Osteochondral tissue regeneration using a bilayered composite hydrogel with modulating dual growth factor release kinetics in a rabbit model

Journal of Controlled Release

Volumn 168, Issue 2, 2013, Pages 166-178

  Kim, Kyobum ^a   Lam, Johnny ^a   Lu, Steven ^a   Spicer, Patrick P ^a   Lueckgen, Aline ^a   Tabata, Yasuhiko ^b   Wong, Mark E ^c   Jansen, John A ^d   Mikos, Antonios G ^a   Kasper, F Kurtis ^a  

^a Rice University   (United States)

^b KYOTO UNIVERSITY   (Japan)

^c UNIVERSITY OF TEXAS   (United States)

^d RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Hydrogel; Insulin like growth factor 1; Osteochondral defect; Transforming growth factor 3

Indexed keywords

GELATIN MICROPARTICLES; HIERARCHICAL STRUCTURES; INSULIN-LIKE GROWTH FACTOR-1; OLIGO(POLY(ETHYLENE GLYCOL)FUMARATE); OSTEOCHONDRAL DEFECTS; OSTEOCHONDRAL TISSUE ENGINEERING; OSTEOCHONDRAL TISSUES; TRANSFORMING GROWTH FACTORS;

CARTILAGE; CELL CULTURE; CELL PROLIFERATION; DEFECTS; INSULIN; KINETICS; MORPHOLOGY; POLYETHYLENE GLYCOLS; STEM CELLS; TISSUE; TISSUE REGENERATION;

HYDROGELS;

GELATIN; GLYCOSAMINOGLYCAN; MACROGOL; OLIGO[POLY(ETHYLENE GLYCOL)FUMARATE]; SOMATOMEDIN C; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA33; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CARTILAGE CELL; CELL POPULATION; COMPOSITE MATERIAL; CONTROLLED STUDY; CYTOKINE RELEASE; HYDROGEL; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; STEM CELL; TISSUE ENGINEERING; TISSUE REGENERATION; TISSUE REPAIR; TISSUE STRUCTURE;

ANIMALS; BONE REGENERATION; CARTILAGE; CHONDROCYTES; FEMUR; GELATIN; GLYCOSAMINOGLYCANS; HYDROGELS; INSULIN-LIKE GROWTH FACTOR I; MALE; POLYESTERS; POLYETHYLENE GLYCOLS; RABBITS; TRANSFORMING GROWTH FACTOR BETA3;

EID: 84877964552     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.03.013     Document Type: Article

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