The dopamine D2/D3 receptor agonist quinpirole increases checking-like behaviour in an operant observing response task with uncertain reinforcement: A novel possible model of OCD

Behavioural Brain Research

Volumn 264, Issue , 2014, Pages 207-229

  Eagle, Dawn M ^a   Noschang, Cristie ^a   d'Angelo, Laure Sophie Camilla ^a   Noble, Christie A ^a   Day, Jacob O ^a   Dongelmans, Marie Louise ^a   Theobald, David E ^a   Mar, Adam C ^a   Urcelay, Gonzalo P ^a   Morein Zamir, Sharon ^a   Robbins, Trevor W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Checking; Dopamine; Obsessive compulsive disorder; Rat

Indexed keywords

DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; QUINPIROLE; SULPIRIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR CHANGE; CONTROLLED STUDY; DRUG EFFECT; ELEVATED PLUS MAZE TEST; MALE; MENTAL TASK; NEUROMODULATION; NONHUMAN; OBSERVING RESPONSE TASK; OBSESSIVE COMPULSIVE DISORDER; PRIORITY JOURNAL; RAT; REINFORCEMENT; REWARD; SENSITIVITY ANALYSIS; TASK PERFORMANCE; TREATMENT RESPONSE; VALIDATION PROCESS;

CHECKING; DOPAMINE; OBSESSIVE-COMPULSIVE DISORDER; RAT;

ANIMALS; ANXIETY; COMPULSIVE BEHAVIOR; CONDITIONING, OPERANT; DISEASE MODELS, ANIMAL; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; MALE; MAZE LEARNING; OBSERVATION; PSYCHOMOTOR PERFORMANCE; QUINPIROLE; RATS; REINFORCEMENT (PSYCHOLOGY); REINFORCEMENT SCHEDULE; STATISTICS, NONPARAMETRIC; SULPIRIDE;

EID: 84894645038     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2013.12.040     Document Type: Article

References (58)

1. Fontenelle L.F., Mendlowicz M.V., Versiani M. The descriptive epidemiology of obsessive-compulsive disorder. Prog Neuro-Psychoph 2006, 30(3):327-337.
2. Zohar A.H. The epidemiology of obsessive-compulsive disorder in children and adolescents. Child Adolesc Psychiatr Clin N Am 1999, 8(3):445-460.
3. Stasik S.M., Naragon-Gainey K., Chmielewski M., Watson D. Core OCD symptoms: exploration of specificity and relations with psychopathology. J Anxiety Disord 2012, 26:859-870.
4. Robbins T.W., Gillan C.M., Smith D.G., de Wit S., Ersche K.D. Neurocognitive endophenotypes of impulsivity and compulsivity: towards dimensional psychiatry. Trends Cogn Sci 2012, 16:81-91.
5. Hinds A.L., Woody E.Z., Van Ameringen M., Schmidt L.A., Szechtman H. When too much is not enough: obsessive-compulsive disorder as a pathology of stopping, rather than starting. PLoS ONE 2012, 7(1):e305. 10.1371/journal.pone.0030586.
6. Linkovski O., Kalanthroff E., Henik A., Anholt G. Did I turn off the stove? Good inhibitory control can protect from influences of repeated checking. J Behav Ther Exp Psy 2013, 44(1):30-36. 10.1016/j.jbtep.2012.07.002.
7. Rotge J.Y., Langbour N., Dilharreguy B., Bordessoulles M., Guehl D., Bioulac B., Martin-Guehl C., Jaafari N., Aouizerate B., Allard M., Burbaud P. Contextual and behavioural influences on uncertainty in obsessive-compulsive disorder. Cortex 2013, (online publication).
8. Menzies L., Chamberlain S.R., Laird A.R., Thelen S., Sahakian B.J., Bullmore E.T. Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited. Neurosci Biobehav Rev 2008, 32:525-549.
9. Rotge J.Y., Guehl D., Dilharreguy B., Cuny E., Tignol J., Bioulac B., et al. Provocation of obsessive-compulsive symptoms: a quantitative voxel-based meta-analysis of functional neuroimaging studies. J Psychiat Neur 2008, 33:405-412.
10. Phillips M.L., Marks I.M., Senior C., Lythgoe D., O'Dwyer A.M., Meehan O., Williams S.C., Brammer M.J., Bullmore E.T., McGuire P.K. A differential neural response in obsessive-compulsive disorder patients with washing compared with checking symptoms to disgust. Psychol Med 2000, 30(5):1037-1050.
11. Mataix-Cols D., Wooderson S., Lawrence N., Brammer M.J., Speckens A., Phillips M.L. Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder. Arch Gen Psychiat 2004, 61:564-576.
12. Pallanti S., Hollander E., Bienstock C., et al. Treatment non-response in OCD: methodological issues and operational definitions. Int J Neuropsychop 2002, 5:181-191.
13. Metin O., Yazici K., Tot S., Yazici A.E. Amisulpiride augmentation in treatment resistant obsessive-compulsive disorder: an open trial. Hum Psychopharmacol 2003, 18(6):463-467.
14. Denys D., Zohar J., Westenberg H.G. The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence. J Clin Psychiat 2004, 65(Suppl. 14):11-17.
15. Denys D., van der Wee N., Janssen J., De Geus F., Westenberg H.G.M. Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder. Biol Psychiatry 2004, 55:1041-1045.
16. Szechtman H., Sulis W., Eilam D. Quinpirole induces compulsive checking behavior in rats: a potential animal model of obsessive-compulsive disorder (OCD). Behav Neurosci 1998, 112(6):1475-1485.
17. Szechtman H., Culver K., Eilam D. Role of dopamine systems in obsessive-compulsive disorder (OCD): implications from a novel psychostimulant-induced animal model. Pol J Pharmacol 1999, 51(1):55-61. Review.
18. Winter C., Mundt A., Jalali R., Joel D., Harnack D., Morgenstern R., Juckel G., Kupsch A. High frequency stimulation and temporary inactivation of the subthalamic nucleus reduce quinpirole-induced compulsive checking behavior in rats. Exp Neurol 2008, 210(1):217-228.
19. Mundt A., Klein J., Joel D., Heinz A., Djodari-Irani A., Harnack D., Kupsch A., Orawa H., Juckel G., Morgenstern R., Winter C. High-frequency stimulation of the nucleus accumbens core and shell reduces quinpirole-induced compulsive checking in rats. Eur J Neurosci 2009, (12):2401-2412. 10.1111/j.1460-9568.2009.06777.x.
20. Dvorkin A., Silva C., McMurran T., Bisnaire L., Foster J., Szechtman H. Features of compulsive checking behavior mediated by nucleus accumbens and orbital frontal cortex. Eur J Neurosci 2010, 32(9):1552-1563. 10.1111/j.1460-9568.2010.07398.
21. Schmidt T.T., Rea E., Shababi-Klein J., Panagis G., Winter C. Enhanced reward-facilitating effects of d-amphetamine in rats in the quinpirole model of obsessive-compulsive disorder. Int J Neuropsychopharmacol 2013, 16(5):1083-1091. 10.1017/S1461145712000983.
22. Tucci M.C., Dvorkin-Gheva A., Graham D., Amodeo S., Cheon P., Kirk A., Peel J., Taji L., Szechtman H. Effects of the serotonergic agonist mCPP on male rats in the quinpirole sensitization model of obsessive-compulsive disorder (OCD). Psychopharmacology (Berl) 2013, 227(2):277-285. 10.1007/s00213-013-2976-1.
23. Shahan T.A. Observing behaviour: effects of rate and magnitude of primary reinforcement. J Exp Anal Behav 2002, 78:161-178.
24. Eckerman D.A. Uncertainty reduction and conditioned reinforcement. Psychol Rec 1973, 23:39-47.
25. Albelda N., Joel D. Animal models of obsessive-compulsive disorder: exploring pharmacology and neural substrates. Neurosci Biobehav Rev 2012, 36(1):47-63.
26. d'Angelo L-SC, Eagle D.M., Grant J.E., Fineberg N.A., Robbins T.W., Chamberlain S.R. Animal models of obsessive-compulsive spectrum disorders. CNS Spectr 2013, 2:1-22.
27. McMillan J.C. Average uncertainty as a determinant of observing behaviour. J Exp Anal Behav 1974, 22:401-408.
28. van den Hout M.A., Kindt M. Repeated checking causes memory distrust. Behav Res Ther 2003, 41:301316. 10.1016/S0005-7967(02)00012-8.
29. van den Hout M.A., Kindt M. Obsessive-compulsive disorder and the paradoxical effects of perseverative behaviour on experienced uncertainty. J Behav Ther Exp Psychiatry 2004, 35:165181. 10.1016/j.jbtep.2004.04.007.
30. Fiorillo C.D., Tobler P.N., Schultz W. Discrete coding of reward probability and uncertainty by dopamine neurons. Science 2003, 299(5614):1898-1902.
31. Cocker P.J., Dinelle K., Kornelson R., Sossi V., Winstanley C.A. Irrational choice under uncertainty correlates with lower striatal D(2/3) receptor binding in rats. J Neurosci 2012, 32(44):15450-15457. 10.1523/JNEUROSCI.0626-12.2012.
32. Floresco S.B. Prefrontal dopamine and behavioral flexibility: shifting from an "inverted-U" toward a family of functions. Front Neurosci 2013, 19(7):62. 10.3389/fnins.2013.00062.
33. Pellow S., File S.E. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav 1986, 24(3):525-529.
34. Njung'e K., Handley S.L. Evaluation of marble-burying behavior as a model of anxiety. Pharmacol Biochem Behav 1991, 38(1):63-67.
35. Cardinal R.N., Aitken M.R. Whisker: a client-server high-performance multimedia research control system. Behav Res Methods 2010, 42:1059-1071.
36. Wyckoff L.B. The role of observing responses in discrimination learning. Psychol Rev 1952, 59:431-442.
37. Szechtman H., Talangbayan H., Eilam D. Environmental and behavioral components of sensitization induced by the dopamine agonist quinpirole. Behav Pharmacol 1993, 4(4):405-410.
38. Di Chiara G., Porceddu M.L., Vargiu L., Argiolas A., Gessa G.L. Evidence for dopamine receptor in the mouse brain mediating sedation. Nature 1976, 264:564.
39. Storey V.J., Middlemiss D.N., Reavill C. Effect of haloperidol and (-)-sulpiride on dopamine agonist-induced hypoactivity. Neuropharmacology 1995, 34(4):449-455.
40. Schneider T., Popik P. Attenuation of estrous cycle-dependent marble burying in female rats by acute treatment with progesterone and antidepressants. Psychoneuroendocrinology 2007, 32:651-659.
41. Passetti F., Levita L., Robbins T.W. Sulpiride alleviates the attentional impairments of rats with medial prefrontal cortex lesions. Behav Brain Res 2003, 138(1):59-69.
42. Howell D.C. Statistical methods for psychology 1997, Duxbury, Belmont, CA. 4th ed.
43. Lieberman D.A. Secondary reinforcement and information as determinants of observing behavior in monkeys (Macaca mulatta). Learn Motiv 1972, 3:341-358.
44. Szechtman H., Eckert M.J., Tse W.S., Boersma J.T., Bonura C.A., McClelland J.Z., Culver K.E., Eilam D. Compulsive checking behavior of quinpirole-sensitized rats as an animal model of Obsessive-Compulsive Disorder (OCD): form and control. BMC Neurosci 2001, 2:4.
45. Einat H., Szechtman H. Long-lasting consequences of chronic treatment with the dopamine agonist quinpirole for the undrugged behavior of rats. Behav Brain Res 1993, 54(1):35-41.
46. Gentes E.L., Ruscio A.M. A meta-analysis of the relation of intolerance of uncertainty to symptoms of generalized anxiety disorder, major depressive disorder, and obsessive-compulsive disorder. Clin Psychol Rev 2011, 31(6):923-933. 10.1016/j.cpr.2011.05.001.
47. Floresco S.B., Jentsch J.D. Pharmacological enhancement of memory and executive functioning in laboratory animals. Neuropsychopharmacology 2010, 36(1):227-250.
48. Naneix F., Marchand A.R., Pichon A., Pape J.-R., Coutureau E. Adolescent stimulation of D2 receptors alters the maturation of dopamine-dependent goal-directed behaviour. Neuropsychopharmacology 2013, 38:1566-1574.
49. Pesek-Cotton E.F., Johnson J.E., Newland M.C. Reinforcing behavioral variability: an analysis of dopamine-receptor subtypes and intermittent reinforcement. Pharmacol Biochem Behav 2011, 97(3):551-559. 10.1016/j.pbb.2010.10.011.
50. Amato D., Milella M.S., Badiani A., Nencini P. Compulsive-like effects of repeated administration of quinpirole on drinking behavior in rats. Behav Brain Res 2006, 172(1):1-13.
51. Boulougouris V., Castañé A., Robbins T.W. Dopamine D2/D3 receptor agonist quinpirole impairs spatial reversal learning in rats: investigation of D3 receptor involvement in persistent behavior. Psychopharmacology (Berl) 2009, 202(4):611-620. 10.1007/s00213-008-1341-2.
52. Joel D., Avisar A., Doljansky J. Enhancement of excessive lever-pressing after post-training signal attenuation in rats by repeated administration of the D1 antagonist SCH 23390 or the D2 agonist quinpirole, but not the D1 agonist SKF 38393 or the D2 antagonist haloperidol. Behav Neurosci 2001, 115(6):1291-1300.
53. Bushnell P.J., Levin E.D. Effects of dopaminergic drugs on working and reference memory in rats. Pharmacol Biochem Behav 1993, 45(4):765-776.
54. Wenger G.R., Dews P.B. The effects of phencyclidine, ketamine, delta-amphetamine and pentobarbital on schedule-controlled behavior in the mouse. J Pharmacol Exp Ther 1976, 196(3):616-624.
55. Robbins T.W. The acquisition of responding with conditioned reinforcement: effects of pipradrol, methylphenidate, d-amphetamine, and nomifensine. Psychopharmacology (Berl) 1978, 58(1):79-87.
56. Vorhees C.V., Johnson H.L., Burns L.N., Williams M.T. Developmental treatment with the dopamine D2/3 agonist quinpirole selectively impairs spatial learning in the Morris water maze. Neurotoxicol Teratol 2009, 31(1):1-10. 10.1016/j.ntt.2008.09.003.
57. Sullivan R.M., Talangbayan H., Einat H., Szechtman H. Effects of quinpirole on central dopamine systems in sensitized and non-sensitized rats. Neuroscience 1998, 83(3):781-789.
58. Chen J.F., Aloyo V.J., Weiss B. Continuous treatment with the D2 dopamine receptor agonist quinpirole decreases D2 dopamine receptors, D2 dopamine receptor messenger RNA and proenkephalin messenger RNA, and increases mu opioid receptors in mouse striatum. Neuroscience 1993, 54(3):669-680.