A novel series of tacrine-selegiline hybrids with cholinesterase and monoamine oxidase inhibition activities for the treatment of Alzheimer's disease

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 745-753

  Lu, Chuanjun ^a   Zhou, Qi ^a   Yan, Jun ^a   Du, Zhiyun ^b   Huang, Ling ^a   Li, Xingshu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGDONG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Alzheimer's disease; Cholinesterase inhibitor; Monoamine oxidase inhibitor; Selegiline; Tacrine

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); CHOLINESTERASE; N (9 (4 (2 (METHYL(PROP 2 YNYL)AMINO)PROPYL)PHENOXY)NONYL) 1,2,3,4 TETRAHYDROACRIDIN 9 AMINE; SELEGILINE; TACRINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; BUTYRYLCHOLINESTERASE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONOAMINE OXIDASE; RECOMBINANT PROTEINS; SELEGILINE; STRUCTURE-ACTIVITY RELATIONSHIP; TACRINE;

EID: 84876001019     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.01.039     Document Type: Article

References (33)

1. M. Prince, and J. Jackson Alzheimer's Dis. Int. World Alzheimer Rep. 2009 2009 1 93
2. E. Scarpini, P. Schelterns, and H. Feldman Lancet Neurol. 2 2003 539 547
3. B. Tasso, M. Catto, O. Nicolotti, F. Novelli, M. Tonelli, I. Giangreco, L. Pisani, A. Sparatore, V. Boido, A. Carotti, and F. Sparatore Eur. J. Med. Chem. 46 2011 2170 2184
4. V. Tumiatti, A. Minarini, M.L. Bolognesi, A. Milelli, M. Rosini, and C. Melchiorre Curr. Med. Chem. 17 2010 1825 1838
5. Y.-P. Pang, P. Quiram, T. Jelacic, F. Hong, and S. Brimijoin J. Biol. Chem. 271 1996 23646 23649
6. N.C. Inestrosa, A. Alvarez, and F. Calderon Mol. Psychiatry 1 1996 359 360
7. M.I. Fernández-Bachiller, C. Pérez, G.C. González-Muñoz, S. Conde, M.G. López, M. Villarroya, A.G. García, and M.I. Rodríguez-Franco J. Med. Chem. 53 2010 4927 4937
8. Y. Wang, X.-L. Guan, P.-F. Wu, C.-M. Wang, H. Cao, L. Li, X.-J. Guo, F. Wang, N. Xie, F.-C. Jiang, and J.-G. Chen J. Med. Chem. 55 2012 3588 3592
9. P. Szymanski, A. Karpiński, and E. Mikiciuk-Olasik Eur. J. Med. Chem. 46 2011 3250 3257
10. W. Luo, Y.-P. Li, Y. He, S.-L. Huang, D. Li, L.-Q. Gu, and Z.-S. Huang Eur. J. Med. Chem. 46 2011 2609 2616
11. W. Luo, Y.-P. Li, Y. He, S.-L. Huang, J.-H. Tan, T.-M. Ou, D. Li, L.-Q. Gu, and Z.-S. Huang Bioorg. Med. Chem. 19 2011 763 770
12. S. Rizzo, A. Bisi, M. Bartolini, F. Mancini, F. Belluti, S. Gobbi, V. Andrisano, and A. Rampa Eur. J. Med. Chem. 46 2011 4336 4343
13. A. Wiȩckowska, M. Bajda, N. Guzior, and B. Malawska Eur. J. Med. Chem. 45 2010 5602 5611
14. N.D. Chaurasiya, S. Ganesan, N.P.D. Nanayakkara, L.R.S. Dias, L.A. Walker, and B.L. Tekwani Bioorg. Med. Chem. Lett. 22 2012 1701 1704
15. J.W. Greenawalt, and C. Schnaitman J. Cell Biol. 46 1970 173 179
16. J. Saura, J.M. Luque, A.M. Cesura, M.D. Prada, V. Chan-Palay, G. Huber, J. Löffler, and J.G. Richards Neuroscience 62 1994 15 30
17. A.S. Kalgutkar, D.K. Dalvie, N. Castagnoli, and T.J. Taylor Chem. Res. Toxicol. 14 2001 1139 1162
18. O. Bar-Am, T. Amit, O. Weinreb, M.B.H. Youdim, and S. Mandel J. Alzheimer's Dis. 21 2010 361 371
19. A. Samadi, C. de los Ríos, I. Bolea, M. Chioua, I. Iriepa, I. Moraleda, M. Bartolini, V. Andrisano, E. Gálvez, C. Valderas, M. Unzeta, and J. Marco-Contelles Eur. J. Med. Chem. 52 2012 251 262
20. F. Mao, L. Huang, Z. Luo, A. Liu, C. Lu, Z. Xie, and X. Li Bioorg. Med. Chem. 20 2012 5884 5892
21. L. Huang, J. Liu, W. Shan, B. Liu, A. Shi, and X. Li Chirality 22 2010 206 211
22. S. Darvesh, C. MacKnight, and K. Rockwood Int. Psychogeriatr. 13 2001 461 464
23. N.H. Greig, T. Utsuki, D.K. Ingram, Y. Wang, G. Pepeu, C. Scali, Q.-S. Yu, J. Mamczarz, H.W. Holloway, T. Giordano, D. Chen, K. Furukawa, K. Sambamurti, A. Brossi, and D.K. Lahiri Proc. Natl. Acad. Sci. U.S.A. 102 2005 17213 17218
24. F. Marcelo, F.V.M. Silva, M. Goulart, J. Justino, P. Sinaÿ, Y. Blériot, and A.P. Rauter Bioorg. Med. Chem. 17 2009 5106 5116
25. R.M. Lane, S.G. Potkin, and A. Enz Int. J. Neuropsychopharmacol. 9 2006 101 124
26. I. Bolea, J. Juárez-Jiménez, C. de los Ríos, M. Chioua, R. Pouplana, F.J. Luque, M. Unzeta, J. Marco-Contelles, and A. Samadi J. Med. Chem. 54 2011 8251 8270
27. F. Chimenti, R. Fioravanti, A. Bolasco, P. Chimenti, D. Secci, F. Rossi, M. Yáñez, F. Orallo, F. Ortuso, and S. Alcaro J. Med. Chem. 52 2009 2818 2824
28. T. Izumi, N. Iwamoto, Y. Kitaichi, A. Kato, T. Inoue, and T. Koyama Eur. J. Pharmacol. 565 2007 105 112
29. J. Tang, J. Li, L. Zhang, S. Ma, D. Shi, Q. Zhang, L. Yang, X. Wang, X. Liu, and C. Liu J. Heterocycl. Chem. 49 2012 533 542
30. G.L. Ellman, K.D. Courtney, V. Andres Jr., and R.M. Featherstone Biochem. Pharmacol. 7 1961 88 95
31. L. Huang, Z. Luo, F. He, J. Lu, and X. Li Bioorg. Med. Chem. 18 2010 4475 4484
32. L. Huang, A. Shi, F. He, and X. Li Bioorg. Med. Chem. 18 2010 1244 1251
33. N. Desideri, A. Bolasco, R. Fioravanti, L. Proietti Monaco, F. Orallo, M. Yáñez, F. Ortuso, and S. Alcaro J. Med. Chem. 54 2011 2155 2164