.-J., Fowler J.S., Tomasi D. Addiction circuitry in the human brain. Annu. Rev. Pharmacol. Toxicol. 2012, 52:321-336.
169. Voon V., Derbyshire K., Ruck C., Irvine M.A., Worbe Y., Enander J., et al. Disorders of compulsivity: a common bias towards learning habits. Mol. Psychiatry 2015, 20(3):345-352.
170. Walitza S., Marinova Z., Grünblatt E., Lazic S.E., Remschmidt H., Vloet T.D., Wendland J.R. Trio study and meta-analysis support the association of genetic variation at the serotonin transporter with early-onset obsessive-compulsive disorder. Neurosci. Lett. 2014, 580:100-103.
171. Wang G.J., Volkow N.D., Logan J., Pappas N.R., Wong C.T., Zhu W., Netusil N., Fowler J.S. Brain dopamine and obesity. Lancet 2001, 357(9253):354-357.
172. Watkins L.H., Sahakian B.J., Robertson M.M., Veale D.M., Rogers R.D., Pickard K.M., et al. Executive function in Tourette's syndrome and obsessive-compulsive disorder. Psychol. Med. 2005, 35:571-582.
173. Welkenhuysen M., Gligorijevic I., Ameye L., Prodanov D., Van Huffel S., Nuttin B. Neuronal activity in the bed nucleus of the stria terminalis in a rat model for obsessive-compulsive disorder. Behav. Brain Res. 2013, 240:52-59.
174. Whiteside S.P., Port J.D., Abramowitz J.S. A meta-analysis of functional neuroimaging in obsessive-compulsive disorder. Psychiatry Res. 2004, 132(1):69-79.
175. Winter C., Mundt A., Jalali R., Joel D., Harnack D., Morgenstern R., Juckel G., Kupsch A. High frequency stimulation and temporary inactivation of the subthalamic nucleus reduce quinpirole-induced compulsive checking behavior in rats. Exp. Neurol. 2008, 210(1):217-218.
176. Woicik P.A., Urban C., Alia-Klein N., Henry A., Maloney T., Telang F., Wang G.J., Volkow N.D., Goldstein R.Z. A pattern of perseveration in cocaine addiction may reveal neurocognitive processes implicit in the Wisconsin card sorting test. Neuropsychologia 2011, 49(7):1660-1669.
177. Wrase J., Schlagenhauf F., Kienast T., Wüstenberg T., Bermpohl F., Kahnt T., Beck A., Ströhle A., Juckel G., Knutson B., Heinz A. Dysfunction of reward processing correlates with alcohol craving in detoxified alcoholics. Neuroimage 2007, 35(2):787-794.
178. Willuhn I., Burgeno L.M., Everitt B.J., Phillips P.E.M. Hierarchical recruitment of phasic dopamine signaling in the striatum during the progression of cocaine use. Proc. Natl. Acad. Sci. USA 2012, 109:20703-20708.
179. Wu K., Hanna G.L., Rosenberg D.R., Arnold P.D. The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder. Pharmacol. Biochem. Behav. 2012, 100(4):726-735.
180. Xie Y., Heida T., Stegenga J., Zhao Y., Moser A., Tronnier V., Feuerstein T.J., Hofmann U.G. High-frequency electrical stimulation suppresses cholinergic accumbens interneurons in acute rat brain slices through GABAB receptors. Eur. J. Neurosci. 2014, 40(11):3653-3662.
181. Xue Y., Steketee J.D., Sun W. Inactivation of the central nucleus of the amygdala reduces the effect of punishment on cocaine self-administration in rats. Eur. J. Neurosci. 2012, 35:775-783.
182. Yan N., Chen N., Zhu H., Zhang J., Sim M., Ma Y., Wang W. High-frequency stimulation of nucleus accumbens changes in dopaminergic reward circuit. PloS One 2013, 8(11):e79318.
183. Yarosh H.L., Hyatt C.J., Meda S.A., Jiantonio-Kelly R., Potenza M.N., Assaf M., Pearlson G. Relationships between reward sensitivity, risk-taking and family history of alcoholism during an interactive competitive fMRI task. PloS One 2014, 9:e88188.