Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo

American Journal of Physiology - Endocrinology and Metabolism

Volumn 304, Issue 3, 2013, Pages

  Quinn, Stephen J ^a   Thomsen, Alex R B ^a,b   Pang, Jian L ^a   Kantham, Lakshmi ^a   Bräuner Osborne, Hans ^b   Pollak, Martin ^c   Goltzman, David ^d   Brown, Edward M ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d MCGILL UNIVERSITY   (Canada)

Author keywords

1,25 dihydroxyvitamin D3; Calcium phosphorus product; Calcium sensing receptor; Fibroblast growth factor 23; Parathyroid hormone

Indexed keywords

CALCITRIOL; CALCIUM; CALCIUM SENSING RECEPTOR; FIBROBLAST GROWTH FACTOR 23; PARATHYROID HORMONE; PHOSPHORUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CALCIUM BLOOD LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DIETARY FIBER; HYPOCALCEMIA; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PHOSPHATE BLOOD LEVEL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN INTERACTION; REGULATORY MECHANISM;

ANIMALS; CALCIUM; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; HOMEOSTASIS; MALE; MICE; MICE, KNOCKOUT; PHOSPHORUS;

EID: 84873370386     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00460.2012     Document Type: Article

References (46)

1. ADHR Consortium. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet 26: 345-348, 2000.
2. Almadén Y, Canalejo A, Ballesteros E, Añón G, Cañadillas S, Rodrí-guez M. Regulation of arachidonic acid production by intracellular calcium in parathyroid cells: effect of extracellular phosphorus. J Am Soc Nephrol 13: 693-698, 2002.
3. Bai X, Miao D, Li J, Goltzman D, Karaplis AC. Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Endocrinology 145: 5269-5279, 2004.
4. Ben-Dov IZ, Galitzer H, Lavi-Moshayoff V, Goetz R, Kuro-o M, Mohammadi M, Sirkis R, Naveh-Many T, Silver J. The parathyroid is a target organ for FGF23 in rats. J Clin Invest 117: 4003-4008, 2007.
5. 2+-sensing receptor from bovine parathyroid. Nature 366: 575-580, 1993.
6. Chang W, Tu C, Chen TH, Bikle D, Shoback D. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal 1: ra1, 2008.
7. Chattopadhyay N, Yano S, Tfelt-Hansen J, Rooney P, Kanuparthi D, Bandyopadhyay S, Ren X, Terwilliger E, Brown EM. Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts. Endocrinology 145: 3451-3462, 2004.
8. Dvorak MM, Siddiqua A, Ward DT, Carter DH, Dallas SL, Nemeth EF, Riccardi D. Physiological changes in extracellular calcium concentration directly control osteoblast function in the absence of calciotropic hormones. Proc Natl Acad Sci USA 101: 5140-5145, 2004.
9. Egbuna O, Quinn S, Kantham L, Butters R, Pang J, Pollak M, Goltzman D, Brown E. The full-length calcium-sensing receptor dampens the calcemic response to 1a,25(OH)2 vitamin D3 in vivo independently of parathyroid hormone. Am J Physiol Renal Physiol 297: F720-F728, 2009.
10. Estepa JC, Aguilera-Tejero E, Lopez I, Almaden Y, Rodriguez M, Felsenfeld AJ. Effect of phosphate on parathyroid hormone secretion in vivo. J Bone Miner Res 14: 1848-1854, 1999.
11. Gattineni J, Bates C, Twombley K, Dwarakanath V, Robinson ML, Goetz R, Mohammadi M, Baum M. FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1. Am J Physiol Renal Physiol 297: F282-F291, 2009.
12. Ho C, Conner DA, Pollak MR, Ladd DJ, Kifor O, Warren HB, Brown EM, Seidman JG, Seidman CE. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nat Genet 11: 389-394, 1995.
13. Ito N, Fukumoto S, Takeuchi Y, Takeda S, Suzuki H, Yamashita T, Fujita T. Effect of acute changes of serum phosphorus on fibroblast growth factor (FGF)23 levels in humans. J Bone Miner Metab 25: 419-422, 2007.
14. +-dependent phosphate cotrans-porters. Pflugers Arch 461: 77-90, 2011.
15. Kantham L, Quinn SJ, Egbuna OI, Baxi K, Butters R, Pang JL, Pollak MR, Goltzman D, Brown EM. The calcium-sensing receptor (CaSR) defends against hypercalcemia independently of its regulation of parathyroid hormone secretion. Am J Physiol Endocrinol Metab 297: E915-E923, 2009.
16. Ketteler M, Rothe H, Krüger T, Biggar PH, Schlieper G. Mechanisms and treatment of extraosseous calcification in chronic kidney disease. Nat Rev Nephrol 7: 509-516, 2011.
17. Khoshniat S, Bourgine A, Julien M, Petit M, Pilet P, Rouillon T, Masson M, Gatius M, Weiss P, Guicheux J, Beck L. Phosphate-dependent stimulation of MGP and OPN expression in osteoblasts via the ERK1/2 pathway is modulated by calcium. Bone 48: 894-902, 2011.
18. Kilav R, Silver J, Naveh-Many T. Parathyroid hormone gene expression in hypophosphorusmic rats. J Clin Invest 96: 327-333, 1995.
19. Kolek OI, Hines ER, Jones MD, LeSueur LK, Lipko MA, Kiela PR, Collins JF, Haussler MR, Ghishan FK. 1a,25-Dihydroxyvitamin D3 upregulates FGF23 gene expression in bone: the final link in a renal-gastrointestinal-skeletal axis that controls phosphate transport. Am J Physiol Gastrointest Liver Physiol 289: G1036-G1042, 2005.
20. Kumar R. Phosphate sensing. Curr Opin Nephrol Hypertens 18: 281-284, 2009.
21. Kurosu H, Ogawa Y, Miyoshi M, Yamamoto M, Nandi A, Rosenblatt KP, Baum MG, Schiavi S, Hu MC, Moe OW, Kuro-o M. Regulation of fibroblast growth factor-23 signaling by klotho. J Biol Chem 281: 6120-6123, 2006.
22. Lavi-Moshayoff V, Wasserman G, Meir T, Silver J, Naveh-Many T. PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop. Am J Physiol Renal Physiol 299: F882-F889, 2010.
23. Liu KP, Russo AF, Hsiung SC, Adlersberg M, Franke TF, Gershon MD, Tamir H. Calcium receptor-induced serotonin secretion by parafollicular cells: role of phosphatidylinositol 3-kinase-dependent signal transduction pathways. J Neurosci 23: 2049-2057, 2003.
24. Liu S, Guo R, Simpson LG, Xiao ZS, Burnham CE, Quarles LD. Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX. J Biol Chem 278: 37419-37426, 2003.
25. López I, Rodríguez-Ortiz ME, Almadén Y, Guerrero F, Oca AM, Pineda C, Shalhoub V, Rodríguez M, Aguilera-Tejero E. Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo. Kidney Int 80: 475-482, 2011.
26. 2+ receptor-stimulated hormone release from sheep thyroid parafollicular cells. J Physiol 502: 31-44, 1997.
27. Miao D, He B, Karaplis AC, Goltzman D. Parathyroid hormone is essential for normal fetal bone formation. J Clin Invest 109: 1173-1182, 2002.
28. Nakatani T, Sarraj B, Ohnishi M, Densmore MJ, Taguchi T, Goetz R, Mohammadi M, Lanske B, Razzaque MS. In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis. FASEB J 23: 433-441, 2009.
29. 2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell 75: 1297-1303, 1993.
30. Raggi P, Vukicevic S, Moysés RM, Wesseling K, Spiegel DM. Ten-year experience with sevelamer and calcium salts as phosphate binders. Clin J Am Soc Nephrol 5, Suppl 1: S31-S40, 2010.
31. Rhee Y, Bivi N, Farrow E, Lezcano V, Plotkin LI, White KE, Bellido T. Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo. Bone 49: 636-643, 2011.
32. 2+-sensing receptor and PTH/PTHrP receptor in rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol 271: F951-F956, 1996.
33. Riccardi D, Park J, Lee WS, Gamba G, Brown EM, Hebert SC. Cloning and functional expression of a rat kidney extracellular calcium/ polyvalent cation-sensing receptor. Proc Natl Acad Sci USA 92: 131-135, 1995.
34. Rodriguez-Ortiz ME, Lopez I, Muñoz-Castañeda JR, Martinez-Moreno JM, Ramírez AP, Pineda C, Canalejo A, Jaeger P, Aguilera-Tejero E, Rodriguez M, Felsenfeld A, Almaden Y. Calcium deficiency reduces circulating levels of FGF23. J Am Soc Nephrol 23: 1190-1197, 2012.
35. +-dependent phosphate co-transport activity and 1a,25-dihy-droxyvitamin D3 production. J Biol Chem 278: 2206-2211, 2003.
36. Samadfam R, Richard C, Nguyen-Yamamoto L, Bolivar I, Goltzman D. Bone formation regulates circulating concentrations of fibroblast growth factor 23. Endocrinology 150: 4835-4845, 2009.
37. Shimada T, Kakitani M, Yamazaki Y, Hasegawa H, Takeuchi Y, Fujita T, Fukumoto S, Tomizuka K, Yamashita T. Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. J Clin Invest 113: 561-568, 2004.
38. Shimada T, Mizutani S, Muto T, Yoneya T, Hino R, Takeda S, Takeuchi Y, Fujita T, Fukumoto S, Yamashita T. Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc Natl Acad Sci USA 98: 6500-6505, 2001.
39. Shimada T, Yamazaki Y, Takahashi M, Hasegawa H, Urakawa I, Oshima T, Ono K, Kakitani M, Tomizuka K, Fujita T, Fukumoto S, Yamashita T. Vitamin D receptor-independent FGF23 actions in regulating phosphate and vitamin D metabolism. Am J Physiol Renal Physiol 289: F1088-F1095, 2005.
40. Tomoe Y, Segawa H, Shiozawa K, Kaneko I, Tominaga R, Hanabusa E, Aranami F, Furutani J, Kuwahara S, Tatsumi S, Matsumoto M, Ito M, Miyamoto K. Phosphaturic action of fibroblast growth factor 23 in Npt2 null mice. Am J Physiol Renal Physiol 298: F1341-F1350, 2010.
41. Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, Fujita T, Fukumoto S, Yamashita T. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature 444: 770-774, 2006.
42. Wirth-Dzie ciolowska E, Karaszewska J, Sadowski T, Pysniak K, Gajewska M. Selected blood serum biochemical indicators in twelve inbred strains of laboratory mice. Anim Sci Pap Rep 27: 159-167, 2009.
43. Yamauchi M, Yamaguchi T, Kaji H, Sugimoto T, Chihara K. Involvement of calcium-sensing receptor in osteoblastic differentiation of mouse MC3T3-E1 cells. Am J Physiol Endocrinol Metab 288: E608-E616, 2005.
44. Yoshida T, Yoshida N, Monkawa T, Hayashi M, Saruta T. Dietary phosphorus deprivation induces 25-hydroxyvitamin D3 1a-hydroxylase gene expression. Endocrinology 142: 1720-1726, 2001.
45. Yoshiko Y, Wang H, Minamizaki T, Ijuin C, Yamamoto R, Suemune S, Kozai K, Tanne K, Aubin JE, Maeda N. Mineralized tissue cells are a principal source of FGF23. Bone 40: 1565-1573, 2007.
46. Zhang R, Lu Y, Ye L, Yuan B, Yu S, Qin C, Xie Y, Gao T, Drezner MK, Bonewald LF, Feng JQ. Unique roles of phosphorus in endochondral bone formation and osteocyte maturation. J Bone Miner Res 26: 1047-1056, 2011.