메뉴 건너뛰기




Volumn 148, Issue 3, 2016, Pages 237-248

Emerging role of microRNAs in regulating macrophage activation and polarization in immune response and inflammation

Author keywords

immune response; inflammation; macrophage polarization; microRNAs; Toll like receptors

Indexed keywords

MICRORNA; MICRORNA 101; MICRORNA 124; MICRORNA 125; MICRORNA 146; MICRORNA 146A; MICRORNA 147; MICRORNA 155; MICRORNA 187; MICRORNA 203; MICRORNA 21; MICRORNA 223; MICRORNA 27; MICRORNA 33; MICRORNA 342 5P; MICRORNA 378 3P; MICRORNA 511 3P; MICRORNA 9; MICRORNA LET 7E; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; CYTOKINE;

EID: 84964666612     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12608     Document Type: Review
Times cited : (102)

References (94)
  • 1
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008; 8:958–69.
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 2
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S. Alternative activation of macrophages. Nat Rev Immunol 2003; 3:23–35.
    • (2003) Nat Rev Immunol , vol.3 , pp. 23-35
    • Gordon, S.1
  • 3
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: mechanism and functions
    • Gordon S, Martinez FO. Alternative activation of macrophages: mechanism and functions. Immunity 2010; 32:593–604.
    • (2010) Immunity , vol.32 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 4
    • 84879103109 scopus 로고    scopus 로고
    • Macrophage activation and polarization as an adaptive component of innate immunity
    • Locati M, Mantovani A, Sica A. Macrophage activation and polarization as an adaptive component of innate immunity. Adv Immunol 2013; 120:163–84.
    • (2013) Adv Immunol , vol.120 , pp. 163-184
    • Locati, M.1    Mantovani, A.2    Sica, A.3
  • 6
  • 7
    • 77956976681 scopus 로고    scopus 로고
    • Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
    • Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol 2010; 11:889–96.
    • (2010) Nat Immunol , vol.11 , pp. 889-896
    • Biswas, S.K.1    Mantovani, A.2
  • 9
    • 80355131976 scopus 로고    scopus 로고
    • Protective and pathogenic functions of macrophage subsets
    • Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol 2011; 11:723–37.
    • (2011) Nat Rev Immunol , vol.11 , pp. 723-737
    • Murray, P.J.1    Wynn, T.A.2
  • 10
    • 84876800337 scopus 로고    scopus 로고
    • Macrophage biology in development, homeostasis and disease
    • Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature 2013; 496:445–55.
    • (2013) Nature , vol.496 , pp. 445-455
    • Wynn, T.A.1    Chawla, A.2    Pollard, J.W.3
  • 11
    • 84952925002 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase acts in a feedback loop with NF-κB pathway to regulate macrophage polarization in alcoholic liver disease
    • Wu XQ, Yang Y, Li WX, Cheng YH, Li XF, Huang C et al. Telomerase reverse transcriptase acts in a feedback loop with NF-κB pathway to regulate macrophage polarization in alcoholic liver disease. Sci Rep 2016; 6:18685.
    • (2016) Sci Rep , vol.6 , pp. 18685
    • Wu, X.Q.1    Yang, Y.2    Li, W.X.3    Cheng, Y.H.4    Li, X.F.5    Huang, C.6
  • 12
    • 84888406185 scopus 로고    scopus 로고
    • Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways
    • Zhou D, Huang C, Lin Z, Zhan S, Kong L, Fang C et al. Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways. Cell Signal 2014; 26:192–7.
    • (2014) Cell Signal , vol.26 , pp. 192-197
    • Zhou, D.1    Huang, C.2    Lin, Z.3    Zhan, S.4    Kong, L.5    Fang, C.6
  • 13
    • 84951908279 scopus 로고    scopus 로고
    • Macrophage development and polarization in chronic inflammation
    • Motwani MP, Gilroy DW. Macrophage development and polarization in chronic inflammation. Semin Immunol 2015; 27:257–66.
    • (2015) Semin Immunol , vol.27 , pp. 257-266
    • Motwani, M.P.1    Gilroy, D.W.2
  • 14
    • 84919457872 scopus 로고    scopus 로고
    • Molecular mechanisms that influence the macrophage M1–M2 polarization balance
    • Wang N, Liang H, Zen K. Molecular mechanisms that influence the macrophage M1–M2 polarization balance. Front Immunol 2014; 5:614.
    • (2014) Front Immunol , vol.5 , pp. 614
    • Wang, N.1    Liang, H.2    Zen, K.3
  • 15
  • 16
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: in vivo veritas
    • Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. J Clin Invest 2012; 122:787–95.
    • (2012) J Clin Invest , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 17
    • 84951310499 scopus 로고    scopus 로고
    • Functions of miR-146a and miR-222 in tumor-associated macrophages in breast cancer
    • Li Y, Zhao L, Shi B, Ma S, Xu Z, Ge Y et al. Functions of miR-146a and miR-222 in tumor-associated macrophages in breast cancer. Sci Rep 2015; 5:18648.
    • (2015) Sci Rep , vol.5 , pp. 18648
    • Li, Y.1    Zhao, L.2    Shi, B.3    Ma, S.4    Xu, Z.5    Ge, Y.6
  • 18
    • 84971646937 scopus 로고    scopus 로고
    • A double feedback loop mediated by microRNA-23a/27a/24-2 regulates M1 versus M2 macrophage polarization and thus regulates cancer progression
    • Ma S, Liu M, Xu Z, Li Y, Guo H, Ge Y et al. A double feedback loop mediated by microRNA-23a/27a/24-2 regulates M1 versus M2 macrophage polarization and thus regulates cancer progression. Oncotarget 2015; 7:13502–19.
    • (2015) Oncotarget , vol.7 , pp. 13502-13519
    • Ma, S.1    Liu, M.2    Xu, Z.3    Li, Y.4    Guo, H.5    Ge, Y.6
  • 19
    • 84952882141 scopus 로고    scopus 로고
    • MicroRNA Cargo of extracellular vesicles from alcohol-exposed monocytes signals naive monocytes to differentiate into M2 macrophages
    • Saha B, Momen-Heravi F, Kodys K, Szabo G. MicroRNA Cargo of extracellular vesicles from alcohol-exposed monocytes signals naive monocytes to differentiate into M2 macrophages. J Biol Chem 2016; 291:149–59.
    • (2016) J Biol Chem , vol.291 , pp. 149-159
    • Saha, B.1    Momen-Heravi, F.2    Kodys, K.3    Szabo, G.4
  • 20
    • 84944326823 scopus 로고    scopus 로고
    • MicroRNA-16 modulates macrophage polarization leading to improved insulin sensitivity in myoblasts
    • Talari M, Kapadia B, Kain V, Seshadri S, Prajapati B, Rajput P et al. MicroRNA-16 modulates macrophage polarization leading to improved insulin sensitivity in myoblasts. Biochimie 2015; 119:16–26.
    • (2015) Biochimie , vol.119 , pp. 16-26
    • Talari, M.1    Kapadia, B.2    Kain, V.3    Seshadri, S.4    Prajapati, B.5    Rajput, P.6
  • 21
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136:215–33.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 23
    • 84875255948 scopus 로고    scopus 로고
    • Expression profiles of miRNAs in polarized macrophages
    • Zhang Y, Zhang M, Zhong M, Suo Q, Lv K. Expression profiles of miRNAs in polarized macrophages. Int J Mol Med 2013; 31:797–802.
    • (2013) Int J Mol Med , vol.31 , pp. 797-802
    • Zhang, Y.1    Zhang, M.2    Zhong, M.3    Suo, Q.4    Lv, K.5
  • 24
    • 84862697885 scopus 로고    scopus 로고
    • Identifying functional microRNAs in macrophages with polarized phenotypes
    • Graff JW, Dickson AM, Clay G, McCaffrey AP, Wilson ME. Identifying functional microRNAs in macrophages with polarized phenotypes. J Biol Chem 2012; 287:21816–25.
    • (2012) J Biol Chem , vol.287 , pp. 21816-21825
    • Graff, J.W.1    Dickson, A.M.2    Clay, G.3    McCaffrey, A.P.4    Wilson, M.E.5
  • 27
    • 38049030287 scopus 로고    scopus 로고
    • Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-α stimulation and their possible roles in regulating the response to endotoxin shock
    • Tili E, Michaille JJ, Cimino A, Costinean S, Dumitru CD, Adair B et al. Modulation of miR-155 and miR-125b levels following lipopolysaccharide/TNF-α stimulation and their possible roles in regulating the response to endotoxin shock. J Immunol 2007; 179:5082–9.
    • (2007) J Immunol , vol.179 , pp. 5082-5089
    • Tili, E.1    Michaille, J.J.2    Cimino, A.3    Costinean, S.4    Dumitru, C.D.5    Adair, B.6
  • 28
    • 84880227738 scopus 로고    scopus 로고
    • Akt1-mediated regulation of macrophage polarization in a murine model of Staphylococcus aureus pulmonary infection
    • Xu F, Kang Y, Zhang H, Piao Z, Yin H, Diao R et al. Akt1-mediated regulation of macrophage polarization in a murine model of Staphylococcus aureus pulmonary infection. J Infect Dis 2013; 208:528–38.
    • (2013) J Infect Dis , vol.208 , pp. 528-538
    • Xu, F.1    Kang, Y.2    Zhang, H.3    Piao, Z.4    Yin, H.5    Diao, R.6
  • 32
    • 70350759666 scopus 로고    scopus 로고
    • MicroRNA-155 regulates inflammatory cytokine production in tumor-associated macrophages via targeting C/EBPbeta
    • He M, Xu Z, Ding T, Kuang DM, Zheng L. MicroRNA-155 regulates inflammatory cytokine production in tumor-associated macrophages via targeting C/EBPbeta. Cell Mol Immunol 2009; 6:343–52.
    • (2009) Cell Mol Immunol , vol.6 , pp. 343-352
    • He, M.1    Xu, Z.2    Ding, T.3    Kuang, D.M.4    Zheng, L.5
  • 35
    • 78751483763 scopus 로고    scopus 로고
    • The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor α1 (IL13Rα1)
    • Martinez-Nunez RT, Louafi F, Sanchez-Elsner T. The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor α1 (IL13Rα1). J Biol Chem 2011; 286:1786–94.
    • (2011) J Biol Chem , vol.286 , pp. 1786-1794
    • Martinez-Nunez, R.T.1    Louafi, F.2    Sanchez-Elsner, T.3
  • 36
    • 77951294330 scopus 로고    scopus 로고
    • Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation
    • Tang B, Xiao B, Liu Z, Li N, Zhu ED, Li BS et al. Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation. FEBS Lett 2010; 584:1481–6.
    • (2010) FEBS Lett , vol.584 , pp. 1481-1486
    • Tang, B.1    Xiao, B.2    Liu, Z.3    Li, N.4    Zhu, E.D.5    Li, B.S.6
  • 37
    • 3943054838 scopus 로고    scopus 로고
    • De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
    • Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S et al. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling. Nature 2004; 430:694–9.
    • (2004) Nature , vol.430 , pp. 694-699
    • Wertz, I.E.1    O'Rourke, K.M.2    Zhou, H.3    Eby, M.4    Aravind, L.5    Seshagiri, S.6
  • 38
    • 84890283575 scopus 로고    scopus 로고
    • miR-125a-5p regulates differential activation of macrophages and inflammation
    • Banerjee S, Cui H, Xie N, Tan Z, Yang S, Icyuz M et al. miR-125a-5p regulates differential activation of macrophages and inflammation. J Biol Chem 2013; 288:35428–36.
    • (2013) J Biol Chem , vol.288 , pp. 35428-35436
    • Banerjee, S.1    Cui, H.2    Xie, N.3    Tan, Z.4    Yang, S.5    Icyuz, M.6
  • 39
    • 77954498935 scopus 로고    scopus 로고
    • Estradiol suppresses NF-κB activation through coordinated regulation of let-7a and miR-125b in primary human macrophages
    • Murphy AJ, Guyre PM, Pioli PA. Estradiol suppresses NF-κB activation through coordinated regulation of let-7a and miR-125b in primary human macrophages. J Immunol 2010; 184:5029–37.
    • (2010) J Immunol , vol.184 , pp. 5029-5037
    • Murphy, A.J.1    Guyre, P.M.2    Pioli, P.A.3
  • 40
    • 84863492212 scopus 로고    scopus 로고
    • miRNA-125b regulates TNF-α production in CD14 +  neonatal monocytes via post-transcriptional regulation
    • Huang HC, Yu HR, Huang LT, Chen RF, Lin IC, Ou CY et al. miRNA-125b regulates TNF-α production in CD14 +  neonatal monocytes via post-transcriptional regulation. J Leukoc Biol 2012; 92:171–82.
    • (2012) J Leukoc Biol , vol.92 , pp. 171-182
    • Huang, H.C.1    Yu, H.R.2    Huang, L.T.3    Chen, R.F.4    Lin, I.C.5    Ou, C.Y.6
  • 41
    • 80054810826 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b
    • Rajaram MV, Ni B, Morris JD, Brooks MN, Carlson TK, Bakthavachalu B et al. Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b. Proc Natl Acad Sci U S A 2011; 108:17408–13.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 17408-17413
    • Rajaram, M.V.1    Ni, B.2    Morris, J.D.3    Brooks, M.N.4    Carlson, T.K.5    Bakthavachalu, B.6
  • 43
    • 84861206450 scopus 로고    scopus 로고
    • MicroRNAs miR-125a and miR-125b constitutively activate the NF-κB pathway by targeting the tumor necrosis factor α-induced protein 3 (TNFAIP3, A20)
    • Kim SW, Ramasamy K, Bouamar H, Lin AP, Jiang D, Aguiar RC. MicroRNAs miR-125a and miR-125b constitutively activate the NF-κB pathway by targeting the tumor necrosis factor α-induced protein 3 (TNFAIP3, A20). Proc Natl Acad Sci U S A 2012; 109:7865–70.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 7865-7870
    • Kim, S.W.1    Ramasamy, K.2    Bouamar, H.3    Lin, A.P.4    Jiang, D.5    Aguiar, R.C.6
  • 44
    • 33747608638 scopus 로고    scopus 로고
    • NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    • Taganov KD, Boldin MP, Chang KJ, Baltimore D. NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A 2006; 103:12481–6.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12481-12486
    • Taganov, K.D.1    Boldin, M.P.2    Chang, K.J.3    Baltimore, D.4
  • 45
    • 68149165370 scopus 로고    scopus 로고
    • MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2
    • Hou J, Wang P, Lin L, Liu X, Ma F, An H et al. MicroRNA-146a feedback inhibits RIG-I-dependent Type I IFN production in macrophages by targeting TRAF6, IRAK1, and IRAK2. J Immunol 2009; 183:2150–8.
    • (2009) J Immunol , vol.183 , pp. 2150-2158
    • Hou, J.1    Wang, P.2    Lin, L.3    Liu, X.4    Ma, F.5    An, H.6
  • 46
    • 84891079308 scopus 로고    scopus 로고
    • Akt2 deficiency protects from acute lung injury via alternative macrophage activation and miR-146a induction in mice
    • Vergadi E, Vaporidi K, Theodorakis EE, Doxaki C, Lagoudaki E, Ieronymaki E et al. Akt2 deficiency protects from acute lung injury via alternative macrophage activation and miR-146a induction in mice. J Immunol 2014; 192:394–406.
    • (2014) J Immunol , vol.192 , pp. 394-406
    • Vergadi, E.1    Vaporidi, K.2    Theodorakis, E.E.3    Doxaki, C.4    Lagoudaki, E.5    Ieronymaki, E.6
  • 48
    • 35148835215 scopus 로고    scopus 로고
    • CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells
    • Ponomarev ED, Maresz K, Tan Y, Dittel BN. CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells. J Neurosci 2007; 27:10714–21.
    • (2007) J Neurosci , vol.27 , pp. 10714-10721
    • Ponomarev, E.D.1    Maresz, K.2    Tan, Y.3    Dittel, B.N.4
  • 49
    • 78651247933 scopus 로고    scopus 로고
    • MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway
    • Ponomarev ED, Veremeyko T, Barteneva N, Krichevsky AM, Weiner HL. MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-α-PU.1 pathway. Nat Med 2011; 17:64–70.
    • (2011) Nat Med , vol.17 , pp. 64-70
    • Ponomarev, E.D.1    Veremeyko, T.2    Barteneva, N.3    Krichevsky, A.M.4    Weiner, H.L.5
  • 50
    • 84869171691 scopus 로고    scopus 로고
    • MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS
    • Ponomarev ED, Veremeyko T, Weiner HL. MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS. Glia 2013; 61:91–103.
    • (2013) Glia , vol.61 , pp. 91-103
    • Ponomarev, E.D.1    Veremeyko, T.2    Weiner, H.L.3
  • 51
    • 84892959681 scopus 로고    scopus 로고
    • IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation
    • Veremeyko T, Siddiqui S, Sotnikov I, Yung A, Ponomarev ED. IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation. PLoS ONE 2013; 8:e81774.
    • (2013) PLoS ONE , vol.8
    • Veremeyko, T.1    Siddiqui, S.2    Sotnikov, I.3    Yung, A.4    Ponomarev, E.D.5
  • 52
    • 17844364875 scopus 로고    scopus 로고
    • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    • Grishok A, Pasquinelli AE, Conte D, Li N, Parrish S, Ha I et al. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 2001; 106:23–34.
    • (2001) Cell , vol.106 , pp. 23-34
    • Grishok, A.1    Pasquinelli, A.E.2    Conte, D.3    Li, N.4    Parrish, S.5    Ha, I.6
  • 54
    • 34547800649 scopus 로고    scopus 로고
    • Enjoy the Silence: The Story of let-7 MicroRNA and Cancer
    • Jerome T, Laurie P, Louis B, Pierre C. Enjoy the Silence: The Story of let-7 MicroRNA and Cancer. Curr Genomics 2007; 8:229–33.
    • (2007) Curr Genomics , vol.8 , pp. 229-233
    • Jerome, T.1    Laurie, P.2    Louis, B.3    Pierre, C.4
  • 55
    • 84879118942 scopus 로고    scopus 로고
    • MicroRNA let-7c regulates macrophage polarization
    • Banerjee S, Xie N, Cui H, Tan Z, Yang S, Icyuz M et al. MicroRNA let-7c regulates macrophage polarization. J Immunol 2013; 190:6542–9.
    • (2013) J Immunol , vol.190 , pp. 6542-6549
    • Banerjee, S.1    Xie, N.2    Cui, H.3    Tan, Z.4    Yang, S.5    Icyuz, M.6
  • 56
    • 84939988436 scopus 로고    scopus 로고
    • Polycomb-mediated loss of microRNA let-7c determines inflammatory macrophage polarization via PAK1-dependent NF-κB pathway
    • Zhang W, Liu H, Liu W, Liu Y, Xu J. Polycomb-mediated loss of microRNA let-7c determines inflammatory macrophage polarization via PAK1-dependent NF-κB pathway. Cell Death Differ 2015; 22:287–97.
    • (2015) Cell Death Differ , vol.22 , pp. 287-297
    • Zhang, W.1    Liu, H.2    Liu, W.3    Liu, Y.4    Xu, J.5
  • 57
    • 84926248014 scopus 로고    scopus 로고
    • MicroRNA let-7 modulates the immune response to Mycobacterium tuberculosis infection via control of A20, an inhibitor of the NF-κB pathway
    • Kumar M, Sahu SK, Kumar R, Subuddhi A, Maji RK, Jana K et al. MicroRNA let-7 modulates the immune response to Mycobacterium tuberculosis infection via control of A20, an inhibitor of the NF-κB pathway. Cell Host Microbe 2015; 17:345–56.
    • (2015) Cell Host Microbe , vol.17 , pp. 345-356
    • Kumar, M.1    Sahu, S.K.2    Kumar, R.3    Subuddhi, A.4    Maji, R.K.5    Jana, K.6
  • 58
    • 79958099199 scopus 로고    scopus 로고
    • MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation
    • Liu Y, Chen Q, Song Y, Lai L, Wang J, Yu H et al. MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation. FEBS Lett 2011; 585:1963–8.
    • (2011) FEBS Lett , vol.585 , pp. 1963-1968
    • Liu, Y.1    Chen, Q.2    Song, Y.3    Lai, L.4    Wang, J.5    Yu, H.6
  • 59
    • 41749113108 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    • Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008; 27:2128–36.
    • (2008) Oncogene , vol.27 , pp. 2128-2136
    • Asangani, I.A.1    Rasheed, S.A.2    Nikolova, D.A.3    Leupold, J.H.4    Colburn, N.H.5    Post, S.6
  • 60
    • 33751580087 scopus 로고    scopus 로고
    • Translational regulation of autoimmune inflammation and lymphoma genesis by programmed cell death 4
    • Hilliard A, Hilliard B, Zheng SJ, Sun H, Miwa T, Song W et al. Translational regulation of autoimmune inflammation and lymphoma genesis by programmed cell death 4. J Immunol 2006; 177:8095–102.
    • (2006) J Immunol , vol.177 , pp. 8095-8102
    • Hilliard, A.1    Hilliard, B.2    Zheng, S.J.3    Sun, H.4    Miwa, T.5    Song, W.6
  • 61
    • 75649113377 scopus 로고    scopus 로고
    • Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21
    • Sheedy FJ, Palsson-McDermott E, Hennessy EJ, Martin C, O'Leary JJ, Ruan Q et al. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21. Nat Immunol 2010; 11:141–7.
    • (2010) Nat Immunol , vol.11 , pp. 141-147
    • Sheedy, F.J.1    Palsson-McDermott, E.2    Hennessy, E.J.3    Martin, C.4    O'Leary, J.J.5    Ruan, Q.6
  • 62
    • 65249106172 scopus 로고    scopus 로고
    • MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression
    • Lu TX, Munitz A, Rothenberg ME. MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol 2009; 182:4994–5002.
    • (2009) J Immunol , vol.182 , pp. 4994-5002
    • Lu, T.X.1    Munitz, A.2    Rothenberg, M.E.3
  • 63
    • 84923345538 scopus 로고    scopus 로고
    • Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21
    • Caescu CI, Guo X, Tesfa L, Bhagat TD, Verma A, Zheng D et al. Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21. Blood 2015; 125:e1–13.
    • (2015) Blood , vol.125 , pp. 13
    • Caescu, C.I.1    Guo, X.2    Tesfa, L.3    Bhagat, T.D.4    Verma, A.5    Zheng, D.6
  • 64
    • 84923622141 scopus 로고    scopus 로고
    • MicroRNA 21 is a homeostatic regulator of macrophage polarization and prevents prostaglandin E2-mediated M2 generation
    • Wang Z, Brandt S, Medeiros A, Wang S, Wu H, Dent A et al. MicroRNA 21 is a homeostatic regulator of macrophage polarization and prevents prostaglandin E2-mediated M2 generation. PLoS ONE 2015; 10:e0115855.
    • (2015) PLoS ONE , vol.10
    • Wang, Z.1    Brandt, S.2    Medeiros, A.3    Wang, S.4    Wu, H.5    Dent, A.6
  • 65
    • 84878062642 scopus 로고    scopus 로고
    • Prostaglandin E2-induced changes in alveolar macrophage scavenger receptor profiles differentially alter phagocytosis of Pseudomonas aeruginosa and Staphylococcus aureus post-bone marrow transplant
    • Domingo-Gonzalez R, Katz S, Serezani CH, Moore TA, Levine AM, Moore BB. Prostaglandin E2-induced changes in alveolar macrophage scavenger receptor profiles differentially alter phagocytosis of Pseudomonas aeruginosa and Staphylococcus aureus post-bone marrow transplant. J Immunol 2013; 190:5809–17.
    • (2013) J Immunol , vol.190 , pp. 5809-5817
    • Domingo-Gonzalez, R.1    Katz, S.2    Serezani, C.H.3    Moore, T.A.4    Levine, A.M.5    Moore, B.B.6
  • 67
    • 84916241169 scopus 로고    scopus 로고
    • The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis
    • Knipe RS, Tager AM, Liao JK. The Rho kinases: critical mediators of multiple profibrotic processes and rational targets for new therapies for pulmonary fibrosis. Pharmacol Rev 2015; 67:103–17.
    • (2015) Pharmacol Rev , vol.67 , pp. 103-117
    • Knipe, R.S.1    Tager, A.M.2    Liao, J.K.3
  • 68
    • 77956361520 scopus 로고    scopus 로고
    • Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice
    • Biswas PS, Gupta S, Chang E, Song L, Stirzaker RA, Liao JK et al. Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. J Clin Invest 2010; 120:3280–95.
    • (2010) J Clin Invest , vol.120 , pp. 3280-3295
    • Biswas, P.S.1    Gupta, S.2    Chang, E.3    Song, L.4    Stirzaker, R.A.5    Liao, J.K.6
  • 69
    • 84926523845 scopus 로고    scopus 로고
    • Macrophages and cancer: from mechanisms to therapeutic implications
    • Ostuni R, Kratochvill F, Murray PJ, Natoli G. Macrophages and cancer: from mechanisms to therapeutic implications. Trends Immunol 2015; 36:229–39.
    • (2015) Trends Immunol , vol.36 , pp. 229-239
    • Ostuni, R.1    Kratochvill, F.2    Murray, P.J.3    Natoli, G.4
  • 70
    • 84958057302 scopus 로고    scopus 로고
    • Cancer stem cells and tumor-associated macrophages: a roadmap for multitargeting strategies
    • Raggi C, Mousa HS, Correnti M, Sica A, Invernizzi P. Cancer stem cells and tumor-associated macrophages: a roadmap for multitargeting strategies. Oncogene 2016; 35:671–82.
    • (2016) Oncogene , vol.35 , pp. 671-682
    • Raggi, C.1    Mousa, H.S.2    Correnti, M.3    Sica, A.4    Invernizzi, P.5
  • 71
    • 84940046539 scopus 로고    scopus 로고
    • MicroRNA profiling reveals opposing expression patterns for miR-511 in alternatively and classically activated macrophages
    • Karo-Atar D, Itan M, Pasmanik-Chor M, Munitz A. MicroRNA profiling reveals opposing expression patterns for miR-511 in alternatively and classically activated macrophages. J Asthma 2015; 52:545–53.
    • (2015) J Asthma , vol.52 , pp. 545-553
    • Karo-Atar, D.1    Itan, M.2    Pasmanik-Chor, M.3    Munitz, A.4
  • 72
    • 77957656146 scopus 로고    scopus 로고
    • miR-378(*) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathway
    • Eichner LJ, Perry MC, Dufour CR, Bertos N, Park M, St-Pierre J et al. miR-378(*) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathway. Cell Metab 2010; 12:352–61.
    • (2010) Cell Metab , vol.12 , pp. 352-361
    • Eichner, L.J.1    Perry, M.C.2    Dufour, C.R.3    Bertos, N.4    Park, M.5    St-Pierre, J.6
  • 73
  • 74
    • 84866392767 scopus 로고    scopus 로고
    • Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo
    • Ruckerl D, Jenkins SJ, Laqtom NN, Gallagher IJ, Sutherland TE, Duncan S et al. Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo. Blood 2012; 120:2307–16.
    • (2012) Blood , vol.120 , pp. 2307-2316
    • Ruckerl, D.1    Jenkins, S.J.2    Laqtom, N.N.3    Gallagher, I.J.4    Sutherland, T.E.5    Duncan, S.6
  • 75
    • 84862150859 scopus 로고    scopus 로고
    • A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation
    • Zhuang G, Meng C, Guo X, Cheruku PS, Shi L, Xu H et al. A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation. Circulation 2012; 125:2892–903.
    • (2012) Circulation , vol.125 , pp. 2892-2903
    • Zhuang, G.1    Meng, C.2    Guo, X.3    Cheruku, P.S.4    Shi, L.5    Xu, H.6
  • 76
    • 84868568561 scopus 로고    scopus 로고
    • IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes
    • Rossato M, Curtale G, Tamassia N, Castellucci M, Mori L, Gasperini S et al. IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes. Proc Natl Acad Sci U S A 2012; 109:E3101–10.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 10
    • Rossato, M.1    Curtale, G.2    Tamassia, N.3    Castellucci, M.4    Mori, L.5    Gasperini, S.6
  • 77
    • 84876222881 scopus 로고    scopus 로고
    • The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis
    • Wei Y, Nazari-Jahantigh M, Chan L, Zhu M, Heyll K, Corbalan-Campos J et al. The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis. Circulation 2013; 127:1609–19.
    • (2013) Circulation , vol.127 , pp. 1609-1619
    • Wei, Y.1    Nazari-Jahantigh, M.2    Chan, L.3    Zhu, M.4    Heyll, K.5    Corbalan-Campos, J.6
  • 78
    • 84875884191 scopus 로고    scopus 로고
    • Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration
    • Sene A, Khan AA, Cox D, Nakamura RE, Santeford A, Kim BM et al. Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration. Cell Metab 2013; 17:549–61.
    • (2013) Cell Metab , vol.17 , pp. 549-561
    • Sene, A.1    Khan, A.A.2    Cox, D.3    Nakamura, R.E.4    Santeford, A.5    Kim, B.M.6
  • 79
    • 84948799436 scopus 로고    scopus 로고
    • MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis
    • Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB et al. MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis. J Clin Invest 2015; 125:4334–48.
    • (2015) J Clin Invest , vol.125 , pp. 4334-4348
    • Ouimet, M.1    Ediriweera, H.N.2    Gundra, U.M.3    Sheedy, F.J.4    Ramkhelawon, B.5    Hutchison, S.B.6
  • 80
    • 84943391651 scopus 로고    scopus 로고
    • MicroRNA-101 overexpression by IL-6 and TNF-α inhibits cholesterol efflux by suppressing ATP-binding cassette transporter A1 expression
    • Zhang N, Lei J, Lei H, Ruan X, Liu Q, Chen Y et al. MicroRNA-101 overexpression by IL-6 and TNF-α inhibits cholesterol efflux by suppressing ATP-binding cassette transporter A1 expression. Exp Cell Res 2015; 336:33–42.
    • (2015) Exp Cell Res , vol.336 , pp. 33-42
    • Zhang, N.1    Lei, J.2    Lei, H.3    Ruan, X.4    Liu, Q.5    Chen, Y.6
  • 81
    • 78650643190 scopus 로고    scopus 로고
    • MicroRNA-101 targets MAPK phosphatase-1 to regulate the activation of MAPKs in macrophages
    • Zhu QY, Liu Q, Chen JX, Lan K, Ge BX. MicroRNA-101 targets MAPK phosphatase-1 to regulate the activation of MAPKs in macrophages. J Immunol 2010; 185:7435–42.
    • (2010) J Immunol , vol.185 , pp. 7435-7442
    • Zhu, Q.Y.1    Liu, Q.2    Chen, J.X.3    Lan, K.4    Ge, B.X.5
  • 82
    • 84900425378 scopus 로고    scopus 로고
    • Genkwanin inhibits proinflammatory mediators mainly through the regulation of miR-101/MKP-1/MAPK pathway in LPS-activated macrophages
    • Gao Y, Liu F, Fang L, Cai R, Zong C, Qi Y. Genkwanin inhibits proinflammatory mediators mainly through the regulation of miR-101/MKP-1/MAPK pathway in LPS-activated macrophages. PLoS ONE 2014; 9:e96741.
    • (2014) PLoS ONE , vol.9
    • Gao, Y.1    Liu, F.2    Fang, L.3    Cai, R.4    Zong, C.5    Qi, Y.6
  • 83
    • 0038242875 scopus 로고    scopus 로고
    • Toll-like receptor signaling pathways
    • Barton GM, Medzhitov R. Toll-like receptor signaling pathways. Science 2003; 300:1524–5.
    • (2003) Science , vol.300 , pp. 1524-1525
    • Barton, G.M.1    Medzhitov, R.2
  • 84
    • 84905050462 scopus 로고    scopus 로고
    • Assembly and localization of Toll-like receptor signalling complexes
    • Gay NJ, Symmons MF, Gangloff M, Bryant CE. Assembly and localization of Toll-like receptor signalling complexes. Nat Rev Immunol 2014; 14:546–58.
    • (2014) Nat Rev Immunol , vol.14 , pp. 546-558
    • Gay, N.J.1    Symmons, M.F.2    Gangloff, M.3    Bryant, C.E.4
  • 85
    • 65249131826 scopus 로고    scopus 로고
    • Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals
    • Bazzoni F, Rossato M, Fabbri M, Gaudiosi D, Mirolo M, Mori L et al. Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals. Proc Natl Acad Sci U S A 2009; 106:5282–7.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 5282-5287
    • Bazzoni, F.1    Rossato, M.2    Fabbri, M.3    Gaudiosi, D.4    Mirolo, M.5    Mori, L.6
  • 86
    • 70349439320 scopus 로고    scopus 로고
    • miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses
    • Liu G, Friggeri A, Yang Y, Park YJ, Tsuruta Y, Abraham E. miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses. Proc Natl Acad Sci U S A 2009; 106:15819–24.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 15819-15824
    • Liu, G.1    Friggeri, A.2    Yang, Y.3    Park, Y.J.4    Tsuruta, Y.5    Abraham, E.6
  • 87
    • 84877635115 scopus 로고    scopus 로고
    • MyD88 as a target of microRNA-203 in regulation of lipopolysaccharide or Bacille Calmette–Guérin induced inflammatory response of macrophage RAW264.7 cells
    • Wei J, Huang X, Zhang Z, Jia W, Zhao Z, Zhang Y et al. MyD88 as a target of microRNA-203 in regulation of lipopolysaccharide or Bacille Calmette–Guérin induced inflammatory response of macrophage RAW264.7 cells. Mol Immunol 2013; 55:303–9.
    • (2013) Mol Immunol , vol.55 , pp. 303-309
    • Wei, J.1    Huang, X.2    Zhang, Z.3    Jia, W.4    Zhao, Z.5    Zhang, Y.6
  • 88
    • 84925858227 scopus 로고    scopus 로고
    • Alcohol-induced miR-27a regulates differentiation and M2 macrophage polarization of normal human monocytes
    • Saha B, Bruneau JC, Kodys K, Szabo G. Alcohol-induced miR-27a regulates differentiation and M2 macrophage polarization of normal human monocytes. J Immunol 2015; 194:3079–87.
    • (2015) J Immunol , vol.194 , pp. 3079-3087
    • Saha, B.1    Bruneau, J.C.2    Kodys, K.3    Szabo, G.4
  • 89
    • 80052158908 scopus 로고    scopus 로고
    • MicroRNAs and the resolution phase of inflammation in macrophages
    • Alam MM, O'Neill LA. MicroRNAs and the resolution phase of inflammation in macrophages. Eur J Immunol 2011; 41:2482–5.
    • (2011) Eur J Immunol , vol.41 , pp. 2482-2485
    • Alam, M.M.1    O'Neill, L.A.2
  • 90
    • 84872975552 scopus 로고    scopus 로고
    • MicroRNAs in immune response and macrophage polarization
    • Liu G, Abraham E. MicroRNAs in immune response and macrophage polarization. Arterioscler Thromb Vasc Biol 2013; 33:170–7.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 170-177
    • Liu, G.1    Abraham, E.2
  • 91
    • 58149386890 scopus 로고    scopus 로고
    • MicroRNAs: novel regulators during the immune response
    • Bi Y, Liu G, Yang R. MicroRNAs: novel regulators during the immune response. J Cell Physiol 2009; 218:467–72.
    • (2009) J Cell Physiol , vol.218 , pp. 467-472
    • Bi, Y.1    Liu, G.2    Yang, R.3
  • 92
    • 84896786148 scopus 로고    scopus 로고
    • MicroRNA let-7a: a novel therapeutic candidate in prostate cancer
    • Wu XQ, Huang C, Liu XH, Li J. MicroRNA let-7a: a novel therapeutic candidate in prostate cancer. Asian J Androl 2014; 16:327–8.
    • (2014) Asian J Androl , vol.16 , pp. 327-328
    • Wu, X.Q.1    Huang, C.2    Liu, X.H.3    Li, J.4
  • 94
    • 84893427735 scopus 로고    scopus 로고
    • In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features
    • Ding Y, Tang Y, Kwok CK, Zhang Y, Bevilacqua PC, Assmann SM. In vivo genome-wide profiling of RNA secondary structure reveals novel regulatory features. Nature 2014; 505:696–700.
    • (2014) Nature , vol.505 , pp. 696-700
    • Ding, Y.1    Tang, Y.2    Kwok, C.K.3    Zhang, Y.4    Bevilacqua, P.C.5    Assmann, S.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.