메뉴 건너뛰기




Volumn 8, Issue DEC, 2014, Pages

Barrier mechanisms in the Drosophila blood-brain barrier

Author keywords

Blood brain barrier; Chemoprotection; Conserved physiology; Drug delivery; Invertebrates

Indexed keywords

ABC TRANSPORTER; DENDRIMER; G PROTEIN COUPLED RECEPTOR; GLYCOPROTEIN P INHIBITOR; INSULIN; NEUREXIN; NEUREXIN IV; ORGANIC ANION TRANSPORTER; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

EID: 84920598380     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2014.00414     Document Type: Review
Times cited : (93)

References (87)
  • 1
    • 17644364388 scopus 로고    scopus 로고
    • Dynamics of CNS barriers: evolution, differentiation, and modulation
    • Abbott, N. J. (2005). Dynamics of CNS barriers: evolution, differentiation, and modulation. Cell. Mol. Neurobiol. 25, 5-23. doi: 10.1007/s10571-004-1374-y
    • (2005) Cell. Mol. Neurobiol , vol.25 , pp. 5-23
    • Abbott, N.J.1
  • 2
    • 84877747508 scopus 로고    scopus 로고
    • Blood-brain barrier structure and function and the challenges for CNS drug delivery
    • Abbott, N. J. (2013). Blood-brain barrier structure and function and the challenges for CNS drug delivery. J. Inherit. Metab. Dis. 36, 437-449. doi: 10.1007/s10545-013-9608-0
    • (2013) J. Inherit. Metab. Dis , vol.36 , pp. 437-449
    • Abbott, N.J.1
  • 4
    • 0030099527 scopus 로고    scopus 로고
    • Transporting therapeutics across the blood-brain barrier
    • Abbott, N. J., and Romero, I. A. (1996). Transporting therapeutics across the blood-brain barrier. Mol. Med. Today 2, 106-113. doi: 10.1016/1357-4310(96)88720-X
    • (1996) Mol. Med. Today , vol.2 , pp. 106-113
    • Abbott, N.J.1    Romero, I.A.2
  • 5
    • 78651253877 scopus 로고    scopus 로고
    • Hijacking solute carriers for proton-coupled drug transport
    • Anderson, C. M., and Thwaites, D. T. (2010). Hijacking solute carriers for proton-coupled drug transport. Physiology (Bethesda) 25, 364-377. doi: 10.1152/physiol.00027.2010
    • (2010) Physiology (Bethesda) , vol.25 , pp. 364-377
    • Anderson, C.M.1    Thwaites, D.T.2
  • 7
    • 0029055716 scopus 로고
    • Gliotactin, a novel transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in Drosophila
    • Auld, V. J., Fetter, R. D., Broadie, K., and Goodman, C. S. (1995). Gliotactin, a novel transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in Drosophila. Cell 81, 757-767. doi: 10.1016/0092-8674(95)90537-5
    • (1995) Cell , vol.81 , pp. 757-767
    • Auld, V.J.1    Fetter, R.D.2    Broadie, K.3    Goodman, C.S.4
  • 8
    • 26244436194 scopus 로고    scopus 로고
    • moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila
    • Bainton, R. J., Tsai, L. T., Schwabe, T., DeSalvo, M., Gaul, U., and Heberlein, U. (2005). moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila. Cell 123, 145-156. doi: 10.1016/j.cell.2005.07.029
    • (2005) Cell , vol.123 , pp. 145-156
    • Bainton, R.J.1    Tsai, L.T.2    Schwabe, T.3    DeSalvo, M.4    Gaul, U.5    Heberlein, U.6
  • 9
    • 0030582713 scopus 로고    scopus 로고
    • A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function
    • Baumgartner, S., Littleton, J. T., Broadie, K., Bhat, M. A., Harbecke, R., Lengyel, J. A., et al. (1996). A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function. Cell 87, 1059-1068. doi: 10.1016/S0092-8674(00)81800-0
    • (1996) Cell , vol.87 , pp. 1059-1068
    • Baumgartner, S.1    Littleton, J.T.2    Broadie, K.3    Bhat, M.A.4    Harbecke, R.5    Lengyel, J.A.6
  • 10
    • 0141920729 scopus 로고    scopus 로고
    • The claudin-like megatrachea is essential in septate junctions for the epithelial barrier function in Drosophila
    • Behr, M., Riedel, D., and Schuh, R. (2003). The claudin-like megatrachea is essential in septate junctions for the epithelial barrier function in Drosophila. Dev. Cell 5, 611-620. doi: 10.1016/S1534-5807(03)00275-2
    • (2003) Dev. Cell , vol.5 , pp. 611-620
    • Behr, M.1    Riedel, D.2    Schuh, R.3
  • 11
    • 0242487890 scopus 로고    scopus 로고
    • Molecular organization of axo-glial junctions
    • Bhat, M. A. (2003). Molecular organization of axo-glial junctions. Curr. Opin. Neurobiol. 13, 552-559. doi: 10.1016/j.conb.2003.09.004
    • (2003) Curr. Opin. Neurobiol , vol.13 , pp. 552-559
    • Bhat, M.A.1
  • 12
    • 0034983566 scopus 로고    scopus 로고
    • Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin
    • Bhat, M. A., Rios, J. C., Lu, Y., Garcia-Fresco, G. P., Ching, W., St Martin, M., et al. (2001). Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin. Neuron 30, 369-383. doi: 10.1016/S0896-6273(01)00294-X
    • (2001) Neuron , vol.30 , pp. 369-383
    • Bhat, M.A.1    Rios, J.C.2    Lu, Y.3    Garcia-Fresco, G.P.4    Ching, W.5    St Martin, M.6
  • 13
    • 67650487534 scopus 로고    scopus 로고
    • Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination
    • Bolis, A., Coviello, S., Visigalli, I., Taveggia, C., Bachi, A., Chishti, A. H., et al. (2009). Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination. J. Neurosci. 29, 8858-8870. doi: 10.1523/JNEUROSCI.1423-09.2009
    • (2009) J. Neurosci , vol.29 , pp. 8858-8870
    • Bolis, A.1    Coviello, S.2    Visigalli, I.3    Taveggia, C.4    Bachi, A.5    Chishti, A.H.6
  • 14
    • 84920575436 scopus 로고    scopus 로고
    • Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic insulin signaling
    • Brankatschk, M., Dunst, S., Nemetschke, L., and Eaton, S. (2014). Delivery of circulating lipoproteins to specific neurons in the Drosophila brain regulates systemic insulin signaling. Elife 3:e02862. doi: 10.7554/eLife.02862
    • (2014) Elife , vol.3
    • Brankatschk, M.1    Dunst, S.2    Nemetschke, L.3    Eaton, S.4
  • 15
    • 77955382127 scopus 로고    scopus 로고
    • Lipoprotein particles cross the blood-brain barrier in Drosophila
    • Brankatschk, M., and Eaton, S. (2010). Lipoprotein particles cross the blood-brain barrier in Drosophila. J. Neurosci. 30, 10441-10447. doi: 10.1523/JNEUROSCI.5943-09.2010
    • (2010) J. Neurosci , vol.30 , pp. 10441-10447
    • Brankatschk, M.1    Eaton, S.2
  • 16
    • 0014481056 scopus 로고
    • Junctions between intimately apposed cell membranes in the vertebrate brain
    • Brightman, M. W., and Reese, T. S. (1969). Junctions between intimately apposed cell membranes in the vertebrate brain. J. Cell Biol. 40, 648-677. doi: 10.1083/jcb.40.3.648
    • (1969) J. Cell Biol , vol.40 , pp. 648-677
    • Brightman, M.W.1    Reese, T.S.2
  • 18
    • 37549061456 scopus 로고    scopus 로고
    • A genomic comparison of in vivo and in vitro brain microvascular endothelial cells
    • Calabria, A. R., and Shusta, E. V. (2008). A genomic comparison of in vivo and in vitro brain microvascular endothelial cells. J. Cereb. Blood Flow Metab. 28, 135-148. doi: 10.1038/sj.jcbfm.9600518
    • (2008) J. Cereb. Blood Flow Metab , vol.28 , pp. 135-148
    • Calabria, A.R.1    Shusta, E.V.2
  • 19
    • 78650503295 scopus 로고    scopus 로고
    • Nutrition-responsive glia control exit of neural stem cells from quiescence
    • Chell, J. M., and Brand, A. H. (2010). Nutrition-responsive glia control exit of neural stem cells from quiescence. Cell 143, 1161-1173. doi: 10.1016/j.cell.2010.12.007
    • (2010) Cell , vol.143 , pp. 1161-1173
    • Chell, J.M.1    Brand, A.H.2
  • 20
    • 58849119932 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis
    • Daneman, R., Agalliu, D., Zhou, L., Kuhnert, F., Kuo, C. J., and Barres, B. A. (2009). Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis. Proc. Natl. Acad. Sci. U.S.A. 106, 641-646. doi: 10.1073/pnas.0805165106
    • (2009) Proc. Natl. Acad. Sci. U.S.A , vol.106 , pp. 641-646
    • Daneman, R.1    Agalliu, D.2    Zhou, L.3    Kuhnert, F.4    Kuo, C.J.5    Barres, B.A.6
  • 21
    • 78149456928 scopus 로고    scopus 로고
    • The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells
    • Daneman, R., Zhou, L., Agalliu, D., Cahoy, J. D., Kaushal, A., and Barres, B. A. (2010). The mouse blood-brain barrier transcriptome: a new resource for understanding the development and function of brain endothelial cells. PLoS ONE 5:e13741. doi: 10.1371/journal.pone.0013741
    • (2010) PLoS ONE , vol.5
    • Daneman, R.1    Zhou, L.2    Agalliu, D.3    Cahoy, J.D.4    Kaushal, A.5    Barres, B.A.6
  • 22
    • 84909587002 scopus 로고    scopus 로고
    • The Drosophila surface glia transcriptome: evolutionary conserved blood-brain barrier processes
    • DeSalvo, M. K., Hindle, S. J., Rusan, Z. M., Orng, S., Eddison, M., Halliwell, K., et al. (2014). The Drosophila surface glia transcriptome: evolutionary conserved blood-brain barrier processes. Front. Neurosci. 8:346. doi: 10.3389/fnins.2014.00346
    • (2014) Front. Neurosci , vol.8 , pp. 346
    • DeSalvo, M.K.1    Hindle, S.J.2    Rusan, Z.M.3    Orng, S.4    Eddison, M.5    Halliwell, K.6
  • 23
    • 79959952037 scopus 로고    scopus 로고
    • Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila
    • DeSalvo, M. K., Mayer, N., Mayer, F., and Bainton, R. J. (2011). Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila. Glia 59, 1322-1340. doi: 10.1002/glia.21147
    • (2011) Glia , vol.59 , pp. 1322-1340
    • DeSalvo, M.K.1    Mayer, N.2    Mayer, F.3    Bainton, R.J.4
  • 24
    • 77950857749 scopus 로고    scopus 로고
    • The functional organisation of glia in the adult brain of Drosophila and other insects
    • Edwards, T. N., and Meinertzhagen, I. A. (2010). The functional organisation of glia in the adult brain of Drosophila and other insects. Prog. Neurobiol. 90, 471-497. doi: 10.1016/j.pneurobio.2010.01.001
    • (2010) Prog. Neurobiol , vol.90 , pp. 471-497
    • Edwards, T.N.1    Meinertzhagen, I.A.2
  • 25
    • 0142074397 scopus 로고    scopus 로고
    • The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning
    • Escalante-Alcalde, D., Hernandez, L., Le Stunff, H., Maeda, R., Lee, H. S., Gang, C. Jr., et al. (2003). The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning. Development 130, 4623-4637. doi: 10.1242/dev.00635
    • (2003) Development , vol.130 , pp. 4623-4637
    • Escalante-Alcalde, D.1    Hernandez, L.2    Le Stunff, H.3    Maeda, R.4    Lee, H.S.5    Gang Jr., C.6
  • 26
    • 8444247453 scopus 로고    scopus 로고
    • Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier function
    • Faivre-Sarrailh, C., Banerjee, S., Li, J., Hortsch, M., Laval, M., and Bhat, M. A. (2004). Drosophila contactin, a homolog of vertebrate contactin, is required for septate junction organization and paracellular barrier function. Development 131, 4931-4942. doi: 10.1242/dev.01372
    • (2004) Development , vol.131 , pp. 4931-4942
    • Faivre-Sarrailh, C.1    Banerjee, S.2    Li, J.3    Hortsch, M.4    Laval, M.5    Bhat, M.A.6
  • 27
    • 79960004981 scopus 로고    scopus 로고
    • Glial solute carrier transporters in Drosophila and mice
    • Featherstone, D. E. (2011). Glial solute carrier transporters in Drosophila and mice. Glia 59, 1351-1363. doi: 10.1002/glia.21085
    • (2011) Glia , vol.59 , pp. 1351-1363
    • Featherstone, D.E.1
  • 28
    • 0028325048 scopus 로고
    • A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene
    • Fehon, R. G., Dawson, I. A., and Artavanis-Tsakonas, S. (1994). A Drosophila homologue of membrane-skeleton protein 4.1 is associated with septate junctions and is encoded by the coracle gene. Development 120, 545-557.
    • (1994) Development , vol.120 , pp. 545-557
    • Fehon, R.G.1    Dawson, I.A.2    Artavanis-Tsakonas, S.3
  • 29
    • 69149110896 scopus 로고    scopus 로고
    • Remote control of insulin secretion by fat cells in Drosophila
    • Geminard, C., Rulifson, E. J., and Leopold, P. (2009). Remote control of insulin secretion by fat cells in Drosophila. Cell Metab. 10, 199-207. doi: 10.1016/j.cmet.2009.08.002
    • (2009) Cell Metab , vol.10 , pp. 199-207
    • Geminard, C.1    Rulifson, E.J.2    Leopold, P.3
  • 30
    • 0038457822 scopus 로고    scopus 로고
    • Neuroglian, Gliotactin, and the Na+/K+ ATPase are essential for septate junction function in Drosophila
    • Genova, J. L., and Fehon, R. G. (2003). Neuroglian, Gliotactin, and the Na+/K+ ATPase are essential for septate junction function in Drosophila. J. Cell Biol. 161, 979-989. doi: 10.1083/jcb.200212054
    • (2003) J. Cell Biol , vol.161 , pp. 979-989
    • Genova, J.L.1    Fehon, R.G.2
  • 31
    • 78951491636 scopus 로고    scopus 로고
    • The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structures
    • Hatan, M., Shinder, V., Israeli, D., Schnorrer, F., and Volk, T. (2011). The Drosophila blood brain barrier is maintained by GPCR-dependent dynamic actin structures. J. Cell Biol. 192, 307-319. doi: 10.1083/jcb.201007095
    • (2011) J. Cell Biol , vol.192 , pp. 307-319
    • Hatan, M.1    Shinder, V.2    Israeli, D.3    Schnorrer, F.4    Volk, T.5
  • 32
    • 1242340323 scopus 로고    scopus 로고
    • The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction
    • Hediger, M. A., Romero, M. F., Peng, J. B., Rolfs, A., Takanaga, H., and Bruford, E. A. (2004). The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction. Pflugers Arch. 447, 465-468. doi: 10.1007/s00424-003-1192-y
    • (2004) Pflugers Arch , vol.447 , pp. 465-468
    • Hediger, M.A.1    Romero, M.F.2    Peng, J.B.3    Rolfs, A.4    Takanaga, H.5    Bruford, E.A.6
  • 33
    • 79952650312 scopus 로고    scopus 로고
    • The Ly6 protein coiled is required for septate junction and blood brain barrier organisation in Drosophila
    • Hijazi, A., Haenlin, M., Waltzer, L., and Roch, F. (2011). The Ly6 protein coiled is required for septate junction and blood brain barrier organisation in Drosophila. PLoS ONE 6:e17763. doi: 10.1371/journal.pone.0017763
    • (2011) PLoS ONE , vol.6
    • Hijazi, A.1    Haenlin, M.2    Waltzer, L.3    Roch, F.4
  • 34
    • 84873494782 scopus 로고    scopus 로고
    • Sex-specific signaling in the blood-brain barrier is required for male courtship in Drosophila
    • Hoxha, V., Lama, C., Chang, P. L., Saurabh, S., Patel, N., Olate, N., et al. (2013). Sex-specific signaling in the blood-brain barrier is required for male courtship in Drosophila. PLoS Genet. 9:e1003217. doi: 10.1371/journal.pgen.1003217
    • (2013) PLoS Genet , vol.9
    • Hoxha, V.1    Lama, C.2    Chang, P.L.3    Saurabh, S.4    Patel, N.5    Olate, N.6
  • 35
    • 84863114688 scopus 로고    scopus 로고
    • Wunen, a Drosophila lipid phosphate phosphatase, is required for septate junction-mediated barrier function
    • Ile, K. E., Tripathy, R., Goldfinger, V., and Renault, A. D. (2012). Wunen, a Drosophila lipid phosphate phosphatase, is required for septate junction-mediated barrier function. Development 139, 2535-2546. doi: 10.1242/dev.077289
    • (2012) Development , vol.139 , pp. 2535-2546
    • Ile, K.E.1    Tripathy, R.2    Goldfinger, V.3    Renault, A.D.4
  • 36
    • 84879415192 scopus 로고    scopus 로고
    • Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position
    • Kalvass, J. C., Polli, J. W., Bourdet, D. L., Feng, B., Huang, S. M., Liu, X., et al. (2013). Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position. Clin. Pharmacol. Ther. 94, 80-94. doi: 10.1038/clpt.2013.34
    • (2013) Clin. Pharmacol. Ther , vol.94 , pp. 80-94
    • Kalvass, J.C.1    Polli, J.W.2    Bourdet, D.L.3    Feng, B.4    Huang, S.M.5    Liu, X.6
  • 37
    • 80052280058 scopus 로고    scopus 로고
    • Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on ADME properties (vol 6, pg 1063, 2011)
    • Kaminskas, L. M., Boyd, B. J., and Porter, C. J. H. (2012). Dendrimer pharmacokinetics: the effect of size, structure and surface characteristics on ADME properties (vol 6, pg 1063, 2011). Nanomedicine 7, 167-168. doi: 10.2217/nnm.11.67
    • (2012) Nanomedicine , vol.7 , pp. 167-168
    • Kaminskas, L.M.1    Boyd, B.J.2    Porter, C.J.H.3
  • 39
    • 84893653202 scopus 로고    scopus 로고
    • Dendrimer as nanocarrier for drug delivery
    • Kesharwani, P., Jain, K., and Jain, N. K. (2014). Dendrimer as nanocarrier for drug delivery. Prog. Polymer Sci. 39, 268-307. doi: 10.1016/j.progpolymsci.2013.07.005
    • (2014) Prog. Polymer Sci , vol.39 , pp. 268-307
    • Kesharwani, P.1    Jain, K.2    Jain, N.K.3
  • 40
    • 77953535866 scopus 로고    scopus 로고
    • Blood-brain barrier defects associated with Rbp9 mutation
    • Kim, J., Kim, Y. J., and Kim-Ha, J. (2010). Blood-brain barrier defects associated with Rbp9 mutation. Mol Cells 29, 93-98. doi: 10.1007/s10059-010-0040-0
    • (2010) Mol Cells , vol.29 , pp. 93-98
    • Kim, J.1    Kim, Y.J.2    Kim-Ha, J.3
  • 41
    • 0032941285 scopus 로고    scopus 로고
    • Requirement of RBP9, a Drosophila Hu homolog, for regulation of cystocyte differentiation and oocyte determination during oogenesis
    • Kim-Ha, J., Kim, J., and Kim, Y. J. (1999). Requirement of RBP9, a Drosophila Hu homolog, for regulation of cystocyte differentiation and oocyte determination during oogenesis. Mol. Cell. Biol. 19, 2505-2514.
    • (1999) Mol. Cell. Biol , vol.19 , pp. 2505-2514
    • Kim-Ha, J.1    Kim, J.2    Kim, Y.J.3
  • 42
    • 78650226814 scopus 로고    scopus 로고
    • Potassium fluxes across the blood brain barrier of the cockroach, Periplaneta americana
    • Kocmarek, A. L., and O'Donnell, M. J. (2011). Potassium fluxes across the blood brain barrier of the cockroach, Periplaneta americana. J. Insect Physiol. 57, 127-135. doi: 10.1016/j.jinsphys.2010.09.011
    • (2011) J. Insect Physiol , vol.57 , pp. 127-135
    • Kocmarek, A.L.1    O'Donnell, M.J.2
  • 43
    • 12344261030 scopus 로고    scopus 로고
    • Active efflux across the blood-brain barrier: role of the solute carrier family
    • Kusuhara, H., and Sugiyama, Y. (2005). Active efflux across the blood-brain barrier: role of the solute carrier family. NeuroRx 2, 73-85. doi: 10.1602/neurorx.2.1.73
    • (2005) NeuroRx , vol.2 , pp. 73-85
    • Kusuhara, H.1    Sugiyama, Y.2
  • 44
    • 33846481841 scopus 로고    scopus 로고
    • A role for the adult fat body in Drosophila male courtship behavior
    • Lazareva, A. A., Roman, G., Mattox, W., Hardin, P. E., and Dauwalder, B. (2007). A role for the adult fat body in Drosophila male courtship behavior. PLoS Genet. 3:e16. doi: 10.1371/journal.pgen.0030016
    • (2007) PLoS Genet , vol.3
    • Lazareva, A.A.1    Roman, G.2    Mattox, W.3    Hardin, P.E.4    Dauwalder, B.5
  • 45
    • 33749350938 scopus 로고    scopus 로고
    • Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity
    • Lee, J. F., Zeng, Q., Ozaki, H., Wang, L., Hand, A. R., Hla, T., et al. (2006). Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. J. Biol. Chem. 281, 29190-29200. doi: 10.1074/jbc. M604310200
    • (2006) J. Biol. Chem , vol.281 , pp. 29190-29200
    • Lee, J.F.1    Zeng, Q.2    Ozaki, H.3    Wang, L.4    Hand, A.R.5    Hla, T.6
  • 46
    • 78650241441 scopus 로고    scopus 로고
    • Drosophila glia use a conserved cotransporter mechanism to regulate extracellular volume
    • Leiserson, W. M., Forbush, B., and Keshishian, H. (2011). Drosophila glia use a conserved cotransporter mechanism to regulate extracellular volume. Glia 59, 320-332. doi: 10.1002/glia.21103
    • (2011) Glia , vol.59 , pp. 320-332
    • Leiserson, W.M.1    Forbush, B.2    Keshishian, H.3
  • 47
    • 17544368685 scopus 로고    scopus 로고
    • Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
    • Leslie, E. M., Deeley, R. G., and Cole, S. P. (2005). Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol. Appl. Pharmacol. 204, 216-237. doi: 10.1016/j.taap.2004.10.012
    • (2005) Toxicol. Appl. Pharmacol , vol.204 , pp. 216-237
    • Leslie, E.M.1    Deeley, R.G.2    Cole, S.P.3
  • 48
    • 23044500398 scopus 로고    scopus 로고
    • Drug resistance in brain diseases and the role of drug efflux transporters
    • Loscher, W., and Potschka, H. (2005). Drug resistance in brain diseases and the role of drug efflux transporters. Nat. Rev. Neurosci. 6, 591-602. doi: 10.1038/nrn1728
    • (2005) Nat. Rev. Neurosci , vol.6 , pp. 591-602
    • Loscher, W.1    Potschka, H.2
  • 49
    • 63849265463 scopus 로고    scopus 로고
    • Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila
    • Mayer, F., Mayer, N., Chinn, L., Pinsonneault, R. L., Kroetz, D., and Bainton, R. J. (2009). Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. J. Neurosci. 29, 3538-3550. doi: 10.1523/JNEUROSCI.5564-08.2009
    • (2009) J. Neurosci , vol.29 , pp. 3538-3550
    • Mayer, F.1    Mayer, N.2    Chinn, L.3    Pinsonneault, R.L.4    Kroetz, D.5    Bainton, R.J.6
  • 50
    • 84908153450 scopus 로고    scopus 로고
    • Glia ECM interactions are required to shape the Drosophila nervous system
    • Meyer, S., Schmidt, I., and Klambt, C. (2014). Glia ECM interactions are required to shape the Drosophila nervous system. Mech. Dev. 133C, 105-116. doi: 10.1016/j.mod.2014.05.003
    • (2014) Mech. Dev , vol.133 C , pp. 105-116
    • Meyer, S.1    Schmidt, I.2    Klambt, C.3
  • 51
    • 77953687856 scopus 로고    scopus 로고
    • Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier
    • Miller, D. S. (2010). Regulation of P-glycoprotein and other ABC drug transporters at the blood-brain barrier. Trends Pharmacol. Sci. 31, 246-254. doi: 10.1016/j.tips.2010.03.003
    • (2010) Trends Pharmacol. Sci , vol.31 , pp. 246-254
    • Miller, D.S.1
  • 52
    • 0023835676 scopus 로고
    • De novo expression of a type IV collagen gene in Drosophila embryos is restricted to mesodermal derivatives and occurs at germ band shortening
    • Mirre, C., Cecchini, J. P., Le Parco, Y., and Knibiehler, B. (1988). De novo expression of a type IV collagen gene in Drosophila embryos is restricted to mesodermal derivatives and occurs at germ band shortening. Development 102, 369-376.
    • (1988) Development , vol.102 , pp. 369-376
    • Mirre, C.1    Cecchini, J.P.2    Le Parco, Y.3    Knibiehler, B.4
  • 53
    • 84870236928 scopus 로고    scopus 로고
    • Integrating body and organ size in Drosophila: recent advances and outstanding problems
    • Mirth, C. K., and Shingleton, A. W. (2012). Integrating body and organ size in Drosophila: recent advances and outstanding problems. Front. Endocrinol. (Lausanne) 3:49. doi: 10.3389/fendo.2012.00049
    • (2012) Front. Endocrinol. (Lausanne) , vol.3 , pp. 49
    • Mirth, C.K.1    Shingleton, A.W.2
  • 54
    • 27844597210 scopus 로고
    • Quintuple-layered membrane junctions at terminal bars between endothelial cells
    • Muir, A. R., and Peters, A. (1962). Quintuple-layered membrane junctions at terminal bars between endothelial cells. J. Cell Biol. 12, 443-448. doi: 10.1083/jcb.12.2.443
    • (1962) J. Cell Biol , vol.12 , pp. 443-448
    • Muir, A.R.1    Peters, A.2
  • 55
    • 84884548805 scopus 로고    scopus 로고
    • Factors that regulate insulin producing cells and their output in Drosophila
    • Nassel, D. R., Kubrak, O. I., Liu, Y., Luo, J., and Lushchak, O. V. (2013). Factors that regulate insulin producing cells and their output in Drosophila. Front. Physiol. 4:252. doi: 10.3389/fphys.2013.00252
    • (2013) Front. Physiol , vol.4 , pp. 252
    • Nassel, D.R.1    Kubrak, O.I.2    Liu, Y.3    Luo, J.4    Lushchak, O.V.5
  • 56
    • 77956134851 scopus 로고    scopus 로고
    • The Drosophila Claudin Kune-kune is required for septate junction organization and tracheal tube size control
    • Nelson, K. S., Furuse, M., and Beitel, G. J. (2010). The Drosophila Claudin Kune-kune is required for septate junction organization and tracheal tube size control. Genetics 185, 831-839. doi: 10.1534/genetics.110.114959
    • (2010) Genetics , vol.185 , pp. 831-839
    • Nelson, K.S.1    Furuse, M.2    Beitel, G.J.3
  • 58
    • 84889872057 scopus 로고    scopus 로고
    • Development, maintenance and disruption of the blood-brain barrier
    • Obermeier, B., Daneman, R., and Ransohoff, R. M. (2013). Development, maintenance and disruption of the blood-brain barrier. Nat. Med. 19, 1584-1596. doi: 10.1038/nm.3407
    • (2013) Nat. Med , vol.19 , pp. 1584-1596
    • Obermeier, B.1    Daneman, R.2    Ransohoff, R.M.3
  • 59
    • 84872309064 scopus 로고    scopus 로고
    • A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila
    • Okamoto, N., Nakamori, R., Murai, T., Yamauchi, Y., Masuda, A., and Nishimura, T. (2013). A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila. Genes Dev. 27, 87-97. doi: 10.1101/gad.204479.112
    • (2013) Genes Dev , vol.27 , pp. 87-97
    • Okamoto, N.1    Nakamori, R.2    Murai, T.3    Yamauchi, Y.4    Masuda, A.5    Nishimura, T.6
  • 60
    • 13544266336 scopus 로고    scopus 로고
    • Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity
    • Olofsson, B., and Page, D. T. (2005). Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity. Dev. Biol. 279, 233-243. doi: 10.1016/j.ydbio.2004.12.020
    • (2005) Dev. Biol , vol.279 , pp. 233-243
    • Olofsson, B.1    Page, D.T.2
  • 61
    • 79961157853 scopus 로고    scopus 로고
    • Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs large
    • Oshima, K., and Fehon, R. G. (2011). Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs large. J. Cell Sci. 124, 2861-2871. doi: 10.1242/jcs.087700
    • (2011) J. Cell Sci , vol.124 , pp. 2861-2871
    • Oshima, K.1    Fehon, R.G.2
  • 62
    • 79954628932 scopus 로고    scopus 로고
    • Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network
    • Partridge, L., Alic, N., Bjedov, I., and Piper, M. D. (2011). Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network. Exp. Gerontol. 46, 376-381. doi: 10.1016/j.exger.2010.09.003
    • (2011) Exp. Gerontol , vol.46 , pp. 376-381
    • Partridge, L.1    Alic, N.2    Bjedov, I.3    Piper, M.D.4
  • 63
    • 79961238713 scopus 로고    scopus 로고
    • Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan
    • Pastor-Pareja, J. C., and Xu, T. (2011). Shaping cells and organs in Drosophila by opposing roles of fat body-secreted Collagen IV and perlecan. Dev. Cell 21, 245-256. doi: 10.1016/j.devcel.2011.06.026
    • (2011) Dev. Cell , vol.21 , pp. 245-256
    • Pastor-Pareja, J.C.1    Xu, T.2
  • 64
    • 0141891960 scopus 로고    scopus 로고
    • The Na+/K+ ATPase is required for septate junction function and epithelial tube-size control in the Drosophila tracheal system
    • Paul, S. M., Ternet, M., Salvaterra, P. M., and Beitel, G. J. (2003). The Na+/K+ ATPase is required for septate junction function and epithelial tube-size control in the Drosophila tracheal system. Development 130, 4963-4974. doi: 10.1242/dev.00691
    • (2003) Development , vol.130 , pp. 4963-4974
    • Paul, S.M.1    Ternet, M.2    Salvaterra, P.M.3    Beitel, G.J.4
  • 65
    • 84866978180 scopus 로고    scopus 로고
    • Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion
    • Rajan, A., and Perrimon, N. (2012). Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. Cell 151, 123-137. doi: 10.1016/j.cell.2012.08.019
    • (2012) Cell , vol.151 , pp. 123-137
    • Rajan, A.1    Perrimon, N.2
  • 66
    • 0014109002 scopus 로고
    • Fine structural localization of a blood-brain barrier to exogenous peroxidase
    • Reese, T. S., and Karnovsky, M. J. (1967). Fine structural localization of a blood-brain barrier to exogenous peroxidase. J. Cell Biol. 34, 207-217. doi: 10.1083/jcb.34.1.207
    • (1967) J. Cell Biol , vol.34 , pp. 207-217
    • Reese, T.S.1    Karnovsky, M.J.2
  • 67
    • 84859876858 scopus 로고    scopus 로고
    • The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity
    • Rodrigues, F., Thuma, L., and Klambt, C. (2012). The regulation of glial-specific splicing of Neurexin IV requires HOW and Cdk12 activity. Development 139, 1765-1776. doi: 10.1242/dev.074070
    • (2012) Development , vol.139 , pp. 1765-1776
    • Rodrigues, F.1    Thuma, L.2    Klambt, C.3
  • 69
    • 84861650766 scopus 로고    scopus 로고
    • Kinesin heavy chain function in Drosophila glial cells controls neuronal activity
    • Schmidt, I., Thomas, S., Kain, P., Risse, B., Naffin, E., and Klambt, C. (2012). Kinesin heavy chain function in Drosophila glial cells controls neuronal activity. J. Neurosci. 32, 7466-7476. doi: 10.1523/JNEUROSCI.0349-12.2012
    • (2012) J. Neurosci , vol.32 , pp. 7466-7476
    • Schmidt, I.1    Thomas, S.2    Kain, P.3    Risse, B.4    Naffin, E.5    Klambt, C.6
  • 70
    • 0038118551 scopus 로고    scopus 로고
    • Gliotactin, a novel marker of tricellular junctions, is necessary for septate junction development in Drosophila
    • Schulte, J., Tepass, U., and Auld, V. J. (2003). Gliotactin, a novel marker of tricellular junctions, is necessary for septate junction development in Drosophila. J. Cell Biol. 161, 991-1000. doi: 10.1083/jcb.200303192
    • (2003) J. Cell Biol , vol.161 , pp. 991-1000
    • Schulte, J.1    Tepass, U.2    Auld, V.J.3
  • 71
    • 26244452168 scopus 로고    scopus 로고
    • GPCR signaling is required for blood-brain barrier formation in drosophila
    • Schwabe, T., Bainton, R. J., Fetter, R. D., Heberlein, U., and Gaul, U. (2005). GPCR signaling is required for blood-brain barrier formation in drosophila. Cell 123, 133-144. doi: 10.1016/j.cell.2005.08.037
    • (2005) Cell , vol.123 , pp. 133-144
    • Schwabe, T.1    Bainton, R.J.2    Fetter, R.D.3    Heberlein, U.4    Gaul, U.5
  • 72
    • 84883440422 scopus 로고    scopus 로고
    • Oatp58Dc contributes to blood-brain barrier function by excluding organic anions from the Drosophila brain
    • Seabrooke, S., and O'Donnell, M. J. (2013). Oatp58Dc contributes to blood-brain barrier function by excluding organic anions from the Drosophila brain. Am. J. Physiol. Cell Physiol. 305, C558-C567. doi: 10.1152/ajpcell.00408.2012
    • (2013) Am. J. Physiol. Cell Physiol , vol.305 , pp. C558-C567
    • Seabrooke, S.1    O'Donnell, M.J.2
  • 73
    • 79953044605 scopus 로고    scopus 로고
    • Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila
    • Sousa-Nunes, R., Yee, L. L., and Gould, A. P. (2011). Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. Nature 471, 508-512. doi: 10.1038/nature09867
    • (2011) Nature , vol.471 , pp. 508-512
    • Sousa-Nunes, R.1    Yee, L.L.2    Gould, A.P.3
  • 74
    • 84905708331 scopus 로고    scopus 로고
    • Gap junction proteins in the blood-brain barrier control nutrient-dependent reactivation of Drosophila neural stem cells
    • Speder, P., and Brand, A. H. (2014). Gap junction proteins in the blood-brain barrier control nutrient-dependent reactivation of Drosophila neural stem cells. Dev. Cell 30, 309-321. doi: 10.1016/j.devcel.2014.05.021
    • (2014) Dev. Cell , vol.30 , pp. 309-321
    • Speder, P.1    Brand, A.H.2
  • 75
    • 0035071025 scopus 로고    scopus 로고
    • Spatially restricted activity of a Drosophila lipid phosphatase guides migrating germ cells
    • Starz-Gaiano, M., Cho, N. K., Forbes, A., and Lehmann, R. (2001). Spatially restricted activity of a Drosophila lipid phosphatase guides migrating germ cells. Development 128, 983-991.
    • (2001) Development , vol.128 , pp. 983-991
    • Starz-Gaiano, M.1    Cho, N.K.2    Forbes, A.3    Lehmann, R.4
  • 76
    • 56749104928 scopus 로고    scopus 로고
    • Canonical wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature
    • Stenman, J. M., Rajagopal, J., Carroll, T. J., Ishibashi, M., McMahon, J., and McMahon, A. P. (2008). Canonical wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature. Science 322, 1247-1250. doi: 10.1126/science.1164594
    • (2008) Science , vol.322 , pp. 1247-1250
    • Stenman, J.M.1    Rajagopal, J.2    Carroll, T.J.3    Ishibashi, M.4    McMahon, J.5    McMahon, A.P.6
  • 77
    • 0019798883 scopus 로고
    • Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: a study using quail-chick transplantation chimeras
    • Stewart, P. A., and Wiley, M. J. (1981). Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: a study using quail-chick transplantation chimeras. Dev. Biol. 84, 183-192. doi: 10.1016/0012-1606(81)90382-1
    • (1981) Dev. Biol , vol.84 , pp. 183-192
    • Stewart, P.A.1    Wiley, M.J.2
  • 78
    • 38549095461 scopus 로고    scopus 로고
    • Organization and function of the blood-brain barrier in Drosophila
    • Stork, T., Engelen, D., Krudewig, A., Silies, M., Bainton, R. J., and Klambt, C. (2008). Organization and function of the blood-brain barrier in Drosophila. J. Neurosci. 28, 587-597. doi: 10.1523/JNEUROSCI.4367-07.2008
    • (2008) J. Neurosci , vol.28 , pp. 587-597
    • Stork, T.1    Engelen, D.2    Krudewig, A.3    Silies, M.4    Bainton, R.J.5    Klambt, C.6
  • 79
    • 79957664703 scopus 로고    scopus 로고
    • The CD59 family member Leaky/Coiled is required for the establishment of the blood-brain barrier in Drosophila
    • Syed, M. H., Krudewig, A., Engelen, D., Stork, T., and Klambt, C. (2011). The CD59 family member Leaky/Coiled is required for the establishment of the blood-brain barrier in Drosophila. J Neurosci 31, 7876-7885. doi: 10.1523/JNEUROSCI.0766-11.2011
    • (2011) J Neurosci , vol.31 , pp. 7876-7885
    • Syed, M.H.1    Krudewig, A.2    Engelen, D.3    Stork, T.4    Klambt, C.5
  • 81
    • 0013894796 scopus 로고
    • The effect of ouabain on the efflux of sodium ions in the nerve cords of two insect species (Periplaneta americana and Carausius morosus)
    • Treherne, J. E. (1966). The effect of ouabain on the efflux of sodium ions in the nerve cords of two insect species (Periplaneta americana and Carausius morosus). J. Exp. Biol. 44, 355-362.
    • (1966) J. Exp. Biol , vol.44 , pp. 355-362
    • Treherne, J.E.1
  • 82
    • 84855303330 scopus 로고    scopus 로고
    • Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrity
    • Unhavaithaya, Y., and Orr-Weaver, T. L. (2012). Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrity. Genes Dev. 26, 31-36. doi: 10.1101/gad.177436.111
    • (2012) Genes Dev , vol.26 , pp. 31-36
    • Unhavaithaya, Y.1    Orr-Weaver, T.L.2
  • 83
    • 0036797713 scopus 로고    scopus 로고
    • Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
    • Vogelgesang, S., Cascorbi, I., Schroeder, E., Pahnke, J., Kroemer, H. K., Siegmund, W., et al. (2002). Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans. Pharmacogenetics 12, 535-541. doi: 10.1097/00008571-200210000-00005
    • (2002) Pharmacogenetics , vol.12 , pp. 535-541
    • Vogelgesang, S.1    Cascorbi, I.2    Schroeder, E.3    Pahnke, J.4    Kroemer, H.K.5    Siegmund, W.6
  • 84
    • 79251504624 scopus 로고    scopus 로고
    • Insulin signalling regulates remating in female Drosophila
    • Wigby, S., Slack, C., Gronke, S., Martinez, P., Calboli, F. C., Chapman, T., et al. (2011). Insulin signalling regulates remating in female Drosophila. Proc. Biol. Sci. 278, 424-431. doi: 10.1098/rspb.2010.1390
    • (2011) Proc. Biol. Sci , vol.278 , pp. 424-431
    • Wigby, S.1    Slack, C.2    Gronke, S.3    Martinez, P.4    Calboli, F.C.5    Chapman, T.6
  • 85
    • 84880161805 scopus 로고    scopus 로고
    • Receptor-mediated endocytosis and brain delivery of therapeutic biologics
    • Xiao, G., and Gan, L. S. (2013). Receptor-mediated endocytosis and brain delivery of therapeutic biologics. Int. J. Cell Biol. 2013:703545. doi: 10.1155/2013/703545
    • (2013) Int. J. Cell Biol , vol.2013 , pp. 703545
    • Xiao, G.1    Gan, L.S.2
  • 86
    • 0031021247 scopus 로고    scopus 로고
    • The Drosophila protein Wunen repels migrating germ cells
    • Zhang, N., Zhang, J., Purcell, K. J., Cheng, Y., and Howard, K. (1997). The Drosophila protein Wunen repels migrating germ cells. Nature 385, 64-67. doi: 10.1038/385064a0
    • (1997) Nature , vol.385 , pp. 64-67
    • Zhang, N.1    Zhang, J.2    Purcell, K.J.3    Cheng, Y.4    Howard, K.5
  • 87
    • 38149090292 scopus 로고    scopus 로고
    • The blood-brain barrier in health and chronic neurodegenerative disorders
    • Zlokovic, B. V. (2008). The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 57, 178-201. doi: 10.1016/j.neuron.2008.01.003
    • (2008) Neuron , vol.57 , pp. 178-201
    • Zlokovic, B.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.