Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease

European Journal of Medicinal Chemistry

Volumn 71, Issue , 2014, Pages 36-45

  Li, Su Yi ^a   Wang, Xiao Bing ^a   Kong, Ling Yi ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Antioxidant; Metal chelator; Neuroprotection; Resveratrol derivatives; Amyloid aggregation

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ANTIOXIDANT; IMINE; IMINE RESVERATROL DERIVATIVE; NOOTROPIC AGENT; REACTIVE OXYGEN METABOLITE; RESVERATROL; UNCLASSIFIED DRUG; 2 (BENZYLIDENEAMINO)PHENOL; 2 [(2 FLUOROBENZYLIDENE)AMINO]PHENOL; 2 [(2 HYDROXYBENZYLIDENE)AMINO]PHENOL; 2 [(3 FLUOROBENZYLIDENE)AMINO]PHENOL; 2 [(3 HYDROXYBENZYLIDENE)AMINO]PHENOL; 2 [(3,4 DIMETHOXYBENZYLIDENE)AMINO]PHENOL; 2 [(4 FLUOROBENZYLIDENE)AMINO]PHENOL; 2 [(4 HYDROXYBENZYLIDENE)AMINO]PHENOL; 2 [(4 METHOXYBENZYLIDENE)AMINO]PHENOL; 2 [(PHENYLIMINO)METHYL]PHENOL; 2 [[(2 FLUOROPHENYL)IMINO]METHYL]PHENOL; 2 [[(3 FLUOROPHENYL)IMINO]METHYL]PHENOL; 2 [[(3 HYDROXYPHENYL)IMINO]METHYL]PHENOL; 2 [[(4 FLUOROPHENYL)IMINO]METHYL]PHENOL; 2 [[(4 HYDROXYPHENYL)IMINO]METHYL]PHENOL; 2 [[4 (DIMETHYLAMINO)BENZYLIDENE]AMINO]PHENOL; 4 CHLORO 2 [(PHENYLIMINO)METHYL]PHENOL; 4 METHOXY 2 [(PHENYLIMINO)METHYL]PHENOL; 4 [[(2 HYDROXYPHENYL)IMINO]METHYL]BENZENE 1,2 DIOL; 4 [[(2 HYDROXYPHENYL)IMINO]METHYL]BENZENE 1,3 DIOL; AMYLOID BETA PROTEIN[1-42]; CUPRIC ION; LEAD; NEUROPROTECTIVE AGENT;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CHELATION; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; MOLECULAR DOCKING; NEUROBLASTOMA CELL; NEUROPROTECTION; OXIDATIVE STRESS; CONTROLLED STUDY; DPPH RADICAL SCAVENGING ASSAY; ENZYME INHIBITION; IC50; PROTEIN AGGREGATION;

ALZHEIMER'S DISEASE; ANTIOXIDANT; BSVVLXIGPDFSEZ-RIYZIHGNSA-N; CHBGIQHEGBKNGA-NTEUORMPSA-N; COFLOZFCNFCJFM-OQLLNIDSSA-N; CPOKOAWVSUHOCZ-MHWRWJLKSA-N; CXQBWMKQSJPURB-XNTDXEJSSA-N; DTKVTDFIUFYZDW-OQLLNIDSSA-N; GJZBNSJPZKCNPU-LFIBNONCSA-N; GRWIZXASAOKOEZ-GXDHUFHOSA-N; IUPUQXNVHRUSEI-OQLLNIDSSA-N; IWCJTSCDZDXKBK-OQLLNIDSSA-N; KILNMRJUXROOCU-NTEUORMPSA-N; METAL CHELATOR; NEUROPROTECTION; OZUBFLPYRPJKQL-XNTDXEJSSA-N; POLJRSQMPKDDIY-NTEUORMPSA-N; PQKMAPANQMNEHB-NTEUORMPSA-N; QIYHCQVVYSSDTI-GXDHUFHOSA-N; RESVERATROL DERIVATIVES; SDHKTTFTBJGDQX-OQLLNIDSSA-N; UALRWOGQNILXLJ-NTEUORMPSA-N; USHSXCMBQPJHEF-OQLLNIDSSA-N; VISLUSLXCVLVTQ-RIYZIHGNSA-N; ZUHWLAWLODQICJ-OQLLNIDSSA-N; Β-AMYLOID AGGREGATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANTIOXIDANTS; CELL LINE, TUMOR; COPPER; HUMANS; NEUROPROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; STILBENES;

EID: 84887792202     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.068     Document Type: Article

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