Articular cartilage repair: Basic science and clinical progress. A review of the current status and prospects

Osteoarthritis and Cartilage

Volumn 10, Issue 6, 2002, Pages 432-463

  Hunziker, E B ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

Articular; Cartilage; Repair; Review

Indexed keywords

AGAROSE; ALGINIC ACID; CARBON FIBER; CHITOSAN; COLLAGEN; DACRON; FIBRIN; GELATIN; GROWTH FACTOR; HYALURONIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID;

ANALYTIC METHOD; ARTICULAR CARTILAGE; CELL TRANSPLANTATION; CONTROLLED STUDY; DISEASE COURSE; EPIDEMIOLOGICAL DATA; GENETIC TRANSFECTION; HUMAN; INTERMETHOD COMPARISON; MEDICAL RESEARCH; OSTEOARTHRITIS; PRIORITY JOURNAL; REVIEW; SOCIOECONOMICS; SURGICAL TECHNIQUE; TISSUE ENGINEERING; TISSUE REPAIR; TISSUE TRANSPLANTATION;

EID: 0036083985     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.2002.0801     Document Type: Article

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229. Comparison of the influence of gelatine and collagen substrates on growth of chondrocytes
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253. Selective differentiation of mammalian bone-marrow stromal cells cultured on three-dimensional polymer foams
254. Generation of cartilage from auricular and rib free perichondrial grafts around a self-reinforced polyglycolic acid mould in rabbits
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261. Joint resurfacing using allograft chondrocytes and synthetic biodegradable polymer scaffolds
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263. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels
264. Identification of an autocrine chondrocyte colony-stimulating factor: Chondromodulin-I stimulates the colony formation of growth plate chondrocytes in agarose culture
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270. Calcification of chick vertebral chondrocytes grown in agarose gels: A biochemical and ultrastructural study
271. The synthesis and immobilisation of cartilage-specific proteoglycan by human chondrocytes in different concentrations of agarose
272. Transplantation of allograft chondrocytes embedded in agarose gel into cartilage defects of rabbits
273. Development of mechanically stable alginate/chondrocyte constructs: Effects of guluronic acid content and matrix synthesis
274. Injectable alginate seeded with chondrocytes as a potential treatment for vesicoureteral reflux
275. Endoscopic treatment of vesicoureteral reflux with a chondrocyte-alginate suspension
276. Reexpression of cartilage-specific genes by dedifferentiated human articular chondrocytes cultured in alginate beads
277. Marrow stromal cells embedded in alginate for repair of osteochondral defects
278. Synthesis and turnover of proteoglycans by human and bovine adult articular chondrocytes cultured in alginate beads
279. Adult human chondrocytes cultured in alginate form a matrix similar to native human articular cartilage
280. Articular cartilage repair in rabbits by using suspensions of allogenic chondrocytes in alginate
281. De novo cartilage generation using calcium alginate-chondrocyte constructs
282. The influence of transforming growth factor beta1 on mesenchymal cell repair of full-thickness cartilage defects
283. Hyaluronic acid-a review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing
284. Immobilisation of sulphated hyaluronan for improved biocompatibility
285. Hyaluronan receptor-directed assembly of chondrocyte pericellular matrix
286. Chondrocyte aggregation and reorganization into three-dimensional scaffolds
287. Substrate-bonded hyaluronic acid exhibits a size-dependent stimulation of chondrogenic differentiation of stage 24 limb mesenchymal cells in culture
288. Hyaluronan-based biopolymers as delivery vehicles for bone-marrow-derived mesenchymal progenitors
289. Hyaluronic acid-based polymers as cell carriers for tissue-engineered repair of bone and cartilage
290. Hyaluronan-based polymers in the treatment of osteochondral defects
291. Matrix accumulation and retention in embryonic cartilage and in-vitro chondrogenesis
292. Hyaluronan-mediated aggregation of limb bud mesenchyme and mesenchymal condensation during chondrogenesis
293. Hyaluronan oligosaccharides perturb cartilage matrix homeostasis and induce chondrocytic chondrolysis
294. New strategy for chemical modification of hyaluronic acid: Preparation of functionalized derivatives and their use in the formation of novel biocompatible hydrogels
295. Chitosan supports the expression of extracellular matrix proteins in human osteoblasts and chondrocytes
296. GAG-augmented polysaccharide hydrogel: A novel biocompatible and biodegradable material to support chondrogenesis
297. Application of chitosan-based polysaccharide biomaterials in cartilage tissue engineering: A review
298. Interaction of cultured chondrocytes with chitosan scaffold
299. N,N-dicarboxymethyl chitosan as delivery agent for bone morphogenetic protein in the repair of articular cartilage
300. Prevention of postsurgical adhesions with N,O-carboxymethyl chitosan: Examination of the most efficacious preparation and the effect of N,O-carboxymethyl chitosan on postsurgical healing
301. Intra-articular implant of filamentous carbon fibre in the experimental animal
302. Foreign body reaction in carbon fiber prosthesis implantation in the knee joint-case report and review of the literature
303. Treatment of painful articular cartilage defects of the patella by carbon-fibre implants
304. Carbon fiber debris within the synovial joint. A time-dependent mechanical and histologic study
305. Carbon fiber implants in osteochondral defects of the rabbit patella
306. The chondrogenic potential of carbon fiber and carbon fiber periosteum implants: An ultrastructural study in the rabbit
307. An experimental intraarticular implantation of woven carbon fiber pad into osteochondral defect of the femoral condyle in rabbit
308. The repair of osteochondral defects in osteoarthritic rabbit knees by the use of carbon fibre
309. Mechanical and histological response of carbon fibre pads implanted in the rabbit patella
310. A quantitative study of articular repair in the guinea pig
311. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
312. Carbon fiber scaffolds in the surgical treatment of cartilage lesions
313. Implants composed of carbon fiber mesh and bone-marrow-derived, chondrocyte-enriched cultures for joint surface reconstruction
314. Hydroxylapatite supported Dacron plugs for repair of isolated full-thickness osteochondral defects of the rabbit femoral condyle: Mechanical and histological evaluations from 6-48 weeks
315. Synthetic implants for the repair of osteochondral defects of the medial femoral condyle: A biomechanical and histological evaluation in the rabbit knee
316. Repair of osteochondral defects in the rabbit knee with Gore-Tex (expanded polytetrafluoroethylene). An experimental study
317. Prosthetic replacement of the rabbit medial meniscus
318. Osteophytic reaction to a polytetrafluoroethylene temporomandibular joint implant. Report of a case
319. Teflon/polyurethane arthroplasty of the knee: The first 2 years preliminary clinical experience in a new concept of artificial resurfacing of full thickness cartilage lesions of the knee
320. The regeneration of articular cartilage using a new polymer system
321. Modifications on Polymers for Controlled Hydrophilicity: The Effect on Surface Properties
322. Modifications of the hydrophilicity of heterocyclic methacrylate copolymers for protein release
323. Water absorption and surface properties of novel poly(ethylmethacrylate) polymer systems for use in bone and cartilage repair
324. The role of protein adsorption on chondrocyte adhesion to a heterocyclic methacrylate polymer system
325. An in-vitro investigation of the PEMA/THFMA polymer system as a biomaterial for cartilage repair
326. A morphological assessment of bovine chondrocytes cultured on poly-(ethyl methacrylate)/tetrahydrofurfuryl methacrylate
327. Biomechanical and histological evaluation of hydrogel implants in articular cartilage
328. Repair of bone defect with cultured chondrocytes bound to hydroxyapatite
329. In vitro cartilage formation on porous hydroxyapatite ceramic granules
330. Phagocytosis of hydroxyapatite or calcium pyrophosphate dihydrate crystals by rabbit articular chondrocytes stimulates release of collagenase, neutral protease, and prostaglandins E2 and F2 alpha
331. Subchondral bone and cartilage repair with bioactive glasses, hydroxyapatite, and hydroxyapatite-glass composite
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337. Experimental meniscal lesions reconstructed with a carbon fiber-polyurethane-poly(L-lactide) graft
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342. Butyric acid and tributyrin induce apoptosis in human hepatic tumour cells
343. Butyric acid and pivaloyloxymethyl butyrate, AN-9, a novel butyric acid derivative, induce apoptosis in HL-60 cells
344. The frontier of substitution medicine: Integrating biomaterials and tissue engineering
345. Zero-order release of lysozyme from poly(ethylene glycol)/poly(butylene terephthalate) matrices
346. Microspheres for protein delivery prepared from amphiphilic multiblock copolymers. 2. Modulation of release rate
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348. The different behaviors of skeletalmuscle cells and chondrocytes on PEGT/PBT block copolymers are related to the surface properties of the substrate
349. Biocompatibility of polyethylene terephthalate-PET-(Trevira strong)-an in-vivo study of the sheep knee
350. A biodegradable composite scaffold for cell transplantation
351. Collagen sponge: Theory and practice of medical applications
352. Collagen in tissue-engineered cartilage: Types, structure, and crosslinks
353. Bioengineering of elastic cartilage with aggregated porcine and human auricular chondrocytes and hydrogels containing alginate, collagen, and kappa-elastin
354. The involvement of β1 integrin in the modulation by collagen of chondrocyte-response to transforming growth factor-β1
355. Pretreatment with platelet derived growth factor-BB modulates the ability of costochondral resting zone chondrocytes incorporated into PLA/PGA scaffolds to form new cartilage in-vivo
356. Degree of differentiation of chondrocytes and their pretreatment with platelet-derived-growth factor. Regulating induction of cartilage formation in resorbable tissue carriers in-vivo
357. Transplantation of isolated chondrocytes in articular cartilage defects. Regeneration of adult hyaline cartilage with fetalchondrocytes
358. Healing of experimentally produced lesions in articular cartilage following chondrocyte transplantation
359. Use of cultured embryonal chick epiphyseal chondrocytes as grafts for defects in chick articular cartilage
360. The use of adhesives in chondrocyte transplantation surgery. Preliminary studies
361. The use of adhesives in chondrocyte transplantation surgery: In-vivo studies
362. Formation of cartilage tissue in-vitro
363. Repair of articular cartilage defects with cultured chondrocytes in Atelocollagen gel. Comparison with cultured chondrocytes in suspension
364. Mesenchymal cell chondrogenesis is stimulated by basement membrane matrix and inhibited by age-associated factors
365. In vitro chondrogenesis of bone-marrow-derived mesenchymal progenitor cells
366. Quantitative structural organization of normal adult human articular cartilage
367. Rabbit articular cartilage defects treated with autologous cultured chondrocytes
368. Autologous chondrocyte transplantation
369. Treatment of articular cartilage defects of the knee with autologous chondrocyte implantation
370. Effect of cultured autologous chondrocytes on repair of chondral defects in a canine model
371. Delamination rates of tissue flaps used in articular cartilage repair
372. Two- to 9-year outcome after autologous chondrocyte transplantation of the knee
373. Chondrocyte-seeded collagen matrices implanted in a chondral defect in a canine model
374. Repair of rabbit articular surfaces with allograft chondrocytes embedded in collagen gel
375. Chondrocyte transplantation using a collagen bilayer matrix for cartilage repair
376. Chondrocyte-laden collagen scaffolds for resurfacing extensive articular cartilage defects
377. Local and remote matrix responses to chondrocyte-laden collagen scaffold implantation in extensive articular cartilage defects
378. Fate of allogeneic embryonal chick chondrocytes implanted orthotopically, as determined by the host's age
379. Repair of articular cartilage defects by carbon fibre plugs loaded with chondrocytes
380. The chondrogenic potential of the perichondrium
381. Histomorphological and proliferative characterization of developing periosteal neochondrocytes in-vitro
382. Localization of chondrocyte precursors in periosteum
383. Articular cartilage repair using allogeneic perichondrocyte-seeded biodegradable porous polylactic acid (PLA): A tissue-engineering study
384. Human periosteum-derived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor age
385. Chondrogenic phenotype of perichondrium-derived chondroprogenitor cells is influenced by transforming growth factor-beta 1
386. Osteochondral repair using perichondrial cells: A 1-year study in rabbits
387. Donor cell fate in tissue engineering for articular cartilage repair
388. Determined and inducible osteogenic precursor cells
389. Precursor cells of mechanocytes
390. Marrow microenvironment transfer by heterotopic transplantation of freshly isolated and cultured cells in porous sponges
391. Stromal stem cells: Marrow-derived osteogenic precursors
392. Stem cell delivery vehicle
393. Multilineage potential of adult human mesenchymal stem cells
394. Autologous mesenchymal progenitor cells in articular cartilage repair
395. Bone progenitor cell deficits and the age-associated decline in bone repair capacity
396. Developmental control of chondrogenesis and osteogenesis
397. Culture expanded canine mesenchymal stem cells possess osteochondrogenic potential in-vivo and in-vitro
398. Dilution of human mesenchymal stem cells with dermal fibroblasts and the effects on in-vitro and in-vivo osteochondrogenesis
399. Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage
400. A quadripotential mesenchymal progenitor cell isolated from the marrow of an adult mouse
401. Regulation of bone-marrow stromal cell differentiation by cytokines whose receptors share the gp130 protein
402. Chondrogenic differentiation of cultured human mesenchymal stem cells from marrow
403. In vitro differentiation of chick embryo bone-marrow stromal cells into cartilaginous and bone-like tissues
404. Differentiation factors induce expression of muscle, fat, cartilage, and bone in a clone of mouse pluripotent mesenchymal stem cells
405. Repair of large bone defects with the use of autologous bone marrow stromal cells
406. Development of articular cartilage: What do we know about it and how may it occur?
407. Synovial activation of chondrocytes: Evidence for complex cytokine interactions
408. An immunohistological study of cartilage and synovium in primary synovial chondromatosis
409. Cartilage destruction and osteophytes in instability-induced murine osteoarthritis-role of Tgf beta in osteophyte formation
410. Induction of swelling, synovial hyperplasia and cartilage proteoglycan loss upon intra-articular injection of transforming growth factor-beta-2 in the rabbit
411. Bone morphogenetic protein-induced muscle- and synovium-derived cartilage differentiation in vitro
412. Pathology of the synovium
413. Synovial neoformations and tumours
414. Synovial chondromatosis of the temporomandibular joint
415. Extra-articular synovial chondromatosis
416. Chondrosarcomas of the synovium
417. Chondroprogenitor cells of synovial tissue
418. Multipotent mesenchymal stem cells from adult human synovial membrane
419. Chondrogenesis in cartilage repair is induced by members of the transforming growth factor-beta superfamily
420. Repair of partial-thickness articular cartilage defects. Cell recruitment from the synovium
421. Functional barrier principle of growth-factor-based articular cartilage repair
422. Clinically Applicable Animal Models in Tissue Engineering
423. Recent stereological methods for cell biology: A brief survey
424. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis
425. The new stereological tools: Dissector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis
426. The efficiency of systematic sampling in stereology and its prediction
427. Current concepts in tissue engineering technique for repair of cartilage defect
428. Repair of osteochondral defects with allogeneic tissue engineered cartilage implants
429. Tissue engineering of cartilage
430. Experimental studies on repair of large osteochondral defects at a high weight bearing area of the knee joint: A tissue engineering study
431. A method for tissue engineering of cartilage by cell seeding on bioresorbable scaffolds
432. Symbiosis of biotechnology and biomaterials: Applications in tissue engineering of bone and cartilage
433. Cartilage-derived morphogenetic proteins and cartilage morphogenesis
434. In vitro engineering of cartilage
435. Growth factors and cartilage repair
436. A recombinant human TGF-beta1 fusion protein with collagen-binding domain promotes migration, growth, and differentiation of bone-marrow mesenchymal cells
437. Engineering of osteochondral tissue with bone-marrow mesenchymal progenitor cells in a derivatized hyaluronan-gelatin composite sponge
438. Role of growth factors in rabbit articular cartilage repair by chondrocytes in agarose
439. Growth-factor-induced healing of partial-thickness defects in adult articular cartilage
440. Genetically augmented tissue engineering of the musculoskeletal system
441. Orthopaedic applications of gene therapy-from concept to clinic
442. Mesenchymal stem cells as vehicles for gene delivery
443. Marrow stromal cells as stem cells for nonhematopoietic tissues
444. Proliferation kinetics and differentiation potential of ex vivo expanded human bone-marrow stromal cells: Implications for their use in cell therapy
445. High-efficiency non-viral transfection of primary chondrocytes and perichondrial cells for ex-vivo gene therapy to repair articular cartilage defects
446. Direct adenovirus-mediated insulin-like growth factor I gene transfer enhances transplant chondrocyte function
447. Expression of human bone morphogenic protein 7 in primary rabbit periosteal cells: Potential utility in gene therapy for osteochondral repair
448. Fibroblast-mediated delivery of growth factor complementary DNA into mouse joints induces chondrogenesis but avoids the disadvantages of direct viral gene transfer
449. Bonding of cartilage matrices with cultured chondrocytes: An experimental model
450. Cell adhesion to collagenous matrices
451. Biological roles of dermatan sulphate proteoglycans
452. Fibronectin-mediated adhesion of fibroblasts: Inhibition by dermatan sulfate proteoglycan and evidence for a cryptic glycosaminoglycan-binding domain
453. Mechanobiology of skeletal regeneration
454. Articular cartilage: Biomechanics
455. The biological effect of continuous passive motion on the healing of full-thickness defects in articular cartilage. An experimental investigation in the rabbit
456. Continuous passive motion stimulates repair of rabbit knee articular cartilage after matrix proteoglycan loss
457. Effects of intermittent pressure-induced strain on the electrophysiology of cultured human chondrocytes: Evidence for the presence of stretch-activated membrane ion channels
458. Functional tissue engineering: The role of biomechanics
459. Mechanotransduction via integrins and interleukin-4 results in altered aggrecan and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic, human articular chondrocytes
460. Chondrogenesis in a cell-polymer-bioreactor system
461. Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage
462. Bioreactor development for tissue-engineered cartilage