Hydrogels and microtechnologies for engineering the cellular microenvironment

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

Volumn 4, Issue 3, 2012, Pages 235-246

  Gauvin, Robert ^a,b,c   Parenteau Bareil, Rémi ^a,b,c,d   Dokmeci, Mehmet R ^a,b   Merryman, W David ^e   Khademhosseini, Ali ^a,b,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HARVARD UNIVERSITY   (United States)

^d UNIVERSITÉ LAVAL   (Canada)

^e VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL INTERACTIONS; BIOMEDICAL APPLICATIONS; CELL BEHAVIORS; CELL SEEDING; CELLULAR MICROENVIRONMENT; DEGRADATION KINETICS; DIFFUSION PROPERTIES; DIRECTED ASSEMBLY; FABRICATION PROCESS; FUNDAMENTAL RESEARCH; IN-VITRO; IN-VIVO; MICRO TECHNOLOGY; MICRO-GELS; MICRO-SCALE STRUCTURES; MICRO-SCALES; MICROENVIRONMENTS; POLYMERIC CHAIN; PRECISE CONTROL; TISSUE MODELS;

BIOCOMPATIBILITY; BIOMECHANICS; CELLS; CYTOLOGY; DEGRADATION; DRUG DELIVERY; MECHANICAL PROPERTIES; MEDICAL APPLICATIONS; THREE DIMENSIONAL COMPUTER GRAPHICS; TISSUE; TISSUE ENGINEERING;

HYDROGELS;

POLYMER; TISSUE SCAFFOLD;

ABSORPTION; BIOCOMPATIBILITY; CELL FUNCTION; DIFFUSION; ENCAPSULATION; HIGH THROUGHPUT SCREENING; HUMAN; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; LIQUID; MICROENVIRONMENT; MICROTECHNOLOGY; PRIORITY JOURNAL; REVIEW; TISSUE ENGINEERING; TOPOGRAPHY; TUMOR MICROENVIRONMENT;

CELLULAR MICROENVIRONMENT; HUMANS; HYDROGELS; MICROTECHNOLOGY; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84864764428     PISSN: 19395116     EISSN: 19390041     Source Type: Journal    
DOI: 10.1002/wnan.171     Document Type: Review

References (84)

1. Slaughter BV, Khurshid SS, Fisher OZ, Khademhosseini A, PeppasNA. Hydrogels in regenerativemedicine. Adv Mater 2009, 21:3307-3329.
2. Benoit DS, Schwartz MP, Durney AR, Anseth KS. Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells. Nat Mater 2008, 7:816-823.
3. Cushing MC, Anseth KS. Materials science. Hydrogel cell cultures. Science 2007, 316:1133-1134.
4. Khademhosseini A, Langer R. Microengineered hydrogels for tissue engineering. Biomaterials 2007, 28:5087-5092.
5. Ingber DE, Mow VC, Butler D, Niklason L, Huard J, Mao J, Yannas I, Kaplan D, Vunjak-Novakovic G. Tissue engineering and developmental biology: going biomimetic. Tissue Eng 2006, 12:3265-3283.
6. Khademhosseini A, Vacanti JP, Langer R. Progress in tissue engineering. Sci Am 2009, 300:64-71.
7. Discher DE, Janmey P, Wang YL. Tissue cells feel and respond to the stiffness of their substrate. Science 2005, 310:1139-1143.
8. Drury JL, Mooney DJ. Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials 2003, 24:4337-4351.
9. Mikos AG, Herring SW, Ochareon P, Elisseeff J, Lu HH, Kandel R, Schoen FJ, Toner M, Mooney D, Atala A, et al. Engineering complex tissues. Tissue Eng 2006, 12:3307-3339.
10. Lutolf MP, Hubbell JA. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nat Biotechnol 2005, 23:47-55.
11. Bryant SJ, Nuttelman CR, Anseth KS. The effects of crosslinking density on cartilage formation in photocrosslinkable hydrogels. Biomed Sci Instrum 1999, 35:309-314.
12. Drury JL, Dennis RG, Mooney DJ. The tensile properties of alginate hydrogels. Biomaterials 2004, 25:3187-3199.
13. Anderson SB, Lin CC, Kuntzler DV, Anseth KS. The performance of human mesenchymal stem cells encapsulated in cell-degradable polymer-peptide hydrogels. Biomaterials 2011, 32:3564-3574.
14. Freed LE, Engelmayr GC Jr, Borenstein JT, Moutos FT, Guilak F. Advanced material strategies for tissue engineering scaffolds. Adv Mater 2009, 21:3410-3418.
15. Rowley JA, Madlambayan G, Mooney DJ. Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials 1999, 20:45-53.
16. Zisch AH, Lutolf MP, Ehrbar M, Raeber GP, Rizzi SC, Davies N, Schmokel H, Bezuidenhout D, Djonov V, Zilla P, et al. Cell-demanded release of VEGF from synthetic, biointeractive cell ingrowth matrices for vascularized tissue growth. FASEB J 2003, 17:2260-2262.
17. Lutolf MP, Weber FE, Schmoekel HG, Schense JC, Kohler T, Muller R, Hubbell JA. Repair of bone defects using synthetic mimetics of collagenous extracellular matrices. Nat Biotechnol 2003, 21:513-518.
18. Khademhosseini A, Langer R, Borenstein J, Vacanti JP. Microscale technologies for tissue engineering and biology. Proc Natl Acad Sci U S A 2006, 103:2480-2487.
19. Xia Y, Kim E, Zhao XM, Rogers JA, Prentiss M, Whitesides GM. Complex optical surfaces formed by replica molding against elastomeric masters. Science 1996, 273:347-349.
20. Whitesides GM, Ostuni E, Takayama S, Jiang X, Ingber DE. Soft lithography in biology and biochemistry. Annu Rev Biomed Eng 2001, 3:335-373.
21. Khademhosseini A, Jon S, Suh KY, Tran TNT, Eng G, Yeh J, Seong J, Langer R. Direct patterning of proteinand cell-resistant polymeric monolayers and microstructures. Adv Mater 2003, 15:1995-2000.
22. Bhatia SN, Balis UJ, Yarmush ML, Toner M. Effect of cell-cell interactions in preservation of cellular phenotype: cocultivation of hepatocytes and nonparenchymal cells. FASEB J 1999, 13:1883-1900.
23. Khademhosseini A, Bettinger C, Karp JM, Yeh J, Ling Y, Borenstein J, Fukuda J, Langer R. Interplay of biomaterials and micro-scale technologies for advancing biomedical applications. J Biomater Sci Polym Ed 2006, 17:1221-1240.
24. Liu VA, Bhatia SN. Three-dimensional photopatterning of hydrogels containing living cells. Biomed Microdevices 2002, 4:257-266.
25. Liu Tsang V, Chen AA, Cho LM, Jadin KD, Sah RL, DeLong S, West JL, Bhatia SN. Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels. FASEB J 2007, 21:790-801.
26. Lu Y, Mapili G, Suhali G, Chen S, Roy K. A digital micro-mirror device-based system for the microfabrication of complex, spatially patterned tissue engineering scaffolds. J Biomed Mater Res A 2006, 77:396-405.
27. Mapili G, Lu Y, Chen S, Roy K. Laser-layered microfabrication of spatially patterned functionalized tissueengineering scaffolds. J Biomed Mater Res B Appl Biomater 2005, 75:414-424.
28. Han LH, Suri S, Schmidt CE, Chen S. Fabrication of three-dimensional scaffolds for heterogeneous tissue engineering. Biomed Microdevices 2010, 12:721-725.
29. Chan V, Zorlutuna P, Jeong JH, Kong H, Bashir R. Three-dimensional photopatterning of hydrogels using stereolithography for long-term cell encapsulation. Lab Chip 2010, 10:2062-2070.
30. Guillotin B, Souquet A, Catros S, Duocastella M, Pippenger B, Bellance S, Bareille R, Remy M, Bordenave L, Amedee J, et al. Laser assisted bioprinting of engineered tissue with high cell density and microscale organization. Biomaterials 2010, 31:7250-7256.
31. Zhu J. Bioactive modification of poly(ethylene glycol) hydrogels for tissue engineering. Biomaterials 2010, 31:4639-4656.
32. Nuttelman CR, Henry SM, Anseth KS. Synthesis and characterization of photocrosslinkable, degradable poly(vinyl alcohol)-based tissue engineering scaffolds. Biomaterials 2002, 23:3617-3626.
33. Kim S, Healy KE. Synthesis and characterization of injectable poly(N-isopropylacrylamide-co-acrylic acid) hydrogels with proteolytically degradable cross-links. Biomacromolecules 2003, 4:1214-1223.
34. Bell E, Ivarsson B, Merrill C. Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferative potential in vitro. Proc Natl Acad Sci U S A 1979, 76:1274-1278.
35. West JL, Hubbell JA. Polymeric biomaterials with degradation sites for proteases involved in cell migration. Macromolecules 1998, 32:241-244.
36. Saha K, Pollock JF, Schaffer DV, Healy KE. Designing synthetic materials to control stem cell phenotype. Curr Opin Chem Biol 2007, 11:381-387.
37. Williams CG, Kim TK, Taboas A, Malik A, Manson P, Elisseeff J. In vitro chondrogenesis of bone marrowderived mesenchymal stem cells in a photopolymerizing hydrogel. Tissue Eng 2003, 9:679-688.
38. Bryant SJ, Arthur JA, Anseth KS. Incorporation of tissue-specific molecules alters chondrocyte metabolism and gene expression in photocrosslinked hydrogels. Acta Biomater 2005, 1:243-252.
39. Burdick JA, Anseth KS. Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering. Biomaterials 2002, 23:4315-4323.
40. Lysaght MJ, Hazlehurst AL. Tissue engineering: the end of the beginning. Tissue Eng 2004, 10:309-320.
41. Khademhosseini A, Suh KY, Jon S, Eng G, Yeh J, Chen GJ, Langer R. A soft lithographic approach to fabricate patterned microfluidic channels. Anal Chem 2004, 76:3675-3681.
42. Cruise GM, Hegre OD, Lamberti FV, Hager SR, Hill R, Scharp DS, Hubbell JA. In vitro and in vivo performance of porcine islets encapsulated in interfacially photopolymerized poly(ethylene glycol) diacrylate membranes. Cell Transplant 1999, 8:293-306.
43. Gross JD, Long RC Jr, Constantinidis I, Sambanis A. Monitoring of dissolved oxygen and cellular bioenergetics within a pancreatic substitute. Biotechnol Bioeng 2007, 98:261-270.
44. Bohl KS, West JL. Nitric oxide-generating polymers reduce platelet adhesion and smooth muscle cell proliferation. Biomaterials 2000, 21:2273-2278.
45. Kretlow JD, Klouda L, Mikos AG. Injectable matrices and scaffolds for drug delivery in tissue engineering. Adv Drug Deliv Rev 2007, 59:263-273.
46. Ifkovits JL, Burdick JA. Review: photopolymerizable and degradable biomaterials for tissue engineering applications. Tissue Eng 2007, 13:2369-2385.
47. Lin CC, Anseth KS. PEG hydrogels for the controlled release of biomolecules in regenerative medicine. Pharm Res 2009, 26:631-643.
48. Burdick JA, Frankel D, Dernell WS, Anseth KS. An initial investigation of photocurable three-dimensional lactic acid based scaffolds in a critical-sized cranial defect. Biomaterials 2003, 24:1613-1620.
49. Richards Grayson AC, Choi IS, Tyler BM, Wang PP, Brem H, Cima MJ, Langer R. Multi-pulse drug delivery from a resorbable polymeric microchip device. Nat Mater 2003, 2:767-772.
50. Sajeesh S, Bouchemal K, Marsaud V, Vauthier C, Sharma CP. Cyclodextrin complexed insulin encapsulated hydrogel microparticles: an oral delivery system for insulin. J Control Release 2010, 147:377-384.
51. Kohane DS, Tse JY, Yeo Y, Padera R, Shubina M, Langer R. Biodegradable polymeric microspheres and nanospheres for drug delivery in the peritoneum. J Biomed Mater Res A 2006, 77:351-361.
52. Anderson DG, Levenberg S, Langer R. Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells. Nat Biotechnol 2004, 22:863-866.
53. Davies MC, Alexander MR, Hook AL, Yang J, Mei Y, Taylor M, Urquhart AJ, Langer R, Anderson DG. High throughput surface characterization: a review of a new tool for screening prospective biomedical material arrays. J Drug Target 18:741-751.
54. Sundberg SA. High-throughput and ultra-high-throughput screening: solution- and cell-based approaches. Curr Opin Biotechnol 2000, 11:47-53.
55. Underhill GH, Bhatia SN. High-throughput analysis of signals regulating stem cell fate and function. Curr Opin Chem Biol 2007, 11:357-366.
56. Mei Y, Hollister-Lock J, Bogatyrev SR, Cho SW, Weir GC, Langer R, Anderson DG. A high throughput micro-array system of polymer surfaces for the manipulation of primary pancreatic islet cells. Biomaterials 31:8989-8995.
57. Flaim CJ, Chien S, Bhatia SN. An extracellular matrix microarray for probing cellular differentiation. Nat Methods 2005, 2:119-125.
58. Soen Y, Mori A, Palmer TD, Brown PO. Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments. Mol Syst Biol 2006, 2:37.
59. Chen S, Do JT, Zhang Q, Yao S, Yan F, Peters EC, Scholer HR, Schultz PG, Ding S. Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A 2006, 103:17266-17271.
60. Mei Y, Saha K, Bogatyrev SR, Yang J, Hook AL, Kalcioglu ZI, Cho SW, Mitalipova M, Pyzocha N, Rojas F, et al. Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells. Nat Mater 2010, 9:768-778.
61. Huh D, Matthews BD, Mammoto A, Montoya-Zavala M, Hsin HY, Ingber DE. Reconstituting organlevel lung functions on a chip. Science 2010, 328:1662-1668.
62. Borenstein JT, Weinberg EJ, Orrick BK, Sundback C, Kaazempur-Mofrad MR, Vacanti JP. Microfabrication of three-dimensional engineered scaffolds. Tissue Eng 2007, 13:1837-1844.
63. Du Y, Lo E, Ali S, Khademhosseini A. Directed assembly of cell-laden microgels for fabrication of 3D tissue constructs. Proc Natl Acad Sci U S A 2008, 105:9522-9527.
64. Chan C, Berthiaume F, Nath BD, Tilles AW, Toner M, Yarmush ML. Hepatic tissue engineering for adjunct and temporary liver support: critical technologies. Liver Transpl 2004, 10:1331-1342.
65. Allen JW, Bhatia SN. Engineering liver therapies for the future. Tissue Eng 2002, 8:725-737.
66. Breen TL, Tien J, Oliver SR, Hadzic T, Whitesides GM. Design and self-assembly of open, regular, 3D mesostructures. Science 1999, 284:948-951.
67. Bowden N, Terfort A, Carbeck J, Whitesides GM. Selfassembly of mesoscale objects into ordered twodimensional arrays. Science 1997, 276:233-235.
68. Chandler D. Interfaces and the driving force of hydrophobic assembly. Nature 2005, 437:640-647.
69. Scott EA, Nichols MD, Kuntz-Willits R, Elbert DL. Modular scaffolds assembled around living cells using poly(ethylene glycol) microspheres with macroporation via a non-cytotoxic porogen. Acta Biomater 2010, 6:29-38.
70. McGuigan AP, Leung B, Sefton MV. Fabrication of cell-containing gel modules to assemble modular tissueengineered constructs. Nat Protoc 2006, 1:2963-2969.
71. Panda P, Ali S, Lo E, Chung BG, Hatton TA, Khademhosseini A, Doyle PS. Stop-flow lithography to generate cell-laden microgel particles. Lab Chip 2008, 8:1056-1061.
72. Fernandez JG, Khademhosseini A. Micro-masonry: construction of 3D structures by microscale selfassembly. Adv Mater 2010, 22:2538-2541.
73. Peppas NA, Hilt JZ, Khademhosseini A, Langer R. Hydrogels in biology and medicine: from molecular principles to bionanotechnology. Adv Mater 2006, 18:1345-1360.
74. Du Y, Ghodousi M, Qi H, Haas N, Xiao W, Khademhosseini A. Sequential assembly of cellladen hydrogel constructs to engineer vascular-like microchannels. Biotechnol Bioeng 2011.
75. Ehrbar M, Djonov VG, Schnell C, Tschanz SA, Martiny-Baron G, Schenk U, Wood J, Burri PH, Hubbell JA, Zisch AH. Cell-demanded liberation of VEGF121 from fibrin implants induces local and controlled blood vessel growth. Circ Res 2004, 94:1124-1132.
76. Peters MC, Polverini PJ, Mooney DJ. Engineering vascular networks in porous polymer matrices. J Biomed Mater Res 2002, 60:668-678.
77. King KR, Wang CJ, Kaazempur-Mofrad MR, Vacanti JP, Borenstein JT. Biodegradable microfluidics. Adv Mater 2004, 16:2007-2012.
78. Fidkowski C, Kaazempur-Mofrad MR, Borenstein J, Vacanti JP, Langer R, Wang Y. Endothelialized microvasculature based on a biodegradable elastomer. Tissue Eng 2005, 11:302-309.
79. Golden AP, Tien J. Fabrication of microfluidic hydrogels using molded gelatin as a sacrificial element. Lab Chip 2007, 7:720-725.
80. Choi NW, Cabodi M, Held B, Gleghorn JP, Bonassar LJ, Stroock AD. Microfluidic scaffolds for tissue engineering. Nat Mater 2007, 6:908-915.
81. Chrobak KM, Potter DR, Tien J. Formation of perfused, functional microvascular tubes in vitro. Microvasc Res 2006, 71:185-196.
82. Borenstein JT, Tupper MM, Mack PJ, Weinberg EJ, Khalil AS, Hsiao J, Garcia-Cardena G. Functional endothelialized microvascular networks with circular cross-sections in a tissue culture substrate. Biomed Microdevices 2010, 12:71-79.
83. Ahn BY, Shoji D, Hansen CJ, Hong E, Dunand DC, Lewis JA. Printed origami structures. Adv Mater 2010, 22:2251-2254.
84. Wu W, Deconinck A, Lewis JA. Omnidirectional printing of 3D microvascular networks. Adv Mater 2011, 23:178-183.