Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B

British Journal of Pharmacology

Volumn 132, Issue 2, 2001, Pages 500-506

  Youdim, Moussa B H ^a   Gross, Aviva ^a   Finberg, John P M ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Brain; Clorgyline; Dopamine; Irreversible inhibitors; Liver; Monoamine oxidase (MAO) A and B; Parkinson's disease; Rasagiline; Selegiline (1 deprenyl); Small intestine

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; CLORGYLINE; DOPAMINE; RASAGILINE; SELEGILINE;

ARTICLE; ENANTIOMER; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME SPECIFICITY; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RACEMIC MIXTURE;

EID: 0035130289     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703826     Document Type: Article

References (37)

1. cDNA cloning of human liver monoamine oxidase A and B: Molecular basis of differences in enzymatic properties
2. Implications of combined treatment with Madopar and I-deprenyl in Parkinson's disease
3. The potentiation of anti-akinetic effect after L-dopa treatment by an inhibitor of MAO-B, deprenyl
4. Multiple forms of human brain mitochondrial monoamine oxidase
5. The turnover of the A and B-forms of monoamine oxidase in rat liver
6. Modification of blood pressure and nictitating membrane response to sympathetic amines by selective monoamine oxidase inhibitors of types A and B in the cat
7. Pharmacology and neuroprotective properties of rasagiline
8. Pharmacology of rasagiline (N-propargyl-IR-aminoindan)
9. Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor
10. Tyramine antagonistic properties of AGN 1135, an irreversible inhibitor of monoamine oxidase type B
11. Slow recovery of human brain MAO B after deprenyl (selegiline) withdrawal
12. Chronic TVP-1012 (rasagiline) dose-activity response of monoamine oxidases A and B in the brain of the common marmoset
13. Evidence for dopamine deamination by both type A and type B monoamine oxidase in rat brain in vivo and for degree of inhibition of enzyme necessary for increased function and activity of dopamine and 5-hydroxytryptamine
14. Neuroprotective effect of rasagiline, a selective monoamine oxidase B inhibitor, against head injury in the mouse
15. Selective 'suicide' acetylenic and reversible inhibitors of monoamine oxidase A and B
16. The covalently bound flavin of hepatic monoamine oxidase I. Isolation and sequence of a flavin peptide and evidence for binding to the 8 ∝-position
17. Some puzzling pharmacological effects of monoamine oxidase inhibitors
18. Deprenyl in Parkinson's Disease
19. Protein measurement with Folin phenol reagent
20. Relation between the degree of monoamine oxidase inhibition and some psychopharmacological responses to monoamine oxidase inhibitors
21. The action of acetylenic inhibitors on mitochondrial monoamine oxidase: Structure of the flavin site in the inhibited enzyme
22. Neuronal monoamine oxidase: Specific enzyme types and their rates of formation
23. The deamination of dopamine by human brain monoamine oxidase. Specificity for the two forms in seven brain regions
24. Selegiline and Parkinson's disease
25. Amphetamine and 2-phenylethylamine in post mortem Parkinson brains after 1-deprenyl administration
26. Selegiline in Parkinson's Disease: An update
27. Selective inhibition of monoamine oxidase type B by propargyl-containing drugs
28. 14C]-deprenyl
29. Cysteinyl flavin in monoamine oxidase from the central nervous system
30. Evidence that deprenyl, a type B monoamine oxidase inhibitor is an indirectly acting sympathomimetic amine
31. Effect of N-propargyl-1R-aminoindan (rasagiline) in models of motor and cognition disorders
32. Multiple forms of monoamine oxidase in intact mitochondria as characterized by selective inhibitors and thermal stability
33. (R)(+)-NPropargyl-1-aminoindan (rasagiline) and derivatives: Highly selective and potent inhibitors of monoamine oxidase B
34. The assay of monoamine oxidase activity
35. 14C-deprenyl
36. Nueroprotective properties of anti-Parkinson drug rasagiline and its optical isomer