A novel MSC-seeded triphasic construct for the repair of osteochondral defects

Journal of Orthopaedic Research

Volumn 28, Issue 12, 2010, Pages 1586-1599

  Marquass, B ^a   Somerson, J S ^a   Hepp, P ^a   Aigner, T ^a   Schwan, S ^b,c   Bader, A ^a   Josten, C ^a   Zscharnack, M ^a   Schulz, R M ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b FRAUNHOFER INSTITUTE FOR MECHANICS OF MATERIALS IWM   (Germany)

^c KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

Author keywords

animal model; cartilage; mesenchymal stem cells; osteoarthritis; osteochondral autografting

Indexed keywords

CALCIUM PHOSPHATE; COLLAGEN TYPE 1; TISSUE SCAFFOLD;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE GRAFT; BONE LESION; BONE REMODELING; CARTILAGE MATRIX; CELL DIFFERENTIATION; CELL STRUCTURE; CHONDROGENESIS; FEMALE; HISTOLOGY; HYDROGEL; MESENCHYMAL STEM CELL; NONHUMAN; OSTEOCHONDRAL AUTOGRAFTING; OSTEOCHONDROSIS; PRIORITY JOURNAL; TISSUE ENGINEERING; ANIMAL; ARTICULAR CARTILAGE; CARTILAGE; CARTILAGE CELL; COMPARATIVE STUDY; INJURY; MESENCHYMAL STEM CELL TRANSPLANTATION; METHODOLOGY; SHEEP; TRANSPLANTATION;

ANIMALS; CARTILAGE; CARTILAGE, ARTICULAR; CHONDROCYTES; FEMALE; MESENCHYMAL STEM CELL TRANSPLANTATION; SHEEP; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 78149487727     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21173     Document Type: Article

References (47)

1. Shelbourne KD, Jari S, Gray T,. 2003. Outcome of untreated traumatic articular cartilage defects of the knee: A natural history study. J Bone Joint Surg Am 85-A (Suppl. 2): 8 -16.
2. Gudas R, Kalesinskas RJ, Kimtys V, et al. 2005. A prospective randomized clinical study of mosaic osteochondral autologous transplantation versus microfracture for the treatment of osteochondral defects in the knee joint in young athletes. Arthroscopy 21: 1066 -1075.
3. Hangody L, Füles P,. 2003. Autologous osteochondral mosaicplasty for the treatment of full-thickness defects of weight-bearing joints: Ten years of experimental and clinical experience. J Bone Joint Surg Am 85-A (Suppl. 2): 25 -32.
4. Hangody L, Vásárhelyi G, Hangody LR, et al. 2008. Autologous osteochondral grafting-Technique and long-term results. Injury 39 (Suppl. 1): S32 -S39.
5. LaPrade RF, Botker JC,. 2004. Donor-site morbidity after osteochondral autograft transfer procedures. Arthroscopy 20: 69 -73.
6. Reddy S, Pedowitz DI, Parekh SG, et al. 2007. The morbidity associated with osteochondral harvest from asymptomatic knees for the treatment of osteochondral lesions of the talus. Am J Sports Med 35: 80 -85.
7. Paul J, Sagstetter A, Kriner M, et al. 2009. Donor-site morbidity after osteochondral autologous transplantation for lesions of the talus. J Bone Joint Surg Am 91: 1683 -1688.
8. Iwasaki N, Kato H, Kamishima T, et al. 2007. Donor site evaluation after autologous osteochondral mosaicplasty for cartilaginous lesions of the elbow joint. Am J Sports Med 35: 2096 -2100.
9. Jackson DW, Scheer MJ, Simon TM,. 2001. Cartilage substitutes: Overview of basic science and treatment options. J Am Acad Orthop Surg 9: 37 -52.
10. Rose T, Craatz S, Hepp P, et al. 2005. The autologous osteochondral transplantation of the knee: Clinical results, radiographic findings and histological aspects. Arch Orthop Trauma Surg 125: 628 -637.
11. Horas U, Pelinkovic D, Herr G, et al. 2003. Autologous chondrocyte implantation and osteochondral cylinder transplantation in cartilage repair of the knee joint. A prospective, comparative trial. J Bone Joint Surg Am 85-A: 185 -192.
12. Lane J, Massie J, Ball S, et al. 2004. Follow-up of osteochondral plug transfers in a goat model: A 6-month study. Am J Sports Med 32: 1440 -1450.
13. Keeney M, Pandit A,. 2009. The osteochondral junction and its repair via bi-phasic tissue engineering scaffolds. Tissue Eng Part B Rev 15: 55 -73.
14. Hung CT, Lima EG, Mauck RL, et al. 2003. Anatomically shaped osteochondral constructs for articular cartilage repair. J Biomech 36: 1853 -1864.
15. Oliveira JM, Rodrigues MT, Silva SS, et al. 2006. Novel hydroxyapatite/chitosan bilayered scaffold for osteochondral tissue-engineering applications: Scaffold design and its performance when seeded with goat bone marrow stromal cells. Biomaterials 27: 6123 -6137.
16. Sherwood JK, Riley SL, Palazzolo R, et al. 2002. A three-dimensional osteochondral composite scaffold for articular cartilage repair. Biomaterials 23: 4739 -4751.
17. Ahn J-H, Lee T-H, Oh J-S, et al. 2009. A novel hyaluronate-atelocollagen/ beta-TCP-hydroxyapatite biphasic scaffold for the repair of osteochondral defects in rabbits. Tissue Eng Part A 15: 2596 -2604.
18. Alhadlaq A, Mao JJ,. 2005. Tissue-engineered osteochondral constructs in the shape of an articular condyle. J Bone Joint Surg Am 87: 936 -944.
19. Frenkel SR, Toolan B, Menche D, et al. 1997. Chondrocyte transplantation using a collagen bilayer matrix for cartilage repair. J Bone Joint Surg Br 79: 831 -836.
20. Gao J, Dennis JE, Solchaga LA, et al. 2002. Repair of osteochondral defect with tissue-engineered two-phase composite material of injectable calcium phosphate and hyaluronan sponge. Tissue Eng 8: 827 -837.
21. Kandel R, Grynpas M, Pilliar R, et al. 2006. Repair of osteochondral defects with biphasic cartilage-calcium polyphosphate constructs in a sheep model. Biomaterials 27: 4120 -4131.
22. Hepp P, Osterhoff G, Niederhagen M, et al. 2009. Perilesional changes of focal osteochondral defects in an ovine model and their relevance to human osteochondral injuries. J Bone Joint Surg Br 91: 1110 -1119.
23. Marquass B, Hepp P, Schmidt S, et al. 2009. Chondrogenic predifferentiation of ovine mesenchymal stem cells leads to a better histological repair of chronic osteochondral defects after one year in a sheep model. In: Beger H, editor. Proceedings of the 13th Annual Meeting on Surgical Research in Langenbecks Arch Surg, Vol. 394. Munich, Germany: Springer Berlin/Heidelberg; p 915 -970.
24. Alhadlaq A, Elisseeff JH, Hong L, et al. 2004. Adult stem cell driven genesis of human-shaped articular condyle. Ann Biomed Eng 32: 911 -923.
25. Cao T, Ho K-H, Teoh S-H,. 2003. Scaffold design and in vitro study of osteochondral coculture in a three-dimensional porous polycaprolactone scaffold fabricated by fused deposition modeling. Tissue Eng 9 (Suppl. 1): S103 -S112.
26. Chen G, Sato T, Tanaka J, et al. 2006. Preparation of a biphasic scaffold for osteochondral tissue engineering. Mater Sci Eng C26: 118 -123.
27. Chen G, Tanaka J, Tateishi T,. 2006. Osteochondral tissue engineering using a PLGA-collagen hybrid mesh. Mater Sci Eng C26: 124 -129.
28. Shao XX, Hutmacher DW, Ho ST, et al. 2006. Evaluation of a hybrid scaffold/cell construct in repair of high-load-bearing osteochondral defects in rabbits. Biomaterials 27: 1071 -1080.
29. Brittberg M, Peterson L,. 1998. Introduction to an articular cartilage classification. ICRS Newsl 1: 8.
30. Peterson L, Minas T, Brittberg M, et al. 2000. Two-to 9-year outcome after autologous chondrocyte transplantation of the knee. Clin Orthop Relat Res 374: 212 -234.
31. Feder N, Wolf M,. 1965. Studies on nucleic acid metachromasy: II. Metachromatic and orthochromatic staining by toluidine blue of nucleic acids in tissue sections. J Cell Biol 27: 327.
32. Laczko J, Levai G,. 1975. A simple differential staining method for semi-thin sections of ossifying cartilage and bone tissues embedded in epoxy resin. Mikroskopie 31: 4.
33. Donath K,. 1988. Die trenn-dünnschliff-technik zur herstellung histologischer präparate von nicht schneidbaren geweben und materialien. Der Präparator 34: 197 -206.
34. Mainil-Varlet P, Aigner T, Brittberg M, et al. 2003. Histological assessment of cartilage repair: A report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS). J Bone Joint Surg Am 85-A (Suppl. 2): 45 -57.
35. O'Driscoll SW, Keeley FW, Salter RB,. 1988. Durability of regenerated articular cartilage produced by free autogenous periosteal grafts in major full-thickness defects in joint surfaces under the influence of continuous passive motion. A follow-up report at one year. J Bone Joint Surg Am 70: 595 -606.
36. Siebert CH, Miltner O, Weber M, et al. 2003. Healing of osteochondral grafts in an ovine model under the influence of bFGF. Arthroscopy 19: 182 -187.
37. Zscharnack M, Hepp P, Richter R, et al. 2010. Repair of chronic osteochondral defects using pre-differentiated mesenchymal stem cells in an ovine model. Am J Sports Med (in press).
38. Pei M, He F, Boyce B, et al. 2009. Repair of full-thickness femoral condyle cartilage defects using allogeneic synovial cell-engineered tissue constructs. Osteoarthritis Cartilage 17: 714 -722.
39. Uematsu K, Hattori K, Ishimoto Y, et al. 2005. Cartilage regeneration using mesenchymal stem cells and a three-dimensional poly-lactic-glycolic acid (PLGA) scaffold. Biomaterials 26: 4273 -4279.
40. Petersen JP, Ueblacker P, Goepfert C, et al. 2008. Long term results after implantation of tissue engineered cartilage for the treatment of osteochondral lesions in a minipig model. J Mater Sci Mater Med 19: 2029 -2038.
41. Bruder SP, Kurth AA, Shea M, et al. 1998. Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells. J Orthop Res 16: 155 -162.
42. Frosch KH, Drengk A, Krause P, et al. 2006. Stem cell-coated titanium implants for the partial joint resurfacing of the knee. Biomaterials 27: 2542 -2549.
43. Guo X, Wang C, Zhang Y, et al. 2004. Repair of large articular cartilage defects with implants of autologous mesenchymal stem cells seeded into beta-tricalcium phosphate in a sheep model. Tissue Eng 10: 1818 -1829.
44. Stockwell RA,. 1971. The interrelationship of cell density and cartilage thickness in mammalian articular cartilage. J Anat 109: 411 -421.
45. Pulliainen O, Vasara A, Hyttinen M, et al. 2007. Poly-LD-lactic acid scaffold in the repair of porcine knee cartilage lesions. Tissue Eng 13: 1347 -1355.
46. Benazzo F, Cadossi M, Cavani F, et al. 2008. Cartilage repair with osteochondral autografts in sheep: Effect of biophysical stimulation with pulsed electromagnetic fields. J Orthop Res 26: 631 -642.
47. von Rechenberg B, Akens MK, Nadler D, et al. 2003. Changes in subchondral bone in cartilage resurfacing-An experimental study in sheep using different types of osteochondral grafts. Osteoarthritis Cartilage 11: 265 -277.