메뉴 건너뛰기




Volumn 5, Issue , 2016, Pages

The biological significance of brain barrier mechanisms: Help or hindrance in drug delivery to the central nervous system?

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD BRAIN BARRIER; BRAIN DISEASE; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CEREBROVASCULAR ACCIDENT; CHOROID PLEXUS; DRUG RESEARCH; HIGH THROUGHPUT SCREENING; HUMAN; MULTIPLE SCLEROSIS; NEUROMODULATION; NONHUMAN; PREGNANT WOMAN; REVIEW; SIGNAL TRANSDUCTION; TANYCYTE; TRANSCYTOSIS; TRANSPORT KINETICS;

EID: 84964612022     PISSN: 20461402     EISSN: 1759796X     Source Type: Journal    
DOI: 10.12688/f1000research.7378.1     Document Type: Review
Times cited : (98)

References (129)
  • 1
    • 0000369917 scopus 로고
    • The active and passive exchanges of inorganic ions through the surfaces of living cells and through living membranes generally
    • 21014293
    • Krogh A: The active and passive exchanges of inorganic ions through the surfaces of living cells and through living membranes generally. Proc R Soc Lond B. 1946;133(871):140-200. 21014293 10.1098/rspb.1946.0008
    • (1946) Proc R Soc Lond B , vol.133 , Issue.871 , pp. 140-200
    • Krogh, A.1
  • 2
    • 84920556742 scopus 로고    scopus 로고
    • The rights and wrongs of blood-brain barrier permeability studies: a walk through 100 years of history
    • 25565938, 4267212
    • Saunders NR Dreifuss JJ Dziegielewska KM: The rights and wrongs of blood-brain barrier permeability studies: a walk through 100 years of history. Front Neurosci. 2014;8:404. 25565938 10.3389/fnins.2014.00404 4267212
    • (2014) Front Neurosci , vol.8 , pp. 404
    • Saunders, N.R.1    Dreifuss, J.J.2    Dziegielewska, K.M.3
  • 3
    • 77953085314 scopus 로고
    • Recherches sur le liquide céphalo-rachidien. 1. Les rapports entre le liquide céphalo-rachidien et la circulation sanguine
    • Stern L Gautier R: Recherches sur le liquide céphalo-rachidien. 1. Les rapports entre le liquide céphalo-rachidien et la circulation sanguine. Arch Int Physiol. 1921;17(2):138-192. 10.3109/13813452109146211
    • (1921) Arch Int Physiol , vol.17 , Issue.2 , pp. 138-192
    • Stern, L.1    Gautier, R.2
  • 4
    • 0003728081 scopus 로고
    • Das Sauerstoffbedürfnis des Organismus. Eine Farbenanalytische Studie
    • Reference Source, Berlin: Hirschwald;.
    • Ehrlich P: Das Sauerstoffbedürfnis des Organismus. Eine Farbenanalytische Studie.Berlin: Hirschwald;1885. Reference Source
    • (1885)
    • Ehrlich, P.1
  • 5
    • 0000971990 scopus 로고
    • Zur Lehre von der Cerebrospinalflüssgkeit
    • Lewandowsky M: Zur Lehre von der Cerebrospinalflüssgkeit. Z Clin Med. 1900;40:480-494.
    • (1900) Z Clin Med , vol.40 , pp. 480-494
    • Lewandowsky, M.1
  • 6
    • 0001220328 scopus 로고
    • Die äussere und innere Sekretion des gesunden und kranken Organismus im Lichte der 'vitalen Färbung
    • Goldmann EE: Die äussere und innere Sekretion des gesunden und kranken Organismus im Lichte der 'vitalen Färbung.1909.
    • (1909)
    • Goldmann, E.E.1
  • 7
    • 80053542940 scopus 로고    scopus 로고
    • Getting to know the cast - cellular interactions and signaling at the neurovascular unit
    • 21827409
    • Mäe M Armulik A Betsholtz C: Getting to know the cast - cellular interactions and signaling at the neurovascular unit. Curr Pharm Des. 2011;17(26):2750-2754. 21827409 10.2174/138161211797440113
    • (2011) Curr Pharm Des , vol.17 , Issue.26 , pp. 2750-2754
    • Mäe, M.1    Armulik, A.2    Betsholtz, C.3
  • 8
    • 84862640700 scopus 로고    scopus 로고
    • Neurovascular unit: a focus on pericytes
    • 22371274
    • Sá-Pereira I Brites D Brito MA: Neurovascular unit: a focus on pericytes. Mol Neurobiol. 2012;45(2):327-347. 22371274 10.1007/s12035-012-8244-2
    • (2012) Mol Neurobiol , vol.45 , Issue.2 , pp. 327-347
    • Sá-Pereira, I.1    Brites, D.2    Brito, M.A.3
  • 9
    • 84911486499 scopus 로고    scopus 로고
    • Focal disturbances in the blood-brain barrier are associated with formation of neuroinflammatory lesions
    • 25448765
    • Alvarez JI Saint-Laurent O Godschalk A: Focal disturbances in the blood-brain barrier are associated with formation of neuroinflammatory lesions. Neurobiol Dis. 2015;74:14-24. 25448765 10.1016/j.nbd.2014.09.016
    • (2015) Neurobiol Dis , vol.74 , pp. 14-24
    • Alvarez, J.I.1    Saint-Laurent, O.2    Godschalk, A.3
  • 10
    • 84940376898 scopus 로고    scopus 로고
    • SnapShot: Astrocytes in Health and Disease
    • 26317476
    • Liddelow S Barres B: SnapShot: Astrocytes in Health and Disease. Cell. 2015;162(5):1170-1170.e1. 26317476 10.1016/j.cell.2015.08.029
    • (2015) Cell , vol.162 , Issue.5 , pp. 1170-1170.e1
    • Liddelow, S.1    Barres, B.2
  • 11
    • 0014481056 scopus 로고
    • Junctions between intimately apposed cell membranes in the vertebrate brain
    • 5765759, 2107650
    • Brightman MW Reese TS: Junctions between intimately apposed cell membranes in the vertebrate brain. J Cell Biol. 1969;40(3):648-677. 5765759 10.1083/jcb.40.3.648 2107650
    • (1969) J Cell Biol , vol.40 , Issue.3 , pp. 648-677
    • Brightman, M.W.1    Reese, T.S.2
  • 12
    • 0016718746 scopus 로고
    • Junctions in the meninges and marginal glia
    • 810497
    • Nabeshima S Reese TS Landis DM: Junctions in the meninges and marginal glia. J Comp Neurol. 1975;164(2):127-169. 810497 10.1002/cne.901640202
    • (1975) J Comp Neurol , vol.164 , Issue.2 , pp. 127-169
    • Nabeshima, S.1    Reese, T.S.2    Landis, D.M.3
  • 13
    • 84924364334 scopus 로고    scopus 로고
    • Outer brain barriers in rat and human development
    • 25852456, 4360706
    • Brøchner CB Holst CB Møllgård K: Outer brain barriers in rat and human development. Front Neurosci. 2015;9:75. 25852456 10.3389/fnins.2015.00075 4360706
    • (2015) Front Neurosci , vol.9 , pp. 75
    • Brøchner, C.B.1    Holst, C.B.2    Møllgård, K.3
  • 14
    • 73449115641 scopus 로고    scopus 로고
    • The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction
    • 19779720
    • Engelhardt B Sorokin L: The blood-brain and the blood-cerebrospinal fluid barriers: function and dysfunction. Semin Immunopathol. 2009;31(4):497-511. 19779720 10.1007/s00281-009-0177-0
    • (2009) Semin Immunopathol , vol.31 , Issue.4 , pp. 497-511
    • Engelhardt, B.1    Sorokin, L.2
  • 15
    • 78649487239 scopus 로고    scopus 로고
    • Pericytes are required for blood-brain barrier integrity during embryogenesis
    • 20944625, 3241506, F1000 Recommendation
    • Daneman R Zhou L Kebede AA: Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature. 2010;468(7323):562-566. 20944625 10.1038/nature09513 3241506 F1000 Recommendation
    • (2010) Nature , vol.468 , Issue.7323 , pp. 562-566
    • Daneman, R.1    Zhou, L.2    Kebede, A.A.3
  • 16
    • 84910025084 scopus 로고    scopus 로고
    • The contribution of CXCL12-expressing radial glia cells to neuro-vascular patterning during human cerebral cortex development
    • 25360079, 4197642
    • Errede M Girolamo F Rizzi M: The contribution of CXCL12-expressing radial glia cells to neuro-vascular patterning during human cerebral cortex development. Front Neurosci. 2014;8:324. 25360079 10.3389/fnins.2014.00324 4197642
    • (2014) Front Neurosci , vol.8 , pp. 324
    • Errede, M.1    Girolamo, F.2    Rizzi, M.3
  • 17
    • 0014711091 scopus 로고
    • Development of the blood vessels and extracellular spaces during postnatal maturation of rat cerebral cortex
    • 5412719
    • Caley DW Maxwell DS: Development of the blood vessels and extracellular spaces during postnatal maturation of rat cerebral cortex. J Comp Neurol. 1970;138(1):31-47. 5412719 10.1002/cne.901380104
    • (1970) J Comp Neurol , vol.138 , Issue.1 , pp. 31-47
    • Caley, D.W.1    Maxwell, D.S.2
  • 18
    • 0348231898 scopus 로고    scopus 로고
    • Mechanisms of disease: the blood-brain barrier
    • 14683550, ;():- discussion 141-2.
    • Neuwelt EA: Mechanisms of disease: the blood-brain barrier. Neurosurgery. 2004;54(1):131-40- discussion 141-2. 14683550 10.1227/01.NEU.0000097715.11966.8E
    • (2004) Neurosurgery , vol.54 , Issue.1 , pp. 131-140
    • Neuwelt, E.A.1
  • 19
    • 0018085098 scopus 로고
    • The functional and structural border of the neurohemal region of the median eminence
    • 359161
    • Krish B Leonhardt H: The functional and structural border of the neurohemal region of the median eminence. Cell Tissue Res. 1978;192(2):327-339. 359161 10.1007/BF00220750
    • (1978) Cell Tissue Res , vol.192 , Issue.2 , pp. 327-339
    • Krish, B.1    Leonhardt, H.2
  • 20
    • 40449138261 scopus 로고    scopus 로고
    • The area postrema: a brain monitor and integrator of systemic autonomic state
    • 18079557
    • Price CJ Hoyda TD Ferguson AV: The area postrema: a brain monitor and integrator of systemic autonomic state. Neuroscientist. 2008;14(2):182-194. 18079557 10.1177/1073858407311100
    • (2008) Neuroscientist , vol.14 , Issue.2 , pp. 182-194
    • Price, C.J.1    Hoyda, T.D.2    Ferguson, A.V.3
  • 21
    • 0023229532 scopus 로고
    • Cell junctions and membrane specializations in the ventricular zone (germinal matrix) of the developing sheep brain: a CSF-brain barrier
    • 3681347
    • Møllgård K Balslev Y Lauritzen B: Cell junctions and membrane specializations in the ventricular zone (germinal matrix) of the developing sheep brain: a CSF-brain barrier. J Neurocytol. 1987;16(4):433-444. 3681347 10.1007/BF01668498
    • (1987) J Neurocytol , vol.16 , Issue.4 , pp. 433-444
    • Møllgård, K.1    Balslev, Y.2    Lauritzen, B.3
  • 22
    • 0022016546 scopus 로고
    • CSF-brain permeability in the immature sheep fetus: a CSF-brain barrier
    • 3986606
    • Fossan G Cavanagh ME Evans CA: CSF-brain permeability in the immature sheep fetus: a CSF-brain barrier. Brain Res. 1985;350(1-2):113-124. 3986606 10.1016/0165-3806(85)90255-X
    • (1985) Brain Res , vol.350 , Issue.1-2 , pp. 113-124
    • Fossan, G.1    Cavanagh, M.E.2    Evans, C.A.3
  • 23
    • 84949114869 scopus 로고    scopus 로고
    • The inner CSF-brain barrier: developmentally controlled access to the brain via intercellular junctions
    • 25729345, 4325900
    • Whish S Dziegielewska KM Møllgård K: The inner CSF-brain barrier: developmentally controlled access to the brain via intercellular junctions. Front Neurosci. 2015;9:16. 25729345 10.3389/fnins.2015.00016 4325900
    • (2015) Front Neurosci , vol.9 , pp. 16
    • Whish, S.1    Dziegielewska, K.M.2    Møllgård, K.3
  • 24
    • 0003620707 scopus 로고    scopus 로고
    • Physiology of the CSF and Blood-Brain Barriers
    • Reference Source, Boca Raton: CRC Press;.
    • Davson H Segal MB: Physiology of the CSF and Blood-Brain Barriers.Boca Raton: CRC Press;1996. Reference Source
    • (1996)
    • Davson, H.1    Segal, M.B.2
  • 25
    • 84885730661 scopus 로고    scopus 로고
    • Cerebrospinal fluid secretion by the choroid plexus
    • 24137023
    • Damkier HH Brown PD Praetorius J: Cerebrospinal fluid secretion by the choroid plexus. Physiol Rev. 2013;93(4):1847-1892. 24137023 10.1152/physrev.00004.2013
    • (2013) Physiol Rev , vol.93 , Issue.4 , pp. 1847-1892
    • Damkier, H.H.1    Brown, P.D.2    Praetorius, J.3
  • 26
    • 84879752859 scopus 로고    scopus 로고
    • Mechanisms that determine the internal environment of the developing brain: a transcriptomic, functional and ultrastructural approach
    • 23843944, 3699566
    • Liddelow SA Dziegielewska KM Ek CJ: Mechanisms that determine the internal environment of the developing brain: a transcriptomic, functional and ultrastructural approach. PLoS One. 2013;8(7):e65629. 23843944 10.1371/journal.pone.0065629 3699566
    • (2013) PLoS One , vol.8 , Issue.7 , pp. e65629
    • Liddelow, S.A.1    Dziegielewska, K.M.2    Ek, C.J.3
  • 27
    • 0015186836 scopus 로고
    • Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
    • 5124307
    • Oldendorf WH: Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection. Am J Physiol. 1971;221(6):1629-1639. 5124307
    • (1971) Am J Physiol , vol.221 , Issue.6 , pp. 1629-1639
    • Oldendorf, W.H.1
  • 28
    • 78149456928 scopus 로고    scopus 로고
    • The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells
    • 21060791, 2966423, F1000 Recommendation
    • Daneman R Zhou L Agalliu D: The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells. PLoS One. 2010;5(10):e13741. 21060791 10.1371/journal.pone.0013741 2966423 F1000 Recommendation
    • (2010) PLoS One , vol.5 , Issue.10 , pp. e13741
    • Daneman, R.1    Zhou, L.2    Agalliu, D.3
  • 29
    • 79961096875 scopus 로고    scopus 로고
    • Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels
    • 21707071, F1000 Recommendation
    • Shawahna R Uchida Y Declèves X: Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol Pharm. 2011;8(4):1332-1341. 21707071 10.1021/mp200129p F1000 Recommendation
    • (2011) Mol Pharm , vol.8 , Issue.4 , pp. 1332-1341
    • Shawahna, R.1    Uchida, Y.2    Declèves, X.3
  • 30
    • 84888001037 scopus 로고    scopus 로고
    • Profiling solute carrier transporters in the human blood-brain barrier
    • 24013810, 3906042, F1000 Recommendation
    • Geier EG Chen EC Webb A: Profiling solute carrier transporters in the human blood-brain barrier. Clin Pharmacol Ther. 2013;94(6):636-639. 24013810 10.1038/clpt.2013.175 3906042 F1000 Recommendation
    • (2013) Clin Pharmacol Ther , vol.94 , Issue.6 , pp. 636-639
    • Geier, E.G.1    Chen, E.C.2    Webb, A.3
  • 31
    • 80051724911 scopus 로고    scopus 로고
    • Transcriptome signature of the adult mouse choroid plexus
    • 21349147, 3042978, F1000 Recommendation
    • Marques F Sousa JC Coppola G: Transcriptome signature of the adult mouse choroid plexus. Fluids Barriers CNS. 2011;8(1):10. 21349147 10.1186/2045-8118-8-10 3042978 F1000 Recommendation
    • (2011) Fluids Barriers CNS , vol.8 , Issue.1 , pp. 10
    • Marques, F.1    Sousa, J.C.2    Coppola, G.3
  • 32
    • 84866167502 scopus 로고    scopus 로고
    • Expression Profiling of Solute Carrier Gene Families at the Blood-CSF Barrier
    • 22936914, 3426838
    • Ho HT Dahlin A Wang J: Expression Profiling of Solute Carrier Gene Families at the Blood-CSF Barrier. Front Pharmacol. 2012;3:154. 22936914 10.3389/fphar.2012.00154 3426838
    • (2012) Front Pharmacol , vol.3 , pp. 154
    • Ho, H.T.1    Dahlin, A.2    Wang, J.3
  • 33
    • 84858667541 scopus 로고    scopus 로고
    • Molecular characterisation of transport mechanisms at the developing mouse blood-CSF interface: a transcriptome approach
    • 22457777, 3310074
    • Liddelow SA Temple S Møllgård K: Molecular characterisation of transport mechanisms at the developing mouse blood-CSF interface: a transcriptome approach. PLoS One. 2012;7(3):e33554. 22457777 10.1371/journal.pone.0033554 3310074
    • (2012) PLoS One , vol.7 , Issue.3 , pp. e33554
    • Liddelow, S.A.1    Temple, S.2    Møllgård, K.3
  • 34
    • 84875191169 scopus 로고    scopus 로고
    • Transporters of the blood-brain and blood-CSF interfaces in development and in the adult
    • 23506907
    • Saunders NR Daneman R Dziegielewska KM: Transporters of the blood-brain and blood-CSF interfaces in development and in the adult. Mol Aspects Med. 2013;34(2-3):742-752. 23506907 10.1016/j.mam.2012.11.006
    • (2013) Mol Aspects Med , vol.34 , Issue.2-3 , pp. 742-752
    • Saunders, N.R.1    Daneman, R.2    Dziegielewska, K.M.3
  • 35
    • 84880912181 scopus 로고    scopus 로고
    • Developmental changes in the transcriptome of the rat choroid plexus in relation to neuroprotection
    • 23915922, 3737068
    • Kratzer I Liddelow SA Saunders NR: Developmental changes in the transcriptome of the rat choroid plexus in relation to neuroprotection. Fluids Barriers CNS. 2013;10(1):25. 23915922 10.1186/2045-8118-10-25 3737068
    • (2013) Fluids Barriers CNS , vol.10 , Issue.1 , pp. 25
    • Kratzer, I.1    Liddelow, S.A.2    Saunders, N.R.3
  • 36
    • 84928168469 scopus 로고    scopus 로고
    • Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study
    • 25972776, 4412010
    • Saunders NR Dziegielewska KM Møllgård K: Influx mechanisms in the embryonic and adult rat choroid plexus: a transcriptome study. Front Neurosci. 2015;9:123. 25972776 10.3389/fnins.2015.00123 4412010
    • (2015) Front Neurosci , vol.9 , pp. 123
    • Saunders, N.R.1    Dziegielewska, K.M.2    Møllgård, K.3
  • 37
    • 0034917716 scopus 로고    scopus 로고
    • The human ATP-binding cassette (ABC) transporter superfamily
    • 11435397
    • Dean M Rzhetsky A Allikmets R: The human ATP-binding cassette (ABC) transporter superfamily. Genome Res. 2001;11(7):1156-1166. 11435397
    • (2001) Genome Res , vol.11 , Issue.7 , pp. 1156-1166
    • Dean, M.1    Rzhetsky, A.2    Allikmets, R.3
  • 38
    • 79951933153 scopus 로고    scopus 로고
    • ABC transporters in the CNS - an inventory
    • 21118088
    • Hartz AMS Bauer B: ABC transporters in the CNS - an inventory. Curr Pharm Biotechnol. 2011;12(4):656-673. 21118088 10.2174/138920111795164020
    • (2011) Curr Pharm Biotechnol , vol.12 , Issue.4 , pp. 656-673
    • Hartz, A.M.S.1    Bauer, B.2
  • 39
    • 84949117688 scopus 로고    scopus 로고
    • Efflux transporters in blood-brain interfaces of the developing brain
    • 25698917, 4318338
    • Strazielle N Ghersi-Egea JF: Efflux transporters in blood-brain interfaces of the developing brain. Front Neurosci. 2015;9:21. 25698917 10.3389/fnins.2015.00021 4318338
    • (2015) Front Neurosci , vol.9 , pp. 21
    • Strazielle, N.1    Ghersi-Egea, J.F.2
  • 40
    • 77953808226 scopus 로고    scopus 로고
    • Efflux mechanisms at the developing brain barriers: ABC-transporters in the fetal and postnatal rat
    • 20466047
    • Ek CJ Wong A Liddelow SA: Efflux mechanisms at the developing brain barriers: ABC-transporters in the fetal and postnatal rat. Toxicol Lett. 2010;197(1):51-59. 20466047 10.1016/j.toxlet.2010.04.025
    • (2010) Toxicol Lett , vol.197 , Issue.1 , pp. 51-59
    • Ek, C.J.1    Wong, A.2    Liddelow, S.A.3
  • 41
    • 0030823912 scopus 로고    scopus 로고
    • P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain
    • 9291129, 1218702
    • Beaulieu E Demeule M Ghitescu L: P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain. Biochem J. 1997;326(Pt 2):539-544. 9291129 10.1042/bj3260539 1218702
    • (1997) Biochem J , vol.326 , pp. 539-544
    • Beaulieu, E.1    Demeule, M.2    Ghitescu, L.3
  • 42
    • 0036605677 scopus 로고    scopus 로고
    • Functional expression and localization of P-glycoprotein at the blood brain barrier
    • 12112443
    • Bendayan R Lee G Bendayan M: Functional expression and localization of P-glycoprotein at the blood brain barrier. Microsc Res Tech. 2002;57(5):365-380. 12112443 10.1002/jemt.10090
    • (2002) Microsc Res Tech , vol.57 , Issue.5 , pp. 365-380
    • Bendayan, R.1    Lee, G.2    Bendayan, M.3
  • 43
    • 49349102757 scopus 로고    scopus 로고
    • Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation
    • 18619525, F1000 Recommendation
    • Roberts LM Black DS Raman C: Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Neuroscience. 2008;155(2):423-438. 18619525 10.1016/j.neuroscience.2008.06.015 F1000 Recommendation
    • (2008) Neuroscience , vol.155 , Issue.2 , pp. 423-438
    • Roberts, L.M.1    Black, D.S.2    Raman, C.3
  • 44
    • 0037113346 scopus 로고    scopus 로고
    • Localisation of breast cancer resistance protein in microvessel endothelium of human brain
    • 12438926, F1000 Recommendation
    • Cooray HC Blackmore CG Maskell L: Localisation of breast cancer resistance protein in microvessel endothelium of human brain. Neuroreport. 2002;13(16):2059-2063. 12438926 10.1097/00001756-200211150-00014 F1000 Recommendation
    • (2002) Neuroreport , vol.13 , Issue.16 , pp. 2059-2063
    • Cooray, H.C.1    Blackmore, C.G.2    Maskell, L.3
  • 45
    • 59849129439 scopus 로고    scopus 로고
    • ABC transporter (P-gp/ABCB1, MRP1/ABCC1, BCRP/ABCG2) expression in the developing human CNS
    • 19165709, 2821654
    • Daood M Tsai C Ahdab-Barmada M: ABC transporter (P-gp/ABCB1, MRP1/ABCC1, BCRP/ABCG2) expression in the developing human CNS. Neuropediatrics. 2008;39(4):211-218. 19165709 10.1055/s-0028-1103272 2821654
    • (2008) Neuropediatrics , vol.39 , Issue.4 , pp. 211-218
    • Daood, M.1    Tsai, C.2    Ahdab-Barmada, M.3
  • 46
    • 44349163325 scopus 로고    scopus 로고
    • Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier
    • 18349876, F1000 Recommendation
    • Bauer B Hartz AM Lucking JR: Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier. J Cereb Blood Flow Metab. 2008;28(6):1222-1234. 18349876 10.1038/jcbfm.2008.16 F1000 Recommendation
    • (2008) J Cereb Blood Flow Metab , vol.28 , Issue.6 , pp. 1222-1234
    • Bauer, B.1    Hartz, A.M.2    Lucking, J.R.3
  • 47
    • 6344265573 scopus 로고    scopus 로고
    • Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain
    • 15501592, F1000 Recommendation
    • Nies AT Jedlitschky G König J: Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain. Neuroscience. 2004;129(2):349-360. 15501592 10.1016/j.neuroscience.2004.07.051 F1000 Recommendation
    • (2004) Neuroscience , vol.129 , Issue.2 , pp. 349-360
    • Nies, A.T.1    Jedlitschky, G.2    König, J.3
  • 48
    • 53149117869 scopus 로고    scopus 로고
    • Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces
    • 18680196, F1000 Recommendation
    • Gazzin S Strazielle N Schmitt C: Differential expression of the multidrug resistance-related proteins ABCb1 and ABCc1 between blood-brain interfaces. J Comp Neurol. 2008;510(5):497-507. 18680196 10.1002/cne.21808 F1000 Recommendation
    • (2008) J Comp Neurol , vol.510 , Issue.5 , pp. 497-507
    • Gazzin, S.1    Strazielle, N.2    Schmitt, C.3
  • 49
    • 0035870289 scopus 로고    scopus 로고
    • Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues
    • 11309308, F1000 Recommendation
    • Maliepaard M Scheffer GL Faneyte IF: Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues. Cancer Res. 2001;61(8):3458-3464. 11309308 F1000 Recommendation
    • (2001) Cancer Res , vol.61 , Issue.8 , pp. 3458-3464
    • Maliepaard, M.1    Scheffer, G.L.2    Faneyte, I.F.3
  • 50
    • 0033526533 scopus 로고    scopus 로고
    • Developmental expression of P-glycoprotein (multidrug resistance gene product) in the rat brain
    • 10363911
    • Matsuoka Y Okazaki M Kitamura Y: Developmental expression of P-glycoprotein (multidrug resistance gene product) in the rat brain. J Neurobiol. 1999;39(3):383-392. 10363911 10.1002/(SICI)1097-4695(19990605)39:3<383::AID-NEU5>3.0.CO;2-4
    • (1999) J Neurobiol , vol.39 , Issue.3 , pp. 383-392
    • Matsuoka, Y.1    Okazaki, M.2    Kitamura, Y.3
  • 51
    • 54349127575 scopus 로고    scopus 로고
    • Evidence that the choroids plexus in female sheep express P-glycoprotein
    • 18766153
    • Bougoin S Lomet D Kerboeuf D: Evidence that the choroids plexus in female sheep express P-glycoprotein. Neuro Endocrinol Lett. 2008;29(4):438-442. 18766153
    • (2008) Neuro Endocrinol Lett , vol.29 , Issue.4 , pp. 438-442
    • Bougoin, S.1    Lomet, D.2    Kerboeuf, D.3
  • 52
    • 4344677966 scopus 로고    scopus 로고
    • Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes
    • 15328029, F1000 Recommendation
    • Mercier C Masseguin C Roux F: Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes. Brain Res. 2004;1021(1):32-40. 15328029 10.1016/j.brainres.2004.06.034 F1000 Recommendation
    • (2004) Brain Res , vol.1021 , Issue.1 , pp. 32-40
    • Mercier, C.1    Masseguin, C.2    Roux, F.3
  • 53
    • 0033616684 scopus 로고    scopus 로고
    • Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier
    • 10097135, 22392
    • Rao VV Dahlheimer JL Bardgett ME: Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier. Proc Natl Acad Sci USA. 1999;96(7):3900-3905. 10097135 10.1073/pnas.96.7.3900 22392
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.7 , pp. 3900-3905
    • Rao, V.V.1    Dahlheimer, J.L.2    Bardgett, M.E.3
  • 54
    • 23044500398 scopus 로고    scopus 로고
    • Drug resistance in brain diseases and the role of drug efflux transporters
    • 16025095
    • Löscher W Potschka H: Drug resistance in brain diseases and the role of drug efflux transporters. Nat Rev Neurosci. 2005;6(8):591-602. 16025095 10.1038/nrn1728
    • (2005) Nat Rev Neurosci , vol.6 , Issue.8 , pp. 591-602
    • Löscher, W.1    Potschka, H.2
  • 55
    • 0026580336 scopus 로고
    • Is the multidrug transporter a flippase?
    • 1374941
    • Higgins CF Gottesman MM: Is the multidrug transporter a flippase? Trends Biochem Sci. 1992;17(1):18-21. 1374941 10.1016/0968-0004(92)90419-A
    • (1992) Trends Biochem Sci , vol.17 , Issue.1 , pp. 18-21
    • Higgins, C.F.1    Gottesman, M.M.2
  • 56
    • 0030838009 scopus 로고    scopus 로고
    • The multidrug-resistance P-glycoprotein (Pgp, MDR1) is an early marker of blood-brain barrier development in the microvessels of the developing human brain
    • 9272437
    • Schumacher U Møllgård K: The multidrug-resistance P-glycoprotein (Pgp, MDR1) is an early marker of blood-brain barrier development in the microvessels of the developing human brain. Histochem Cell Biol. 1997;108(2):179-182. 9272437 10.1007/s004180050159
    • (1997) Histochem Cell Biol , vol.108 , Issue.2 , pp. 179-182
    • Schumacher, U.1    Møllgård, K.2
  • 57
    • 37649002802 scopus 로고    scopus 로고
    • Fetal blood-brain barrier P-glycoprotein contributes to brain protection during human development
    • 18091560, F1000 Recommendation
    • Virgintino D Errede M Girolamo F: Fetal blood-brain barrier P-glycoprotein contributes to brain protection during human development. J Neuropathol Exp Neurol. 2008;67(1):50-61. 18091560 10.1097/nen.0b013e31815f65d9 F1000 Recommendation
    • (2008) J Neuropathol Exp Neurol , vol.67 , Issue.1 , pp. 50-61
    • Virgintino, D.1    Errede, M.2    Girolamo, F.3
  • 58
    • 84905401438 scopus 로고    scopus 로고
    • Cell-culture models of the blood-brain barrier
    • 24938839, 4668829, F1000 Recommendation
    • He Y Yao Y Tsirka SE: Cell-culture models of the blood-brain barrier. Stroke. 2014;45(8):2514-2526. 24938839 10.1161/STROKEAHA.114.005427 4668829 F1000 Recommendation
    • (2014) Stroke , vol.45 , Issue.8 , pp. 2514-2526
    • He, Y.1    Yao, Y.2    Tsirka, S.E.3
  • 59
    • 57449121882 scopus 로고    scopus 로고
    • Getting into the brain: approaches to enhance brain drug delivery
    • 19062774, F1000 Recommendation
    • Patel MM Goyal BR Bhadada SV: Getting into the brain: approaches to enhance brain drug delivery. CNS Drugs. 2009;23(1):35-58. 19062774 10.2165/0023210-200923010-00003 F1000 Recommendation
    • (2009) CNS Drugs , vol.23 , Issue.1 , pp. 35-58
    • Patel, M.M.1    Goyal, B.R.2    Bhadada, S.V.3
  • 60
    • 84920768217 scopus 로고    scopus 로고
    • Targeting receptor-mediated transport for delivery of biologics across the blood-brain barrier
    • 25340933, F1000 Recommendation
    • Lajoie JM Shusta EV: Targeting receptor-mediated transport for delivery of biologics across the blood-brain barrier. Annu Rev Pharmacol Toxicol. 2015;55:613-631. 25340933 10.1146/annurev-pharmtox-010814-124852 F1000 Recommendation
    • (2015) Annu Rev Pharmacol Toxicol , vol.55 , pp. 613-631
    • Lajoie, J.M.1    Shusta, E.V.2
  • 61
    • 84926661937 scopus 로고    scopus 로고
    • st century: current and prospective technologies
    • 25098812, 4225221
    • Palmiotti CA Prasad S Naik P: In vitro cerebrovascular modeling in the 21 st century: current and prospective technologies. Pharm Res. 2014;31(12):3229-3250. 25098812 10.1007/s11095-014-1464-6 4225221
    • (2014) Pharm Res , vol.31 , Issue.12 , pp. 3229-3250
    • Palmiotti, C.A.1    Prasad, S.2    Naik, P.3
  • 62
    • 84900023528 scopus 로고    scopus 로고
    • In vitro models of the blood-brain barrier for the study of drug delivery to the brain
    • 24641309
    • Wilhelm I Krizbai IA: In vitro models of the blood-brain barrier for the study of drug delivery to the brain. Mol Pharm. 2014;11(7):1949-1963. 24641309 10.1021/mp500046f
    • (2014) Mol Pharm , vol.11 , Issue.7 , pp. 1949-1963
    • Wilhelm, I.1    Krizbai, I.A.2
  • 63
    • 84921485397 scopus 로고    scopus 로고
    • Blood-brain barrier models: in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics
    • 25388782
    • Stanimirovic DB Bani-Yaghoub M Perkins M: Blood-brain barrier models: in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics. Expert Opin Drug Discov. 2015;10(2):141-155. 25388782 10.1517/17460441.2015.974545
    • (2015) Expert Opin Drug Discov , vol.10 , Issue.2 , pp. 141-155
    • Stanimirovic, D.B.1    Bani-Yaghoub, M.2    Perkins, M.3
  • 64
    • 84939268433 scopus 로고    scopus 로고
    • In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches
    • 25630899
    • Wolff A Antfolk M Brodin B: In Vitro Blood-Brain Barrier Models-An Overview of Established Models and New Microfluidic Approaches. J Pharm Sci. 2015;104(9):2727-2746. 25630899 10.1002/jps.24329
    • (2015) J Pharm Sci , vol.104 , Issue.9 , pp. 2727-2746
    • Wolff, A.1    Antfolk, M.2    Brodin, B.3
  • 65
    • 0028352475 scopus 로고
    • Transendothelial electrical potential across pial vessels in anaesthetised rats: a study of ion permeability and transport at the blood-brain barrier
    • 7525022
    • Revest PA Jones HC Abbott NJ: Transendothelial electrical potential across pial vessels in anaesthetised rats: a study of ion permeability and transport at the blood-brain barrier. Brain Res. 1994;652(1):76-82. 7525022 10.1016/0006-8993(94)90319-0
    • (1994) Brain Res , vol.652 , Issue.1 , pp. 76-82
    • Revest, P.A.1    Jones, H.C.2    Abbott, N.J.3
  • 66
    • 77952035085 scopus 로고    scopus 로고
    • Endothelial cell heterogeneity of blood-brain barrier gene expression along the cerebral microvasculature
    • 20025060, F1000 Recommendation
    • Macdonald JA Murugesan N Pachter JS: Endothelial cell heterogeneity of blood-brain barrier gene expression along the cerebral microvasculature. J Neurosci Res. 2010;88(7):1457-1474. 20025060 10.1002/jnr.22316 F1000 Recommendation
    • (2010) J Neurosci Res , vol.88 , Issue.7 , pp. 1457-1474
    • Macdonald, J.A.1    Murugesan, N.2    Pachter, J.S.3
  • 67
    • 84872159164 scopus 로고    scopus 로고
    • Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model
    • 23137377
    • Ohtsuki S Ikeda C Uchida Y: Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model. Mol Pharm. 2013;10(1):289-296. 23137377 10.1021/mp3004308
    • (2013) Mol Pharm , vol.10 , Issue.1 , pp. 289-296
    • Ohtsuki, S.1    Ikeda, C.2    Uchida, Y.3
  • 68
    • 0014260608 scopus 로고
    • Experimental treatment of parkinsonism with L-Dopa
    • 4869717
    • Cotzias GC Papavasiliou PS Gellene R: Experimental treatment of parkinsonism with L-Dopa. Neurology. 1968;18(3):276-277. 4869717
    • (1968) Neurology , vol.18 , Issue.3 , pp. 276-277
    • Cotzias, G.C.1    Papavasiliou, P.S.2    Gellene, R.3
  • 69
    • 84952639354 scopus 로고    scopus 로고
    • Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders
    • 26187753, 4681613
    • Qosa H Miller DS Pasinelli P: Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders. Brain Res. 2015;1628(Pt B):298-316. 26187753 10.1016/j.brainres.2015.07.005 4681613
    • (2015) Brain Res , vol.1628 , pp. 298-316
    • Qosa, H.1    Miller, D.S.2    Pasinelli, P.3
  • 70
    • 33845424655 scopus 로고    scopus 로고
    • Developmental neurotoxicity of industrial chemicals
    • 17174709
    • Grandjean P Landrigan PJ: Developmental neurotoxicity of industrial chemicals. Lancet. 2006;368(9553):2167-2178. 17174709 10.1016/S0140-6736(06)69665-7
    • (2006) Lancet , vol.368 , Issue.9553 , pp. 2167-2178
    • Grandjean, P.1    Landrigan, P.J.2
  • 71
    • 0015218539 scopus 로고
    • Reversible osmotic opening of the blood-brain barrier
    • 5098961, 10.1126/science.173.4001.1026
    • Rapoport SI Hori M Klatzo I: Reversible osmotic opening of the blood-brain barrier. Science. 1971;173(4001):1026-1028. 5098961 10.1126/science.173.4001.1026
    • (1971) Science , vol.173 , Issue.4001 , pp. 1026-1028
    • Rapoport, S.I.1    Hori, M.2    Klatzo, I.3
  • 72
    • 0015734630 scopus 로고
    • Osmotic opening of tight junctions in cerebral endothelium
    • 4784295
    • Brightman MW Hori M Rapoport SI: Osmotic opening of tight junctions in cerebral endothelium. J Comp Neurol. 1973;152(4):317-325. 4784295 10.1002/cne.901520402
    • (1973) J Comp Neurol , vol.152 , Issue.4 , pp. 317-325
    • Brightman, M.W.1    Hori, M.2    Rapoport, S.I.3
  • 73
    • 0018776967 scopus 로고
    • Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery
    • 457877, 372166
    • Neuwelt EA Maravilla KR Frenkel EP: Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery. J Clin Invest. 1979;64(2):684-688. 457877 10.1172/JCI109509 372166
    • (1979) J Clin Invest , vol.64 , Issue.2 , pp. 684-688
    • Neuwelt, E.A.1    Maravilla, K.R.2    Frenkel, E.P.3
  • 74
    • 84907997688 scopus 로고    scopus 로고
    • Delivery of chemotherapeutics across the blood-brain barrier: challenges and advances
    • 25307218, F1000 Recommendation
    • Doolittle ND Muldoon LL Culp AY: Delivery of chemotherapeutics across the blood-brain barrier: challenges and advances. Adv Pharmacol. 2014;71:203-243. 25307218 10.1016/bs.apha.2014.06.002 F1000 Recommendation
    • (2014) Adv Pharmacol , vol.71 , pp. 203-243
    • Doolittle, N.D.1    Muldoon, L.L.2    Culp, A.Y.3
  • 75
    • 51249091226 scopus 로고    scopus 로고
    • Recent advances in blood-brain barrier disruption as a CNS delivery strategy
    • 18446517, 2751463, F1000 Recommendation
    • Bellavance MA Blanchette M Fortin D: Recent advances in blood-brain barrier disruption as a CNS delivery strategy. AAPS J. 2008;10(1):166-177. 18446517 10.1208/s12248-008-9018-7 2751463 F1000 Recommendation
    • (2008) AAPS J , vol.10 , Issue.1 , pp. 166-177
    • Bellavance, M.A.1    Blanchette, M.2    Fortin, D.3
  • 76
    • 84940758944 scopus 로고    scopus 로고
    • Neurosurgical Techniques for Disruption of the Blood-Brain Barrier for Glioblastoma Treatment
    • 26247958, 4588193
    • Rodriguez A Tatter SB Debinski W: Neurosurgical Techniques for Disruption of the Blood-Brain Barrier for Glioblastoma Treatment. Pharmaceutics. 2015;7(3):175-187. 26247958 10.3390/pharmaceutics7030175 4588193
    • (2015) Pharmaceutics , vol.7 , Issue.3 , pp. 175-187
    • Rodriguez, A.1    Tatter, S.B.2    Debinski, W.3
  • 77
    • 84865987503 scopus 로고
    • Development of the blood-brain barrier
    • The blood brain barrier, with special regard to the use of radioactive isotopes, In: Bakay L, editor.
    • Bakay L: Development of the blood-brain barrier. In: Bakay L, editor. The blood brain barrier, with special regard to the use of radioactive isotopes. Springfield, IL: Charles C Thomas;1956;77-149.
    • (1956) , pp. 77-149
    • Bakay, L.1
  • 79
    • 0034876083 scopus 로고    scopus 로고
    • Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits
    • 11526261, F1000 Recommendation
    • Hynynen K McDannold N Vykhodtseva N: Noninvasive MR imaging-guided focal opening of the blood-brain barrier in rabbits. Radiology. 2001;220(3):640-646. 11526261 10.1148/radiol.2202001804 F1000 Recommendation
    • (2001) Radiology , vol.220 , Issue.3 , pp. 640-646
    • Hynynen, K.1    McDannold, N.2    Vykhodtseva, N.3
  • 80
    • 84924351678 scopus 로고    scopus 로고
    • Multiple sessions of liposomal doxorubicin delivery via focused ultrasound mediated blood-brain barrier disruption: a safety study
    • 25724272, 4385501, F1000 Recommendation
    • Aryal M Vykhodtseva N Zhang YZ: Multiple sessions of liposomal doxorubicin delivery via focused ultrasound mediated blood-brain barrier disruption: a safety study. J Control Release. 2015;204:60-69. 25724272 10.1016/j.jconrel.2015.02.033 4385501 F1000 Recommendation
    • (2015) J Control Release , vol.204 , pp. 60-69
    • Aryal, M.1    Vykhodtseva, N.2    Zhang, Y.Z.3
  • 81
    • 84873661847 scopus 로고    scopus 로고
    • Neuronavigation-guided focused ultrasound-induced blood-brain barrier opening: a preliminary study in swine
    • 22723060, F1000 Recommendation
    • Wei KC Tsai HC Lu YJ: Neuronavigation-guided focused ultrasound-induced blood-brain barrier opening: a preliminary study in swine. AJNR Am J Neuroradiol. 2013;34(1):115-120. 22723060 10.3174/ajnr.A3150 F1000 Recommendation
    • (2013) AJNR Am J Neuroradiol , vol.34 , Issue.1 , pp. 115-120
    • Wei, K.C.1    Tsai, H.C.2    Lu, Y.J.3
  • 82
    • 84876536636 scopus 로고    scopus 로고
    • Noninvasive and targeted drug delivery to the brain using focused ultrasound
    • 23379618, 3629738
    • Burgess A Hynynen K: Noninvasive and targeted drug delivery to the brain using focused ultrasound. ACS Chem Neurosci. 2013;4(4):519-526. 23379618 10.1021/cn300191b 3629738
    • (2013) ACS Chem Neurosci , vol.4 , Issue.4 , pp. 519-526
    • Burgess, A.1    Hynynen, K.2
  • 83
    • 84947485225 scopus 로고    scopus 로고
    • Drug and gene delivery across the blood-brain barrier with focused ultrasound
    • 26362698, 4656107
    • Timbie KF Mead BP Price RJ: Drug and gene delivery across the blood-brain barrier with focused ultrasound. J Control Release. 2015;219:61-75. 26362698 10.1016/j.jconrel.2015.08.059 4656107
    • (2015) J Control Release , vol.219 , pp. 61-75
    • Timbie, K.F.1    Mead, B.P.2    Price, R.J.3
  • 84
    • 84940726416 scopus 로고    scopus 로고
    • Facilitation of Drug Transport across the Blood-Brain Barrier with Ultrasound and Microbubbles
    • 26404357, 4588200
    • Meairs S: Facilitation of Drug Transport across the Blood-Brain Barrier with Ultrasound and Microbubbles. Pharmaceutics. 2015;7(3):275-293. 26404357 10.3390/pharmaceutics7030275 4588200
    • (2015) Pharmaceutics , vol.7 , Issue.3 , pp. 275-293
    • Meairs, S.1
  • 85
    • 84873709408 scopus 로고    scopus 로고
    • Novel 3D analysis of Claudin-5 reveals significant endothelial heterogeneity among CNS microvessels
    • 23261753, 3570614, F1000 Recommendation
    • Paul D Cowan AE Ge S: Novel 3D analysis of Claudin-5 reveals significant endothelial heterogeneity among CNS microvessels. Microvasc Res. 2013;86:1-10. 23261753 10.1016/j.mvr.2012.12.001 3570614 F1000 Recommendation
    • (2013) Microvasc Res , vol.86 , pp. 1-10
    • Paul, D.1    Cowan, A.E.2    Ge, S.3
  • 86
    • 0036463371 scopus 로고    scopus 로고
    • Drug and gene targeting to the brain with molecular Trojan horses
    • 12120094
    • Pardridge WM: Drug and gene targeting to the brain with molecular Trojan horses. Nat Rev Drug Discov. 2002;1(2):131-139. 12120094 10.1038/nrd725
    • (2002) Nat Rev Drug Discov , vol.1 , Issue.2 , pp. 131-139
    • Pardridge, W.M.1
  • 87
    • 84920598380 scopus 로고    scopus 로고
    • Barrier mechanisms in the Drosophila blood-brain barrier
    • 25565944, 4267209
    • Hindle SJ Bainton RJ: Barrier mechanisms in the Drosophila blood-brain barrier. Front Neurosci. 2014;8:414. 25565944 10.3389/fnins.2014.00414 4267209
    • (2014) Front Neurosci , vol.8 , pp. 414
    • Hindle, S.J.1    Bainton, R.J.2
  • 88
    • 84910033118 scopus 로고    scopus 로고
    • The Drosophila blood-brain barrier: development and function of a glial endothelium
    • 25452710, 4231875
    • Limmer S Weiler A Volkenhoff A: The Drosophila blood-brain barrier: development and function of a glial endothelium. Front Neurosci. 2014;8:365. 25452710 10.3389/fnins.2014.00365 4231875
    • (2014) Front Neurosci , vol.8 , pp. 365
    • Limmer, S.1    Weiler, A.2    Volkenhoff, A.3
  • 89
    • 84867874859 scopus 로고    scopus 로고
    • Zebrafish as a model to study drug transporters at the blood-brain barrier
    • 23047649
    • Umans RA Taylor MR: Zebrafish as a model to study drug transporters at the blood-brain barrier. Clin Pharmacol Ther. 2012;92(5):567-570. 23047649 10.1038/clpt.2012.168
    • (2012) Clin Pharmacol Ther , vol.92 , Issue.5 , pp. 567-570
    • Umans, R.A.1    Taylor, M.R.2
  • 90
    • 84885739130 scopus 로고    scopus 로고
    • Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish
    • 24147021, 3797749
    • Fleming A Diekmann H Goldsmith P: Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish. PLoS One. 2013;8(10):e77548. 24147021 10.1371/journal.pone.0077548 3797749
    • (2013) PLoS One , vol.8 , Issue.10 , pp. e77548
    • Fleming, A.1    Diekmann, H.2    Goldsmith, P.3
  • 91
    • 84937121870 scopus 로고    scopus 로고
    • Nature and uses of fluorescent dyes for drug transporter studies
    • 26050735, F1000 Recommendation
    • Fardel O Le Vee M Jouan E: Nature and uses of fluorescent dyes for drug transporter studies. Expert Opin Drug Metab Toxicol. 2015;11(8):1233-1251. 26050735 10.1517/17425255.2015.1053462 F1000 Recommendation
    • (2015) Expert Opin Drug Metab Toxicol , vol.11 , Issue.8 , pp. 1233-1251
    • Fardel, O.1    Le Vee, M.2    Jouan, E.3
  • 92
    • 79951922143 scopus 로고    scopus 로고
    • Engaging neuroscience to advance translational research in brain barrier biology
    • 21331083, 3335275
    • Neuwelt EA Bauer B Fahlke C: Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci. 2011;12(3):169-182. 21331083 10.1038/nrn2995 3335275
    • (2011) Nat Rev Neurosci , vol.12 , Issue.3 , pp. 169-182
    • Neuwelt, E.A.1    Bauer, B.2    Fahlke, C.3
  • 93
    • 84983164490 scopus 로고    scopus 로고
    • Formation and maintenance of the BBB
    • 26215350
    • Blanchette M Daneman R: Formation and maintenance of the BBB. Mech Dev. 2015;138(Pt 1):8-16. 26215350 10.1016/j.mod.2015.07.007
    • (2015) Mech Dev , vol.138 , pp. 8-16
    • Blanchette, M.1    Daneman, R.2
  • 94
    • 84927586383 scopus 로고    scopus 로고
    • The choroid plexus is modulated by various peripheral stimuli: implications to diseases of the central nervous system
    • 26236190, 4394702
    • Marques F Sousa JC: The choroid plexus is modulated by various peripheral stimuli: implications to diseases of the central nervous system. Front Cell Neurosci. 2015;9:136. 26236190 10.3389/fncel.2015.00136 4394702
    • (2015) Front Cell Neurosci , vol.9 , pp. 136
    • Marques, F.1    Sousa, J.C.2
  • 95
    • 61849149792 scopus 로고    scopus 로고
    • Review: Role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases
    • 19077110
    • Stolp HB Dziegielewska KM: Review: Role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases. Neuropathol Appl Neurobiol. 2009;35(2):132-146. 19077110 10.1111/j.1365-2990.2008.01005.x
    • (2009) Neuropathol Appl Neurobiol , vol.35 , Issue.2 , pp. 132-146
    • Stolp, H.B.1    Dziegielewska, K.M.2
  • 96
    • 9344226762 scopus 로고    scopus 로고
    • Molecular mechanisms of cerebrospinal fluid production
    • 15561411, 1890044
    • Brown PD Davies SL Speake T: Molecular mechanisms of cerebrospinal fluid production. Neuroscience. 2004;129(4):957-970. 15561411 10.1016/j.neuroscience.2004.07.003 1890044
    • (2004) Neuroscience , vol.129 , Issue.4 , pp. 957-970
    • Brown, P.D.1    Davies, S.L.2    Speake, T.3
  • 97
    • 0024498754 scopus 로고
    • 22Na transfer across the blood-brain and blood-CSF barriers
    • 2926388
    • Murphy VA Johanson CE: Acidosis, acetazolamide, and amiloride: effects on 22Na transfer across the blood-brain and blood-CSF barriers. J Neurochem. 1989;52(4):1058-1063. 2926388 10.1111/j.1471-4159.1989.tb01847.x
    • (1989) J Neurochem , vol.52 , Issue.4 , pp. 1058-1063
    • Murphy, V.A.1    Johanson, C.E.2
  • 98
    • 36048993018 scopus 로고    scopus 로고
    • +-dependent anion transporters in selected human tissues
    • 17715183
    • Damkier HH Nielsen S Praetorius J: Molecular expression of SLC4-derived Na +-dependent anion transporters in selected human tissues. Am J Physiol Regul Integr Comp Physiol. 2007;293(5):R2136-46. 17715183 10.1152/ajpregu.00356.2007
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.293 , Issue.5 , pp. R2136-R2146
    • Damkier, H.H.1    Nielsen, S.2    Praetorius, J.3
  • 99
    • 0022371023 scopus 로고
    • Choroid plexus Na+/K+-activated adenosine triphosphatase and cerebrospinal fluid formation
    • 2999636
    • Pollay M Hisey B Reynolds E: Choroid plexus Na+/K+-activated adenosine triphosphatase and cerebrospinal fluid formation. Neurosurgery. 1985;17(5):768-772. 2999636
    • (1985) Neurosurgery , vol.17 , Issue.5 , pp. 768-772
    • Pollay, M.1    Hisey, B.2    Reynolds, E.3
  • 100
    • 44949263894 scopus 로고    scopus 로고
    • Multiplicity of cerebrospinal fluid functions: New challenges in health and disease
    • 3rd, 18479516, 2412840
    • Johanson CE Duncan JA 3rd Klinge PM: Multiplicity of cerebrospinal fluid functions: New challenges in health and disease. Cerebrospinal Fluid Res. 2008;5:10. 18479516 10.1186/1743-8454-5-10 2412840
    • (2008) Cerebrospinal Fluid Res , vol.5 , pp. 10
    • Johanson, C.E.1    Duncan, J.A.2    Klinge, P.M.3
  • 101
    • 11244254968 scopus 로고    scopus 로고
    • Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1
    • 15533949
    • Oshio K Watanabe H Song Y: Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1. FASEB J. 2005;19(1):76-78. 15533949 10.1096/fj.04-1711fje
    • (2005) FASEB J , vol.19 , Issue.1 , pp. 76-78
    • Oshio, K.1    Watanabe, H.2    Song, Y.3
  • 102
    • 77956837672 scopus 로고    scopus 로고
    • Aquaporins: relevance to cerebrospinal fluid physiology and therapeutic potential in hydrocephalus
    • 20860832, 2949735
    • Owler BK Pitham T Wang D: Aquaporins: relevance to cerebrospinal fluid physiology and therapeutic potential in hydrocephalus. Cerebrospinal Fluid Res. 2010;7:15. 20860832 2949735
    • (2010) Cerebrospinal Fluid Res , vol.7 , pp. 15
    • Owler, B.K.1    Pitham, T.2    Wang, D.3
  • 103
    • 0016142989 scopus 로고
    • The ontogenetic development of concentration differences for protein and ions between plasma and cerebrospinal fluid in rabbits and rats
    • 4141371, 1330714
    • Amtorp O Sorensen SC: The ontogenetic development of concentration differences for protein and ions between plasma and cerebrospinal fluid in rabbits and rats. J Physiol. 1974;243(2):387-400. 4141371 10.1113/jphysiol.1974.sp010759 1330714
    • (1974) J Physiol , vol.243 , Issue.2 , pp. 387-400
    • Amtorp, O.1    Sorensen, S.C.2
  • 104
    • 0025441770 scopus 로고
    • Acetazolamide and insulin alter choroid plexus epithelial cell [Na+], pH, and volume
    • 2193541
    • Johanson CE Murphy VA: Acetazolamide and insulin alter choroid plexus epithelial cell [Na+], pH, and volume. Am J Physiol. 1990;258(6 Pt 2):F1538-46. 2193541
    • (1990) Am J Physiol , vol.258 , Issue.6 , pp. F1538-F1546
    • Johanson, C.E.1    Murphy, V.A.2
  • 105
    • 0015939506 scopus 로고
    • 14C)inulin after intrathecal infusion
    • 4739806
    • Bass NH Lundborg P: Postnatal development of bulk flow in the cerebrospinal fluid system of the albino rat: clearance of carboxyl-( 14C)inulin after intrathecal infusion. Brain Res. 1973;52:323-332. 4739806 10.1016/0006-8993(73)90668-9
    • (1973) Brain Res , vol.52 , pp. 323-332
    • Bass, N.H.1    Lundborg, P.2
  • 106
    • 0000248386 scopus 로고
    • Changes in CSF flow and extracellular space in the developing rat
    • Drugs and the developing brain., In "
    • Johanson CE Woodbury DM: Changes in CSF flow and extracellular space in the developing rat. In " Drugs and the developing brain." Vernadakis A, Weiner N, editors. New York: Plenum;1974;281-287. 10.1007/978-1-4684-3063-9_15
    • (1974) , pp. 281-287
    • Johanson, C.E.1    Woodbury, D.M.2
  • 107
    • 0017124544 scopus 로고
    • Developmental studies of the compartmentalization of water and electrolytes in the choroid plexus of the neonatal rat brain
    • 974769
    • Johanson CE Reed DJ Woodbury DM: Developmental studies of the compartmentalization of water and electrolytes in the choroid plexus of the neonatal rat brain. Brain Res. 1976;116(1):35-48. 974769 10.1016/0006-8993(76)90247-X
    • (1976) Brain Res , vol.116 , Issue.1 , pp. 35-48
    • Johanson, C.E.1    Reed, D.J.2    Woodbury, D.M.3
  • 108
    • 84868573143 scopus 로고    scopus 로고
    • Drug transport across the blood-brain barrier
    • 22929442, 3494002
    • Pardridge WM: Drug transport across the blood-brain barrier. J Cereb Blood Flow Metab. 2012;32(11):1959-1972. 22929442 10.1038/jcbfm.2012.126 3494002
    • (2012) J Cereb Blood Flow Metab , vol.32 , Issue.11 , pp. 1959-1972
    • Pardridge, W.M.1
  • 109
    • 84939948900 scopus 로고    scopus 로고
    • The physiological role of drug transporters
    • 25797421, 4417677
    • Liang Y Li S Chen L: The physiological role of drug transporters. Protein Cell. 2015;6(5):334-350. 25797421 10.1007/s13238-015-0148-2 4417677
    • (2015) Protein Cell , vol.6 , Issue.5 , pp. 334-350
    • Liang, Y.1    Li, S.2    Chen, L.3
  • 110
    • 12744253433 scopus 로고    scopus 로고
    • Modulation of p-glycoprotein transport function at the blood-brain barrier
    • 15673560
    • Bauer B Hartz AM Fricker G: Modulation of p-glycoprotein transport function at the blood-brain barrier. Exp Biol Med (Maywood). 2005;230(2):118-127. 15673560
    • (2005) Exp Biol Med (Maywood) , vol.230 , Issue.2 , pp. 118-127
    • Bauer, B.1    Hartz, A.M.2    Fricker, G.3
  • 111
    • 84892582274 scopus 로고    scopus 로고
    • Influence of neuropathology on convection-enhanced delivery in the rat hippocampus
    • 24260433, 3832660
    • Kantorovich S Astary GW King MA: Influence of neuropathology on convection-enhanced delivery in the rat hippocampus. PLoS One. 2013;8(11):e80606. 24260433 10.1371/journal.pone.0080606 3832660
    • (2013) PLoS One , vol.8 , Issue.11 , pp. e80606
    • Kantorovich, S.1    Astary, G.W.2    King, M.A.3
  • 112
    • 84877747508 scopus 로고    scopus 로고
    • Blood-brain barrier structure and function and the challenges for CNS drug delivery
    • 23609350
    • Abbott NJ: Blood-brain barrier structure and function and the challenges for CNS drug delivery. J Inherit Metab Dis. 2013;36(3):437-449. 23609350 10.1007/s10545-013-9608-0
    • (2013) J Inherit Metab Dis , vol.36 , Issue.3 , pp. 437-449
    • Abbott, N.J.1
  • 113
    • 84891878822 scopus 로고    scopus 로고
    • Novel siRNA delivery strategy: a new "strand" in CNS translational medicine?
    • 23508806
    • Gherardini L Bardi G Gennaro M: Novel siRNA delivery strategy: a new "strand" in CNS translational medicine? Cell Mol Life Sci. 2014;71(1):1-20. 23508806 10.1007/s00018-013-1310-8
    • (2014) Cell Mol Life Sci , vol.71 , Issue.1 , pp. 1-20
    • Gherardini, L.1    Bardi, G.2    Gennaro, M.3
  • 114
    • 3242758984 scopus 로고    scopus 로고
    • Blood-brain barrier opened by stimulation of the parasympathetic sphenopalatine ganglion: a new method for macromolecule delivery to the brain
    • 15309923
    • Yarnitsky D Gross Y Lorian A: Blood-brain barrier opened by stimulation of the parasympathetic sphenopalatine ganglion: a new method for macromolecule delivery to the brain. J Neurosurg. 2004;101(2):303-309. 15309923 10.3171/jns.2004.101.2.0303
    • (2004) J Neurosurg , vol.101 , Issue.2 , pp. 303-309
    • Yarnitsky, D.1    Gross, Y.2    Lorian, A.3
  • 115
    • 3342948514 scopus 로고    scopus 로고
    • Increased BBB permeability by parasympathetic sphenopalatine ganglion stimulation in dogs
    • 15276883
    • Yarnitsky D Gross Y Lorian A: Increased BBB permeability by parasympathetic sphenopalatine ganglion stimulation in dogs. Brain Res. 2004;1018(2):236-240. 15276883 10.1016/j.brainres.2004.05.103
    • (2004) Brain Res , vol.1018 , Issue.2 , pp. 236-240
    • Yarnitsky, D.1    Gross, Y.2    Lorian, A.3
  • 116
    • 0017693091 scopus 로고
    • An experimental permeabilization of the blood-brain barrier by electric field application
    • 902668
    • Dereymaeker A Gonsette R: An experimental permeabilization of the blood-brain barrier by electric field application. Eur Neurol. 1977;15(6):333-339. 902668 10.1159/000114822
    • (1977) Eur Neurol , vol.15 , Issue.6 , pp. 333-339
    • Dereymaeker, A.1    Gonsette, R.2
  • 117
    • 84865958935 scopus 로고    scopus 로고
    • Barrier mechanisms in the developing brain
    • 22479246, 3314990
    • Saunders NR Liddelow SA Dziegielewska KM: Barrier mechanisms in the developing brain. Front Pharmacol. 2012;3:46. 22479246 10.3389/fphar.2012.00046 3314990
    • (2012) Front Pharmacol , vol.3 , pp. 46
    • Saunders, N.R.1    Liddelow, S.A.2    Dziegielewska, K.M.3
  • 118
    • 0015494421 scopus 로고
    • Route of passive ion permeation in epithelia
    • 4502409
    • Frömter E Diamond J: Route of passive ion permeation in epithelia. Nat New Biol. 1972;235(53):9-13. 4502409 10.1038/newbio235009a0
    • (1972) Nat New Biol , vol.235 , Issue.53 , pp. 9-13
    • Frömter, E.1    Diamond, J.2
  • 119
    • 33645460483 scopus 로고    scopus 로고
    • Functional effectiveness of the blood-brain barrier to small water-soluble molecules in developing and adult opossum (Monodelphis domestica)
    • 16528724, 2634607
    • Ek CJ Dziegielewska KM Stolp H: Functional effectiveness of the blood-brain barrier to small water-soluble molecules in developing and adult opossum ( Monodelphis domestica). J Comp Neurol. 2006;496(1):13-26. 16528724 10.1002/cne.20885 2634607
    • (2006) J Comp Neurol , vol.496 , Issue.1 , pp. 13-26
    • Ek, C.J.1    Dziegielewska, K.M.2    Stolp, H.3
  • 120
    • 84922337429 scopus 로고    scopus 로고
    • Blood-brain barrier breakdown involves four distinct stages of vascular damage in various models of experimental focal cerebral ischemia
    • 25425076, 4426746
    • Krueger M Bechmann I Immig K: Blood-brain barrier breakdown involves four distinct stages of vascular damage in various models of experimental focal cerebral ischemia. J Cereb Blood Flow Metab. 2015;35(2):292-303. 25425076 10.1038/jcbfm.2014.199 4426746
    • (2015) J Cereb Blood Flow Metab , vol.35 , Issue.2 , pp. 292-303
    • Krueger, M.1    Bechmann, I.2    Immig, K.3
  • 121
    • 84899967644 scopus 로고    scopus 로고
    • Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke
    • 24746419, 4016169
    • Knowland D Arac A Sekiguchi KJ: Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke. Neuron. 2014;82(3):603-617. 24746419 10.1016/j.neuron.2014.03.003 4016169
    • (2014) Neuron , vol.82 , Issue.3 , pp. 603-617
    • Knowland, D.1    Arac, A.2    Sekiguchi, K.J.3
  • 122
    • 84930195020 scopus 로고    scopus 로고
    • Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview
    • 25632404, 4306190
    • Prasad S Sajja RK Naik P: Diabetes Mellitus and Blood-Brain Barrier Dysfunction: An Overview. J Pharmacovigil. 2014;2(2):125. 25632404 10.4172/2329-6887.1000125 4306190
    • (2014) J Pharmacovigil , vol.2 , Issue.2 , pp. 125
    • Prasad, S.1    Sajja, R.K.2    Naik, P.3
  • 123
    • 84954357440 scopus 로고    scopus 로고
    • Expression of ATP-Binding Cassette Transporters B1 and C1 after Severe Traumatic Brain Injury in Humans
    • 25891836, 4722575
    • Willyerd FA , Empey PE , Philbrick A: Expression of ATP-Binding Cassette Transporters B1 and C1 after Severe Traumatic Brain Injury in Humans. J Neurotrauma. 2016;33(2):226-231. 25891836 10.1089/neu.2015.3879 4722575
    • (2016) J Neurotrauma , vol.33 , Issue.2 , pp. 226-231
    • Willyerd, F.A.1    Empey, P.E.2    Philbrick, A.3
  • 124
    • 84946545976 scopus 로고    scopus 로고
    • Markers for blood-brain barrier integrity: how appropriate is Evans blue in the twenty-first century and what are the alternatives?
    • 26578854, 4624851
    • Saunders NR Dziegielewska KM Møllgård K: Markers for blood-brain barrier integrity: how appropriate is Evans blue in the twenty-first century and what are the alternatives? Front Neurosci. 2015;9:385. 26578854 10.3389/fnins.2015.00385 4624851
    • (2015) Front Neurosci , vol.9 , pp. 385
    • Saunders, N.R.1    Dziegielewska, K.M.2    Møllgård, K.3
  • 125
    • 84942410929 scopus 로고    scopus 로고
    • Implications of the discovery of brain lymphatic pathways
    • 26376966, 4655610
    • Iliff JJ Goldman SA Nedergaard M: Implications of the discovery of brain lymphatic pathways. Lancet Neurol. 2015;14(10):977-9. 26376966 10.1016/S1474-4422(15)00221-5 4655610
    • (2015) Lancet Neurol , vol.14 , Issue.10 , pp. 977-979
    • Iliff, J.J.1    Goldman, S.A.2    Nedergaard, M.3
  • 126
    • 84940489065 scopus 로고    scopus 로고
    • Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation
    • 26259873, 4530226, F1000 Recommendation
    • Korogod N Petersen CC Knott GW: Ultrastructural analysis of adult mouse neocortex comparing aldehyde perfusion with cryo fixation. eLife. 2015;4:e05793. 26259873 10.7554/eLife.05793 4530226 F1000 Recommendation
    • (2015) eLife , vol.4 , pp. e05793
    • Korogod, N.1    Petersen, C.C.2    Knott, G.W.3
  • 127
    • 45949107902 scopus 로고    scopus 로고
    • On the rate and extent of drug delivery to the brain
    • 18058202, 2469271, F1000 Recommendation
    • Hammarlund-Udenaes M Fridén M Syvänen S: On the rate and extent of drug delivery to the brain. Pharm Res. 2008;25(8):1737-1750. 18058202 10.1007/s11095-007-9502-2 2469271 F1000 Recommendation
    • (2008) Pharm Res , vol.25 , Issue.8 , pp. 1737-1750
    • Hammarlund-Udenaes, M.1    Fridén, M.2    Syvänen, S.3
  • 128
    • 0036349375 scopus 로고    scopus 로고
    • Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain
    • 12162757
    • de Lange EC Danhof M: Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain. Clin Pharmacokinet. 2002;41(10):691-703. 12162757 10.2165/00003088-200241100-00001
    • (2002) Clin Pharmacokinet , vol.41 , Issue.10 , pp. 691-703
    • de Lange, E.C.1    Danhof, M.2
  • 129
    • 84936871460 scopus 로고    scopus 로고
    • Structural and functional features of central nervous system lymphatic vessels
    • 26030524, 4506234
    • Louveau A Smirnov I Keyes TJ: Structural and functional features of central nervous system lymphatic vessels. Nature. 2015;523(7560):337-341. 26030524 10.1038/nature14432 4506234
    • (2015) Nature , vol.523 , Issue.7560 , pp. 337-341
    • Louveau, A.1    Smirnov, I.2    Keyes, T.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.