Wnt signaling pathway, a potential target for Alzheimer's disease treatment, is activated by a novel multitarget compound ASS234

CNS Neuroscience and Therapeutics

Volumn 20, Issue 6, 2014, Pages 568-570

  del Pino, Javier ^a   Ramos, Eva ^a   Aguilera, Oscar M Bautista ^b   Marco Contelles, José ^b   Romero, Alejandro ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ASS 234; N [[5 [3 (1 BENZYLPIPERIDIN 4 YL)PROPOXY] 1 METHYL 1H INDOL 2 YL]METHYL] N METHYLPROP 2 YN 1 AMINE; NOOTROPIC AGENT; UNCLASSIFIED DRUG; ENZYME INHIBITOR; INDOLE DERIVATIVE; N-((5-(3-(1-BENZYLPIPERIDIN-4-YL)PROPOXY)-1-METHYL-1H-INDOL-2-YL)METHYL)-N-METHYLPROP-2-YN-1-AMINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PIPERIDINE DERIVATIVE;

ALZHEIMER DISEASE; BLOOD BRAIN BARRIER; GENE EXPRESSION; HUMAN; LETTER; NEUROPROTECTION; WNT SIGNALING PATHWAY; DRUG EFFECTS; METABOLISM; NEUROBLASTOMA; PATHOLOGY; TUMOR CELL LINE;

CELL LINE, TUMOR; ENZYME INHIBITORS; GENE EXPRESSION; HUMANS; INDOLES; NEUROBLASTOMA; PIPERIDINES; PPAR ALPHA; WNT SIGNALING PATHWAY;

EID: 84900554029     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12269     Document Type: Letter

References (10)

1. Bolea I, Juárez-Jiménez J, de los Ríos C, et al. Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease. J Med Chem 2011;54:8251-8270.
2. Bolea I, Gella A, Monjas L, et al. The multipotent, permeable drug ASS234 inhibits Aβ aggregation, possesses antioxidant properties and protects from Aβ-induced apoptosis. Curr Alzheimer Res 2013;9:797-808.
3. Stasiak A, Mussur M, Unzeta M, Samadi A, Marco-Contelles JL, Fogel WA. Effects of novel monoamine oxidases and cholinesterases targeting compounds on brain neurotransmitters and behavior in rat model of vascular dementia. Curr Pharm Des 2014;20:161-171.
4. Toledo EM, Colombres M, Inestrosa NC. Wnt signaling in neuroprotection and stem cell differentiation. Prog Neurobiol 2008;86:281-296.
5. Maiese K, Li F, Chong ZZ, Shang YC. The Wnt signaling pathway: Aging gracefully as a protectionist? Pharmacol Ther 2008;118:58-81.
6. Reyes AE, Chacon MA, Dinamarca MC, Cerpa W, Morgan C, Inestrosa NC. Acetylcholinesterase-Ab complexes are more toxic than Ab fibrils in rat hippocampus: Effect on rat b-amyloid aggregation, laminin expression, reactive astrocytosis, and neuronal cell loss. Am J Pathol 2004;164:2163-2174.
7. Inestrosa NC, Montecinos-Oliva C, Fuenzalida M. Wnt signaling: Role in Alzheimer disease and schizophrenia. J Neuroimmune Pharmacol 2012;7:788-807.
8. Inestrosa NC, Urra S, Colombres M. Acetylcholinesterase (AChE)-amyloid-beta-peptide complexes in Alzheimer's disease. The Wnt signaling pathway. Curr Alzheimer Res 2004;1:249-254.
9. Kim HJ, Hama SA, Paek KS, et al. Transcriptional up-regulation of antioxidant genes by PPARd inhibits angiotensin II-induced premature senescence in vascular smooth muscle cells. Biochem Biophys Res Commun 2011;406:564-569.
10. Vargas JY, Fuenzalida M, Inestrosa NC. In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model. J Neurosci 2014;34:2191-2202.