Age-related decline in brain and hepatic clearance of amyloid-beta is rectified by the cholinesterase inhibitors donepezil and rivastigmine in rats

ACS Chemical Neuroscience

Volumn 6, Issue 5, 2015, Pages 725-736

  Mohamed, Loqman A ^a   Qosa, Hisham ^a   Kaddoumi, Amal ^a  

^a UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

Alzheimer's disease; amyloid clearance; BBB; Donepezil; liver; rivastigmine

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40] I 125; DONEPEZIL; GALANTAMINE; IODINE 125; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MEMANTINE; MULTIDRUG RESISTANCE PROTEIN; RIVASTIGMINE; TACRINE; UNCLASSIFIED DRUG; CHOLINESTERASE INHIBITOR; INDAN DERIVATIVE; PIPERIDINE DERIVATIVE;

ACTIVE TRANSPORT; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILIARY CLEARANCE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; GROUPS BY AGE; IN VITRO STUDY; IN VIVO STUDY; LIVER CLEARANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION; ANIMAL; BRAIN; DRUG EFFECTS; LIVER; MALE; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

AGING; AMYLOID BETA-PEPTIDES; ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CHOLINESTERASE INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; INDANS; LIVER; MALE; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RIVASTIGMINE;

EID: 84930221989     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/acschemneuro.5b00040     Document Type: Article

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