Cartilage Repair Using Hydrogels: A Critical Review of in Vivo Experimental Designs

ACS Biomaterials Science and Engineering

Volumn 1, Issue 9, 2015, Pages 726-739

  Vilela, C A ^a,b,c   Correia, C ^e   Oliveira, J M ^a   Sousa, R A ^e   Espregueira Mendes, J ^a,b,d   Reis, R L ^a,e  

^a UNIVERSITY OF MINHO   (Portugal)

^b UNIVERSITY OF MINHO   (Portugal)

^c Centro Hospitalar Do Alto Ave   (Portugal)

^d Espregueira Mendes Sports Centre   (Portugal)

^e Stemmatters   (Portugal)

Author keywords

animal; cartilage repair; gels; hydrogels; in vivo; tissue engineering

Indexed keywords

AGE; ANIMAL MODEL; ARTICULAR CARTILAGE; CELLS BY BODY ANATOMY; HYDROGEL; IN VIVO STUDY; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; TISSUE REPAIR; TISSUE SCAFFOLD; WEIGHT;

EID: 84969244006     PISSN: None     EISSN: 23739878     Source Type: Journal    
DOI: 10.1021/acsbiomaterials.5b00245     Document Type: Review

References (151)

1. Buckwalter, J. A. Articular cartilage: injuries and potential for healing J. Orthop Sports Phys. Ther 1998, 28 (4) 192-202 10.2519/jospt.1998.28.4.192
2. Hunziker, E. B. Articular cartilage repair: are the intrinsic biological constraints undermining this process insuperable? Osteoarthritis Cartilage 1999, 7 (1) 15-28 10.1053/joca.1998.0159
3. Hjelle, K.; Solheim, E.; Strand, T.; Muri, R.; Brittberg, M. Articular cartilage defects in 1,000 knee arthroscopies Arthroscopy 2002, 18 (7) 730-4 10.1053/jars.2002.32839
4. Hunziker, E. B. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects Osteoarthritis Cartilage 2002, 10 (6) 432-63 10.1053/joca.2002.0801
5. Tanna, S. Background Paper 6.12 Osteoarthritis. In Priority Medicines for Europe and the World A Public Health Approach to Innovation, Wittenauer, R.; Smith, L.; Aden, K., Eds.; World Health Organization: Geneva, Switzerland, 2013.
6. Jackson, D. W.; Simon, T. M.; Aberman, H. M. Symptomatic articular cartilage degeneration: the impact in the new millennium Clin. Orthop. Relat. Res. 2001, 391 Suppl, S14-25 10.1097/00003086-200110001-00003
7. Tins, B. J.; McCall, I. W.; Takahashi, T.; Cassar-Pullicino, V.; Roberts, S.; Ashton, B.; Richardson, J. Autologous chondrocyte implantation in knee joint: MR imaging and histologic features at 1-year follow-up Radiology 2005, 234 (2) 501-8 10.1148/radiol.2342031970
8. Gobbi, A.; Nunag, P.; Malinowski, K. Treatment of full thickness chondral lesions of the knee with microfracture in a group of athletes Knee Surg Sports Traumatol Arthrosc 2005, 13 (3) 213-21 10.1007/s00167-004-0499-3
9. Luyten, F. P.; Vanlauwe, J. Tissue engineering approaches for osteoarthritis Bone 2012, 51 (2) 289-96 10.1016/j.bone.2011.10.007
10. Brittberg, M.; Lindahl, A.; Nilsson, A.; Ohlsson, C.; Isaksson, O.; Peterson, L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation N. Engl. J. Med. 1994, 331 (14) 889-95 10.1056/NEJM199410063311401
11. Cabral, J.; Moratti, S. C. Hydrogels for biomedical applications Future Med. Chem. 2011, 3 (15) 1877-88 10.4155/fmc.11.134
12. Baroli, B. Hydrogels for tissue engineering and delivery of tissue-inducing substances J. Pharm. Sci. 2007, 96 (9) 2197-223 10.1002/jps.20873
13. Gauvin, R.; Parenteau-Bareil, R.; Dokmeci, M. R.; Merryman, W. D.; Khademhosseini, A. Hydrogels and microtechnologies for engineering the cellular microenvironment Wiley Interdiscip Rev. Nanomed Nanobiotechnol 2012, 4 (3) 235-46 10.1002/wnan.171
14. Oliveira, J. T.; Reis, R. L. Polysaccharide-based materials for cartilage tissue engineering applications J. Tissue Eng. Regener. Med. 2011, 5 (6) 421-36 10.1002/term.335
15. Khademhosseini, A.; Langer, R.; Borenstein, J.; Vacanti, J. P. Microscale technologies for tissue engineering and biology Proc. Natl. Acad. Sci. U. S. A. 2006, 103 (8) 2480-7 10.1073/pnas.0507681102
16. Khademhosseini, A.; Langer, R. Microengineered hydrogels for tissue engineering Biomaterials 2007, 28 (34) 5087-92 10.1016/j.biomaterials.2007.07.021
17. Filova, E.; Jelinek, F.; Handl, M.; Lytvynets, A.; Rampichova, M.; Varga, F.; Cinatl, J.; Soukup, T.; Trc, T.; Amler, E. Novel composite hyaluronan/type I collagen/fibrin scaffold enhances repair of osteochondral defect in rabbit knee J. Biomed. Mater. Res., Part B 2008, 87 (2) 415-424 10.1002/jbm.b.31119
18. Pei, M.; He, F.; Boyce, B. M.; Kish, V. L. Repair of full-thickness femoral condyle cartilage defects using allogeneic synovial cell-engineered tissue constructs Osteoarthritis Cartilage 2009, 17 (6) 714-22 10.1016/j.joca.2008.11.017
19. Siu, R. K.; Zara, J. N.; Hou, Y.; James, A. W.; Kwak, J.; Zhang, X.; Ting, K.; Wu, B. M.; Soo, C.; Lee, M. NELL-1 promotes cartilage regeneration in an in vivo rabbit model Tissue Eng., Part A 2012, 18 (3-4) 252-261 10.1089/ten.tea.2011.0142
20. Wang, W.; Li, B.; Yang, J.; Xin, L.; Li, Y.; Yin, H.; Qi, Y.; Jiang, Y.; Ouyang, H.; Gao, C. The restoration of full-thickness cartilage defects with BMSCs and TGF-beta 1 loaded PLGA/fibrin gel constructs Biomaterials 2010, 31 (34) 8964-73 10.1016/j.biomaterials.2010.08.018
21. Adachi, N.; Sato, K.; Usas, A.; Fu, F. H.; Ochi, M.; Han, C. W.; Niyibizi, C.; Huard, J. Muscle derived, cell based ex vivo gene therapy for treatment of full thickness articular cartilage defects J. Rheumatol. 2002, 29 (9) 1920-1930
22. Han, C. W.; Chu, C. R.; Adachi, N.; Usas, A.; Fu, F. H.; Huard, J.; Pan, Y. Analysis of rabbit articular cartilage repair after chondrocyte implantation using optical coherence tomography Osteoarthritis Cartilage 2003, 11 (2) 111-21 10.1053/joca.2002.0862
23. Cohen, S. B.; Meirisch, C. M.; Wilson, H. A.; Diduch, D. R. The use of absorbable co-polymer pads with alginate and cells for articular cartilage repair in rabbits Biomaterials 2003, 24 (15) 2653-2660 10.1016/S0142-9612(03)00058-9
24. Fukuda, A.; Kato, K.; Hasegawa, M.; Hirata, H.; Sudo, A.; Okazaki, K.; Tsuta, K.; Shikinami, Y.; Uchida, A. Enhanced repair of large osteochondral defects using a combination of artificial cartilage and basic fibroblast growth factor Biomaterials 2005, 26 (20) 4301-8 10.1016/j.biomaterials.2004.11.007
25. Yanai, T.; Ishii, T.; Chang, F.; Ochiai, N. Repair of large full-thickness articular cartilage defects in the rabbit: the effects of joint distraction and autologous bone-marrow-derived mesenchymal cell transplantation J. Bone Jt. Surg., Br. Vol. 2005, 87 (5) 721-9 10.1302/0301-620X.87B5.15542
26. Lee, J. H.; Prakash, K. V.; Pengatteeri, Y. H.; Park, S. E.; Koh, H. S.; Han, C. W. Chondrocyte apoptosis in the regenerated articular cartilage after allogenic chondrocyte transplantation in the rabbit knee J. Bone Jt. Surg., Br. Vol. 2007, 89 (7) 977-983 10.1302/0301-620X.89B7.18983
27. Kang, S. W.; Bada, L. P.; Kang, C. S.; Lee, J. S.; Kim, C. H.; Park, J. H.; Kim, B. S. Articular cartilage regeneration with microfracture and hyaluronic acid Biotechnol. Lett. 2008, 30 (3) 435-9 10.1007/s10529-007-9576-2
28. Koga, H.; Muneta, T.; Nagase, T.; Nimura, A.; Ju, Y. J.; Mochizuki, T.; Sekiya, I. Comparison of mesenchymal tissues-derived stem cells for in vivo chondrogenesis: suitable conditions for cell therapy of cartilage defects in rabbit Cell Tissue Res. 2008, 333 (2) 207-15 10.1007/s00441-008-0633-5
29. Chang, F.; Ishii, T.; Yanai, T.; Mishima, H.; Akaogi, H.; Ogawa, T.; Ochiai, N. Repair of large full-thickness articular cartilage defects by transplantation of autologous uncultured bone-marrow-derived mononuclear cells J. Orthop. Res. 2008, 26 (1) 18-26 10.1002/jor.20470
30. Aulin, C.; Bergman, K.; Jensen-Waern, M.; Hedenqvist, P.; Hilborn, J.; Engstrand, T. In situ cross-linkable hyaluronan hydrogel enhances chondrogenesis J. Tissue Eng. Regener. Med. 2011, 5 (8) e188-96 10.1002/term.415
31. Aulin, C.; Jensen-Waern, M.; Ekman, S.; Hagglund, M.; Engstrand, T.; Hilborn, J.; Hedenqvist, P. Cartilage repair of experimentally 11 induced osteochondral defects in New Zealand White rabbits Lab. Anim. 2013, 47 (1) 58-65 10.1177/0023677212473716
32. Pulkkinen, H. J.; Tiitu, V.; Valonen, P.; Jurvelin, J. S.; Rieppo, L.; Toyras, J.; Silvast, T. S.; Lammi, M. J.; Kiviranta, I. Repair of osteochondral defects with recombinant human type II collagen gel and autologous chondrocytes in rabbit Osteoarthritis Cartilage 2013, 21 (3) 481-90 10.1016/j.joca.2012.12.004
33. Wilke, M. M.; Nydam, D. V.; Nixon, A. J. Enhanced early chondrogenesis in articular defects following arthroscopic mesenchymal stem cell implantation in an equine model J. Orthop. Res. 2007, 25 (7) 913-25 10.1002/jor.20382
34. Marquass, B.; Somerson, J. S.; Hepp, P.; Aigner, T.; Schwan, S.; Bader, A.; Josten, C.; Zscharnack, M.; Schulz, R. M. A novel MSC-seeded triphasic construct for the repair of osteochondral defects J. Orthop. Res. 2010, 28 (12) 1586-99 10.1002/jor.21173
35. Shah, R. N.; Shah, N. A.; Del Rosario Lim, M. M.; Hsieh, C.; Nuber, G.; Stupp, S. I. Supramolecular design of self-assembling nanofibers for cartilage regeneration Proc. Natl. Acad. Sci. U. S. A. 2010, 107 (8) 3293-8 10.1073/pnas.0906501107
36. Portron, S.; Merceron, C.; Gauthier, O.; Lesoeur, J.; Sourice, S.; Masson, M.; Fellah, B. H.; Geffroy, O.; Lallemand, E.; Weiss, P.; Guicheux, J.; Vinatier, C. Effects of in vitro low oxygen tension preconditioning of adipose stromal cells on their in vivo chondrogenic potential: application in cartilage tissue repair PLoS One 2013, 8 (4) e62368 10.1371/journal.pone.0062368
37. Madry, H.; Cucchiarini, M.; Stein, U.; Remberger, K.; Menger, M. D.; Kohn, D.; Trippel, S. B. Sustained transgene expression in cartilage defects in vivo after transplantation of articular chondrocytes modified by lipid-mediated gene transfer in a gel suspension delivery system J. Gene Med. 2003, 5 (6) 502-9 10.1002/jgm.368
38. Mierisch, C. M.; Wilson, H. A.; Turner, M. A.; Milbrandt, T. A.; Berthoux, L.; Hammarskjold, M. L.; Rekosh, D.; Balian, G.; Diduch, D. R. Chondrocyte transplantation into articular cartilage defects with use of calcium alginate: the fate of the cells J. Bone Jt. Surg. Am. 2003, 85 (9) 1757-1767
39. Chang, C. H.; Kuo, T. F.; Lin, F. H.; Wang, J. H.; Hsu, Y. M.; Huang, H. T.; Loo, S. T.; Fang, H. W.; Liu, H. C.; Wang, W. C. Tissue engineering-based cartilage repair with mesenchymal stem cells in a porcine model J. Orthop. Res. 2011, 29 (12) 1874-80 10.1002/jor.21461
40. Heiligenstein, S.; Cucchiarini, M.; Laschke, M. W.; Bohle, R. M.; Kohn, D.; Menger, M. D.; Madry, H. In vitro and in vivo characterization of nonbiomedical- and biomedical-grade alginates for articular chondrocyte transplantation Tissue Eng., Part C 2011, 17 (8) 829-42 10.1089/ten.tec.2010.0681
41. Filova, E.; Rampichova, M.; Litvinec, A.; Drzik, M.; Mickova, A.; Buzgo, M.; Kostakova, E.; Martinova, L.; Usvald, D.; Prosecka, E.; Uhlik, J.; Motlik, J.; Vajner, L.; Amler, E. A cell-free nanofiber composite scaffold regenerated osteochondral defects in miniature pigs Int. J. Pharm. 2013, 447 (1-2) 139-49 10.1016/j.ijpharm.2013.02.056
42. Martins, E. A.; Michelacci, Y. M.; Baccarin, R. Y.; Cogliati, B.; Silva, L. C. Evaluation of chitosan-GP hydrogel biocompatibility in osteochondral defects: an experimental approach BMC Vet. Res. 2014, 10 (1) 197 10.1186/s12917-014-0197-4
43. Hui, J. H.; Ren, X.; Afizah, M. H.; Chian, K. S.; Mikos, A. G. Oligo[poly(ethylene glycol)fumarate] hydrogel enhances osteochondral repair in porcine femoral condyle defects Clin. Orthop. Relat. Res. 2013, 471 (4) 1174-85 10.1007/s11999-012-2487-0
44. Guo, X.; Park, H.; Young, S.; Kretlow, J. D.; van den Beucken, J. J.; Baggett, L. S.; Tabata, Y.; Kasper, F. K.; Mikos, A. G.; Jansen, J. A. Repair of osteochondral defects with biodegradable hydrogel composites encapsulating marrow mesenchymal stem cells in a rabbit model Acta Biomater. 2010, 6 (1) 39-47 10.1016/j.actbio.2009.07.041
45. Ferretti, M.; Marra, K. G.; Kobayashi, K.; Defail, A. J.; Chu, C. R. Controlled in vivo degradation of genipin crosslinked polyethylene glycol hydrogels within osteochondral defects Tissue Eng. 2006, 12 (9) 2657-63 10.1089/ten.2006.12.2657
46. Holland, T. A.; Bodde, E. W.; Cuijpers, V. M.; Baggett, L. S.; Tabata, Y.; Mikos, A. G.; Jansen, J. A. Degradable hydrogel scaffolds for in vivo delivery of single and dual growth factors in cartilage repair Osteoarthritis Cartilage 2007, 15 (2) 187-97 10.1016/j.joca.2006.07.006
47. Mimura, T.; Imai, S.; Kubo, M.; Isoya, E.; Ando, K.; Okumura, N.; Matsusue, Y. A novel exogenous concentration-gradient collagen scaffold augments full-thickness articular cartilage repair Osteoarthritis Cartilage 2008, 16 (9) 1083-91 10.1016/j.joca.2008.02.003
48. Sun, J.; Hou, X. K.; Li, X.; Tang, T. T.; Zhang, R. M.; Kuang, Y.; Shi, M. Mosaicplasty associated with gene enhanced tissue engineering for the treatment of acute osteochondral defects in a goat model Arch Orthop Trauma Surg 2009, 129 (6) 757-71 10.1007/s00402-008-0761-0
49. Rampichova, M.; Filova, E.; Varga, F.; Lytvynets, A.; Prosecka, E.; Kolacna, L.; Motlik, J.; Necas, A.; Vajner, L.; Uhlik, J.; Amler, E. Fibrin/hyaluronic acid composite hydrogels as appropriate scaffolds for in vivo artificial cartilage implantation ASAIO J. 2010, 56 (6) 563-8 10.1097/MAT.0b013e3181fcbe24
50. Yamazoe, K.; Mishima, H.; Torigoe, K.; Iijima, H.; Watanabe, K.; Sakai, H.; Kudo, T. Effects of atelocollagen gel containing bone marrow-derived stromal cells on repair of osteochondral defect in a dog J. Vet. Med. Sci. 2007, 69 (8) 835-9 10.1292/jvms.69.835
51. Zheng, Y.; Lv, H.; Wang, Y.; Lu, H.; Qing, L.; Xi, T. Performance of novel bioactive hybrid hydrogels in vitro and in vivo used for artificial cartilage Biomed. Mater. 2009, 4 (1) 015015 10.1088/1748-6041/4/1/015015
52. Tanaka, H.; Mizokami, H.; Shiigi, E.; Murata, H.; Ogasa, H.; Mine, T.; Kawai, S. Effects of basic fibroblast growth factor on the repair of large osteochondral defects of articular cartilage in rabbits: dose-response effects and long-term outcomes Tissue Eng. 2004, 10 (3-4) 633-41 10.1089/107632704323061988
53. Tanaka, T.; Komaki, H.; Chazono, M.; Fujii, K. Use of a biphasic graft constructed with chondrocytes overlying a beta-tricalcium phosphate block in the treatment of rabbit osteochondral defects Tissue Eng. 2005, 11 (1-2) 331-9 10.1089/ten.2005.11.331
54. Shao, X. X.; Hutmacher, D. W.; Ho, S. T.; Goh, J. C.; Lee, E. H. Evaluation of a hybrid scaffold/cell construct in repair of high-load-bearing osteochondral defects in rabbits Biomaterials 2006, 27 (7) 1071-80 10.1016/j.biomaterials.2005.07.040
55. Kim, K.; Lam, J.; Lu, S.; Spicer, P. P.; Lueckgen, A.; Tabata, Y.; Wong, M. E.; Jansen, J. A.; Mikos, A. G.; Kasper, F. K. Osteochondral tissue regeneration using a bilayered composite hydrogel with modulating dual growth factor release kinetics in a rabbit model J. Controlled Release 2013, 168 (2) 166-78 10.1016/j.jconrel.2013.03.013
56. Qi, B. W.; Yu, A. X.; Zhu, S. B.; Zhou, M.; Wu, G. Chitosan/poly(vinyl alcohol) hydrogel combined with Ad-hTGF-beta1 transfected mesenchymal stem cells to repair rabbit articular cartilage defects Exp. Biol. Med. (London, U. K.) 2013, 238 (1) 23 10.1258/ebm.2012.012223
57. Lee, K. B.; Hui, J. H.; Song, I. C.; Ardany, L.; Lee, E. H. Injectable mesenchymal stem cell therapy for large cartilage defects - a porcine model Stem Cells 2007, 25 (11) 2964-71 10.1634/stemcells.2006-0311
58. Zhang, Y.; Wang, F.; Chen, J.; Ning, Z.; Yang, L. Bone marrow-derived mesenchymal stem cells versus bone marrow nucleated cells in the treatment of chondral defects Int. Orthop. 2012, 36 (5) 1079-86 10.1007/s00264-011-1362-z
59. Wang, W.; Li, B.; Li, Y.; Jiang, Y.; Ouyang, H.; Gao, C. In vivo restoration of full-thickness cartilage defects by poly(lactide-co-glycolide) sponges filled with fibrin gel, bone marrow mesenchymal stem cells and DNA complexes Biomaterials 2010, 31 (23) 5953-65 10.1016/j.biomaterials.2010.04.029
60. Filova, E.; Rampichova, M.; Handl, M.; Lytvynets, A.; Halouzka, R.; Usvald, D.; Hlucilova, J.; Prochazka, R.; Dezortova, M.; Rolencova, E.; Kostakova, E.; Trc, T.; Stastny, E.; Kolacna, L.; Hajek, M.; Motlik, J.; Amler, E. Composite hyaluronate-type I collagen-fibrin scaffold in the therapy of osteochondral defects in miniature pigs Physiol. Res. 2007, 56 (Suppl 1) S5-S16
61. Kuo, T. F.; Lin, M. F.; Lin, Y. H.; Lin, Y. C.; Su, R. J.; Lin, H. W.; Chan, W. P. Implantation of platelet-rich fibrin and cartilage granules facilitates cartilage repair in the injured rabbit knee: preliminary report Clinics (Sao Paulo) 2011, 66 (10) 1835-8 10.1590/S1807-59322011001000026
62. Mierisch, C. M.; Cohen, S. B.; Jordan, L. C.; Robertson, P. G.; Balian, G.; Diduch, D. R. Transforming growth factor-beta in calcium alginate beads for the treatment of articular cartilage defects in the rabbit Arthroscopy 2002, 18 (8) 892-900 10.1053/jars.2002.36117
63. Zscharnack, M.; Hepp, P.; Richter, R.; Aigner, T.; Schulz, R.; Somerson, J.; Josten, C.; Bader, A.; Marquass, B. Repair of chronic osteochondral defects using predifferentiated mesenchymal stem cells in an ovine model Am. J. Sports Med. 2010, 38 (9) 1857-69 10.1177/0363546510365296
64. Marquass, B.; Schulz, R.; Hepp, P.; Zscharnack, M.; Aigner, T.; Schmidt, S.; Stein, F.; Richter, R.; Osterhoff, G.; Aust, G.; Josten, C.; Bader, A. Matrix-associated implantation of predifferentiated mesenchymal stem cells versus articular chondrocytes: in vivo results of cartilage repair after 1 year Am. J. Sports Med. 2011, 39 (7) 1401-12 10.1177/0363546511398646
65. Miller, R. E.; Grodzinsky, A. J.; Vanderploeg, E. J.; Lee, C.; Ferris, D. J.; Barrett, M. F.; Kisiday, J. D.; Frisbie, D. D. Effect of self-assembling peptide, chondrogenic factors, and bone marrow-derived stromal cells on osteochondral repair Osteoarthritis Cartilage 2010, 18 (12) 1608-19 10.1016/j.joca.2010.09.004
66. Chiang, H.; Kuo, T. F.; Tsai, C. C.; Lin, M. C.; She, B. R.; Huang, Y. Y.; Lee, H. S.; Shieh, C. S.; Chen, M. H.; Ramshaw, J. A.; Werkmeister, J. A.; Tuan, R. S.; Jiang, C. C. Repair of porcine articular cartilage defect with autologous chondrocyte transplantation J. Orthop. Res. 2005, 23 (3) 584-93 10.1016/j.orthres.2004.11.003
67. Schagemann, J. C.; Erggelet, C.; Chung, H. W.; Lahm, A.; Kurz, H.; Mrosek, E. H. Cell-laden and cell-free biopolymer hydrogel for the treatment of osteochondral defects in a sheep model Tissue Eng., Part A 2009, 15 (1) 75-82 10.1089/ten.tea.2008.0087
68. Liu, Y.; Shu, X. Z.; Prestwich, G. D. Osteochondral defect repair with autologous bone marrow-derived mesenchymal stem cells in an injectable, in situ, cross-linked synthetic extracellular matrix Tissue Eng. 2006, 12 (12) 3405-16 10.1089/ten.2006.12.3405
69. Duarte Campos, D. F.; Drescher, W.; Rath, B.; Tingart, M.; Fischer, H. Supporting Biomaterials for Articular Cartilage Repair Cartilage 2012, 3 (3) 205-21 10.1177/1947603512444722
70. Cao, Z.; Dou, C.; Dong, S. Scaffolding Biomaterials for Cartilage Regeneration J. Nanomater. 2014, 2014, 1-8 10.1155/2014/489128
71. Katayama, R.; Wakitani, S.; Tsumaki, N.; Morita, Y.; Matsushita, I.; Gejo, R.; Kimura, T. Repair of articular cartilage defects in rabbits using CDMP1 gene-transfected autologous mesenchymal cells derived from bone marrow Rheumatology (Oxford) 2004, 43 (8) 980-5 10.1093/rheumatology/keh240
72. Yokoo, N.; Saito, T.; Uesugi, M.; Kobayashi, N.; Xin, K. Q.; Okuda, K.; Mizukami, H.; Ozawa, K.; Koshino, T. Repair of articular cartilage defect by autologous transplantation of basic fibroblast growth factor gene-transduced chondrocytes with adeno-associated virus vector Arthritis Rheum. 2005, 52 (1) 164-70 10.1002/art.20739
73. Kubo, M.; Imai, S.; Fujimiya, M.; Isoya, E.; Ando, K.; Mimura, T.; Matsusue, Y. Exogenous collagen-enhanced recruitment of mesenchymal stem cells during rabbit articular cartilage repair Acta Orthop. 2007, 78 (6) 845-55 10.1080/17453670710014653
74. Mimura, T.; Imai, S.; Okumura, N.; Li, L.; Nishizawa, K.; Araki, S.; Ueba, H.; Kubo, M.; Mori, K.; Matsusue, Y. Spatiotemporal control of proliferation and differentiation of bone marrow-derived mesenchymal stem cells recruited using collagen hydrogel for repair of articular cartilage defects J. Biomed. Mater. Res., Part B 2011, 98 (2) 360-8 10.1002/jbm.b.31859
75. Schneider, U.; Schmidt-Rohlfing, B.; Gavenis, K.; Maus, U.; Mueller-Rath, R.; Andereya, S. A comparative study of 3 different cartilage repair techniques Knee Surg Sports Traumatol Arthrosc 2011, 19 (12) 2145-52 10.1007/s00167-011-1460-x
76. Chen, J.; Wang, F.; Zhang, Y.; Jin, X.; Zhang, L.; Feng, Y.; Lin, X.; Yang, L. In vivo tracking of superparamagnetic iron oxide nanoparticle labeled chondrocytes in large animal model Ann. Biomed. Eng. 2012, 40 (12) 2568-78 10.1007/s10439-012-0621-5
77. Igarashi, T.; Iwasaki, N.; Kasahara, Y.; Minami, A. A cellular implantation system using an injectable ultra-purified alginate gel for repair of osteochondral defects in a rabbit model J. Biomed. Mater. Res., Part A 2010, 94 (3) 844-855 10.1002/jbm.a.32762
78. Re'em, T.; Witte, F.; Willbold, E.; Ruvinov, E.; Cohen, S. Simultaneous regeneration of articular cartilage and subchondral bone induced by spatially presented TGF-beta and BMP-4 in a bilayer affinity binding system Acta Biomater. 2012, 8 (9) 3283-93 10.1016/j.actbio.2012.05.014
79. Lopiz-Morales, Y.; Abarrategi, A.; Ramos, V.; Moreno-Vicente, C.; Lopez-Duran, L.; Lopez-Lacomba, J. L.; Marco, F. In vivo comparison of the effects of rhBMP-2 and rhBMP-4 in osteochondral tissue regeneration Eur. Cell Mater. 2010, 20, 367-78
80. Araki, S.; Imai, S.; Ishigaki, H.; Mimura, T.; Nishizawa, K.; Ueba, H.; Kumagai, K.; Kubo, M.; Mori, K.; Ogasawara, K.; Matsusue, Y. Improved quality of cartilage repair by bone marrow mesenchymal stem cells for treatment of an osteochondral defect in a cynomolgus macaque model Acta Orthop 2015, 86 (1) 119-26 10.3109/17453674.2014.958807
81. Dragoo, J. L.; Carlson, G.; McCormick, F.; Khan-Farooqi, H.; Zhu, M.; Zuk, P. A.; Benhaim, P. Healing full-thickness cartilage defects using adipose-derived stem cells Tissue Eng. 2007, 13 (7) 1615-21 10.1089/ten.2006.0249
82. Lee, J. M.; Im, G. I. SOX trio-co-transduced adipose stem cells in fibrin gel to enhance cartilage repair and delay the progression of osteoarthritis in the rat Biomaterials 2012, 33 (7) 2016-24 10.1016/j.biomaterials.2011.11.050
83. Lee, J. C.; Min, H. J.; Park, H. J.; Lee, S.; Seong, S. C.; Lee, M. C. Synovial membrane-derived mesenchymal stem cells supported by platelet-rich plasma can repair osteochondral defects in a rabbit model Arthroscopy 2013, 29 (6) 1034-46 10.1016/j.arthro.2013.02.026
84. Kayakabe, M.; Tsutsumi, S.; Watanabe, H.; Kato, Y.; Takagishi, K. Transplantation of autologous rabbit BM-derived mesenchymal stromal cells embedded in hyaluronic acid gel sponge into osteochondral defects of the knee Cytotherapy 2006, 8 (4) 343-53 10.1080/14653240600845070
85. Fisher, M. B.; Belkin, N. S.; Milby, A. H.; Henning, E. A.; Bostrom, M.; Kim, M.; Pfeifer, C.; Meloni, G.; Dodge, G. R.; Burdick, J. A.; Schaer, T. P.; Steinberg, D. R.; Mauck, R. L. Cartilage repair and subchondral bone remodeling in response to focal lesions in a mini-pig model: implications for tissue engineering Tissue Eng., Part A 2015, 21 (3-4) 850-860 10.1089/ten.tea.2014.0384
86. Oliveira, J. T.; Gardel, L. S.; Rada, T.; Martins, L.; Gomes, M. E.; Reis, R. L. Injectable gellan gum hydrogels with autologous cells for the treatment of rabbit articular cartilage defects J. Orthop. Res. 2010, 28 (9) 1193-9 10.1002/jor.21114
87. Hao, T.; Wen, N.; Cao, J. K.; Wang, H. B.; Lu, S. H.; Liu, T.; Lin, Q. X.; Duan, C. M.; Wang, C. Y. The support of matrix accumulation and the promotion of sheep articular cartilage defects repair in vivo by chitosan hydrogels Osteoarthritis Cartilage 2010, 18 (2) 257-65 10.1016/j.joca.2009.08.007
88. Albuquerque, P. C.; Aguiar, J. L.; Santos, S. M.; Pontes Filho, N.; Mello, R. J.; Costa, M. L.; Albuquerque, C. M.; Almeida, T. M.; Santos, A. H.; Silva, J. C. Comparative study of the areas of osteochondral defects produced in the femoral condyles of rabbits treated with gel of sugarcane biopolymer Acta Cir Bras 2011, 26 (5) 383-6 10.1590/S0102-86502011000500010
89. Lim, C. T.; Ren, X.; Afizah, M. H.; Tarigan-Panjaitan, S.; Yang, Z.; Wu, Y.; Chian, K. S.; Mikos, A. G.; Hui, J. H. Repair of osteochondral defects with rehydrated freeze-dried oligo[poly(ethylene glycol) fumarate] hydrogels seeded with bone marrow mesenchymal stem cells in a porcine model Tissue Eng., Part A 2013, 19 (15-16) 1852-1861 10.1089/ten.tea.2012.0621
90. Park, J. S.; Woo, D. G.; Yang, H. N.; Lim, H. J.; Park, K. M.; Na, K.; Park, K. H. Chondrogenesis of human mesenchymal stem cells encapsulated in a hydrogel construct: neocartilage formation in animal models as both mice and rabbits J. Biomed. Mater. Res., Part A 2010, 92 (3) 988-996 10.1002/jbm.a.32341
91. Jung, Y.; Park, M. S.; Lee, J. W.; Kim, Y. H.; Kim, S. H. Cartilage regeneration with highly-elastic three-dimensional scaffolds prepared from biodegradable poly(L-lactide-co-epsilon-caprolactone) Biomaterials 2008, 29 (35) 4630-4636 10.1016/j.biomaterials.2008.08.031
92. Dahlin, R. L.; Kinard, L. A.; Lam, J.; Needham, C. J.; Lu, S.; Kasper, F. K.; Mikos, A. G. Articular chondrocytes and mesenchymal stem cells seeded on biodegradable scaffolds for the repair of cartilage in a rat osteochondral defect model Biomaterials 2014, 35 (26) 7460-9 10.1016/j.biomaterials.2014.05.055
93. Nettles, D. L.; Kitaoka, K.; Hanson, N. A.; Flahiff, C. M.; Mata, B. A.; Hsu, E. W.; Chilkoti, A.; Setton, L. A. In situ crosslinking elastin-like polypeptide gels for application to articular cartilage repair in a goat osteochondral defect model Tissue Eng., Part A 2008, 14 (7) 1133-1140 10.1089/ten.tea.2007.0245
94. Hui, J. H.; Chan, S. W.; Li, J.; Goh, J. C.; Li, L.; Ren, X. F.; Lee, E. H. Intra-articular delivery of chondroitin sulfate for the treatment of joint defects in rabbit model J. Mol. Histol. 2007, 38 (5) 483-9 10.1007/s10735-007-9120-7
95. Dausse, Y.; Grossin, L.; Miralles, G.; Pelletier, S.; Mainard, D.; Hubert, P.; Baptiste, D.; Gillet, P.; Dellacherie, E.; Netter, P.; Payan, E. Cartilage repair using new polysaccharidic biomaterials: macroscopic, histological and biochemical approaches in a rat model of cartilage defect Osteoarthritis Cartilage 2003, 11 (1) 16-28 10.1053/joca.2002.0859
96. Nishida, T.; Kubota, S.; Kojima, S.; Kuboki, T.; Nakao, K.; Kushibiki, T.; Tabata, Y.; Takigawa, M. Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor) J. Bone Miner. Res. 2004, 19 (8) 1308-19 10.1359/JBMR.040322
97. Ishii, I.; Mizuta, H.; Sei, A.; Hirose, J.; Kudo, S.; Hiraki, Y. Healing of full-thickness defects of the articular cartilage in rabbits using fibroblast growth factor-2 and a fibrin sealant J. Bone Jt. Surg., Br. Vol. 2007, 89 (5) 693-700 10.1302/0301-620X.89B5.18450
98. Park, S. H.; Cui, J. H.; Park, S. R.; Min, B. H. Potential of fortified fibrin/hyaluronic acid composite gel as a cell delivery vehicle for chondrocytes Artif. Organs 2009, 33 (6) 439-47 10.1111/j.1525-1594.2009.00744.x
99. Lee, J. C.; Lee, S. Y.; Min, H. J.; Han, S. A.; Jang, J.; Lee, S.; Seong, S. C.; Lee, M. C. Synovium-derived mesenchymal stem cells encapsulated in a novel injectable gel can repair osteochondral defects in a rabbit model Tissue Eng., Part A 2012, 18 (19-20) 2173-2186 10.1089/ten.tea.2011.0643
100. Park, J. S.; Yang, H. N.; Woo, D. G.; Jeon, S. Y.; Park, K. H. Chondrogenesis of human mesenchymal stem cells in fibrin constructs evaluated in vitro and in nude mouse and rabbit defects models Biomaterials 2011, 32 (6) 1495-507 10.1016/j.biomaterials.2010.11.003
101. Yasuda, K.; Kitamura, N.; Gong, J. P.; Arakaki, K.; Kwon, H. J.; Onodera, S.; Chen, Y. M.; Kurokawa, T.; Kanaya, F.; Ohmiya, Y.; Osada, Y. A novel double-network hydrogel induces spontaneous articular cartilage regeneration in vivo in a large osteochondral defect Macromol. Biosci. 2009, 9 (4) 307-16 10.1002/mabi.200800223
102. Imabuchi, R.; Ohmiya, Y.; Kwon, H. J.; Onodera, S.; Kitamura, N.; Kurokawa, T.; Gong, J. P.; Yasuda, K. Gene expression profile of the cartilage tissue spontaneously regenerated in vivo by using a novel double-network gel: comparisons with the normal articular cartilage BMC Musculoskeletal Disord. 2011, 12, 213 10.1186/1471-2474-12-213
103. Yokota, M.; Yasuda, K.; Kitamura, N.; Arakaki, K.; Onodera, S.; Kurokawa, T.; Gong, J. P. Spontaneous hyaline cartilage regeneration can be induced in an osteochondral defect created in the femoral condyle using a novel double-network hydrogel BMC Musculoskeletal Disord. 2011, 12, 49 10.1186/1471-2474-12-49
104. Kitamura, N.; Yasuda, K.; Ogawa, M.; Arakaki, K.; Kai, S.; Onodera, S.; Kurokawa, T.; Gong, J. P. Induction of spontaneous hyaline cartilage regeneration using a double-network gel: efficacy of a novel therapeutic strategy for an articular cartilage defect Am. J. Sports Med. 2011, 39 (6) 1160-9 10.1177/0363546511399383
105. Ogawa, M.; Kitamura, N.; Kurokawa, T.; Arakaki, K.; Tanaka, Y.; Gong, J. P.; Yasuda, K. Poly(2-acrylamido-2-methylpropanesulfonic acid) gel induces articular cartilage regeneration in vivo: comparisons of the induction ability between single- and double-network gels J. Biomed. Mater. Res., Part A 2012, 100 (9) 2244-2251 10.1002/jbm.a.34165
106. Matsuda, H.; Kitamura, N.; Kurokawa, T.; Arakaki, K.; Gong, J. P.; Kanaya, F.; Yasuda, K. Influence of the gel thickness on in vivo hyaline cartilage regeneration induced by double-network gel implanted at the bottom of a large osteochondral defect: short-term results BMC Musculoskeletal Disord. 2013, 14, 50 10.1186/1471-2474-14-50
107. Degoricija, L.; Bansal, P. N.; Sontjens, S. H.; Joshi, N. S.; Takahashi, M.; Snyder, B.; Grinstaff, M. W. Hydrogels for osteochondral repair based on photocrosslinkable carbamate dendrimers Biomacromolecules 2008, 9 (10) 2863-72 10.1021/bm800658x
108. Shokrgozar, M. A.; Bonakdar, S.; Dehghan, M. M.; Emami, S. H.; Montazeri, L.; Azari, S.; Rabbani, M. Biological evaluation of polyvinyl alcohol hydrogel crosslinked by polyurethane chain for cartilage tissue engineering in rabbit model J. Mater. Sci.: Mater. Med. 2013, 24 (10) 2449-2460 10.1007/s10856-013-4995-1
109. Fukui, T.; Kitamura, N.; Kurokawa, T.; Yokota, M.; Kondo, E.; Gong, J. P.; Yasuda, K. Intra-articular administration of hyaluronic acid increases the volume of the hyaline cartilage regenerated in a large osteochondral defect by implantation of a double-network gel J. Mater. Sci.: Mater. Med. 2014, 25 (4) 1173-82 10.1007/s10856-013-5139-3
110. Holland, T. A.; Bodde, E. W.; Baggett, L. S.; Tabata, Y.; Mikos, A. G.; Jansen, J. A. Osteochondral repair in the rabbit model utilizing bilayered, degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds J. Biomed. Mater. Res., Part A 2005, 75 (1) 156-167 10.1002/jbm.a.30379
111. Ito, Y.; Ochi, M.; Adachi, N.; Sugawara, K.; Yanada, S.; Ikada, Y.; Ronakorn, P. Repair of osteochondral defect with tissue-engineered chondral plug in a rabbit model Arthroscopy 2005, 21 (10) 1155-63 10.1016/j.arthro.2005.06.016
112. Funayama, A.; Niki, Y.; Matsumoto, H.; Maeno, S.; Yatabe, T.; Morioka, H.; Yanagimoto, S.; Taguchi, T.; Tanaka, J.; Toyama, Y. Repair of full-thickness articular cartilage defects using injectable type II collagen gel embedded with cultured chondrocytes in a rabbit model J. Orthop. Sci. 2008, 13 (3) 225-32 10.1007/s00776-008-1220-z
113. Lind, M.; Larsen, A.; Clausen, C.; Osther, K.; Everland, H. Cartilage repair with chondrocytes in fibrin hydrogel and MPEG polylactide scaffold: an in vivo study in goats Knee Surg Sports Traumatol Arthrosc 2008, 16 (7) 690-8 10.1007/s00167-008-0522-1
114. Lee, C. H.; Cook, J. L.; Mendelson, A.; Moioli, E. K.; Yao, H.; Mao, J. J. Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study Lancet 2010, 376 (9739) 440-8 10.1016/S0140-6736(10)60668-X
115. Toh, W. S.; Lee, E. H.; Guo, X. M.; Chan, J. K.; Yeow, C. H.; Choo, A. B.; Cao, T. Cartilage repair using hyaluronan hydrogel-encapsulated human embryonic stem cell-derived chondrogenic cells Biomaterials 2010, 31 (27) 6968-80 10.1016/j.biomaterials.2010.05.064
116. Kim, M.; Kim, S. E.; Kang, S. S.; Kim, Y. H.; Tae, G. The use of de-differentiated chondrocytes delivered by a heparin-based hydrogel to regenerate cartilage in partial-thickness defects Biomaterials 2011, 32 (31) 7883-96 10.1016/j.biomaterials.2011.07.015
117. Kim, M.; Hong, B.; Lee, J.; Kim, S. E.; Kang, S. S.; Kim, Y. H.; Tae, G. Composite system of PLCL scaffold and heparin-based hydrogel for regeneration of partial-thickness cartilage defects Biomacromolecules 2012, 13 (8) 2287-98 10.1021/bm3005353
118. Lee, H. R.; Park, K. M.; Joung, Y. K.; Park, K. D.; Do, S. H. Platelet-rich plasma loaded hydrogel scaffold enhances chondrogenic differentiation and maturation with up-regulation of CB1 and CB2 J. Controlled Release 2012, 159 (3) 332-7 10.1016/j.jconrel.2012.02.008
119. Ohshika, S.; Ishibashi, Y.; Kon, A.; Kusumi, T.; Kijima, H.; Toh, S. Potential of exogenous cartilage proteoglycan as a new material for cartilage regeneration Int. Orthop 2012, 36 (4) 869-77 10.1007/s00264-011-1335-2
120. Li, B.; Yang, J.; Ma, L.; Li, F.; Tu, Z.; Gao, C. Fabrication of poly(lactide-co-glycolide) scaffold filled with fibrin gel, mesenchymal stem cells, and poly(ethylene oxide)-b-poly(L-lysine)/TGF-beta1 plasmid DNA complexes for cartilage restoration in vivo J. Biomed. Mater. Res., Part A 2013, 101 (11) 3097-3108 10.1002/jbm.a.34618
121. Solchaga, L. A.; Temenoff, J. S.; Gao, J.; Mikos, A. G.; Caplan, A. I.; Goldberg, V. M. Repair of osteochondral defects with hyaluronan- and polyester-based scaffolds Osteoarthritis Cartilage 2005, 13 (4) 297-309 10.1016/j.joca.2004.12.016
122. Frenkel, S. R.; Bradica, G.; Brekke, J. H.; Goldman, S. M.; Ieska, K.; Issack, P.; Bong, M. R.; Tian, H.; Gokhale, J.; Coutts, R. D.; Kronengold, R. T. Regeneration of articular cartilage - evaluation of osteochondral defect repair in the rabbit using multiphasic implants Osteoarthritis Cartilage 2005, 13 (9) 798-807 10.1016/j.joca.2005.04.018
123. Vinatier, C.; Gauthier, O.; Fatimi, A.; Merceron, C.; Masson, M.; Moreau, A.; Moreau, F.; Fellah, B.; Weiss, P.; Guicheux, J. An injectable cellulose-based hydrogel for the transfer of autologous nasal chondrocytes in articular cartilage defects Biotechnol. Bioeng. 2009, 102 (4) 1259-67 10.1002/bit.22137
124. Lam, J.; Lu, S.; Lee, E. J.; Trachtenberg, J. E.; Meretoja, V. V.; Dahlin, R. L.; van den Beucken, J. J.; Tabata, Y.; Wong, M. E.; Jansen, J. A.; Mikos, A. G.; Kasper, F. K. Osteochondral defect repair using bilayered hydrogels encapsulating both chondrogenically and osteogenically pre-differentiated mesenchymal stem cells in a rabbit model Osteoarthritis Cartilage 2014, 22 (9) 1291-300 10.1016/j.joca.2014.06.035
125. Wang, W.; Sun, L.; Zhang, P.; Song, J.; Liu, W. An anti-inflammatory cell-free collagen/resveratrol scaffold for repairing osteochondral defects in rabbits Acta Biomater. 2014, 10 (12) 4983-95 10.1016/j.actbio.2014.08.022
126. Lu, S.; Lam, J.; Trachtenberg, J. E.; Lee, E. J.; Seyednejad, H.; van den Beucken, J. J.; Tabata, Y.; Wong, M. E.; Jansen, J. A.; Mikos, A. G.; Kasper, F. K. Dual growth factor delivery from bilayered, biodegradable hydrogel composites for spatially-guided osteochondral tissue repair Biomaterials 2014, 35 (31) 8829-39 10.1016/j.biomaterials.2014.07.006
127. Needham, C. J.; Shah, S. R.; Dahlin, R. L.; Kinard, L. A.; Lam, J.; Watson, B. M.; Lu, S.; Kasper, F. K.; Mikos, A. G. Osteochondral tissue regeneration through polymeric delivery of DNA encoding for the SOX trio and RUNX2 Acta Biomater. 2014, 10 (10) 4103-12 10.1016/j.actbio.2014.05.011
128. Han, F.; Yang, X.; Zhao, J.; Zhao, Y.; Yuan, X. Photocrosslinked layered gelatin-chitosan hydrogel with graded compositions for osteochondral defect repair J. Mater. Sci.: Mater. Med. 2015, 26 (4) 160 10.1007/s10856-015-5489-0
129. Mazaki, T.; Shiozaki, Y.; Yamane, K.; Yoshida, A.; Nakamura, M.; Yoshida, Y.; Zhou, D.; Kitajima, T.; Tanaka, M.; Ito, Y.; Ozaki, T.; Matsukawa, A. A novel, visible light-induced, rapidly cross-linkable gelatin scaffold for osteochondral tissue engineering Sci. Rep. 2014, 4, 4457 10.1038/srep04457
130. Leone, G.; Fini, M.; Torricelli, P.; Giardino, R.; Barbucci, R. An amidated carboxymethylcellulose hydrogel for cartilage regeneration J. Mater. Sci.: Mater. Med. 2008, 19 (8) 2873-80 10.1007/s10856-008-3412-7
131. Bal, B. S.; Rahaman, M. N.; Jayabalan, P.; Kuroki, K.; Cockrell, M. K.; Yao, J. Q.; Cook, J. L. In vivo outcomes of tissue-engineered osteochondral grafts J. Biomed. Mater. Res., Part B 2010, 93 (1) 164-174 10.1002/jbm.b.31571
132. Zhang, W.; Lian, Q.; Li, D.; Wang, K.; Hao, D.; Bian, W.; He, J.; Jin, Z. Cartilage repair and subchondral bone migration using 3D printing osteochondral composites: a one-year-period study in rabbit trochlea BioMed Res. Int. 2014, 2014, 746138 10.1155/2014/746138
133. Ge, Z.; Li, C.; Heng, B. C.; Cao, G.; Yang, Z. Functional biomaterials for cartilage regeneration J. Biomed. Mater. Res., Part A 2012, 100 (9) 2526-2536 10.1002/jbm.a.34147
134. Toh, W. S.; Spector, M.; Lee, E. H.; Cao, T. Biomaterial-mediated delivery of microenvironmental cues for repair and regeneration of articular cartilage Mol. Pharmaceutics 2011, 8 (4) 994-1001 10.1021/mp100437a
135. Chu, C. R.; Szczodry, M.; Bruno, S. Animal models for cartilage regeneration and repair Tissue Eng., Part B 2010, 16 (1) 105-115 10.1089/ten.teb.2009.0452
136. Rasanen, T.; Messner, K. Regional variations of indentation stiffness and thickness of normal rabbit knee articular cartilage J. Biomed. Mater. Res. 1996, 31 (4) 519-524 10.1002/(SICI)1097-4636(199608)31:4<519::AID-JBM12>3.3.CO;2-O
137. Ahern, B. J.; Parvizi, J.; Boston, R.; Schaer, T. P. Preclinical animal models in single site cartilage defect testing: a systematic review Osteoarthritis Cartilage 2009, 17 (6) 705-13 10.1016/j.joca.2008.11.008
138. Aigner, T.; Cook, J. L.; Gerwin, N.; Glasson, S. S.; Laverty, S.; Little, C. B.; McIlwraith, W.; Kraus, V. B. Histopathology atlas of animal model systems-overview of guiding principles Osteoarthritis Cartilage 2010, 18 (Suppl 3) S2-S6 10.1016/j.joca.2010.07.013
139. Shapiro, F.; Koide, S.; Glimcher, M. J. Cell origin and differentiation in the repair of full-thickness defects of articular cartilage J. Bone Joint Surg Am. 1993, 75 (4) 532-553
140. Koch, T. G.; Betts, D. H. Stem cell therapy for joint problems using the horse as a clinically relevant animal model Expert Opin. Biol. Ther. 2007, 7 (11) 1621-6 10.1517/14712598.7.11.1621
141. Convery, F. R.; Akeson, W. H.; Keown, G. H. The repair of large osteochondral defects. An experimental study in horses Clin. Orthop. Relat. Res. 1972, 82, 253-262 10.1097/00003086-197201000-00033
142. Shortkroff, S.; Barone, L.; Hsu, H. P.; Wrenn, C.; Gagne, T.; Chi, T.; Breinan, H.; Minas, T.; Sledge, C. B.; Tubo, R.; Spector, M. Healing of chondral and osteochondral defects in a canine model: the role of cultured chondrocytes in regeneration of articular cartilage Biomaterials 1996, 17 (2) 147-154 10.1016/0142-9612(96)85759-0
143. Lu, Y.; Markel, M. D.; Swain, C.; Kaplan, L. D. Development of partial thickness articular cartilage injury in an ovine model J. Orthop. Res. 2006, 24 (10) 1974-82 10.1002/jor.20249
144. Frisbie, D. D.; Cross, M. W.; McIlwraith, C. W. A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee Vet. Comp. Orthop. Traumatol. 2006, 19 (3) 142-146
145. Hepp, P.; Osterhoff, G.; Niederhagen, M.; Marquass, B.; Aigner, T.; Bader, A.; Josten, C.; Schulz, R. Perilesional changes of focal osteochondral defects in an ovine model and their relevance to human osteochondral injuries J. Bone Jt. Surg., Br. Vol. 2009, 91 (8) 1110-1119 10.1302/0301-620X.91B8.22057
146. Kim, H. K.; Moran, M. E.; Salter, R. B. The potential for regeneration of articular cartilage in defects created by chondral shaving and subchondral abrasion. An experimental investigation in rabbits J. Bone Joint Surg Am. 1991, 73 (9) 1301-1315
147. Bonasia, D. E.; Marmotti, A.; Massa, A. D.; Ferro, A.; Blonna, D.; Castoldi, F.; Rossi, R. Intra- and inter-observer reliability of ten major histological scoring systems used for the evaluation of in vivo cartilage repair Knee Surg. Sports Traumatol. Arthrosc. 2014, 10.1007/s00167-014-2975-8
148. Rutgers, M.; van Pelt, M. J.; Dhert, W. J.; Creemers, L. B.; Saris, D. B. Evaluation of histological scoring systems for tissue-engineered, repaired and osteoarthritic cartilage Osteoarthritis Cartilage 2010, 18 (1) 12-23 10.1016/j.joca.2009.08.009
149. Orth, P.; Zurakowski, D.; Wincheringer, D.; Madry, H. Reliability, Reproducibility, and Validation of Five Major Histological Scoring Systems for Experimental Articular Cartilage Repair in the Rabbit Model Tissue Eng., Part C 2012, 18 (5) 329-339 10.1089/ten.tec.2011.0462
150. Hurtig, M. B.; Buschmann, M. D.; Fortier, L. A.; Caroline, D.; Hoemann Ernest, B.; Hunziker; Jurvelin, J. S.; Mainil-Varlet, P.; Mcllwraith, C. W.; Sah, R. L.; Whiteside, R. A., Preclinical Studies for Cartilage Repair: Recommendations from International Cartilage Repair Society. Cartilage 2011, 2 (2), 137-152, DOI. 10.1177/1947603511401905
151. Standard Guide for in Vivo Assessement of Implantable Devices Intended to Repair or Regenerate Articular Cartilage; ASTM F2451-05; ASTM International: West Conshohocken, NJ, 2010.