GABAB receptors as a therapeutic strategy in substance use disorders: Focus on positive allosteric modulators

Neuropharmacology

Volumn 88, Issue , 2015, Pages 36-47

  Filip, Małgorzata ^a   Frankowska, Małgorzata ^a   Sadakierska Chudy, Anna ^a   Suder, Agata ^a   Szumiec, Łukasz ^a   Mierzejewski, Paweł ^b   Bienkowski, Przemyslaw ^b   Przegaliński, Edmund ^a   Cryan, John F ^c,d  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

^b INSTITUTE OF PSYCHIATRY AND NEUROLOGY   (Poland)

^c UNIVERSITY COLLEGE CORK   (Ireland)

^d UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Abuse; Addiction; Discrimination; Drug seeking behavior; GABAB receptors; Reward; Sensitization

Indexed keywords

2 [1 [2 (4 CHLOROPHENYL) 5 METHYLPYRAZOLO[1,5 A]PYRIMIDIN 7 YL] 2 PIPERIDINYL]ETHANOL; 2,6 DI TERT BUTYL 4 (3 HYDROXY 2,2 DIMETHYLPROPYL)PHENOL; 3,5 BIS(1,1 DIMETHYLETHYL) 4 HYDROXY ALPHA,ALPHA DIMETHYLBENZENEPROPANAL; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; 5,7 BIS(1,1 DIMETHYLETHYL) 3 HYDROXY 3(TRIFLUOROMETHYL) 2(3H) BENZOFURANONE; ADX 71441; BACLOFEN; BHF 177; DRUGS USED IN THE TREATMENT OF ADDICTION; METHYL 2 (1 ADAMANTANECARBOXAMIDO) 4 ETHYL 5 METHYLTHIOPHENE 3 CARBOXYLIC ACID; METHYL 2 (CYCLOHEXANECARBOXAMIDO) 4 ETHYL 5 METHYLTHIOPHENE 3 CARBOXYLIC ACID; N [5 [4 (4 CYANO 3 METHOXYBENZYL) 6 METHOXY 3,5 DIOXY 4,5 DIHYDRO 1,2,4 TRIAIN 2(3H) YL] 2 FLUOROPHENYL]ACETAMIDE; N,N' DICYCLOPENTYL 2 METHYLTHIO 5 NITRO 4,6 PYRIMIDINEDIAMINE; NVP BHF 177; UNCLASSIFIED DRUG; BENZODIAZEPINE RECEPTOR AFFECTING AGENT;

ALCOHOL ABUSE; ALCOHOLISM; ALLOSTERISM; ANALGESIC ACTIVITY; COCAINE DEPENDENCE; DEPRESSION; DIZZINESS; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG RESEARCH; DRUG TARGETING; HUMAN; HYPERTHERMIA; LOW DRUG DOSE; MENTAL DISEASE; METHAMPHETAMINE DEPENDENCE; MUSCLE WEAKNESS; NAUSEA; NERVE CELL PLASTICITY; NEUROCHEMISTRY; NONHUMAN; OSTEOARTHRITIS; PROTEIN EXPRESSION; REVIEW; REWARD; SEDATION; SUBSTANCE ABUSE; TOBACCO DEPENDENCE; TRANQUILIZING ACTIVITY; TREATMENT OUTCOME; VISCERAL PAIN; WITHDRAWAL SYNDROME; ANIMAL; CLINICAL TRIAL (TOPIC); METABOLISM; PATHOPHYSIOLOGY; SUBSTANCE-RELATED DISORDERS;

ALLOSTERIC REGULATION; ANIMALS; CLINICAL TRIALS AS TOPIC; GABA MODULATORS; HUMANS; RECEPTORS, GABA-B; SUBSTANCE-RELATED DISORDERS;

EID: 84908401519     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.06.016     Document Type: Review

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