Deficits in dopamine D 2 receptors and presynaptic dopamine in heroin dependence: Commonalities and differences with other types of addiction

Biological Psychiatry

Volumn 71, Issue 3, 2012, Pages 192-198

  Martinez, Diana ^a   Saccone, Phillip A ^a   Liu, Fei ^a   Slifstein, Mark ^a   Orlowska, Daria ^a   Grassetti, Alex ^a   Cook, Stephanie ^a   Broft, Allegra ^a   Van Heertum, Ronald ^b   Comer, Sandra D ^a  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b NONE   (United States)

Author keywords

Addiction; dopamine; dopamine receptors; drug self administration; heroin dependence; PET imaging

Indexed keywords

DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; METHYLPHENIDATE; RACLOPRIDE C 11;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; CORRELATIONAL STUDY; DOPAMINE RELEASE; DOPAMINERGIC TRANSMISSION; DRUG SEEKING BEHAVIOR; DRUG SELF ADMINISTRATION; FEMALE; HEROIN DEPENDENCE; HUMAN; MALE; POSITRON EMISSION TOMOGRAPHY; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PUTAMEN; RECEPTOR BINDING;

ADULT; BEHAVIOR, ADDICTIVE; CHOICE BEHAVIOR; CORPUS STRIATUM; DOPAMINE; FEMALE; HEROIN; HEROIN DEPENDENCE; HUMANS; MALE; METHYLPHENIDATE; NEUROIMAGING; POSITRON-EMISSION TOMOGRAPHY; PRESYNAPTIC TERMINALS; RACLOPRIDE; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE D2; SELF ADMINISTRATION;

EID: 84855442420     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2011.08.024     Document Type: Article

References (44)

1. D. Martinez, J.H. Kim, J. Krystal, A. Abi-Dargham Imaging the neurochemistry of alcohol and substance abuse Neuroimaging Clin N Am 17 2007 539 555 x (Pubitemid 350026399)
2. N.D. Volkow, J.S. Fowler, G.J. Wang, R. Baler, F. Telang Imaging dopamine's role in drug abuse and addiction Neuropharmacology 56 Suppl 1 2009 3 9
3. A. Breier, T.P. Su, R. Saunders, R.E. Carson, B.S. Kolachana, A. deBartolomeis Schizophrenia is associated with elevated amphetamine-induced synaptic dopamine concentrations: Evidence from a novel positron emission tomography method Proc Natl Acad Sci U S A 94 1997 2569 2574 (Pubitemid 27136916)
4. M. Laruelle Imaging synaptic neurotransmission with in vivo binding competition techniques: A critical review J Cereb Blood Flow Metab 20 2000 423 451 (Pubitemid 30164887)
5. 11C]raclopride in the human brain Synapse 16 1994 255 262 (Pubitemid 24111524)
6. J. Hietala, C. West, E. Syvalahti, K. Nagren, P. Lehikoinen, P. Sonninen Striatal D2 dopamine receptor binding characteristics in vivo in patients with alcohol dependence Psychopharmacology 116 1994 285 290 (Pubitemid 24345278)
7. N.D. Volkow, G.J. Wang, J.S. Fowler, J. Logan, R. Hitzemann, Y.S. Ding Decreases in dopamine receptors but not in dopamine transporters in alcoholics Alcohol Clin Exp Res 20 1996 1594 1598 (Pubitemid 26428110)
8. G.J. Wang, N.D. Volkow, J.S. Fowler, J. Logan, N.N. Abumrad, R.J. Hitzemann Dopamine D2 receptor availability in opiate-dependent subjects before and after naloxone-precipitated withdrawal Neuropsychopharmacology 16 1997 174 182 (Pubitemid 27086432)
9. N.D. Volkow, L. Chang, G.J. Wang, J.S. Fowler, Y.S. Ding, M. Sedler Low level of brain dopamine D2 receptors in methamphetamine abusers: Association with metabolism in the orbitofrontal cortex Am J Psychiatry 158 2001 2015 2021 (Pubitemid 33104107)
10. N.D. Volkow, J.S. Fowler, G.J. Wang, R. Hitzemann, J. Logan, D.J. Schlyer Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers Synapse 14 1993 169 177 (Pubitemid 23157765)
11. D. Martinez, A. Broft, R.W. Foltin, M. Slifstein, D.R. Hwang, Y. Huang Cocaine dependence and d2 receptor availability in the functional subdivisions of the striatum: Relationship with cocaine-seeking behavior Neuropsychopharmacology 29 2004 1190 1202 (Pubitemid 38670055)
12. B. Lee, E.D. London, R.A. Poldrack, J. Farahi, A. Nacca, J.R. Monterosso Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity J Neurosci 29 2009 14734 14740
13. F. Zijlstra, J. Booij, W. van den Brink, I.H. Franken Striatal dopamine D2 receptor binding and dopamine release during cue-elicited craving in recently abstinent opiate-dependent males Eur Neuropsychopharmacol 18 2008 262 270
14. C. Fehr, I. Yakushev, N. Hohmann, H.G. Buchholz, C. Landvogt, H. Deckers Association of low striatal dopamine d2 receptor availability with nicotine dependence similar to that seen with other drugs of abuse Am J Psychiatry 165 2008 507 514 (Pubitemid 351694294)
15. N.D. Volkow, G.J. Wang, J.S. Fowler, J. Logan, S.J. Gatley, R. Hitzemann Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects Nature 386 1997 830 833 (Pubitemid 27181256)
16. D. Martinez, R. Gil, M. Slifstein, D.R. Hwang, Y. Huang, A. Perez Alcohol dependence is associated with blunted dopamine transmission in the ventral striatum Biol Psychiatry 58 2005 779 786 (Pubitemid 41677416)
17. D. Martinez, R. Narendran, R.W. Foltin, M. Slifstein, D.R. Hwang, A. Broft Amphetamine-induced dopamine release: Markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine Am J Psychiatry 164 2007 622 629 (Pubitemid 46650194)
18. N.D. Volkow, G.J. Wang, J.S. Fowler, J. Logan, S.J. Gatley, A. Gifford Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels Am J Psychiatry 156 1999 1440 1443 (Pubitemid 29416545)
19. N.D. Volkow, G.J. Wang, J.S. Fowler, P. Thanos, J. Logan, S.J. Gatley Brain DA D2 receptors predict reinforcing effects of stimulants in humans: Replication study Synapse 46 2002 79 82
20. P.K. Thanos, N.D. Volkow, P. Freimuth, H. Umegaki, H. Ikari, G. Roth Overexpression of dopamine D2 receptors reduces alcohol self-administration J Neurochem 78 2001 1094 1103 (Pubitemid 32823158)
21. P.K. Thanos, M. Michaelides, H. Umegaki, N.D. Volkow D2R DNA transfer into the nucleus accumbens attenuates cocaine self-administration in rats Synapse 62 2008 481 486 (Pubitemid 351794174)
22. D. Morgan, K.A. Grant, H.D. Gage, R.H. Mach, J.R. Kaplan, O. Prioleau Social dominance in monkeys: Dopamine D2 receptors and cocaine self-administration Nat Neurosci 5 2002 169 174 (Pubitemid 34121585)
23. R.I. Wang, R.L. Wiesen, S. Lamid, B.L. Roh Rating the presence and severity of opiate dependence Clin Pharmacol Ther 16 1974 653 658
24. N.D. Volkow, G. Wang, J.S. Fowler, J. Logan, M. Gerasimov, L. Maynard Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain J Neurosci 21 2001 RC121
25. Martinez D, Carpenter KM, Liu F, Slifstein M, Broft A, Friedman AC, et al. Imaging dopamine transmission in cocaine dependence: Link between neurochemistry and response to treatment. Am J Psychiatry 168:634641.
26. A.A. Lammertsma, S.P. Hume Simplified reference tissue model for PET receptor studies Neuroimage 4 1996 153 158
27. R.B. Innis, V.J. Cunningham, J. Delforge, M. Fujita, A. Gjedde, R.N. Gunn Consensus nomenclature for in vivo imaging of reversibly binding radioligands J Cereb Blood Flow Metab 27 2007 1533 1539 (Pubitemid 47301451)
28. M. Slifstein, M. Laruelle Models and methods for derivation of in vivo neuroreceptor parameters with PET and SPECT reversible radiotracers Nucl Med Biol 28 2001 595 608 (Pubitemid 32539407)
29. O. Mawlawi, D. Martinez, M. Slifstein, A. Broft, R. Chatterjee, D.R. Hwang Imaging human mesolimbic dopamine transmission with PET: I Accuracy and precision of D2 parameter measurements in the ventral striatum J Cereb Blood Flow Metab 21 2001 1034 1057 (Pubitemid 32823740)
30. D. Martinez, M. Slifstein, A. Broft, O. Mawlawi, D.R. Hwang, Y. Huang Imaging human mesolimbic dopamine transmission with positron emission tomography Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum J Cereb Blood Flow Metab 23 2003 285 300 (Pubitemid 36307573)
31. S.D. Comer, M.A. Sullivan, R.A. Whittington, S.K. Vosburg, W.J. Kowalczyk Abuse liability of prescription opioids compared to heroin in morphine-maintained heroin abusers Neuropsychopharmacology 33 2008 1179 1191 (Pubitemid 351367537)
32. S.D. Comer, E.D. Collins, R.B. MacArthur, M.W. Fischman Comparison of intravenous and intranasal heroin self-administration by morphine-maintained humans Psychopharmacology 143 1999 327 338 (Pubitemid 29222477)
33. F. Georges, L. Stinus, B. Bloch, C. Le Moine Chronic morphine exposure and spontaneous withdrawal are associated with modifications of dopamine receptor and neuropeptide gene expression in the rat striatum Eur J Neurosci 11 1999 481 490 (Pubitemid 29050450)
34. P. Sanchez-Cardoso, A. Higuera-Matas, S. Martin, M. Miguens, N. Del Olmo, C. Garcia-Lecumberri Strain differences between Lewis and Fischer 344 rats in the modulation of dopaminergic receptors after morphine self-administration and during extinction Neuropharmacology 57 2009 8 17
35. M. Melis, S. Spiga, M. Diana The dopamine hypothesis of drug addiction: Hypodopaminergic state Int Rev Neurobiol 63 2005 101 154 (Pubitemid 43631260)
36. M. Diana, M. Pistis, A. Muntoni, G. Gessa Profound decrease of mesolimbic dopaminergic neuronal activity in morphine withdrawn rats J Pharmacol Exp Ther 272 1995 781 785
37. M. Diana, A.L. Muntoni, M. Pistis, M. Melis, G.L. Gessa Lasting reduction in mesolimbic dopamine neuronal activity after morphine withdrawal Eur J Neurosci 11 1999 1037 1041 (Pubitemid 29106063)
38. S. Spiga, G.P. Serra, M.C. Puddu, M. Foddai, M. Diana Morphine withdrawal-induced abnormalities in the VTA: Confocal laser scanning microscopy Eur J Neurosci 17 2003 605 612 (Pubitemid 36255897)
39. A. Bonci, J.T. Williams Increased probability of GABA release during withdrawal from morphine J Neurosci 17 1997 796 803 (Pubitemid 27024591)
40. A. Madhavan, A. Bonci, J.L. Whistler Opioid-Induced GABA potentiation after chronic morphine attenuates the rewarding effects of opioids in the ventral tegmental area J Neurosci 30 2010 14029 14035
41. O.J. Manzoni, J.T. Williams Presynaptic regulation of glutamate release in the ventral tegmental area during morphine withdrawal J Neurosci 19 1999 6629 6636 (Pubitemid 29347462)
42. G. Di Chiara, V. Bassareo Reward system and addiction: What dopamine does and doesn't do Curr Opin Pharmacol 7 2007 69 76 (Pubitemid 46238042)
43. S.D. Comer, E.D. Collins, M.W. Fischman Choice between money and intranasal heroin in morphine-maintained humans Behav Pharmacol 8 1997 677 690 (Pubitemid 28039999)
44. Skinbjerg M, Liow JS, Seneca N, Hong J, Lu S, Thorsell A, et al. D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: A PET study in a receptor internalization-deficient mouse model. Neuroimage 50:14021407.