Parathyroid-Specific Deletion of Klotho Unravels a Novel Calcineurin-Dependent FGF23 Signaling Pathway That Regulates PTH Secretion

PLoS Genetics

Volumn 9, Issue 12, 2013, Pages

  Olauson, Hannes ^a   Lindberg, Karolina ^a   Amin, Risul ^a   Sato, Tadatoshi ^b   Jia, Ting ^a   Goetz, Regina ^c   Mohammadi, Moosa ^c   Andersson, Göran ^d   Lanske, Beate ^b   Larsson, Tobias E ^a,d  

^a KAROLINSKA INSTITUTE   (Sweden)

^b HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CALCIUM; CYCLOSPORIN A; FIBROBLAST GROWTH FACTOR 23; KLOTHO PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MODULATORY CALCINEURIN INTERACTING PROTEIN 1; NUCLEAR PROTEIN; PARATHYROID HORMONE; TRANSCRIPTION FACTOR NFATC2; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM BLOOD LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; EX VIVO STUDY; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; KIDNEY FAILURE; KLOTHO GENE; MALE; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PARATHYROID GLAND; PARATHYROID HORMONE BLOOD LEVEL; PARATHYROID HORMONE RELEASE; PHARMACOLOGICAL BLOCKING; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SECONDARY HYPERPARATHYROIDISM; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY;

ANIMALS; CALCINEURIN; CALCIUM; CYCLOSPORINE; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; HUMANS; KIDNEY; MEMBRANE PROTEINS; MICE; PARATHYROID GLANDS; PARATHYROID HORMONE; SEQUENCE DELETION; SIGNAL TRANSDUCTION; VITAMIN D;

EID: 84892774990     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1003975     Document Type: Article

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