Simultaneous regeneration of articular cartilage and subchondral bone induced by spatially presented TGF-beta and BMP-4 in a bilayer affinity binding system

Acta Biomaterialia

Volumn 8, Issue 9, 2012, Pages 3283-3293

  Re'Em, Tali ^a   Witte, Frank ^a,b   Willbold, Elmar ^b   Ruvinov, Emil ^a   Cohen, Smadar ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Affinity binding scaffold; Bilayer; BMP 4; Subchondral defect; TGF 1

Indexed keywords

CARTILAGE; CELL CULTURE; DEFECTS; HYDROGELS; OSTEOBLASTS; REPAIR; STEM CELLS;

AFFINITY BINDING; AFFINITY-BINDING SCAFFOLD; ARTICULAR CARTILAGES; BI-LAYER; BILAYER SYSTEMS; BINDING SYSTEMS; BONE MORPHOGENETIC PROTEIN-4; DEFECT REPAIR; SUBCHONDRAL DEFECTS; TRANSFORMING GROWTH FACTOR-Β1;

BONE;

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 4; COLLAGEN TYPE 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEOGLYCAN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BONE DEFECT; BONE MINERALIZATION; BONE REGENERATION; CARTILAGE CELL; CELL DIFFERENTIATION; CELL LINEAGE; CELL MIGRATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EXPERIMENTAL RABBIT; EXTRACELLULAR MATRIX; FEMALE; HUMAN; HUMAN CELL; HYALINE CARTILAGE; HYALINE CARTILAGE REGENERATION; HYDROGEL; MESENCHYMAL STEM CELL; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSSIFICATION; POROSITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SUBCHONDRAL BONE REGENERATION; TISSUE REGENERATION;

ORYCTOLAGUS CUNICULUS;

EID: 84864413986     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.05.014     Document Type: Article

References (35)

1. M. Marcacci, M. Berruto, D. Brocchetta, A. Delcogliano, D. Ghinelli, and A. Gobbi Articular cartilage engineering with Hyalograft C: 3-year clinical results Clin Orthop Relat Res 435 2005 96 105 (Pubitemid 40798651)
2. D.C. Crawford, C.M. Heveran, W.D. Cannon Jr., L.F. Foo, and H.G. Potter An autologous cartilage tissue implant NeoCart for treatment of grade III chondral injury to the distal femur: prospective clinical safety trial at 2 years Am J Sports Med 37 2009 1334 1343
3. D.J. Prockop Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms Mol Ther 17 2009 939 946
4. R.N. Shah, N.A. Shah, M.M. Del Rosario Lim, C. Hsieh, G. Nuber, and S.I. Stupp Supramolecular design of self-assembling nanofibers for cartilage regeneration Proc Natl Acad Sci USA 107 2010 3293 3298
5. A.J. Nixon, L.A. Fortier, J. Williams, and H. Mohammed Enhanced repair of extensive articular defects by insulin-like growth factor-I-laden fibrin composites J Orthop Res 17 1999 475 487 (Pubitemid 29383606)
6. T. Gotterbarm, W. Richter, M. Jung, S. Berardi Vilei, P. Mainil-Varlet, and T. Yamashita An in vivo study of a growth-factor enhanced, cell free, two-layered collagen-tricalcium phosphate in deep osteochondral defects Biomaterials 27 2006 3387 3395
7. D.J. Laird, U.H. von Andrian, and A.J. Wagers Stem cell trafficking in tissue development, growth, and disease Cell 132 2008 612 630 (Pubitemid 351253693)
8. J.M. Karp, and G.S. Leng Teo Mesenchymal stem cell homing: the devil is in the details Cell Stem Cell 4 2009 206 216
9. Y. Miura, J.S. Fitzsimmons, C.N. Commisso, S.H. Gallay, and S.W. O'Driscoll Enhancement of periosteal chondrogenesis in vitro. Dose-response for transforming growth factor-beta 1 (TGF-beta 1) Clin Orthop Relat Res 301 1994 271 280 (Pubitemid 24119286)
10. K. Lavery, P. Swain, D. Falb, and M.H. Alaoui-Ismaili BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells J Biol Chem 283 2008 20948 20958
11. T. Cordonnier, A. Langonne, J. Sohier, P. Layrolle, P. Rosset, and L. Sensebe Consistent osteoblastic differentiation of human mesenchymal stem cells with bone morphogenetic protein 4 and low serum Tissue Eng Part C: Methods 17 2011 249 259
12. P.C. Bessa, M.T. Cerqueira, T. Rada, M.E. Gomes, N.M. Neves, and A. Nobre Expression, purification and osteogenic bioactivity of recombinant human BMP-4, -9, -10, -11 and -14 Protein Expr Purif 63 2009 89 94
13. T. Re'em, Y. Kaminer-Israeli, E. Ruvinov, and S. Cohen Chondrogenesis of hMSC in affinity-bound TGF-beta scaffolds Biomaterials 33 2012 751 761
14. I. Freeman, A. Kedem, and S. Cohen The effect of sulfation of alginate hydrogels on the specific binding and controlled release of heparin-binding proteins Biomaterials 29 2008 3260 3268
15. I. Freeman, and S. Cohen The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization Biomaterials 30 2009 2122 2131
16. E. Ruvinov, J. Leor, and S. Cohen The effects of controlled HGF delivery from an affinity-binding alginate biomaterial on angiogenesis and blood perfusion in a hindlimb ischemia model Biomaterials 31 2010 4573 4582
17. E. Ruvinov, J. Leor, and S. Cohen The promotion of myocardial repair by the sequential delivery of IGF-1 and HGF from an injectable alginate biomaterial in a model of acute myocardial infarction Biomaterials 32 2011 565 578
18. L. Shapiro, and S. Cohen Novel alginate sponges for cell culture and transplantation Biomaterials 18 1997 583 590 (Pubitemid 27186866)
19. M. Kohan, R. Breuer, and N. Berkman Osteopontin induces airway remodeling and lung fibroblast activation in a murine model of asthma Am J Respir Cell Mol Biol 41 2009 290 296
20. O. Levy, T. Dvir, O. Tsur-Gang, Y. Granot, and S. Cohen Signal transducer and activator of transcription 3-A key molecular switch for human mesenchymal stem cell proliferation Int J Biochem Cell Biol 40 2008 2606 2618
21. C.E. Bills, H. Eisenberg, and S.L. Pallante Complexes of organic acids with calcium phosphate: the von Kossa stain as a clue to the composition of bone mineral Johns Hopkins Med J 128 1971 194 207
22. O. Levy, E. Ruvinov, T. Reem, Y. Granot, and S. Cohen Highly efficient osteogenic differentiation of human mesenchymal stem cells by eradication of STAT3 signaling Int J Biochem Cell Biol 42 2010 1823 1830
23. O. Kozawa, D. Hatakeyama, and T. Uematsu Divergent regulation by p44/p42 MAP kinase and p38 MAP kinase of bone morphogenetic protein-4-stimulated osteocalcin synthesis in osteoblasts J Cell Biochem 84 2002 583 589 (Pubitemid 34111192)
24. H. Qi, D.J. Aguiar, S.M. Williams, A. La Pean, W. Pan, and C.M. Verfaillie Identification of genes responsible for osteoblast differentiation from human mesodermal progenitor cells Proc Natl Acad Sci USA 100 2003 3305 3310 (Pubitemid 36356578)
25. M.B. Goldring, K. Tsuchimochi, and K. Ijiri The control of chondrogenesis J Cell Biochem 97 2006 33 44 (Pubitemid 43050970)
26. C.C. Rider Heparin/heparan sulphate binding in the TGF-beta cytokine superfamily Biochem Soc Trans 34 2006 458 460 (Pubitemid 43954012)
27. Q. Hu, N. Ueno, and R.R. Behringer Restriction of BMP4 activity domains in the developing neural tube of the mouse embryo EMBO Rep 5 2004 734 739 (Pubitemid 39173011)
28. B. Ohkawara, S. Iemura, P. ten Dijke, and N. Ueno Action range of BMP is defined by its N-terminal basic amino acid core Curr Biol 12 2002 205 209 (Pubitemid 34122375)
29. Q. Huang, J.C. Goh, D.W. Hutmacher, and E.H. Lee In vivo mesenchymal cell recruitment by a scaffold loaded with transforming growth factor beta1 and the potential for in situ chondrogenesis Tissue Eng 8 2002 469 482 (Pubitemid 34747803)
30. T.A. Holland, E.W. Bodde, L.S. Baggett, Y. Tabata, A.G. Mikos, and J.A. Jansen Osteochondral repair in the rabbit model utilizing bilayered, degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds J Biomed Mater Res A 75 2005 156 167 (Pubitemid 41298197)
31. G.D. Smith, G. Knutsen, and J.B. Richardson A clinical review of cartilage repair techniques J Bone Joint Surg Br 87 2005 445 449 (Pubitemid 40575762)
32. S.N. Redman, S.F. Oldfield, and C.W. Archer Current strategies for articular cartilage repair Eur Cell Mater 9 2005 23 32 [discussion 23-32] (Pubitemid 41008175)
33. T. Dvir, A. Kedem, E. Ruvinov, O. Levy, I. Freeman, and N. Landa Prevascularization of cardiac patch on the omentum improves its therapeutic outcome Proc Natl Acad Sci USA 106 2009 14990 14995
34. D. Schaefer, I. Martin, G. Jundt, J. Seidel, M. Heberer, and A. Grodzinsky Tissue-engineered composites for the repair of large osteochondral defects Arthritis Rheum 46 2002 2524 2534
35. X.X. Shao, D.W. Hutmacher, S.T. Ho, J.C. Goh, and E.H. Lee Evaluation of a hybrid scaffold/cell construct in repair of high-load-bearing osteochondral defects in rabbits Biomaterials 27 2006 1071 1080 (Pubitemid 41566700)