메뉴 건너뛰기




Volumn 10, Issue APR, 2016, Pages

One for all? Hitting multiple Alzheimer's disease targets with one drug

Author keywords

Alzheimer's Disease; Datamining; In silico; Multi target drugs; Rational drug design; Repurposing

Indexed keywords

ANTIDIABETIC AGENT; CENTRAL NERVOUS SYSTEM AGENTS; CHOLINESTERASE INHIBITOR; CLIOQUINOL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DONECOPRIDE; DONEPEZIL; GALANTAMINE; LIRAGLUTIDE; OXOISOAPORPHINE; RASAGILINE; RESVERATROL; RIVASTIGMINE; SELEGILINE; SEROTONIN ANTAGONIST; TACRINE; THIOCTIC ACID; UNCLASSIFIED DRUG;

EID: 84966377266     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2016.00177     Document Type: Short Survey
Times cited : (78)

References (81)
  • 1
    • 84896720479 scopus 로고    scopus 로고
    • Multi-target-directed ligands and other therapeutic strategies in the search of a real solution for alzheimer's disease
    • Agis-Torres, A., Sölhuber, M., Fernandez, M., and Sanchez-Montero, J. M. (2014). Multi-target-directed ligands and other therapeutic strategies in the search of a real solution for alzheimer's disease. Curr. Neuropharmacol. 12, 2-36. doi: 10.2174/1570159X113116660047.
    • (2014) Curr. Neuropharmacol , vol.12 , pp. 2-36
    • Agis-Torres, A.1    Sölhuber, M.2    Fernandez, M.3    Sanchez-Montero, J.M.4
  • 2
    • 84886600387 scopus 로고    scopus 로고
    • Therapeutics of Alzheimer's disease: past, present and future
    • Anand, R., Gill, K. D., and Mahdi, A. A. (2014). Therapeutics of Alzheimer's disease: past, present and future. Neuropharmacology 76, 27-50. doi: 10.1016/j.neuropharm.2013.07.004.
    • (2014) Neuropharmacology , vol.76 , pp. 27-50
    • Anand, R.1    Gill, K.D.2    Mahdi, A.A.3
  • 3
    • 2642529309 scopus 로고    scopus 로고
    • Regulation of protein kinase C by the anti-parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo
    • Bar-Am, O., Yogev-Falach, M., Amit, T., Sagi, Y., and Youdim, M. B. H. (2004). Regulation of protein kinase C by the anti-parkinson drug, MAO-B inhibitor, rasagiline and its derivatives, in vivo. J. Neurochem. 89, 1119-1125. doi: 10.1111/j.1471-4159.2004.02425.x.
    • (2004) J. Neurochem , vol.89 , pp. 1119-1125
    • Bar-Am, O.1    Yogev-Falach, M.2    Amit, T.3    Sagi, Y.4    Youdim, M.B.H.5
  • 4
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus, R. T., Dean, R. L. III, Beer, B., and Lippa, A. S. (1982). The cholinergic hypothesis of geriatric memory dysfunction. Science 217, 408-417. doi: 10.1126/science.7046051.
    • (1982) Science , vol.217 , pp. 408-417
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3    Lippa, A.S.4
  • 5
    • 84893943097 scopus 로고    scopus 로고
    • Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease
    • Bautista-Aguilera, O. M., Esteban, G., Bolea, I., Nikolic, K., Agbaba, D., Moraleda, I., et al. (2014a). Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease. Eur. J. Med. Chem. 75, 82-95. doi: 10.1016/j.ejmech.2013.12.028.
    • (2014) Eur. J. Med. Chem , vol.75 , pp. 82-95
    • Bautista-Aguilera, O.M.1    Esteban, G.2    Bolea, I.3    Nikolic, K.4    Agbaba, D.5    Moraleda, I.6
  • 6
    • 84920175684 scopus 로고    scopus 로고
    • N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual
    • Bautista-Aguilera, O. M., Samadi, A., Chioua, M., Nikolic, K., Filipic, S., Agbaba, D., et al. (2014b). N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual. J. Med. Chem. 57, 10455-10463. doi: 10.1021/jm501501a.
    • (2014) J. Med. Chem , vol.57 , pp. 10455-10463
    • Bautista-Aguilera, O.M.1    Samadi, A.2    Chioua, M.3    Nikolic, K.4    Filipic, S.5    Agbaba, D.6
  • 7
    • 67149130229 scopus 로고    scopus 로고
    • Repurposing with a difference
    • Boguski, M. S., Mandl, K. D., and Sukhatme, V. P. (2009). Repurposing with a difference. Science 324, 1394-1395. doi: 10.1126/science.1169920.
    • (2009) Science , vol.324 , pp. 1394-1395
    • Boguski, M.S.1    Mandl, K.D.2    Sukhatme, V.P.3
  • 8
    • 84888071608 scopus 로고    scopus 로고
    • Multipotent, permeable drug ASS234 inhibits A beta aggregation, possesses antioxidant properties and protects from A beta-induced apoptosis in vitro
    • Bolea, I., Gella, A., Monjas, L., Perez, C., Rodriguez-Franco, M. I., Marco-Contelles, J., et al. (2013). Multipotent, permeable drug ASS234 inhibits A beta aggregation, possesses antioxidant properties and protects from A beta-induced apoptosis in vitro. Curr. Alzheimer Res. 10, 797-808. doi: 10.2174/15672050113109990151.
    • (2013) Curr. Alzheimer Res , vol.10 , pp. 797-808
    • Bolea, I.1    Gella, A.2    Monjas, L.3    Perez, C.4    Rodriguez-Franco, M.I.5    Marco-Contelles, J.6
  • 9
    • 84055217642 scopus 로고    scopus 로고
    • Synthesis, biological evaluation, and molecular modeling of donepezil and N-(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl-N-methylprop-2-yn-1-ami ne hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease
    • Bolea, I., Juarez-Jimenez, J., de los Rios, C., Chioua, M., Pouplana, R., Javier Luque, F., et al. (2011). Synthesis, biological evaluation, and molecular modeling of donepezil and N-(5-(Benzyloxy)-1-methyl-1H-indol-2-yl)methyl-N-methylprop-2-yn-1-ami ne hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease. J. Med. Chem. 54, 8251-8270. doi: 10.1021/jm200853t.
    • (2011) J. Med. Chem , vol.54 , pp. 8251-8270
    • Bolea, I.1    Juarez-Jimenez, J.2    de los Rios, C.3    Chioua, M.4    Pouplana, R.5    Javier Luque, F.6
  • 10
    • 84865404667 scopus 로고    scopus 로고
    • MBX-500, a hybrid antibiotic with in vitro and in vivo efficacy against toxigenic clostridium difficile
    • Butler, M. M., Shinabarger, D. L., Citron, D. M., Kelly, C. P., Dvoskin, S., Wright, G. E., et al. (2012). MBX-500, a hybrid antibiotic with in vitro and in vivo efficacy against toxigenic clostridium difficile. Antimicrob. Agents Chemother. 56, 4786-4792. doi: 10.1128/AAC.00508-12.
    • (2012) Antimicrob. Agents Chemother , vol.56 , pp. 4786-4792
    • Butler, M.M.1    Shinabarger, D.L.2    Citron, D.M.3    Kelly, C.P.4    Dvoskin, S.5    Wright, G.E.6
  • 11
    • 84887972850 scopus 로고    scopus 로고
    • The multifactorial nature of Alzheimer's disease for developing potential therapeutics
    • Carreiras, M. C., Mendes, E., Jesus Perry, M. J., Francisco, A. P., and Marco-Contelles, J. (2013). The multifactorial nature of Alzheimer's disease for developing potential therapeutics. Curr. Top. Med. Chem. 13, 1745-1770. doi: 10.2174/15680266113139990135.
    • (2013) Curr. Top. Med. Chem , vol.13 , pp. 1745-1770
    • Carreiras, M.C.1    Mendes, E.2    Jesus Perry, M.J.3    Francisco, A.P.4    Marco-Contelles, J.5
  • 13
    • 33751403136 scopus 로고    scopus 로고
    • Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival
    • Cho, S., and Hu, Y. (2007). Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival. Exp. Neurol. 203, 274-278. doi: 10.1016/j.expneurol.2006.07.021.
    • (2007) Exp. Neurol , vol.203 , pp. 274-278
    • Cho, S.1    Hu, Y.2
  • 15
    • 84885923924 scopus 로고    scopus 로고
    • Drug repositioning: an opportunity to develop novel treatments for Alzheimer's disease
    • Corbett, A., Williams, G., and Ballard, C. (2013). Drug repositioning: an opportunity to develop novel treatments for Alzheimer's disease. Pharmaceuticals 6, 1304-1321. doi: 10.3390/ph6101304.
    • (2013) Pharmaceuticals , vol.6 , pp. 1304-1321
    • Corbett, A.1    Williams, G.2    Ballard, C.3
  • 16
    • 0029991888 scopus 로고    scopus 로고
    • Modifications of neuronal phosphorylated tau immunoreactivity induced by NMDA toxicity
    • Couratier, P., Lesort, M., Sindou, P., Esclaire, F., Yardin, C., and Hugon, J. (1996). Modifications of neuronal phosphorylated tau immunoreactivity induced by NMDA toxicity. Mol. Chem. Neuropathol. 27, 259-273. doi: 10.1007/BF02815108.
    • (1996) Mol. Chem. Neuropathol , vol.27 , pp. 259-273
    • Couratier, P.1    Lesort, M.2    Sindou, P.3    Esclaire, F.4    Yardin, C.5    Hugon, J.6
  • 17
    • 84855613853 scopus 로고    scopus 로고
    • Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment a pilot clinical trial
    • Craft, S., Baker, L. D., Montine, T. J., Minoshima, S., Watson, G. S., Claxton, A., et al. (2012). Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment a pilot clinical trial. Arch. Neurol. 69, 29-38. doi: 10.1001/archneurol.2011.233.
    • (2012) Arch. Neurol , vol.69 , pp. 29-38
    • Craft, S.1    Baker, L.D.2    Montine, T.J.3    Minoshima, S.4    Watson, G.S.5    Claxton, A.6
  • 18
    • 84938416296 scopus 로고    scopus 로고
    • The use of cholinesterase inhibitors across all stages of Alzheimer's disease
    • Deardorff, W. J., Feen, E., and Grossberg, G. T. (2015). The use of cholinesterase inhibitors across all stages of Alzheimer's disease. Drugs Aging 32, 537-547. doi: 10.1007/s40266-015-0273-x.
    • (2015) Drugs Aging , vol.32 , pp. 537-547
    • Deardorff, W.J.1    Feen, E.2    Grossberg, G.T.3
  • 19
    • 84900554029 scopus 로고    scopus 로고
    • Wnt signaling pathway, a potential target for Alzheimer's disease treatment, is activated by a novel multitarget compound ASS234
    • del Pino, J., Ramos, E., Bautista-Aguilera, O. M., Marco-Contelles, J., and Romero, A. (2014). Wnt signaling pathway, a potential target for Alzheimer's disease treatment, is activated by a novel multitarget compound ASS234. CNS Neurosci. Ther. 20, 568-570. doi: 10.1111/cns.12269.
    • (2014) CNS Neurosci. Ther , vol.20 , pp. 568-570
    • del Pino, J.1    Ramos, E.2    Bautista-Aguilera, O.M.3    Marco-Contelles, J.4    Romero, A.5
  • 20
    • 84872712864 scopus 로고    scopus 로고
    • Multitarget ligands in antibacterial research: progress and opportunities
    • East, S. P., and Silver, L. L. (2013). Multitarget ligands in antibacterial research: progress and opportunities. Expert Opin. Drug Discov. 8, 143-156. doi: 10.1517/17460441.2013.743991.
    • (2013) Expert Opin. Drug Discov , vol.8 , pp. 143-156
    • East, S.P.1    Silver, L.L.2
  • 22
    • 34548304745 scopus 로고    scopus 로고
    • In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling
    • Ekins, S., Mestres, J., and Testa, B. (2007a). In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling. Br. J. Pharmacol. 152, 9-20. doi: 10.1038/sj.bjp.0707305.
    • (2007) Br. J. Pharmacol , vol.152 , pp. 9-20
    • Ekins, S.1    Mestres, J.2    Testa, B.3
  • 23
    • 34548319111 scopus 로고    scopus 로고
    • In silico pharmacology for drug discovery: applications to targets and beyond
    • Ekins, S., Mestres, J., and Testa, B. (2007b). In silico pharmacology for drug discovery: applications to targets and beyond. Br. J. Pharmacol. 152, 21-37. doi: 10.1038/sj.bjp.0707306.
    • (2007) Br. J. Pharmacol , vol.152 , pp. 21-37
    • Ekins, S.1    Mestres, J.2    Testa, B.3
  • 24
    • 84856378492 scopus 로고    scopus 로고
    • Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and Prion diseases
    • Galdeano, C., Viayna, E., Sola, I., Formosa, X., Camps, P., Badia, A., et al. (2012). Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and Prion diseases. J. Med. Chem. 55, 661-669. doi: 10.1021/jm200840c.
    • (2012) J. Med. Chem , vol.55 , pp. 661-669
    • Galdeano, C.1    Viayna, E.2    Sola, I.3    Formosa, X.4    Camps, P.5    Badia, A.6
  • 25
    • 82755176046 scopus 로고    scopus 로고
    • Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice
    • Gengler, S., McClean, P. L., McCurtin, R., Gault, V. A., and Hoelscher, C. (2012). Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice. Neurobiol. Aging 33, 265-276. doi: 10.1016/j.neurobiolaging.2010.02.014.
    • (2012) Neurobiol. Aging , vol.33 , pp. 265-276
    • Gengler, S.1    McClean, P.L.2    McCurtin, R.3    Gault, V.A.4    Hoelscher, C.5
  • 26
    • 84897848470 scopus 로고    scopus 로고
    • Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases
    • Hölscher, C. (2014). Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases. J. Endocrinol. 221, T31-T41. doi: 10.1530/JOE-13-0221.
    • (2014) J. Endocrinol , vol.221 , pp. T31-T41
    • Hölscher, C.1
  • 27
    • 54249155522 scopus 로고    scopus 로고
    • Network pharmacology: the next paradigm in drug discovery
    • Hopkins, A. L. (2008). Network pharmacology: the next paradigm in drug discovery. Nat. Chem. Biol. 4, 682-690. doi: 10.1038/nchembio.118.
    • (2008) Nat. Chem. Biol , vol.4 , pp. 682-690
    • Hopkins, A.L.1
  • 28
    • 84954158868 scopus 로고    scopus 로고
    • Neurological dysfunctions associated with altered BACE1-dependent neuregulin-1 signaling
    • Hu, X., Fan, Q., Hou, H., and Yan, R. (2016). Neurological dysfunctions associated with altered BACE1-dependent neuregulin-1 signaling. J. Neurochem. 136, 234-249. doi: 10.1111/jnc.13395.
    • (2016) J. Neurochem , vol.136 , pp. 234-249
    • Hu, X.1    Fan, Q.2    Hou, H.3    Yan, R.4
  • 29
    • 84858713174 scopus 로고    scopus 로고
    • Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis
    • Hunter, K., and Hölscher, C. (2012). Drugs developed to treat diabetes, liraglutide and lixisenatide, cross the blood brain barrier and enhance neurogenesis. BMC Neurosci. 13:33. doi: 10.1186/1471-2202-13-33.
    • (2012) BMC Neurosci , vol.13 , pp. 33
    • Hunter, K.1    Hölscher, C.2
  • 30
    • 61849148824 scopus 로고    scopus 로고
    • Natural products and drug discovery can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?
    • Ji, H.-F., Li, X.-J., and Zhang, H.-Y. (2009). Natural products and drug discovery can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia? EMBO Rep. 10, 194-200. doi: 10.1038/embor.2009.12.
    • (2009) EMBO , pp. 194-200
    • Ji, H.-F.1    Li, X.-J.2    Zhang, H.-Y.3
  • 31
    • 84904038318 scopus 로고    scopus 로고
    • The normal and pathologic roles of the Alzheimer's beta-secretase, BACE1
    • Kandalepas, P. C., and Vassar, R. (2014). The normal and pathologic roles of the Alzheimer's beta-secretase, BACE1. Curr. Alzheimer Res. 11, 441-449. doi: 10.2174/1567205011666140604122059.
    • (2014) Curr. Alzheimer Res , vol.11 , pp. 441-449
    • Kandalepas, P.C.1    Vassar, R.2
  • 32
    • 80052266213 scopus 로고    scopus 로고
    • The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
    • 698-U1600
    • Karran, E., Mercken, M., and De Strooper, B. (2011). The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat. Rev. Drug Discov. 10, 698-U1600. doi: 10.1038/nrd3505.
    • (2011) Nat. Rev. Drug Discov , vol.10
    • Karran, E.1    Mercken, M.2    De Strooper, B.3
  • 33
    • 84926649589 scopus 로고    scopus 로고
    • Drug repositioning approaches for the discovery of new therapeutics for Alzheimer's disease
    • Kim, T.-W. (2015). Drug repositioning approaches for the discovery of new therapeutics for Alzheimer's disease. Neurotherapeutics 12, 132-142. doi: 10.1007/s13311-014-0325-7.
    • (2015) Neurotherapeutics , vol.12 , pp. 132-142
    • Kim, T.-W.1
  • 34
    • 84869992747 scopus 로고    scopus 로고
    • The complex PrPc-Fyn couples human oligomeric A beta with pathological tau changes in Alzheimer's disease
    • Larson, M., Sherman, M. A., Amar, F., Nuvolone, M., Schneider, J. A., Bennett, D. A., et al. (2012). The complex PrPc-Fyn couples human oligomeric A beta with pathological tau changes in Alzheimer's disease. J. Neurosci. 32, 16857. doi: 10.1523/JNEUROSCI.1858-12.2012.
    • (2012) J. Neurosci , vol.32 , pp. 16857
    • Larson, M.1    Sherman, M.A.2    Amar, F.3    Nuvolone, M.4    Schneider, J.A.5    Bennett, D.A.6
  • 35
    • 84907001204 scopus 로고    scopus 로고
    • Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment
    • Lecoutey, C., Hedou, D., Freret, T., Giannoni, P., Gaven, F., Since, M., et al. (2014). Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment. Proc. Natl. Acad. Sci. U.S.A. 111, E3825-E3830. doi: 10.1073/pnas.1410315111.
    • (2014) Proc. Natl. Acad. Sci. U.S.A , vol.111 , pp. E3825-E3830
    • Lecoutey, C.1    Hedou, D.2    Freret, T.3    Giannoni, P.4    Gaven, F.5    Since, M.6
  • 36
    • 34248570473 scopus 로고    scopus 로고
    • 5-HT4 receptor and Alzheimer's disease: the amyloid connection
    • Lezoualc'h, F. (2007). 5-HT4 receptor and Alzheimer's disease: the amyloid connection. Exp. Neurol. 205, 325-329. doi: 10.1016/j.expneurol.2007.02.001.
    • (2007) Exp. Neurol , vol.205 , pp. 325-329
    • Lezoualc'h, F.1
  • 37
    • 84887792202 scopus 로고    scopus 로고
    • Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease
    • Li, S.-Y., Wang, X.-B., and Kong, L.-Y. (2014). Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease. Eur. J. Med. Chem. 71, 36-45. doi: 10.1016/j.ejmech.2013.10.068.
    • (2014) Eur. J. Med. Chem , vol.71 , pp. 36-45
    • Li, S.-Y.1    Wang, X.-B.2    Kong, L.-Y.3
  • 38
    • 77952753353 scopus 로고    scopus 로고
    • Effects of the 5-HT4 receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels
    • Licht, C. L., Knudsen, G. M., and Sharp, T. (2010). Effects of the 5-HT4 receptor agonist RS67333 and paroxetine on hippocampal extracellular 5-HT levels. Neurosci. Lett. 476, 58-61. doi: 10.1016/j.neulet.2010.04.002.
    • (2010) Neurosci. Lett , vol.476 , pp. 58-61
    • Licht, C.L.1    Knudsen, G.M.2    Sharp, T.3
  • 39
    • 33645095476 scopus 로고    scopus 로고
    • Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond
    • Lipton, S. A. (2006). Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Nat. Rev. Drug Discov. 5, 160-170. doi: 10.1038/nrd1958.
    • (2006) Nat. Rev. Drug Discov , vol.5 , pp. 160-170
    • Lipton, S.A.1
  • 40
    • 84899849734 scopus 로고    scopus 로고
    • AlzPlatform: an Alzheimer's disease domain-specific chemogenornics knowledgebase for polypharmacology and target identification research
    • Liu, H., Wang, L., Lv, M., Pei, R., Li, P., Pei, Z., et al. (2014). AlzPlatform: an Alzheimer's disease domain-specific chemogenornics knowledgebase for polypharmacology and target identification research. J. Chem. Inf. Model. 54, 1050-1060. doi: 10.1021/ci500004h.
    • (2014) J. Chem. Inf. Model , vol.54 , pp. 1050-1060
    • Liu, H.1    Wang, L.2    Lv, M.3    Pei, R.4    Li, P.5    Pei, Z.6
  • 41
    • 84861647877 scopus 로고    scopus 로고
    • Cheminformatic/bioinformatic analysis of large corporate databases: application to drug repurposing
    • Loging, W., Rodriguez-Esteban, R., Hill, J., Freeman, T. B., and Miglietta, J. (2011). Cheminformatic/bioinformatic analysis of large corporate databases: application to drug repurposing. Drug Discov. Today Ther. Strateg. 8, 109-116. doi: 10.1016/j.ddstr.2011.06.004.
    • (2011) Drug Discov. Today Ther. Strateg , vol.8 , pp. 109-116
    • Loging, W.1    Rodriguez-Esteban, R.2    Hill, J.3    Freeman, T.B.4    Miglietta, J.5
  • 42
    • 84880915278 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease
    • Lu, C., Guo, Y., Yan, J., Luo, Z., Luo, H.-B., Yan, M., et al. (2013a). Design, synthesis, and evaluation of multitarget-directed resveratrol derivatives for the treatment of Alzheimer's disease. J. Med. Chem. 56, 5843-5859. doi: 10.1021/jm400567s.
    • (2013) J. Med. Chem , vol.56 , pp. 5843-5859
    • Lu, C.1    Guo, Y.2    Yan, J.3    Luo, Z.4    Luo, H.-B.5    Yan, M.6
  • 43
    • 84876001019 scopus 로고    scopus 로고
    • A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease
    • Lu, C., Zhou, Q., Yan, J., Du, Z., Huang, L., and Li, X. (2013b). A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease. Eur. J. Med. Chem. 62, 745-753. doi: 10.1016/j.ejmech.2013.01.039.
    • (2013) Eur. J. Med. Chem , vol.62 , pp. 745-753
    • Lu, C.1    Zhou, Q.2    Yan, J.3    Du, Z.4    Huang, L.5    Li, X.6
  • 44
    • 84886592674 scopus 로고    scopus 로고
    • Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease
    • McClean, P. L., and Hölscher, C. (2014). Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease. Neuropharmacology 76, 57-67. doi: 10.1016/j.neuropharm.2013.08.005.
    • (2014) Neuropharmacology , vol.76 , pp. 57-67
    • McClean, P.L.1    Hölscher, C.2
  • 45
    • 79955749452 scopus 로고    scopus 로고
    • The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease
    • McClean, P. L., Parthsarathy, V., Faivre, E., and Hölscher, C. (2011). The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease. J. Neurosci. 31, 6587-6594. doi: 10.1523/JNEUROSCI.0529-11.2011.
    • (2011) J. Neurosci , vol.31 , pp. 6587-6594
    • McClean, P.L.1    Parthsarathy, V.2    Faivre, E.3    Hölscher, C.4
  • 46
    • 84930221989 scopus 로고    scopus 로고
    • Age-related decline in brain and hepatic clearance of amyloid-beta is rectified by the cholinesterase inhibitors donepezil and rivastignnine in rats
    • Mohamed, L. A., Qosa, H., and Kaddoumi, A. (2015). Age-related decline in brain and hepatic clearance of amyloid-beta is rectified by the cholinesterase inhibitors donepezil and rivastignnine in rats. ACS Chem. Neurosci. 6, 725-736. doi: 10.1021/acschemneuro.5b00040.
    • (2015) ACS Chem. Neurosci , vol.6 , pp. 725-736
    • Mohamed, L.A.1    Qosa, H.2    Kaddoumi, A.3
  • 47
    • 71349085957 scopus 로고    scopus 로고
    • Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
    • Moloney, A. M., Griffin, R. J., Timmons, S., O'Connor, R., Ravid, R., and O'Neill, C. (2010). Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol. Aging 31, 224-243. doi: 10.1016/j.neurobiolaging.2008.04.002.
    • (2010) Neurobiol. Aging , vol.31 , pp. 224-243
    • Moloney, A.M.1    Griffin, R.J.2    Timmons, S.3    O'Connor, R.4    Ravid, R.5    O'Neill, C.6
  • 48
    • 84893832278 scopus 로고    scopus 로고
    • Fyn kinase inhibition as a novel therapy for Alzheimer's disease
    • Nygaard, H. B., van Dyck, C. H., and Strittmatter, S. M. (2014). Fyn kinase inhibition as a novel therapy for Alzheimer's disease. Alzheimers Res. Ther. 6:8 doi: 10.1186/alzrt238.
    • (2014) Alzheimers Res. Ther , vol.6 , pp. 8
    • Nygaard, H.B.1    van Dyck, C.H.2    Strittmatter, S.M.3
  • 49
    • 84913604131 scopus 로고    scopus 로고
    • Resistance-resistant antibiotics
    • Oldfield, E., and Feng, X. (2014). Resistance-resistant antibiotics. Trends Pharmacol. Sci. 35, 664-674. doi: 10.1016/j.tips.2014.10.007.
    • (2014) Trends Pharmacol. Sci , vol.35 , pp. 664-674
    • Oldfield, E.1    Feng, X.2
  • 50
    • 84871717564 scopus 로고    scopus 로고
    • Synthesis, molecular modeling and evaluation of novel N '-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and A beta aggregation
    • Ozer, E. O., Tan, O. U., Ozadali, K., Kucukkilinc, T., Balkan, A., and Ucar, G. (2013). Synthesis, molecular modeling and evaluation of novel N '-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and A beta aggregation. Bioorg. Med. Chem. Lett. 23, 440-443. doi: 10.1016/j.bmcl.2012.11.064.
    • (2013) Bioorg. Med. Chem. Lett , vol.23 , pp. 440-443
    • Ozer, E.O.1    Tan, O.U.2    Ozadali, K.3    Kucukkilinc, T.4    Balkan, A.5    Ucar, G.6
  • 51
    • 79952442060 scopus 로고    scopus 로고
    • Neuroprotective therapeutics for Alzheimer's disease: progress and prospects
    • Palmer, A. M. (2011). Neuroprotective therapeutics for Alzheimer's disease: progress and prospects. Trends Pharmacol. Sci. 32, 141-147. doi: 10.1016/j.tips.2010.12.007.
    • (2011) Trends Pharmacol. Sci , vol.32 , pp. 141-147
    • Palmer, A.M.1
  • 52
    • 0033023543 scopus 로고    scopus 로고
    • Relevance of benzyloxy group in 2-indolyl methylamines in the selective MAO-B inhibition
    • Pérez, V., Marco, J. L., Férnandez-Alvarez, E., and Unzeta, M. (1999). Relevance of benzyloxy group in 2-indolyl methylamines in the selective MAO-B inhibition. Br. J. Pharmacol. 127, 869-876. doi: 10.1038/sj.bjp.0702600.
    • (1999) Br. J. Pharmacol , vol.127 , pp. 869-876
    • Pérez, V.1    Marco, J.L.2    Férnandez-Alvarez, E.3    Unzeta, M.4
  • 53
    • 84903268791 scopus 로고    scopus 로고
    • Two diseases, one approach: multitarget drug discovery in Alzheimer's and neglected tropical diseases
    • Prati, F., Uliassi, E., and Bolognesi, M. L. (2014). Two diseases, one approach: multitarget drug discovery in Alzheimer's and neglected tropical diseases. MedChemComm 5, 853-861. doi: 10.1039/c4md00069b.
    • (2014) MedChemComm , vol.5 , pp. 853-861
    • Prati, F.1    Uliassi, E.2    Bolognesi, M.L.3
  • 54
    • 79955444505 scopus 로고    scopus 로고
    • A phase II trial of huperzine A in mild to moderate Alzheimer disease
    • Rafii, M. S., Walsh, S., Little, J. T., Behan, K., Reynolds, B., Ward, C., et al. (2011). A phase II trial of huperzine A in mild to moderate Alzheimer disease. Neurology 76, 1389-1394. doi: 10.1212/WNL.0b013e318216eb7b.
    • (2011) Neurology , vol.76 , pp. 1389-1394
    • Rafii, M.S.1    Walsh, S.2    Little, J.T.3    Behan, K.4    Reynolds, B.5    Ward, C.6
  • 55
    • 84927773140 scopus 로고    scopus 로고
    • Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride
    • Rochais, C., Lecoutey, C., Gaven, F., Giannoni, P., Hamidouche, K., Hedou, D., et al. (2015). Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride. J. Med. Chem. 58, 3172-3187. doi: 10.1021/acs.jmedchem.5b00115.
    • (2015) J. Med. Chem , vol.58 , pp. 3172-3187
    • Rochais, C.1    Lecoutey, C.2    Gaven, F.3    Giannoni, P.4    Hamidouche, K.5    Hedou, D.6
  • 56
    • 80054960254 scopus 로고    scopus 로고
    • Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease
    • Rosini, M., Simoni, E., Bartolini, M., Tarozzi, A., Matera, R., Milelli, A., et al. (2011). Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. Eur. J. Med. Chem. 46, 5435-5442. doi: 10.1016/j.ejmech.2011.09.001.
    • (2011) Eur. J. Med. Chem , vol.46 , pp. 5435-5442
    • Rosini, M.1    Simoni, E.2    Bartolini, M.3    Tarozzi, A.4    Matera, R.5    Milelli, A.6
  • 57
    • 65449154371 scopus 로고    scopus 로고
    • Design, synthesis, and biological evaluation of new 5-HT(4) receptor agonists: application as amyloid cascade modulators and potential therapeutic utility in Alzheimer's disease
    • Russo, O., Cachard-Chastel, M., Riviere, C., Giner, M., Soulier, J.-L., Berthouze, M., et al. (2009). Design, synthesis, and biological evaluation of new 5-HT(4) receptor agonists: application as amyloid cascade modulators and potential therapeutic utility in Alzheimer's disease. J. Med. Chem. 52, 2214-2225. doi: 10.1021/jm801327q.
    • (2009) J. Med. Chem , vol.52 , pp. 2214-2225
    • Russo, O.1    Cachard-Chastel, M.2    Riviere, C.3    Giner, M.4    Soulier, J.-L.5    Berthouze, M.6
  • 58
    • 84860318738 scopus 로고    scopus 로고
    • Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine
    • Samadi, A., de los Ríos, C., Bolea, I., Chioua, M., Iriepa, I., Moraleda, I., et al. (2012). Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine. Eur. J. Med. Chem. 52, 251-262. doi: 10.1016/j.ejmech.2012.03.022.
    • (2012) Eur. J. Med. Chem , vol.52 , pp. 251-262
    • Samadi, A.1    de los Ríos, C.2    Bolea, I.3    Chioua, M.4    Iriepa, I.5    Moraleda, I.6
  • 60
    • 84867338003 scopus 로고    scopus 로고
    • Discovery and preclinical validation of drug indications using compendia of public gene expression data
    • Sirota, M., Dudley, J. T., Kim, J., Chiang, A. P., Morgan, A. A., Sweet-Cordero, A., et al. (2011). Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci. Transl. Med. 3:96ra77. doi: 10.1126/scitranslmed.3001318.
    • (2011) Sci. Transl. Med , vol.3
    • Sirota, M.1    Dudley, J.T.2    Kim, J.3    Chiang, A.P.4    Morgan, A.A.5    Sweet-Cordero, A.6
  • 61
    • 33750339874 scopus 로고    scopus 로고
    • Parallel screening: A novel concept in pharmacophore modeling and virtual screening
    • Steindl, T. M., Schuster, D., Laggner, C., and Langer, T. (2006). Parallel screening: A novel concept in pharmacophore modeling and virtual screening. J. Chem. Inf. Model. 46, 2146-2157. doi: 10.1021/ci6002043.
    • (2006) J. Chem. Inf. Model , vol.46 , pp. 2146-2157
    • Steindl, T.M.1    Schuster, D.2    Laggner, C.3    Langer, T.4
  • 63
    • 80053215324 scopus 로고    scopus 로고
    • Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation inhibitors
    • Tang, H., Zhao, L.-Z., Zhao, H.-T., Huang, S.-L., Zhong, S.-M., Qin, J.-K., et al. (2011). Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation inhibitors. Eur. J. Med. Chem. 46, 4970-4979. doi: 10.1016/j.ejmech.2011.08.002.
    • (2011) Eur. J. Med. Chem , vol.46 , pp. 4970-4979
    • Tang, H.1    Zhao, L.-Z.2    Zhao, H.-T.3    Huang, S.-L.4    Zhong, S.-M.5    Qin, J.-K.6
  • 64
    • 84966441580 scopus 로고    scopus 로고
    • Alzheimer's disease multi-target directed inhibitor design using sequential virtual screening techniques
    • Tyagi, A., Gupta, S., Pandey, A., and Mohan, C. G. (2010). Alzheimer's disease multi-target directed inhibitor design using sequential virtual screening techniques. Curr. Res. Inf. Pharm. Sci. 11, 29-32. Available online at: http://www.niper.ac.in/29_crips.pdf.
    • (2010) Curr. Res. Inf. Pharm. Sci , vol.11 , pp. 29-32
    • Tyagi, A.1    Gupta, S.2    Pandey, A.3    Mohan, C.G.4
  • 65
    • 84928122845 scopus 로고    scopus 로고
    • BACE1 inhibitor drugs in clinical trials for Alzheimer's disease
    • Vassar, R. (2014). BACE1 inhibitor drugs in clinical trials for Alzheimer's disease. Alzheimer's Res. Ther. 6, 89-89. doi: 10.1186/s13195-014-0089-7.
    • (2014) Alzheimer's Res. Ther , vol.6 , pp. 89-89
    • Vassar, R.1
  • 66
    • 84877055652 scopus 로고    scopus 로고
    • Target hunter: an in silico target identification tool for predicting therapeutic potential of small organic molecules based on chemogenomic database
    • Wang, L., Ma, C., Wipf, P., Liu, H., Su, W., and Xie, X.-Q. (2013). Target hunter: an in silico target identification tool for predicting therapeutic potential of small organic molecules based on chemogenomic database. Aaps J. 15, 395-406. doi: 10.1208/s12248-012-9449-z.
    • (2013) Aaps J , vol.15 , pp. 395-406
    • Wang, L.1    Ma, C.2    Wipf, P.3    Liu, H.4    Su, W.5    Xie, X.-Q.6
  • 67
    • 77956092544 scopus 로고    scopus 로고
    • Rasagiline: a novel anti-parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity
    • Weinreb, O., Amit, T., Bar-Am, O., and Youdim, M. B. H. (2010). Rasagiline: a novel anti-parkinsonian monoamine oxidase-B inhibitor with neuroprotective activity. Prog. Neurobiol. 92, 330-344. doi: 10.1016/j.pneurobio.2010.06.008.
    • (2010) Prog. Neurobiol , vol.92 , pp. 330-344
    • Weinreb, O.1    Amit, T.2    Bar-Am, O.3    Youdim, M.B.H.4
  • 68
    • 2942514710 scopus 로고    scopus 로고
    • Cholinesterase inhibitors used in the treatment of Alzheimer's disease the relationship between pharmacological effects and clinical efficacy
    • Wilkinson, D. G., Francis, P. T., Schwam, E., and Payne-Parrish, J. (2004). Cholinesterase inhibitors used in the treatment of Alzheimer's disease the relationship between pharmacological effects and clinical efficacy. Drugs Aging 21, 453-478. doi: 10.2165/00002512-200421070-00004.
    • (2004) Drugs Aging , vol.21 , pp. 453-478
    • Wilkinson, D.G.1    Francis, P.T.2    Schwam, E.3    Payne-Parrish, J.4
  • 69
    • 84897954317 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer's disease
    • Wisniewski, T., and Goñi, F. (2014). Immunotherapy for Alzheimer's disease. Biochem. Pharmacol. 88, 499-507. doi: 10.1016/j.bcp.2013.12.020.
    • (2014) Biochem. Pharmacol , vol.88 , pp. 499-507
    • Wisniewski, T.1    Goñi, F.2
  • 70
    • 84896832064 scopus 로고    scopus 로고
    • Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis
    • Xing, S.-H., Zhu, C.-X., Zhang, R., and An, L. (2014). Huperzine a in the treatment of Alzheimer's disease and vascular dementia: a meta-analysis. Evid. Based Complement. Alternat. Med. 2014, 363985-363985. doi: 10.1155/2014/363985.
    • (2014) Evid. Based Complement. Alternat. Med , vol.2014
    • Xing, S.-H.1    Zhu, C.-X.2    Zhang, R.3    An, L.4
  • 71
    • 0029112606 scopus 로고
    • Efficacy of tablet huperzine-a on memory, cognition, and behavior in Alzheimers-disease
    • Xu, S. S., Gao, Z. X., Zheng, W., Du, Z. M., Xu, W. A., Yang, J. S., et al. (1995). Efficacy of tablet huperzine-a on memory, cognition, and behavior in Alzheimers-disease. Acta Pharmacol. Sin. 16, 391-395.
    • (1995) Acta Pharmacol. Sin , vol.16 , pp. 391-395
    • Xu, S.S.1    Gao, Z.X.2    Zheng, W.3    Du, Z.M.4    Xu, W.A.5    Yang, J.S.6
  • 72
    • 0642303109 scopus 로고    scopus 로고
    • The importance of propargylamine moiety in the anti-Parkinson drug rasagiline and its derivatives for MAPK-dependent amyloid precursor protein processing
    • Yogev-Falach, M., Amit, T., Bar-Am, O., and Youdim, M. B. H. (2003). The importance of propargylamine moiety in the anti-Parkinson drug rasagiline and its derivatives for MAPK-dependent amyloid precursor protein processing. FASEB J. 17, 2325. doi: 10.1096/fj.03-0078fje.
    • (2003) FASEB J , vol.17 , pp. 2325
    • Yogev-Falach, M.1    Amit, T.2    Bar-Am, O.3    Youdim, M.B.H.4
  • 73
    • 33846076665 scopus 로고    scopus 로고
    • The path from anti Parkinson drug selegiline and rasagiline to multi-functional neuroprotective anti Alzheimer drugs ladostigil and M30
    • Youdim, M. B. H. (2006). The path from anti Parkinson drug selegiline and rasagiline to multi-functional neuroprotective anti Alzheimer drugs ladostigil and M30. Curr. Alzheimer Res. 3, 541-550. doi: 10.2174/156720506779025288.
    • (2006) Curr. Alzheimer Res , vol.3 , pp. 541-550
    • Youdim, M.B.H.1
  • 74
    • 84885962163 scopus 로고    scopus 로고
    • Multi target neuroprotective and neurorestorative anti-Parkinson and anti-Alzheimer drugs ladostigil and m30 derived from rasagiline
    • Youdim, M. B. H. (2013). Multi target neuroprotective and neurorestorative anti-Parkinson and anti-Alzheimer drugs ladostigil and m30 derived from rasagiline. Exp. Neurobiol. 22, 1-10. doi: 10.5607/en.2013.22.1.1.
    • (2013) Exp. Neurobiol , vol.22 , pp. 1-10
    • Youdim, M.B.H.1
  • 76
    • 0035130289 scopus 로고    scopus 로고
    • Rasagiline N-propargyl-1R(+)-aminoindan, a selective and potent inhibitor of mitochondrial monoamine oxidase B
    • Youdim, M. B. H., Gross, A., and Finberg, J. P. M. (2001). Rasagiline N-propargyl-1R(+)-aminoindan, a selective and potent inhibitor of mitochondrial monoamine oxidase B. Br. J. Pharmacol. 132, 500-506. doi: 10.1038/sj.bjp.0703826.
    • (2001) Br. J. Pharmacol , vol.132 , pp. 500-506
    • Youdim, M.B.H.1    Gross, A.2    Finberg, J.P.M.3
  • 77
    • 23144441835 scopus 로고    scopus 로고
    • Neuropharmacological, neuroprotective and amyloid precursor processing properties of selective MAO-B inhibitor antiparkinsonian drug, rasagiline
    • Youdim, M. B. H., Maruyama, W., and Naoi, M. (2005). Neuropharmacological, neuroprotective and amyloid precursor processing properties of selective MAO-B inhibitor antiparkinsonian drug, rasagiline. Drugs Today 41, 369-391. doi: 10.1358/dot.2005.41.6.893613.
    • (2005) Drugs Today , vol.41 , pp. 369-391
    • Youdim, M.B.H.1    Maruyama, W.2    Naoi, M.3
  • 78
    • 84893494195 scopus 로고    scopus 로고
    • From single target to multitarget/network therapeutics in Alzheimer's therapy
    • Zheng, H., Fridkin, M., and Youdim, M. (2014). From single target to multitarget/network therapeutics in Alzheimer's therapy. Pharmaceuticals 7, 113-135. doi: 10.3390/ph7020113.
    • (2014) Pharmaceuticals , vol.7 , pp. 113-135
    • Zheng, H.1    Fridkin, M.2    Youdim, M.3
  • 79
    • 78651312050 scopus 로고    scopus 로고
    • Site-activated chelators derived from anti-parkinson drug rasagiline as a potential safer and more effective approach to the treatment of Alzheimer's disease
    • Zheng, H., Fridkin, M., and Youdim, M. B. H. (2010a). Site-activated chelators derived from anti-parkinson drug rasagiline as a potential safer and more effective approach to the treatment of Alzheimer's disease. Neurochem. Res. 35, 2117-2123. doi: 10.1007/s11064-010-0293-1.
    • (2010) Neurochem. Res , vol.35 , pp. 2117-2123
    • Zheng, H.1    Fridkin, M.2    Youdim, M.B.H.3
  • 80
    • 25644461154 scopus 로고    scopus 로고
    • Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition
    • Zheng, H., Gal, S., Weiner, L. M., Bar-Am, O., Warshawsky, A., Fridkin, M., et al. (2005). Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition. J. Neurochem. 95, 68-78. doi: 10.1111/j.1471-4159.2005.03340.x.
    • (2005) J. Neurochem , vol.95 , pp. 68-78
    • Zheng, H.1    Gal, S.2    Weiner, L.M.3    Bar-Am, O.4    Warshawsky, A.5    Fridkin, M.6
  • 81
    • 77953864734 scopus 로고    scopus 로고
    • Site-activated chelators targeting acetylcholinesterase and monoamine oxidase for Alzheimer's therapy
    • Zheng, H., Youdim, M. B. H., and Fridkin, M. (2010b). Site-activated chelators targeting acetylcholinesterase and monoamine oxidase for Alzheimer's therapy. ACS Chem. Biol. 5, 603-610. doi: 10.1021/cb900264w.
    • (2010) ACS Chem. Biol , vol.5 , pp. 603-610
    • Zheng, H.1    Youdim, M.B.H.2    Fridkin, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.