Response perseveration in stimulant dependence is associated with striatal dysfunction and can be ameliorated by a D 2/3 receptor agonist

Biological Psychiatry

Volumn 70, Issue 8, 2011, Pages 754-762

  Ersche, Karen D ^a,b   Roiser, Jonathan P ^d   Abbott, Sanja ^b,c   Craig, Kevin J ^b   Mller, Ulrich ^a   Suckling, John ^a,b   Ooi, Cinly ^a,b   Shabbir, Shaila S ^e   Clark, Luke ^b,c   Sahakian, Barbara J ^a,b   Fineberg, Naomi A ^g   Merlo Pich, Emilio V ^f   Robbins, Trevor W ^b,c   Bullmore, Edward T ^a,b,e  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c University of Cambridge   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e GLAXOSMITHKLINE   (United Kingdom)

^f Neurosciences Centre for Excellence in Drug Discovery   (Italy)

^g QUEEN ELIZABETH II HOSPITAL   (United Kingdom)

Author keywords

Dopamine; fMRI; obsessive compulsive disorder; pramipexole; probabilistic reversal learning; substance dependence

Indexed keywords

AMISULPRIDE; PLACEBO; PRAMIPEXOLE;

ADULT; ARTICLE; BRAIN DYSFUNCTION; CAUDATE NUCLEUS; CLINICAL ARTICLE; COMPULSION; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DEPENDENCE; DRUG MEGADOSE; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MALE; MIDDLE FRONTAL GYRUS; OBSESSIVE COMPULSIVE DISORDER; OXYGEN BLOOD LEVEL; PARIETAL GYRUS; PERSEVERATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; STIMULANT DEPENDENCE; TASK PERFORMANCE;

ADULT; AMPHETAMINE-RELATED DISORDERS; BENZOTHIAZOLES; BRAIN MAPPING; COCAINE-RELATED DISORDERS; COMPULSIVE BEHAVIOR; CORPUS STRIATUM; DOPAMINE AGONISTS; DOPAMINE ANTAGONISTS; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; OBSESSIVE-COMPULSIVE DISORDER; REVERSAL LEARNING; SULPIRIDE;

EID: 80053499190     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2011.06.033     Document Type: Article

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