Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice

PLoS Genetics

Volumn 8, Issue 5, 2012, Pages

  Wang, Xiaofang ^a   Wang, Suzhen ^a   Li, Changcheng ^a,b   Gao, Tian ^a   Liu, Ying ^a   Rangiani, Afsaneh ^a   Sun, Yao ^a   Hao, Jianjun ^c   George, Anne ^d   Lu, Yongbo ^a   Groppe, Jay ^a   Yuan, Baozhi ^e,f   Feng, Jian Q ^a   Qin, Chunlin ^a  

^a BAYLOR COLLEGE OF DENTISTRY   (United States)

^b HARBIN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^e UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^f VA Geriatrics Research Education and Clinical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; DENTIN MATRIX PROTEIN 1; FAMILY WITH SEQUENCE SIMILARITY 20 MEMBER C PROTEIN; FIBROBLAST GROWTH FACTOR 23; REGULATOR PROTEIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG; CALCIUM BINDING PROTEIN; DMP1 PROTEIN, MOUSE; FAM20C PROTEIN, MOUSE; FIBROBLAST GROWTH FACTOR; SCLEROPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; CELL DIFFERENTIATION; CONTROLLED STUDY; CROSS BREEDING; DOWN REGULATION; FAMILY WITH SEQUENCE SIMILARITY 20 MEMBER C GENE; FEMALE; GAIN OF FUNCTION MUTATION; GENE; GENE SILENCING; HUMAN; HUMAN CELL; HYPOPHOSPHATEMIC RICKETS; IN VITRO STUDY; KNOCKOUT MOUSE; LOSS OF FUNCTION MUTATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSSIFICATION; OSTEOBLAST; PHENOTYPE; PHOSPHATE METABOLISM; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TRANSGENE; UPREGULATION; ANIMAL; CELL LINE; CONGENITAL MALFORMATION; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; GROWTH PLATE; MESENCHYMAL STEM CELL; METABOLISM; MOUSE MUTANT; ODONTOBLAST; X LINKED HYPOPHOSPHATEMIC RICKETS;

MAMMALIA; MUS; MUS MUSCULUS;

ANIMALS; CALCIFICATION, PHYSIOLOGIC; CALCIUM-BINDING PROTEINS; CELL DIFFERENTIATION; CELL LINE; EXTRACELLULAR MATRIX PROTEINS; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GROWTH PLATE; HUMANS; HYPOPHOSPHATEMIC RICKETS, X-LINKED DOMINANT; MESENCHYMAL STEM CELLS; MICE; MICE, KNOCKOUT; ODONTOBLASTS; OSTEOGENESIS;

EID: 84863698813     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002708     Document Type: Article

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