Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease

European Journal of Medicinal Chemistry

Volumn 75, Issue , 2014, Pages 82-95

  Bautista Aguilera, Oscar M ^a   Esteban, Gerard ^b   Bolea, Irene ^b   Nikolic, Katarina ^c   Agbaba, Danica ^c   Moraleda, Ignacio ^d   Iriepa, Isabel ^d   Samadi, Abdelouahid ^a   Soriano, Elena ^e   Unzeta, Mercedes ^b   Marco Contelles, José ^a  

^a INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c UNIVERSITY OF BELGRADE   (Serbia)

^d UNIVERSITY OF ALCALÁ   (Spain)

^e CSIC   (Spain)

Author keywords

3D QSAR; ADMET; Donepezil; Donepezil indolyl hybrids; EeAChE; eqBuChE; hMAO A; hMAO B; Inhibitors; Molecular modeling

Indexed keywords

3D-QSAR; ADMET; DONEPEZIL; DONEPEZIL-INDOLYL HYBRIDS; EEACHE; EQBUCHE; HMAO A; HMAO B; INHIBITORS; MOLECULAR MODELING;

ALZHEIMER DISEASE; ANIMALS; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; DRUG DESIGN; ELECTROPHORUS; HORSES; HUMANS; INDANS; INDOLES; MODELS, MOLECULAR; MONOAMINE OXIDASE; MONOAMINE OXIDASE INHIBITORS; PIPERIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84893943097     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.12.028     Document Type: Article

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