Increased BBB permeability by parasympathetic sphenopalatine ganglion stimulation in dogs

Brain Research

Volumn 1018, Issue 2, 2004, Pages 236-240

  Yarnitsky, David ^a   Gross, Yossi ^b   Lorian, Adi ^c   Shalev, Alon ^b   Shorer, Shy ^b   Tanaka, Toshiki ^d   Ayajiki, Kazuhide ^d   Fujimiya, Mineko ^d   Okamura, Tomio ^d  

^a RAMBAM MEDICAL CENTER   (Israel)

^b Raanana   (Israel)

^c Poriya Hospital   (Israel)

^d SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Blood brain barrier; Electrical stimulation; Parasympathetic; Sphenopalatine ganglion

Indexed keywords

DEXTRAN; FLUORESCEIN ISOTHIOCYANATE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL INNERVATION; BRAIN ANGIOGRAPHY; BRAIN DEPTH STIMULATION; BRAIN DISEASE; BRAIN PERFUSION; BRAIN REGION; CEREBELLUM; CHOLINERGIC SYSTEM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEGENERATIVE DISEASE; DOG; FLUORESCENCE; GANGLION; HEART ATRIUM PACING; MOLECULE; NERVE STIMULATION; NONHUMAN; PERMEABILITY; PONS; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TISSUE HOMOGENATE; VASODILATATION; VERTEBRAL ARTERY;

ANIMALS; BLOOD-BRAIN BARRIER; CEREBRAL CORTEX; DEXTRANS; DOGS; ELECTRIC STIMULATION; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; FUNCTIONAL LATERALITY; GANGLIA, PARASYMPATHETIC; MALE; NERVE FIBERS; PALATE; PERMEABILITY; SPHENOID SINUS; TEARS; VASODILATION;

EID: 3342948514     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.05.103     Document Type: Article

References (15)

1. Goadsby P.J. Sphenopalatine ganglion stimulation increases regional cerebral blood flow independent of glucose utilization in the cat. Brain Res. 506:1990;145-148
2. Hara H., Zhang Q.J., Kuroyanagi T., Kobayashi S. Parasympathetic cerebrovascular innervation: an anterograde tracing from the sphenopalatine ganglion in the rat. Neurosurgery. 32:1993;822-827
3. Mayhan W.G. Nitric oxide donor-induced increase in permeability of the blood-brain barrier. Brain Res. 866:2000;101-108
4. Moskowitz M.A. Neurogenic inflammation in the pathophysiology of migraine. Neurology. 43(Suppl. 3):1993;S16-S20
5. Ruskell G.L. The orbital branches of the pterygopalatine ganglion and their relationship with internal carotid nerve branches in primates. J. Anat. 106:1970;323-339
6. Suzuki N., Hardebo J.E., Kahrstrom J., Owman C. Selective electrical stimulation of postganglionic cerebrovascular parasympathetic nerve fibers originating from the sphenopalatine ganglion enhances cortical blood flow in the rat. J. Cereb. Blood Flow Metab. 10:1990;383-391
7. Suzuki N., Hardebo J.E., Skagerberg G., Owman C. Central origins of preganglionic fibers to the sphenopalatine ganglion in the rat. A fluorescent retrograde tracer study with special reference to its relation to central catecholaminergic systems. J. Auton. Nerv. Syst. 30:1990;101-110
8. Thiel V.E., Audus K.L. Nitric oxide and blood-brain barrier integrity. Antioxid. Redox Signal. 3:2001;273-278
9. Toda N., Okamura T. The pharmacology of nitric oxide in the peripheral nervous system of blood vessels. Pharmacol. Rev. 55:2003;271-324
10. Toda N., Ayajiki K., Okamura T. New mechanism underlying basilar arterial constriction by intracisternal L-NNA in anesthetized dogs. Am. J. Physiol. 265:1993;H103-H107
11. Toda N., Ayajiki K., Tanaka T., Okamura T. Preganglionic and postganglionic neurons responsible for cerebral vasodilation mediated by nitric oxide in anesthetized dogs. J. Cereb. Blood Flow Metab. 20:2000;700-708
12. Toda N., Tanaka T., Ayajiki K., Okamura T. Cerebral vasodilatation induced by stimulation of the pterygopalatine ganglion and greater petrosal nerve in anesthesized monkeys. Neuroscience. 96:2000;393-398
13. Tyler K.L. Prognosis of acute viral encephalitis. Gilchrist J.M. Prognosis in Neurology. 1998;233-238 Butterworth-Heinemann, Boston
14. Weyerbrock A., Walbridge S., Pluta R.M., Saavedra J.E., Keefer L.K., Oldfield E.H. Selective opening of the blood tumor barrier by nitric oxide donor and long-term survival in rats with C6 gliomas. J. Neurosurg. 99:2003;728-737
15. D. Yarnitsky, Y. Gross, A. Lorian, A. Shalev, I. Lamensdorf, R. Borenshtain, S. Shorer, A. Mayevsky, K.P. Patel, N.J. Abbott, W.J. Mayhan, Blood-Brain Barrier opening by parasympathetic Sphenopalatine ganglion stimulation: a new method for macromolecule delivery to the brain, Journal of Neurosurgery, in press.