Multiple sessions of liposomal doxorubicin delivery via focused ultrasound mediated blood-brain barrier disruption: A safety study

Journal of Controlled Release

Volumn 204, Issue , 2015, Pages 60-69

  Aryal, Muna ^a   Vykhodtseva, Natalia ^a   Zhang, Yong Zhi ^a   McDannold, Nathan ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Blood brain barrier; DOXIL; Drug delivery; Histology; Microbubbles; MRI guided focused ultrasound

Indexed keywords

BLOOD; CHEMOTHERAPY; DRUG DELIVERY; HISTOLOGY; MAGNETIC RESONANCE IMAGING; SONICATION; TUMORS; ULTRASONICS;

BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEMS; CHEMOTHERAPY AGENTS; DOXIL; FOCUSED ULTRASOUND; LIPOSOMAL DOXORUBICIN; MICROBUBBLES; SONICATION PARAMETERS;

RATS;

DOXORUBICIN; ANTINEOPLASTIC ANTIBIOTIC; MACROGOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CANCER SURVIVAL; CAPILLARY; CONTROLLED STUDY; CYST; DISEASE SEVERITY; DRUG SAFETY; GLIOMA; HISTOLOGY; MICROBUBBLE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SCAR; ULTRASOUND; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; CAPILLARY PERMEABILITY; DRUG DELIVERY SYSTEM; MALE; METABOLISM; NUCLEAR MAGNETIC RESONANCE IMAGING; PROCEDURES; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION; VASCULARIZATION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARY PERMEABILITY; DOXORUBICIN; DRUG DELIVERY SYSTEMS; MAGNETIC RESONANCE IMAGING; MALE; POLYETHYLENE GLYCOLS; RATS, SPRAGUE-DAWLEY; SONICATION; TISSUE DISTRIBUTION;

EID: 84924351678     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.02.033     Document Type: Article

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