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Volumn 31, Issue 12, 2014, Pages 3229-3250

In vitro cerebrovascular modeling in the 21st century: Current and prospective technologies

Author keywords

alternative; biotechnology; cell lines; drug development; endothelial; microfluidic; permeability; pharmacodynamic; pharmacokinetic; tight junction; translational

Indexed keywords

ANIMAL; BIOLOGICAL MODEL; BLOOD BRAIN BARRIER; BRAIN CIRCULATION; COMPUTER SIMULATION; HUMAN; IN VITRO STUDY; MICROFLUIDIC ANALYSIS; NEUROLOGIC DISEASE; PATHOPHYSIOLOGY; PHYSIOLOGY;

EID: 84926661937     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-014-1464-6     Document Type: Review
Times cited : (46)

References (189)
  • 1
    • 77649215791 scopus 로고    scopus 로고
    • Blood-brain barrier as a regulatory interface
    • 1:CAS:528:DC%2BC3cXjslantrc%3D 19955778
    • Banks WA. Blood-brain barrier as a regulatory interface. Forum Nutr. 2010;63:102-10.
    • (2010) Forum Nutr , vol.63 , pp. 102-110
    • Banks, W.A.1
  • 2
    • 78651106773 scopus 로고    scopus 로고
    • Review: Molecular pathogenesis of blood-brain barrier breakdown in acute brain injury
    • 1:CAS:528:DC%2BC3MXhvV2rt7Y%3D 20946242
    • Nag S, Kapadia A, Stewart DJ. Review: molecular pathogenesis of blood-brain barrier breakdown in acute brain injury. Neuropathol Appl Neurobiol. 2011;37:3-23.
    • (2011) Neuropathol Appl Neurobiol , vol.37 , pp. 3-23
    • Nag, S.1    Kapadia, A.2    Stewart, D.J.3
  • 3
    • 79955752356 scopus 로고    scopus 로고
    • The role of shear stress in blood-brain barrier endothelial physiology
    • 1:CAS:528:DC%2BC3MXmsV2isbc%3D 3103473 21569296
    • Cucullo L, Hossain M, Puvenna V, Marchi N, Janigro D. The role of shear stress in blood-brain barrier endothelial physiology. BMC Neurosci. 2011;12:40.
    • (2011) BMC Neurosci , vol.12 , pp. 40
    • Cucullo, L.1    Hossain, M.2    Puvenna, V.3    Marchi, N.4    Janigro, D.5
  • 4
    • 78651063705 scopus 로고    scopus 로고
    • Review: Leucocyte-endothelial cell crosstalk at the blood-brain barrier: A prerequisite for successful immune cell entry to the brain
    • 1:CAS:528:DC%2BC3MXhvV2rtL4%3D 20946472
    • Greenwood J, Heasman SJ, Alvarez JI, Prat A, Lyck R, Engelhardt B. Review: leucocyte-endothelial cell crosstalk at the blood-brain barrier: a prerequisite for successful immune cell entry to the brain. Neuropathol Appl Neurobiol. 2011;37:24-39.
    • (2011) Neuropathol Appl Neurobiol , vol.37 , pp. 24-39
    • Greenwood, J.1    Heasman, S.J.2    Alvarez, J.I.3    Prat, A.4    Lyck, R.5    Engelhardt, B.6
  • 5
    • 84876355101 scopus 로고    scopus 로고
    • Diabetes and hypercholesterolemia increase blood-brain barrier permeability and brain amyloid deposition: Beneficial effects of the LpPLA2 inhibitor darapladib
    • 1:CAS:528:DC%2BC3sXlsVGrsbs%3D 23388174
    • Acharya NK, Levin EC, Clifford PM, Han M, Tourtellotte R, Chamberlain D, et al. Diabetes and hypercholesterolemia increase blood-brain barrier permeability and brain amyloid deposition: beneficial effects of the LpPLA2 inhibitor darapladib. J Alzheimers Dis. 2013;35:179-98.
    • (2013) J Alzheimers Dis , vol.35 , pp. 179-198
    • Acharya, N.K.1    Levin, E.C.2    Clifford, P.M.3    Han, M.4    Tourtellotte, R.5    Chamberlain, D.6
  • 6
    • 29244463365 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions at the blood-brain barrier
    • 1:CAS:528:DC%2BD2MXhtlaktbjP 16371949
    • Abbott NJ, Ronnback L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci. 2006;7:41-53.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 41-53
    • Abbott, N.J.1    Ronnback, L.2    Hansson, E.3
  • 8
    • 78649487239 scopus 로고    scopus 로고
    • Pericytes are required for blood-brain barrier integrity during embryogenesis
    • 1:CAS:528:DC%2BC3cXht1yjs7bI 3241506 20944625
    • Daneman R, Zhou L, Kebede AA, Barres BA. Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature. 2010;468:562-6.
    • (2010) Nature , vol.468 , pp. 562-566
    • Daneman, R.1    Zhou, L.2    Kebede, A.A.3    Barres, B.A.4
  • 9
    • 79951922143 scopus 로고    scopus 로고
    • Engaging neuroscience to advance translational research in brain barrier biology
    • 1:CAS:528:DC%2BC3MXitVOnsb4%3D 3335275 21331083
    • Neuwelt EA, Bauer B, Fahlke C, Fricker G, Iadecola C, Janigro D, et al. Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci. 2011;12:169-82.
    • (2011) Nat Rev Neurosci , vol.12 , pp. 169-182
    • Neuwelt, E.A.1    Bauer, B.2    Fahlke, C.3    Fricker, G.4    Iadecola, C.5    Janigro, D.6
  • 10
    • 84899136901 scopus 로고    scopus 로고
    • The role of pericytes in neurovascular unit remodeling in brain disorders
    • 4013640 24743889
    • ElAli A, Theriault P, Rivest S. The role of pericytes in neurovascular unit remodeling in brain disorders. Int J Mol Sci. 2014;15:6453-74.
    • (2014) Int J Mol Sci , vol.15 , pp. 6453-6474
    • Elali, A.1    Theriault, P.2    Rivest, S.3
  • 11
  • 13
    • 82255163077 scopus 로고    scopus 로고
    • Elucidating the principles of the molecular organization of heteropolymeric tight junction strands
    • 1:CAS:528:DC%2BC3MXhsVGnu7vK 21533891
    • Piontek J, Fritzsche S, Cording J, Richter S, Hartwig J, Walter M, et al. Elucidating the principles of the molecular organization of heteropolymeric tight junction strands. Cell Mol Life Sci. 2011;68:3903-18.
    • (2011) Cell Mol Life Sci , vol.68 , pp. 3903-3918
    • Piontek, J.1    Fritzsche, S.2    Cording, J.3    Richter, S.4    Hartwig, J.5    Walter, M.6
  • 14
    • 0036627211 scopus 로고    scopus 로고
    • Tight junctions of the blood-brain barrier: Development, composition and regulation
    • 1:CAS:528:DC%2BD38XosF2kt7w%3D
    • Wolburg H, Lippoldt A. Tight junctions of the blood-brain barrier: development, composition and regulation. Vasc Pharmacol. 2002;38:323-37.
    • (2002) Vasc Pharmacol , vol.38 , pp. 323-337
    • Wolburg, H.1    Lippoldt, A.2
  • 15
    • 0033526176 scopus 로고    scopus 로고
    • P-Glycoprotein, a gatekeeper in the blood-brain barrier
    • 1:CAS:528:DyaK1MXhvVCgu7Y%3D 10837715
    • Schinkel AH. P-Glycoprotein, a gatekeeper in the blood-brain barrier. Adv Drug Deliv Rev. 1999;36:179-94.
    • (1999) Adv Drug Deliv Rev , vol.36 , pp. 179-194
    • Schinkel, A.H.1
  • 17
    • 49349102757 scopus 로고    scopus 로고
    • Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation
    • 1:CAS:528:DC%2BD1cXhtVentr3J 18619525
    • Roberts LM, Black DS, Raman C, Woodford K, Zhou M, Haggerty JE, et al. Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Neuroscience. 2008;155:423-38.
    • (2008) Neuroscience , vol.155 , pp. 423-438
    • Roberts, L.M.1    Black, D.S.2    Raman, C.3    Woodford, K.4    Zhou, M.5    Haggerty, J.E.6
  • 18
    • 79952557219 scopus 로고    scopus 로고
    • Cellular localization and functional significance of CYP3A4 in the human epileptic brain
    • 1:CAS:528:DC%2BC3MXnvVaqur4%3D 3056924 21294720
    • Ghosh C, Marchi N, Desai NK, Puvenna V, Hossain M, Gonzalez-Martinez J, et al. Cellular localization and functional significance of CYP3A4 in the human epileptic brain. Epilepsia. 2011;52:562-71.
    • (2011) Epilepsia , vol.52 , pp. 562-571
    • Ghosh, C.1    Marchi, N.2    Desai, N.K.3    Puvenna, V.4    Hossain, M.5    Gonzalez-Martinez, J.6
  • 19
    • 84883739935 scopus 로고    scopus 로고
    • Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains
    • 1:CAS:528:DC%2BC3sXhsVWrsbjO 3805835 23865846
    • Ghosh C, Hossain M, Puvenna V, Martinez-Gonzalez J, Alexopolous A, Janigro D, et al. Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains. Epilepsia. 2013;54:1562-70.
    • (2013) Epilepsia , vol.54 , pp. 1562-1570
    • Ghosh, C.1    Hossain, M.2    Puvenna, V.3    Martinez-Gonzalez, J.4    Alexopolous, A.5    Janigro, D.6
  • 20
    • 23044500398 scopus 로고    scopus 로고
    • Drug resistance in brain diseases and the role of drug efflux transporters
    • 16025095
    • Loscher W, Potschka H. Drug resistance in brain diseases and the role of drug efflux transporters. Nat Rev Neurosci. 2005;6:591-602.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 591-602
    • Loscher, W.1    Potschka, H.2
  • 21
    • 84870408539 scopus 로고    scopus 로고
    • The blood-brain barrier in health and disease
    • 1:CAS:528:DC%2BC3sXnt1Wj 23280789
    • Daneman R. The blood-brain barrier in health and disease. Ann Neurol. 2012;72:648-72.
    • (2012) Ann Neurol , vol.72 , pp. 648-672
    • Daneman, R.1
  • 23
    • 78650185098 scopus 로고    scopus 로고
    • Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE
    • 1:CAS:528:DC%2BC3cXhsVGitrzE 20832870
    • Bennett J, Basivireddy J, Kollar A, Biron KE, Reickmann P, Jefferies WA, et al. Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE. J Neuroimmunol. 2010;229:180-91.
    • (2010) J Neuroimmunol , vol.229 , pp. 180-191
    • Bennett, J.1    Basivireddy, J.2    Kollar, A.3    Biron, K.E.4    Reickmann, P.5    Jefferies, W.A.6
  • 25
    • 58249126857 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their multiple roles in neurodegenerative diseases
    • 1:CAS:528:DC%2BD1MXisFCgu7k%3D 19161911
    • Rosenberg GA. Matrix metalloproteinases and their multiple roles in neurodegenerative diseases. Lancet Neurol. 2009;8:205-16.
    • (2009) Lancet Neurol , vol.8 , pp. 205-216
    • Rosenberg, G.A.1
  • 26
    • 0034870813 scopus 로고    scopus 로고
    • Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease
    • 1:CAS:528:DC%2BD3MXlslGitbg%3D 11493021
    • Poduslo JF, Curran GL, Wengenack TM, Malester B, Duff K. Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2001;8:555-67.
    • (2001) Neurobiol Dis , vol.8 , pp. 555-567
    • Poduslo, J.F.1    Curran, G.L.2    Wengenack, T.M.3    Malester, B.4    Duff, K.5
  • 27
    • 84872197814 scopus 로고    scopus 로고
    • Mechanisms underlying blood-brain barrier dysfunction in brain pathology and epileptogenesis: Role of astroglia
    • 1:CAS:528:DC%2BC3sXjtVOnsw%3D%3D 23134496
    • Kovacs R, Heinemann U, Steinhauser C. Mechanisms underlying blood-brain barrier dysfunction in brain pathology and epileptogenesis: role of astroglia. Epilepsia. 2012;53 Suppl 6:53-9.
    • (2012) Epilepsia , vol.53 , pp. 53-59
    • Kovacs, R.1    Heinemann, U.2    Steinhauser, C.3
  • 28
    • 33747781747 scopus 로고    scopus 로고
    • Inflammation in stroke and focal cerebral ischemia
    • 16935624
    • Huang J, Upadhyay UM, Tamargo RJ. Inflammation in stroke and focal cerebral ischemia. Surg Neurol. 2006;66:232-45.
    • (2006) Surg Neurol , vol.66 , pp. 232-245
    • Huang, J.1    Upadhyay, U.M.2    Tamargo, R.J.3
  • 29
    • 33751074192 scopus 로고    scopus 로고
    • Biomarkers indicative of blood-brain barrier disruption in multiple sclerosis
    • 1:CAS:528:DC%2BD28Xht1SmtrfI 3850823 17124345
    • Waubant E. Biomarkers indicative of blood-brain barrier disruption in multiple sclerosis. Dis Markers. 2006;22:235-44.
    • (2006) Dis Markers , vol.22 , pp. 235-244
    • Waubant, E.1
  • 30
    • 33645092394 scopus 로고    scopus 로고
    • Upregulation of vascular growth factors in multiple sclerosis: Correlation with MRI findings
    • 1:CAS:528:DC%2BD28XisF2rtbk%3D 16376944
    • Su JJ, Osoegawa M, Matsuoka T, Minohara M, Tanaka M, Ishizu T, et al. Upregulation of vascular growth factors in multiple sclerosis: correlation with MRI findings. J Neurol Sci. 2006;243:21-30.
    • (2006) J Neurol Sci , vol.243 , pp. 21-30
    • Su, J.J.1    Osoegawa, M.2    Matsuoka, T.3    Minohara, M.4    Tanaka, M.5    Ishizu, T.6
  • 31
    • 84875696199 scopus 로고    scopus 로고
    • Neuronal oxidative stress in acute ischemic stroke: Sources and contribution to cell injury
    • 1:CAS:528:DC%2BC3sXkvF2qtQ%3D%3D 23201332
    • Manzanero S, Santro T, Arumugam TV. Neuronal oxidative stress in acute ischemic stroke: sources and contribution to cell injury. Neurochem Int. 2013;62:712-8.
    • (2013) Neurochem Int , vol.62 , pp. 712-718
    • Manzanero, S.1    Santro, T.2    Arumugam, T.V.3
  • 32
    • 72649096229 scopus 로고    scopus 로고
    • Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease
    • 1:CAS:528:DC%2BC3cXotFCl 19914330
    • Padurariu M, Ciobica A, Hritcu L, Stoica B, Bild W, Stefanescu C. Changes of some oxidative stress markers in the serum of patients with mild cognitive impairment and Alzheimer's disease. Neurosci Lett. 2010;469:6-10.
    • (2010) Neurosci Lett , vol.469 , pp. 6-10
    • Padurariu, M.1    Ciobica, A.2    Hritcu, L.3    Stoica, B.4    Bild, W.5    Stefanescu, C.6
  • 33
    • 61349102361 scopus 로고    scopus 로고
    • Blood-brain barrier permeability in Alzheimer's disease: A case-control MRI study
    • 1:CAS:528:DC%2BD1MXisFSjtrk%3D 19211227
    • Starr JM, Farrall AJ, Armitage P, McGurn B, Wardlaw J. Blood-brain barrier permeability in Alzheimer's disease: a case-control MRI study. Psychiatry Res. 2009;171:232-41.
    • (2009) Psychiatry Res , vol.171 , pp. 232-241
    • Starr, J.M.1    Farrall, A.J.2    Armitage, P.3    McGurn, B.4    Wardlaw, J.5
  • 34
    • 79960793961 scopus 로고    scopus 로고
    • Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy
    • 1:CAS:528:DC%2BC3MXpsVOktL4%3D 21294650
    • Carrano A, Hoozemans JJ, van der Vies SM, Rozemuller AJ, Van HJ, de Vries HE. Amyloid Beta induces oxidative stress-mediated blood-brain barrier changes in capillary amyloid angiopathy. Antioxid Redox Signal. 2011;15:1167-78.
    • (2011) Antioxid Redox Signal , vol.15 , pp. 1167-1178
    • Carrano, A.1    Hoozemans, J.J.2    Van Der Vies, S.M.3    Rozemuller, A.J.4    Van, H. J.5    De Vries, H.E.6
  • 35
    • 84862885703 scopus 로고    scopus 로고
    • Abeta(1)(-)(4)(2)-RAGE interaction disrupts tight junctions of the blood-brain barrier via Ca(2)(+)-calcineurin signaling
    • 1:CAS:528:DC%2BC38XpvFOnsbo%3D 22745485
    • Kook SY, Hong HS, Moon M, Ha CM, Chang S, Mook-Jung I. Abeta(1)(-)(4)(2)-RAGE interaction disrupts tight junctions of the blood-brain barrier via Ca(2)(+)-calcineurin signaling. J Neurosci. 2012;32:8845-54.
    • (2012) J Neurosci , vol.32 , pp. 8845-8854
    • Kook, S.Y.1    Hong, H.S.2    Moon, M.3    Ha, C.M.4    Chang, S.5    Mook-Jung, I.6
  • 36
    • 80053504148 scopus 로고    scopus 로고
    • Blood-brain barrier P-glycoprotein function in neurodegenerative disease
    • 1:CAS:528:DC%2BC3MXhsVSis7vE 21831040
    • Bartels AL. Blood-brain barrier P-glycoprotein function in neurodegenerative disease. Curr Pharm Des. 2011;17:2771-7.
    • (2011) Curr Pharm des , vol.17 , pp. 2771-2777
    • Bartels, A.L.1
  • 37
    • 71949096119 scopus 로고    scopus 로고
    • Cerebral ischemia-reperfusion injury in rats-a 3 T MRI study on biphasic blood-brain barrier opening and the dynamics of edema formation
    • 2848453 19654585
    • Pillai DR, Dittmar MS, Baldaranov D, Heidemann RM, Henning EC, Schuierer G, et al. Cerebral ischemia-reperfusion injury in rats-a 3 T MRI study on biphasic blood-brain barrier opening and the dynamics of edema formation. J Cereb Blood Flow Metab. 2009;29:1846-55.
    • (2009) J Cereb Blood Flow Metab , vol.29 , pp. 1846-1855
    • Pillai, D.R.1    Dittmar, M.S.2    Baldaranov, D.3    Heidemann, R.M.4    Henning, E.C.5    Schuierer, G.6
  • 38
    • 79955922988 scopus 로고    scopus 로고
    • Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult
    • 1:CAS:528:DC%2BC3MXlsVWit7g%3D 21318404
    • Jiao H, Wang Z, Liu Y, Wang P, Xue Y. Specific role of tight junction proteins claudin-5, occludin, and ZO-1 of the blood-brain barrier in a focal cerebral ischemic insult. J Mol Neurosci. 2011;44:130-9.
    • (2011) J Mol Neurosci , vol.44 , pp. 130-139
    • Jiao, H.1    Wang, Z.2    Liu, Y.3    Wang, P.4    Xue, Y.5
  • 39
    • 77649125731 scopus 로고    scopus 로고
    • Blood-brain barrier disruption in humans is independently associated with increased matrix metalloproteinase-9
    • 1:CAS:528:DC%2BC3cXitlejtLk%3D 2827673 20035078
    • Barr TL, Latour LL, Lee KY, Schaewe TJ, Luby M, Chang GS, et al. Blood-brain barrier disruption in humans is independently associated with increased matrix metalloproteinase-9. Stroke. 2010;41:e123-8.
    • (2010) Stroke , vol.41 , pp. 123-e128
    • Barr, T.L.1    Latour, L.L.2    Lee, K.Y.3    Schaewe, T.J.4    Luby, M.5    Chang, G.S.6
  • 40
    • 84885190635 scopus 로고    scopus 로고
    • Traumatic brain injury, neuroinflammation, and post-traumatic headaches
    • 4089888 24090534
    • Mayer CL, Huber BR, Peskind E. Traumatic brain injury, neuroinflammation, and post-traumatic headaches. Headache. 2013;53:1523-30.
    • (2013) Headache , vol.53 , pp. 1523-1530
    • Mayer, C.L.1    Huber, B.R.2    Peskind, E.3
  • 41
    • 83355166774 scopus 로고    scopus 로고
    • Blood-brain barrier pathophysiology in traumatic brain injury
    • 1:CAS:528:DC%2BC3MXhs1ajt7%2FO 3268209 22299022
    • Chodobski A, Zink BJ, Szmydynger-Chodobska J. Blood-brain barrier pathophysiology in traumatic brain injury. Transl Stroke Res. 2011;2:492-516.
    • (2011) Transl Stroke Res , vol.2 , pp. 492-516
    • Chodobski, A.1    Zink, B.J.2    Szmydynger-Chodobska, J.3
  • 42
    • 84919431478 scopus 로고    scopus 로고
    • Efficacy and side effects of Natalizumab therapy in patients with multiple sclerosis
    • 4011812 24855407
    • Hoepner R, Faissner S, Salmen A, Gold R, Chan A. Efficacy and side effects of Natalizumab therapy in patients with multiple sclerosis. J Cent Nerv Syst Dis. 2014;6:41-9.
    • (2014) J Cent Nerv Syst Dis , vol.6 , pp. 41-49
    • Hoepner, R.1    Faissner, S.2    Salmen, A.3    Gold, R.4    Chan, A.5
  • 43
    • 34447300469 scopus 로고    scopus 로고
    • Natalizumab (Tysabri) treatment for relapsing multiple sclerosis
    • 17622909
    • Johnson KP. Natalizumab (Tysabri) treatment for relapsing multiple sclerosis. Neurologist. 2007;13:182-7.
    • (2007) Neurologist , vol.13 , pp. 182-187
    • Johnson, K.P.1
  • 44
    • 84872328331 scopus 로고    scopus 로고
    • Topiramate reduces blood-brain barrier disruption and inhibits seizure activity in hyperthermia-induced seizures in rats with cortical dysplasia
    • 1:CAS:528:DC%2BC38XhvVymu7fP 23201444
    • Gurses C, Orhan N, Ahishali B, Yilmaz CU, Kemikler G, Elmas I, et al. Topiramate reduces blood-brain barrier disruption and inhibits seizure activity in hyperthermia-induced seizures in rats with cortical dysplasia. Brain Res. 2013;1494:91-100.
    • (2013) Brain Res , vol.1494 , pp. 91-100
    • Gurses, C.1    Orhan, N.2    Ahishali, B.3    Yilmaz, C.U.4    Kemikler, G.5    Elmas, I.6
  • 45
    • 84879820014 scopus 로고    scopus 로고
    • Disruption of the blood-brain barrier after generalized tonic-clonic seizures correlates with cerebrospinal fluid MMP-9 levels
    • 3706217 23829879
    • Li YJ, Wang ZH, Zhang B, Zhe X, Wang MJ, Shi ST, et al. Disruption of the blood-brain barrier after generalized tonic-clonic seizures correlates with cerebrospinal fluid MMP-9 levels. J Neuroinflammation. 2013;10:80.
    • (2013) J Neuroinflammation , vol.10 , pp. 80
    • Li, Y.J.1    Wang, Z.H.2    Zhang, B.3    Zhe, X.4    Wang, M.J.5    Shi, S.T.6
  • 46
    • 84876472995 scopus 로고    scopus 로고
    • Prognostic value of early epileptic seizures on mortality and functional disability in acute stroke: The Dijon Stroke Registry (1985-2010)
    • 23180187
    • Hamidou B, Aboa-Eboule C, Durier J, Jacquin A, Lemesle-Martin M, Giroud M, et al. Prognostic value of early epileptic seizures on mortality and functional disability in acute stroke: the Dijon Stroke Registry (1985-2010). J Neurol. 2013;260:1043-51.
    • (2013) J Neurol , vol.260 , pp. 1043-1051
    • Hamidou, B.1    Aboa-Eboule, C.2    Durier, J.3    Jacquin, A.4    Lemesle-Martin, M.5    Giroud, M.6
  • 47
    • 0033664346 scopus 로고    scopus 로고
    • Xenobiotic transport across isolated brain microvessels studied by confocal microscopy
    • 1:CAS:528:DC%2BD3cXovFeqs7w%3D 11093774
    • Miller DS, Nobmann SN, Gutmann H, Toeroek M, Drewe J, Fricker G. Xenobiotic transport across isolated brain microvessels studied by confocal microscopy. Mol Pharmacol. 2000;58:1357-67.
    • (2000) Mol Pharmacol , vol.58 , pp. 1357-1367
    • Miller, D.S.1    Nobmann, S.N.2    Gutmann, H.3    Toeroek, M.4    Drewe, J.5    Fricker, G.6
  • 48
    • 77953141219 scopus 로고    scopus 로고
    • ABC transporters and drug efflux at the blood-brain barrier
    • 1:CAS:528:DC%2BC3cXmtFKqu7c%3D 20458886
    • Shen S, Zhang W. ABC transporters and drug efflux at the blood-brain barrier. Rev Neurosci. 2010;21:29-53.
    • (2010) Rev Neurosci , vol.21 , pp. 29-53
    • Shen, S.1    Zhang, W.2
  • 49
    • 80053496670 scopus 로고    scopus 로고
    • Blood-brain barrier P450 enzymes and multidrug transporters in drug resistance: A synergistic role in neurological diseases
    • 1:CAS:528:DC%2BC38XjtVSrsbk%3D 21568937
    • Ghosh C, Puvenna V, Gonzalez-Martinez J, Janigro D, Marchi N. Blood-brain barrier P450 enzymes and multidrug transporters in drug resistance: a synergistic role in neurological diseases. Curr Drug Metab. 2011;12(8):742-9.
    • (2011) Curr Drug Metab , vol.12 , Issue.8 , pp. 742-749
    • Ghosh, C.1    Puvenna, V.2    Gonzalez-Martinez, J.3    Janigro, D.4    Marchi, N.5
  • 50
    • 81555200043 scopus 로고    scopus 로고
    • Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
    • 1:CAS:528:DC%2BC3MXhsVSktbzP 4036520 22048062
    • Zlokovic BV. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci. 2011;12:723-38.
    • (2011) Nat Rev Neurosci , vol.12 , pp. 723-738
    • Zlokovic, B.V.1
  • 51
    • 65749094191 scopus 로고    scopus 로고
    • Blood brain barrier compromise with endothelial inflammation may lead to autoimmune loss of myelin during multiple sclerosis
    • 1:CAS:528:DC%2BC3cXislyjt7g%3D 19442163
    • Simka M. Blood brain barrier compromise with endothelial inflammation may lead to autoimmune loss of myelin during multiple sclerosis. Curr Neurovasc Res. 2009;6:132-9.
    • (2009) Curr Neurovasc Res , vol.6 , pp. 132-139
    • Simka, M.1
  • 52
    • 84869096277 scopus 로고    scopus 로고
    • Blood-brain barrier dysfunction and epilepsy: Pathophysiologic role and therapeutic approaches
    • 22905812
    • Marchi N, Granata T, Ghosh C, Janigro D. Blood-brain barrier dysfunction and epilepsy: pathophysiologic role and therapeutic approaches. Epilepsia. 2012;53:1877-86.
    • (2012) Epilepsia , vol.53 , pp. 1877-1886
    • Marchi, N.1    Granata, T.2    Ghosh, C.3    Janigro, D.4
  • 53
    • 25844469583 scopus 로고    scopus 로고
    • Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery
    • 1201315 16489365
    • Alavijeh MS, Chishty M, Qaiser MZ, Palmer AM. Drug metabolism and pharmacokinetics, the blood-brain barrier, and central nervous system drug discovery. NeuroRx. 2005;2:554-71.
    • (2005) NeuroRx , vol.2 , pp. 554-571
    • Alavijeh, M.S.1    Chishty, M.2    Qaiser, M.Z.3    Palmer, A.M.4
  • 54
    • 0141958109 scopus 로고    scopus 로고
    • In silico prediction of blood-brain barrier permeation
    • 1:CAS:528:DC%2BD3sXnvFSiu70%3D 14554156
    • Clark DE. In silico prediction of blood-brain barrier permeation. Drug Discov Today. 2003;8:927-33.
    • (2003) Drug Discov Today , vol.8 , pp. 927-933
    • Clark, D.E.1
  • 56
    • 0037837211 scopus 로고    scopus 로고
    • Development of biologically active compounds by combining 3D QSAR and structure-based design methods
    • 1:CAS:528:DC%2BD3sXjvFyjtbs%3D 12825795
    • Sippl W. Development of biologically active compounds by combining 3D QSAR and structure-based design methods. J Comput Aided Mol Des. 2002;16:825-30.
    • (2002) J Comput Aided Mol des , vol.16 , pp. 825-830
    • Sippl, W.1
  • 57
    • 84865653455 scopus 로고    scopus 로고
    • Comparison of prediction models for blood brain barrier permeability and analysis of the molecular descriptors
    • 1:CAS:528:DC%2BC38XhtVOhurfI 22888521
    • Wu ZY, Pan J, Yuan Y, Hui AL, Yang Y, Zhou A. Comparison of prediction models for blood brain barrier permeability and analysis of the molecular descriptors. Pharmazie. 2012;67:628-34.
    • (2012) Pharmazie , vol.67 , pp. 628-634
    • Wu, Z.Y.1    Pan, J.2    Yuan, Y.3    Hui, A.L.4    Yang, Y.5    Zhou, A.6
  • 58
    • 15344343054 scopus 로고    scopus 로고
    • In silico ADME modelling: Prediction models for blood-brain barrier permeation using a systematic variable selection method
    • 1:CAS:528:DC%2BD2MXisVCgtrg%3D 15781411
    • Narayanan R, Gunturi SB. In silico ADME modelling: prediction models for blood-brain barrier permeation using a systematic variable selection method. Bioorg Med Chem. 2005;13:3017-28.
    • (2005) Bioorg Med Chem , vol.13 , pp. 3017-3028
    • Narayanan, R.1    Gunturi, S.B.2
  • 59
    • 77249170294 scopus 로고    scopus 로고
    • Rational design of indoleamine 2,3-dioxygenase inhibitors
    • 1:CAS:528:DC%2BC3cXit1emsA%3D%3D 20055453
    • Rohrig UF, Awad L, Grosdidier A, Larrieu P, Stroobant V, Colau D, et al. Rational design of indoleamine 2,3-dioxygenase inhibitors. J Med Chem. 2010;53:1172-89.
    • (2010) J Med Chem , vol.53 , pp. 1172-1189
    • Rohrig, U.F.1    Awad, L.2    Grosdidier, A.3    Larrieu, P.4    Stroobant, V.5    Colau, D.6
  • 60
    • 79951555163 scopus 로고    scopus 로고
    • Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors
    • 1:CAS:528:DC%2BC3MXhvFKhtLY%3D 21269836
    • Dolusic E, Larrieu P, Blanc S, Sapunaric F, Norberg B, Moineaux L, et al. Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. Bioorg Med Chem. 2011;19:1550-61.
    • (2011) Bioorg Med Chem , vol.19 , pp. 1550-1561
    • Dolusic, E.1    Larrieu, P.2    Blanc, S.3    Sapunaric, F.4    Norberg, B.5    Moineaux, L.6
  • 61
    • 84876417690 scopus 로고    scopus 로고
    • Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico-in vivo extrapolation and physiologically-based pharmacokinetic modeling approach
    • 1:CAS:528:DC%2BC3sXisVKhs7s%3D 23280406
    • Malmborg J, Ploeger BA. Predicting human exposure of active drug after oral prodrug administration, using a joined in vitro/in silico-in vivo extrapolation and physiologically-based pharmacokinetic modeling approach. J Pharmacol Toxicol Methods. 2013;67:203-13.
    • (2013) J Pharmacol Toxicol Methods , vol.67 , pp. 203-213
    • Malmborg, J.1    Ploeger, B.A.2
  • 62
    • 84862890235 scopus 로고    scopus 로고
    • A Bayesian approach to in silico blood-brain barrier penetration modeling
    • 1:CAS:528:DC%2BC38Xnt1Wqu74%3D 22612593
    • Martins IF, Teixeira AL, Pinheiro L, Falcao AO. A Bayesian approach to in silico blood-brain barrier penetration modeling. J Chem Inf Model. 2012;52:1686-97.
    • (2012) J Chem Inf Model , vol.52 , pp. 1686-1697
    • Martins, I.F.1    Teixeira, A.L.2    Pinheiro, L.3    Falcao, A.O.4
  • 63
    • 84886953855 scopus 로고    scopus 로고
    • Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models
    • 1:CAS:528:DC%2BC3sXhsVKrsrzL 24050973
    • Fortuna A, Alves G, Soares-da-Silva P, Falcao A. Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: new set of data for predictive in silico ADME models. Epilepsy Res. 2013;107:37-50.
    • (2013) Epilepsy Res , vol.107 , pp. 37-50
    • Fortuna, A.1    Alves, G.2    Soares-Da-Silva, P.3    Falcao, A.4
  • 64
    • 1042275637 scopus 로고    scopus 로고
    • In silico prediction models for blood-brain barrier permeation
    • 1:CAS:528:DC%2BD2cXktlKksrw%3D 15180567
    • Ecker GF, Noe CR. In silico prediction models for blood-brain barrier permeation. Curr Med Chem. 2004;11:1617-28.
    • (2004) Curr Med Chem , vol.11 , pp. 1617-1628
    • Ecker, G.F.1    Noe, C.R.2
  • 65
    • 0035524138 scopus 로고    scopus 로고
    • Assessing the absorption of new pharmaceuticals
    • 1:CAS:528:DC%2BD3MXotFaksbs%3D 11899104
    • Hidalgo IJ. Assessing the absorption of new pharmaceuticals. Curr Top Med Chem. 2001;1:385-401.
    • (2001) Curr Top Med Chem , vol.1 , pp. 385-401
    • Hidalgo, I.J.1
  • 66
    • 0029058745 scopus 로고
    • IAM chromatography: An in vitro screen for predicting drug membrane permeability
    • 1:CAS:528:DyaK2MXjsFahsrc%3D 7861406
    • Pidgeon C, Ong S, Liu H, Qiu X, Pidgeon M, Dantzig AH, et al. IAM chromatography: an in vitro screen for predicting drug membrane permeability. J Med Chem. 1995;38:590-4.
    • (1995) J Med Chem , vol.38 , pp. 590-594
    • Pidgeon, C.1    Ong, S.2    Liu, H.3    Qiu, X.4    Pidgeon, M.5    Dantzig, A.H.6
  • 67
    • 0029991481 scopus 로고    scopus 로고
    • Immobilized-artificial-membrane chromatography: Measurements of membrane partition coefficient and predicting drug membrane permeability
    • 1:CAS:528:DyaK28XjtFehsr8%3D 8673230
    • Ong S, Liu H, Pidgeon C. Immobilized-artificial-membrane chromatography: measurements of membrane partition coefficient and predicting drug membrane permeability. J Chromatogr A. 1996;728:113-28.
    • (1996) J Chromatogr A , vol.728 , pp. 113-128
    • Ong, S.1    Liu, H.2    Pidgeon, C.3
  • 68
    • 0025881654 scopus 로고
    • Immobilized artificial membrane chromatography: Rapid purification of functional membrane proteins
    • 1:CAS:528:DyaK3MXit1Crsbc%3D 1907812
    • Pidgeon C, Stevens J, Otto S, Jefcoate C, Marcus C. Immobilized artificial membrane chromatography: rapid purification of functional membrane proteins. Anal Biochem. 1991;194:163-73.
    • (1991) Anal Biochem , vol.194 , pp. 163-173
    • Pidgeon, C.1    Stevens, J.2    Otto, S.3    Jefcoate, C.4    Marcus, C.5
  • 69
    • 52449102676 scopus 로고    scopus 로고
    • Alternative measures of lipophilicity: From octanol-water partitioning to IAM retention
    • 1:CAS:528:DC%2BD1cXpsVOrsrk%3D 18553641
    • Giaginis C, Tsantili-Kakoulidou A. Alternative measures of lipophilicity: from octanol-water partitioning to IAM retention. J Pharm Sci. 2008;97:2984-3004.
    • (2008) J Pharm Sci , vol.97 , pp. 2984-3004
    • Giaginis, C.1    Tsantili-Kakoulidou, A.2
  • 70
    • 84897417806 scopus 로고    scopus 로고
    • Human ABC transporters at blood-CNS interfaces as determinants of CNS drug penetration
    • 1:CAS:528:DC%2BC2cXlt1eru7s%3D 23789951
    • Chaves C, Shawahna R, Jacob A, Scherrmann JM, Decleves X. Human ABC transporters at blood-CNS interfaces as determinants of CNS drug penetration. Curr Pharm Des. 2014;20(10):1450-62.
    • (2014) Curr Pharm des , vol.20 , Issue.10 , pp. 1450-1462
    • Chaves, C.1    Shawahna, R.2    Jacob, A.3    Scherrmann, J.M.4    Decleves, X.5
  • 71
    • 33644895842 scopus 로고    scopus 로고
    • The rise of PAMPA
    • 1:CAS:528:DC%2BD2MXhtVKltLfL 16922646
    • Avdeef A. The rise of PAMPA. Expert Opin Drug Metab Toxicol. 2005;1:325-42.
    • (2005) Expert Opin Drug Metab Toxicol , vol.1 , pp. 325-342
    • Avdeef, A.1
  • 73
    • 84855219592 scopus 로고    scopus 로고
    • Prediction of the intestinal first-pass metabolism of CYP3A and UGT substrates in humans from in vitro data
    • 1:CAS:528:DC%2BC38Xnt1Ggs7c%3D 21878741
    • Nishimuta H, Sato K, Yabuki M, Komuro S. Prediction of the intestinal first-pass metabolism of CYP3A and UGT substrates in humans from in vitro data. Drug Metab Pharmacokinet. 2011;26:592-601.
    • (2011) Drug Metab Pharmacokinet , vol.26 , pp. 592-601
    • Nishimuta, H.1    Sato, K.2    Yabuki, M.3    Komuro, S.4
  • 74
    • 77954257369 scopus 로고    scopus 로고
    • Application of PAMPA-models to predict BBB permeability including efflux ratio, plasma protein binding and physicochemical parameters
    • Mensch J, LJ L, Sanderson W, Melis A, Mackie C, Verreck G, et al. Application of PAMPA-models to predict BBB permeability including efflux ratio, plasma protein binding and physicochemical parameters. Int J Pharm 2010.
    • (2010) Int J Pharm
    • Mensch, J.1    Lj, L.2    Sanderson, W.3    Melis, A.4    Mackie, C.5    Verreck, G.6
  • 75
    • 84891694044 scopus 로고    scopus 로고
    • PAMPA study of the temperature effect on permeability
    • 1:CAS:528:DC%2BC2cXhs1ahs7o%3D 24361474
    • Vizseralek G, Balogh T, Takacs-Novak K, Sinko B. PAMPA study of the temperature effect on permeability. Eur J Pharm Sci. 2014;53:45-9.
    • (2014) Eur J Pharm Sci , vol.53 , pp. 45-49
    • Vizseralek, G.1    Balogh, T.2    Takacs-Novak, K.3    Sinko, B.4
  • 76
    • 84874941955 scopus 로고    scopus 로고
    • PH-gradient PAMPA-based in vitro model assay for drug-induced phospholipidosis in early stage of drug discovery
    • 1:CAS:528:DC%2BC3sXks1Sjtrc%3D 23439241
    • Balogh GT, Muller J, Konczol A. pH-gradient PAMPA-based in vitro model assay for drug-induced phospholipidosis in early stage of drug discovery. Eur J Pharm Sci. 2013;49:81-9.
    • (2013) Eur J Pharm Sci , vol.49 , pp. 81-89
    • Balogh, G.T.1    Muller, J.2    Konczol, A.3
  • 77
    • 77649180725 scopus 로고    scopus 로고
    • Evaluation of various PAMPA models to identify the most discriminating method for the prediction of BBB permeability
    • 1:CAS:528:DC%2BC3cXivFGrsbg%3D 20067834
    • Mensch J, Melis A, Mackie C, Verreck G, Brewster ME, Augustijns P. Evaluation of various PAMPA models to identify the most discriminating method for the prediction of BBB permeability. Eur J Pharm Biopharm. 2010;74:495-502.
    • (2010) Eur J Pharm Biopharm , vol.74 , pp. 495-502
    • Mensch, J.1    Melis, A.2    Mackie, C.3    Verreck, G.4    Brewster, M.E.5    Augustijns, P.6
  • 78
    • 33644895433 scopus 로고    scopus 로고
    • PAMPA - A drug absorption in vitro model 13. Chemical selectivity due to membrane hydrogen bonding: In combo comparisons of HDM-, DOPC-, and DS-PAMPA models
    • 1:CAS:528:DC%2BD28Xit1Chtb0%3D 16476536
    • Avdeef A, Tsinman O. PAMPA - a drug absorption in vitro model 13. Chemical selectivity due to membrane hydrogen bonding: in combo comparisons of HDM-, DOPC-, and DS-PAMPA models. Eur J Pharm Sci. 2006;28:43-50.
    • (2006) Eur J Pharm Sci , vol.28 , pp. 43-50
    • Avdeef, A.1    Tsinman, O.2
  • 80
    • 0027049962 scopus 로고
    • Neutral amino acid transport by the blood-brain barrier. Membrane vesicle studies
    • 1:CAS:528:DyaK38Xmt1ymtr0%3D 1464608
    • Sanchez del Pino MM, Hawkins RA, Peterson DR. Neutral amino acid transport by the blood-brain barrier. Membrane vesicle studies. J Biol Chem. 1992;267:25951-7.
    • (1992) J Biol Chem , vol.267 , pp. 25951-25957
    • Sanchez Del Pino, M.M.1    Hawkins, R.A.2    Peterson, D.R.3
  • 81
    • 0031010377 scopus 로고    scopus 로고
    • Glucose transport by isolated plasma membranes of the bovine blood-brain barrier
    • 1:CAS:528:DyaK2sXjsFGisb0%3D 9176146
    • Lee WJ, Peterson DR, Sukowski EJ, Hawkins RA. Glucose transport by isolated plasma membranes of the bovine blood-brain barrier. Am J Physiol. 1997;272:C1552-7.
    • (1997) Am J Physiol , vol.272 , pp. 1552-C1557
    • Lee, W.J.1    Peterson, D.R.2    Sukowski, E.J.3    Hawkins, R.A.4
  • 83
    • 0025886201 scopus 로고
    • Isolation and characterization of microvessels from normal brain and brain tumors
    • 1:STN:280:DyaK38%2FhsVWksA%3D%3D 1919646
    • Silbergeld DL, Ali-Osman F. Isolation and characterization of microvessels from normal brain and brain tumors. J Neurooncol. 1991;11:49-55.
    • (1991) J Neurooncol , vol.11 , pp. 49-55
    • Silbergeld, D.L.1    Ali-Osman, F.2
  • 84
    • 0032934863 scopus 로고    scopus 로고
    • A comparison of blood-brain barrier and blood-nerve barrier endothelial cell markers
    • 1:STN:280:DyaK1M3nslKgtg%3D%3D
    • Orte C, Lawrenson JG, Finn TM, Reid AR, Allt G. A comparison of blood-brain barrier and blood-nerve barrier endothelial cell markers. Anat Embryol (Berlin). 1999;199:509-17.
    • (1999) Anat Embryol (Berlin) , vol.199 , pp. 509-517
    • Orte, C.1    Lawrenson, J.G.2    Finn, T.M.3    Reid, A.R.4    Allt, G.5
  • 85
    • 0035160994 scopus 로고    scopus 로고
    • Contractile proteins in pericytes at the blood-brain and blood-retinal barriers
    • 1:CAS:528:DC%2BD3MXptlGjsLk%3D 11577244
    • Bandopadhyay R, Orte C, Lawrenson JG, Reid AR, De SS, Allt G. Contractile proteins in pericytes at the blood-brain and blood-retinal barriers. J Neurocytol. 2001;30:35-44.
    • (2001) J Neurocytol , vol.30 , pp. 35-44
    • Bandopadhyay, R.1    Orte, C.2    Lawrenson, J.G.3    Reid, A.R.4    De, S. S.5    Allt, G.6
  • 86
    • 0027787707 scopus 로고
    • Calponin and SM 22 as differentiation markers of smooth muscle: Spatiotemporal distribution during avian embryonic development
    • 1:CAS:528:DyaK2cXivFCmtr0%3D 8299876
    • Duband JL, Gimona M, Scatena M, Sartore S, Small JV. Calponin and SM 22 as differentiation markers of smooth muscle: spatiotemporal distribution during avian embryonic development. Differentiation. 1993;55:1-11.
    • (1993) Differentiation , vol.55 , pp. 1-11
    • Duband, J.L.1    Gimona, M.2    Scatena, M.3    Sartore, S.4    Small, J.V.5
  • 89
    • 0027203228 scopus 로고
    • Platelet-activating factor stimulates protein kinase C translocation in cerebral microvessels
    • 1:CAS:528:DyaK3sXktVGmt7g%3D 8484756
    • Catalan RE, Martinez AM, Aragones MD, Garde E, Diaz G. Platelet-activating factor stimulates protein kinase C translocation in cerebral microvessels. Biochem Biophys Res Commun. 1993;192:446-51.
    • (1993) Biochem Biophys Res Commun , vol.192 , pp. 446-451
    • Catalan, R.E.1    Martinez, A.M.2    Aragones, M.D.3    Garde, E.4    Diaz, G.5
  • 90
    • 0025652137 scopus 로고
    • The glucose transporter and blood-brain barrier of human brain tumors
    • 1:CAS:528:DyaK3MXltFWktr8%3D 2178329
    • Guerin C, Laterra J, Hruban RH, Brem H, Drewes LR, Goldstein GW. The glucose transporter and blood-brain barrier of human brain tumors. Ann Neurol. 1990;28:758-65.
    • (1990) Ann Neurol , vol.28 , pp. 758-765
    • Guerin, C.1    Laterra, J.2    Hruban, R.H.3    Brem, H.4    Drewes, L.R.5    Goldstein, G.W.6
  • 91
    • 84870595984 scopus 로고    scopus 로고
    • 1alpha,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells
    • 1:CAS:528:DC%2BC38XhslKrsLfM 3538370 23035695
    • Durk MR, Chan GN, Campos CR, Peart JC, Chow EC, Lee E, et al. 1alpha,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells. J Neurochem. 2012;123:944-53.
    • (2012) J Neurochem , vol.123 , pp. 944-953
    • Durk, M.R.1    Chan, G.N.2    Campos, C.R.3    Peart, J.C.4    Chow, E.C.5    Lee, E.6
  • 92
    • 75349108100 scopus 로고    scopus 로고
    • Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor
    • 1:CAS:528:DC%2BC3cXhsVOru70%3D 2830816 20107068
    • Hawkins BT, Sykes DB, Miller DS. Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor. J Neurosci. 2010;30:1417-25.
    • (2010) J Neurosci , vol.30 , pp. 1417-1425
    • Hawkins, B.T.1    Sykes, D.B.2    Miller, D.S.3
  • 94
    • 77954288447 scopus 로고    scopus 로고
    • Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier
    • 1:CAS:528:DC%2BC3cXot1WrtLw%3D 3109429 20595955
    • Bernas MJ, Cardoso FL, Daley SK, Weinand ME, Campos AR, Ferreira AJ, et al. Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier. Nat Protoc. 2010;5:1265-72.
    • (2010) Nat Protoc , vol.5 , pp. 1265-1272
    • Bernas, M.J.1    Cardoso, F.L.2    Daley, S.K.3    Weinand, M.E.4    Campos, A.R.5    Ferreira, A.J.6
  • 95
    • 79961096875 scopus 로고    scopus 로고
    • Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels
    • 1:CAS:528:DC%2BC3MXos1WhtLY%3D 21707071
    • Shawahna R, Uchida Y, Decleves X, Ohtsuki S, Yousif S, Dauchy S, et al. Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels. Mol Pharm. 2011;8:1332-41.
    • (2011) Mol Pharm , vol.8 , pp. 1332-1341
    • Shawahna, R.1    Uchida, Y.2    Decleves, X.3    Ohtsuki, S.4    Yousif, S.5    Dauchy, S.6
  • 96
    • 0023605484 scopus 로고
    • Isolation of intact capillaries and capillary plasma membranes from frozen human brain
    • 1:CAS:528:DyaL1cXntFKiuw%3D%3D 3694717
    • Pardridge WM, Yang J, Eisenberg J, Tourtellotte WW. Isolation of intact capillaries and capillary plasma membranes from frozen human brain. J Neurosci Res. 1987;18:352-7.
    • (1987) J Neurosci Res , vol.18 , pp. 352-357
    • Pardridge, W.M.1    Yang, J.2    Eisenberg, J.3    Tourtellotte, W.W.4
  • 97
    • 84878746600 scopus 로고    scopus 로고
    • A simple method to quickly and simultaneously purify and enrich intact rat brain microcapillaries and endothelial and glial cells for ex vivo studies and cell culture
    • 1:CAS:528:DC%2BC3sXotlGktrY%3D 23665392
    • Lenhard T, Hulsermann U, Martinez-Torres F, Fricker G, Meyding-Lamade U. A simple method to quickly and simultaneously purify and enrich intact rat brain microcapillaries and endothelial and glial cells for ex vivo studies and cell culture. Brain Res. 2013;1519:9-18.
    • (2013) Brain Res , vol.1519 , pp. 9-18
    • Lenhard, T.1    Hulsermann, U.2    Martinez-Torres, F.3    Fricker, G.4    Meyding-Lamade, U.5
  • 98
    • 84866844026 scopus 로고    scopus 로고
    • Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain
    • 1:CAS:528:DC%2BC38XhsFCrs7fJ 3465435 22949658
    • Cannon RE, Peart JC, Hawkins BT, Campos CR, Miller DS. Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain. Proc Natl Acad Sci U S A. 2012;109:15930-5.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 15930-15935
    • Cannon, R.E.1    Peart, J.C.2    Hawkins, B.T.3    Campos, C.R.4    Miller, D.S.5
  • 99
    • 80053548451 scopus 로고    scopus 로고
    • In vitro modeling of the blood-brain barrier: Simplicity versus complexity
    • 1:CAS:528:DC%2BC3MXhsVSis7vK 21827410
    • Ogunshola OO. In vitro modeling of the blood-brain barrier: simplicity versus complexity. Curr Pharm Des. 2011;17:2755-61.
    • (2011) Curr Pharm des , vol.17 , pp. 2755-2761
    • Ogunshola, O.O.1
  • 100
    • 84872799173 scopus 로고    scopus 로고
    • Delivery of paclitaxel across cellular barriers using a dendrimer-based nanocarrier
    • 1:CAS:528:DC%2BC38Xhs1GhtbfO 23089576
    • Teow HM, Zhou Z, Najlah M, Yusof SR, Abbott NJ, D'Emanuele A. Delivery of paclitaxel across cellular barriers using a dendrimer-based nanocarrier. Int J Pharm. 2013;441:701-11.
    • (2013) Int J Pharm , vol.441 , pp. 701-711
    • Teow, H.M.1    Zhou, Z.2    Najlah, M.3    Yusof, S.R.4    Abbott, N.J.5    D'Emanuele, A.6
  • 101
    • 0842346110 scopus 로고    scopus 로고
    • Development of an in vitro blood-brain barrier model-cytotoxicity of mercury and aluminum
    • 1:CAS:528:DC%2BD2cXhtVOksb4%3D 14962507
    • Toimela T, Maenpaa H, Mannerstrom M, Tahti H. Development of an in vitro blood-brain barrier model-cytotoxicity of mercury and aluminum. Toxicol Appl Pharmacol. 2004;195:73-82.
    • (2004) Toxicol Appl Pharmacol , vol.195 , pp. 73-82
    • Toimela, T.1    Maenpaa, H.2    Mannerstrom, M.3    Tahti, H.4
  • 103
    • 84879317981 scopus 로고    scopus 로고
    • Establishment of a simplified in vitro porcine blood-brain barrier model with high transendothelial electrical resistance
    • 1:CAS:528:DC%2BC3sXmtV2gtLw%3D 3694297 22789905
    • Patabendige A, Skinner RA, Abbott NJ. Establishment of a simplified in vitro porcine blood-brain barrier model with high transendothelial electrical resistance. Brain Res. 2013;1521:1-15.
    • (2013) Brain Res , vol.1521 , pp. 1-15
    • Patabendige, A.1    Skinner, R.A.2    Abbott, N.J.3
  • 104
    • 84855947240 scopus 로고    scopus 로고
    • An improved in vitro blood-brain barrier model: Rat brain endothelial cells co-cultured with astrocytes
    • 1:CAS:528:DC%2BC38XhslWisrbP 22144323
    • Abbott NJ, Dolman DE, Drndarski S, Fredriksson SM. An improved in vitro blood-brain barrier model: rat brain endothelial cells co-cultured with astrocytes. Methods Mol Biol. 2012;814:415-30.
    • (2012) Methods Mol Biol , vol.814 , pp. 415-430
    • Abbott, N.J.1    Dolman, D.E.2    Drndarski, S.3    Fredriksson, S.M.4
  • 105
    • 77956513445 scopus 로고    scopus 로고
    • Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood-brain barrier function
    • 1:CAS:528:DC%2BC3cXhtVyhu7nF 20458752
    • Sano Y, Shimizu F, Abe M, Maeda T, Kashiwamura Y, Ohtsuki S, et al. Establishment of a new conditionally immortalized human brain microvascular endothelial cell line retaining an in vivo blood-brain barrier function. J Cell Physiol. 2010;225:519-28.
    • (2010) J Cell Physiol , vol.225 , pp. 519-528
    • Sano, Y.1    Shimizu, F.2    Abe, M.3    Maeda, T.4    Kashiwamura, Y.5    Ohtsuki, S.6
  • 106
    • 0026677532 scopus 로고
    • HMEC-1: Establishment of an immortalized human microvascular endothelial cell line
    • 1:STN:280:DyaK3s7gslOnsw%3D%3D 1361507
    • Ades EW, Candal FJ, Swerlick RA, George VG, Summers S, Bosse DC, et al. HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J Investig Dermatol. 1992;99:683-90.
    • (1992) J Investig Dermatol , vol.99 , pp. 683-690
    • Ades, E.W.1    Candal, F.J.2    Swerlick, R.A.3    George, V.G.4    Summers, S.5    Bosse, D.C.6
  • 107
    • 0042442134 scopus 로고    scopus 로고
    • Regulation of plasminogen activation: A role for melanotransferrin (p97) in cell migration
    • 1:CAS:528:DC%2BD3sXntFaru74%3D 12750156
    • Demeule M, Bertrand Y, Michaud-Levesque J, Jodoin J, Rolland Y, Gabathuler R, et al. Regulation of plasminogen activation: a role for melanotransferrin (p97) in cell migration. Blood. 2003;102:1723-31.
    • (2003) Blood , vol.102 , pp. 1723-1731
    • Demeule, M.1    Bertrand, Y.2    Michaud-Levesque, J.3    Jodoin, J.4    Rolland, Y.5    Gabathuler, R.6
  • 108
    • 79960389341 scopus 로고    scopus 로고
    • Natural haemozoin modulates matrix metalloproteinases and induces morphological changes in human microvascular endothelium
    • 1:CAS:528:DC%2BC3MXpsF2qtLg%3D 21707906
    • Prato M, D'Alessandro S, Van den Steen PE, Opdenakker G, Arese P, Taramelli D, et al. Natural haemozoin modulates matrix metalloproteinases and induces morphological changes in human microvascular endothelium. Cell Microbiol. 2011;13:1275-85.
    • (2011) Cell Microbiol , vol.13 , pp. 1275-1285
    • Prato, M.1    D'Alessandro, S.2    Van Den Steen, P.E.3    Opdenakker, G.4    Arese, P.5    Taramelli, D.6
  • 109
    • 84876161205 scopus 로고    scopus 로고
    • The hCMEC/D3 cell line as a model of the human blood brain barrier
    • 3623852 23531482
    • Weksler B, Romero IA, Couraud PO. The hCMEC/D3 cell line as a model of the human blood brain barrier. Fluids Barriers CNS. 2013;10:16.
    • (2013) Fluids Barriers CNS , vol.10 , pp. 16
    • Weksler, B.1    Romero, I.A.2    Couraud, P.O.3
  • 110
    • 38549096764 scopus 로고    scopus 로고
    • Immortalized human brain endothelial cells and flow-based vascular modeling: A marriage of convenience for rational neurovascular studies
    • 1:CAS:528:DC%2BD1cXhtVKnsbk%3D 17609686
    • Cucullo L, Couraud PO, Weksler B, Romero IA, Hossain M, Rapp E, et al. Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies. J Cereb Blood Flow Metab. 2008;28:312-28.
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 312-328
    • Cucullo, L.1    Couraud, P.O.2    Weksler, B.3    Romero, I.A.4    Hossain, M.5    Rapp, E.6
  • 111
    • 84893833082 scopus 로고    scopus 로고
    • Differences in amyloid-beta clearance across mouse and human blood-brain barrier models: Kinetic analysis and mechanistic modeling
    • 1:CAS:528:DC%2BC2cXjsVWgsbk%3D 24467845
    • Qosa H, Abuasal BS, Romero IA, Weksler B, Couraud PO, Keller JN, et al. Differences in amyloid-beta clearance across mouse and human blood-brain barrier models: Kinetic analysis and mechanistic modeling. Neuropharmacology. 2014;79:668-78.
    • (2014) Neuropharmacology , vol.79 , pp. 668-678
    • Qosa, H.1    Abuasal, B.S.2    Romero, I.A.3    Weksler, B.4    Couraud, P.O.5    Keller, J.N.6
  • 112
    • 72449202243 scopus 로고    scopus 로고
    • Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformans
    • 1:CAS:528:DC%2BD1MXhsFSku7rN 2772405 19767445
    • Vu K, Weksler B, Romero I, Couraud PO, Gelli A. Immortalized human brain endothelial cell line HCMEC/D3 as a model of the blood-brain barrier facilitates in vitro studies of central nervous system infection by Cryptococcus neoformans. Eukaryot Cell. 2009;8:1803-7.
    • (2009) Eukaryot Cell , vol.8 , pp. 1803-1807
    • Vu, K.1    Weksler, B.2    Romero, I.3    Couraud, P.O.4    Gelli, A.5
  • 113
    • 84900399375 scopus 로고    scopus 로고
    • Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: Is smoking reduced or nicotine-free products really safe?
    • 4020608 24755281
    • Naik P, Fofaria N, Prasad S, Sajja RK, Weksler B, Couraud PO, et al. Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe? BMC Neurosci. 2014;15:51.
    • (2014) BMC Neurosci , vol.15 , pp. 51
    • Naik, P.1    Fofaria, N.2    Prasad, S.3    Sajja, R.K.4    Weksler, B.5    Couraud, P.O.6
  • 114
    • 84898914479 scopus 로고    scopus 로고
    • Impact of altered glycaemia on blood-brain barrier endothelium: An in vitro study using the hCMEC/D3 cell line
    • 3985548 24708805
    • Sajja RK, Prasad S, Cucullo L. Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line. Fluids Barriers CNS. 2014;11:8.
    • (2014) Fluids Barriers CNS , vol.11 , pp. 8
    • Sajja, R.K.1    Prasad, S.2    Cucullo, L.3
  • 115
    • 33847625066 scopus 로고    scopus 로고
    • Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs
    • 1:CAS:528:DC%2BD2sXksVaktbs%3D 17326793
    • Cucullo L, Hossain M, Rapp E, Manders T, Marchi N, Janigro D. Development of a humanized in vitro blood-brain barrier model to screen for brain penetration of antiepileptic drugs. Epilepsia. 2007;48:505-16.
    • (2007) Epilepsia , vol.48 , pp. 505-516
    • Cucullo, L.1    Hossain, M.2    Rapp, E.3    Manders, T.4    Marchi, N.5    Janigro, D.6
  • 116
    • 77955336780 scopus 로고    scopus 로고
    • Pattern of P450 expression at the human blood-brain barrier: Roles of epileptic condition and laminar flow
    • 1:CAS:528:DC%2BC3cXhtFKktrjP 3386640 20074231
    • Ghosh C, Gonzalez-Martinez J, Hossain M, Cucullo L, Fazio V, Janigro D, et al. Pattern of P450 expression at the human blood-brain barrier: roles of epileptic condition and laminar flow. Epilepsia. 2010;51:1408-17.
    • (2010) Epilepsia , vol.51 , pp. 1408-1417
    • Ghosh, C.1    Gonzalez-Martinez, J.2    Hossain, M.3    Cucullo, L.4    Fazio, V.5    Janigro, D.6
  • 117
    • 77955629588 scopus 로고    scopus 로고
    • Nanoparticulate formulations for paclitaxel delivery across MDCK cell monolayer
    • 1:CAS:528:DC%2BC3cXhtFertrfL 20618154
    • Xie J, Lei C, Hu Y, Gay GK, Bin Jamali NH, Wang CH. Nanoparticulate formulations for paclitaxel delivery across MDCK cell monolayer. Curr Pharm Des. 2010;16:2331-40.
    • (2010) Curr Pharm des , vol.16 , pp. 2331-2340
    • Xie, J.1    Lei, C.2    Hu, Y.3    Gay, G.K.4    Bin Jamali, N.H.5    Wang, C.H.6
  • 118
    • 0035997330 scopus 로고    scopus 로고
    • Prediction of drug transport through the blood-brain barrier in vivo: A comparison between two in vitro cell models
    • 1:CAS:528:DC%2BD38Xltl2isLo%3D 12180550
    • Lundquist S, Renftel M, Brillault J, Fenart L, Cecchelli R, Dehouck MP. Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models. Pharm Res. 2002;19:976-81.
    • (2002) Pharm Res , vol.19 , pp. 976-981
    • Lundquist, S.1    Renftel, M.2    Brillault, J.3    Fenart, L.4    Cecchelli, R.5    Dehouck, M.P.6
  • 119
    • 33745991935 scopus 로고    scopus 로고
    • A novel flow based hollow-fiber blood-brain barrier in vitro model with immortalised cell line PBMEC/C1-2
    • 1:CAS:528:DC%2BD28XntlCks70%3D 16730091
    • Neuhaus W, Lauer R, Oelzant S, Fringeli UP, Ecker GF, Noe CR. A novel flow based hollow-fiber blood-brain barrier in vitro model with immortalised cell line PBMEC/C1-2. J Biotechnol. 2006;125:127-41.
    • (2006) J Biotechnol , vol.125 , pp. 127-141
    • Neuhaus, W.1    Lauer, R.2    Oelzant, S.3    Fringeli, U.P.4    Ecker, G.F.5    Noe, C.R.6
  • 120
    • 39749202248 scopus 로고    scopus 로고
    • Effect of nicotine and polyaromtic hydrocarbons on cerebral endothelial cells
    • 1:CAS:528:DC%2BD1cXivVyhu7o%3D 17920942
    • Hutamekalin P, Farkas AE, Orbok A, Wilhelm I, Nagyoszi P, Veszelka S, et al. Effect of nicotine and polyaromtic hydrocarbons on cerebral endothelial cells. Cell Biol Int. 2008;32:198-209.
    • (2008) Cell Biol Int , vol.32 , pp. 198-209
    • Hutamekalin, P.1    Farkas, A.E.2    Orbok, A.3    Wilhelm, I.4    Nagyoszi, P.5    Veszelka, S.6
  • 121
    • 33747770301 scopus 로고    scopus 로고
    • Side by side comparison between dynamic versus static models of blood-brain barrier in vitro: A permeability study
    • 1:CAS:528:DC%2BD28XovVShtrY%3D 16857178
    • Santaguida S, Janigro D, Hossain M, Oby E, Rapp E, Cucullo L. Side by side comparison between dynamic versus static models of blood-brain barrier in vitro: a permeability study. Brain Res. 2006;1109:1-13.
    • (2006) Brain Res , vol.1109 , pp. 1-13
    • Santaguida, S.1    Janigro, D.2    Hossain, M.3    Oby, E.4    Rapp, E.5    Cucullo, L.6
  • 122
    • 84864874302 scopus 로고    scopus 로고
    • Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells
    • 1:CAS:528:DC%2BC38XovFyksLw%3D 3467331 22729031
    • Lippmann ES, Azarin SM, Kay JE, Nessler RA, Wilson HK, Al-Ahmad A, et al. Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells. Nat Biotechnol. 2012;30:783-91.
    • (2012) Nat Biotechnol , vol.30 , pp. 783-791
    • Lippmann, E.S.1    Azarin, S.M.2    Kay, J.E.3    Nessler, R.A.4    Wilson, H.K.5    Al-Ahmad, A.6
  • 123
    • 3543036432 scopus 로고    scopus 로고
    • Transport screening of drug cocktails through an in vitro blood-brain barrier: Is it a good strategy for increasing the throughput of the discovery pipeline?
    • 1:CAS:528:DC%2BD2cXjs1Kisro%3D 15180330
    • Berezowski V, Landry C, Lundquist S, Dehouck L, Cecchelli R, Dehouck MP, et al. Transport screening of drug cocktails through an in vitro blood-brain barrier: is it a good strategy for increasing the throughput of the discovery pipeline? Pharm Res. 2004;21:756-60.
    • (2004) Pharm Res , vol.21 , pp. 756-760
    • Berezowski, V.1    Landry, C.2    Lundquist, S.3    Dehouck, L.4    Cecchelli, R.5    Dehouck, M.P.6
  • 124
    • 41149178098 scopus 로고    scopus 로고
    • Human brain microvascular endothelial cells and umbilical vein endothelial cells differentially facilitate leukocyte recruitment and utilize chemokines for T cell migration
    • 2248224 18320011
    • Man S, Ubogu EE, Williams KA, Tucky B, Callahan MK, Ransohoff RM. Human brain microvascular endothelial cells and umbilical vein endothelial cells differentially facilitate leukocyte recruitment and utilize chemokines for T cell migration. Clin Dev Immunol. 2008;2008:384982.
    • (2008) Clin Dev Immunol , vol.2008 , pp. 384982
    • Man, S.1    Ubogu, E.E.2    Williams, K.A.3    Tucky, B.4    Callahan, M.K.5    Ransohoff, R.M.6
  • 125
    • 0019299131 scopus 로고
    • Some properties of isolated endothelial cells in culture
    • 1:CAS:528:DyaL3MXksV2juw%3D%3D 6108055
    • DeBault LE, Cancilla PA. Some properties of isolated endothelial cells in culture. Adv Exp Med Biol. 1980;131:69-78.
    • (1980) Adv Exp Med Biol , vol.131 , pp. 69-78
    • Debault, L.E.1    Cancilla, P.A.2
  • 126
    • 79551646454 scopus 로고    scopus 로고
    • Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insult
    • Al AA, Taboada CB, Gassmann M, Ogunshola OO. Astrocytes and pericytes differentially modulate blood-brain barrier characteristics during development and hypoxic insult. J Cereb Blood Flow Metab. 2011;31:693-705.
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 693-705
    • Al, A.A.1    Taboada, C.B.2    Gassmann, M.3    Ogunshola, O.O.4
  • 127
    • 27844518332 scopus 로고    scopus 로고
    • The critical component to establish in vitro BBB model: Pericyte
    • 1:CAS:528:DC%2BD2MXht1GisbbL 16199092
    • Lai CH, Kuo KH. The critical component to establish in vitro BBB model: Pericyte. Brain Res Brain Res Rev. 2005;50:258-65.
    • (2005) Brain Res Brain Res Rev , vol.50 , pp. 258-265
    • Lai, C.H.1    Kuo, K.H.2
  • 128
    • 0036319335 scopus 로고    scopus 로고
    • Astrocyte-endothelial interactions and blood-brain barrier permeability
    • 1:CAS:528:DC%2BD3sXjtFemt7w%3D 1570746 12162730
    • Abbott NJ. Astrocyte-endothelial interactions and blood-brain barrier permeability. J Anat. 2002;200:629-38.
    • (2002) J Anat , vol.200 , pp. 629-638
    • Abbott, N.J.1
  • 129
  • 130
    • 3342996554 scopus 로고    scopus 로고
    • Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte-derived soluble factor(s)
    • 1:CAS:528:DC%2BD2cXmsFersb8%3D 15255930
    • Hori S, Ohtsuki S, Tachikawa M, Kimura N, Kondo T, Watanabe M, et al. Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte-derived soluble factor(s). J Neurochem. 2004;90:526-36.
    • (2004) J Neurochem , vol.90 , pp. 526-536
    • Hori, S.1    Ohtsuki, S.2    Tachikawa, M.3    Kimura, N.4    Kondo, T.5    Watanabe, M.6
  • 131
    • 60549085837 scopus 로고    scopus 로고
    • Physiological pathway for low-density lipoproteins across the blood-brain barrier: Transcytosis through brain capillary endothelial cells in vitro
    • 1:CAS:528:DC%2BD1cXhsVyru7zO 19065317
    • Candela P, Gosselet F, Miller F, Buee-Scherrer V, Torpier G, Cecchelli R, et al. Physiological pathway for low-density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro. Endothelium. 2008;15:254-64.
    • (2008) Endothelium , vol.15 , pp. 254-264
    • Candela, P.1    Gosselet, F.2    Miller, F.3    Buee-Scherrer, V.4    Torpier, G.5    Cecchelli, R.6
  • 133
    • 79960279229 scopus 로고    scopus 로고
    • Development of a three-dimensional, all-human in vitro model of the blood-brain barrier using mono-, co-, and tri-cultivation Transwell models
    • 21609734
    • Hatherell K, Couraud PO, Romero IA, Weksler B, Pilkington GJ. Development of a three-dimensional, all-human in vitro model of the blood-brain barrier using mono-, co-, and tri-cultivation Transwell models. J Neurosci Methods. 2011;199:223-9.
    • (2011) J Neurosci Methods , vol.199 , pp. 223-229
    • Hatherell, K.1    Couraud, P.O.2    Romero, I.A.3    Weksler, B.4    Pilkington, G.J.5
  • 134
    • 34147098912 scopus 로고    scopus 로고
    • Human astrocytes/astrocyte-conditioned medium and shear stress enhance the barrier properties of human brain microvascular endothelial cells
    • 1:CAS:528:DC%2BD2sXksVOqtLc%3D 2691862 17368578
    • Siddharthan V, Kim YV, Liu S, Kim KS. Human astrocytes/astrocyte-conditioned medium and shear stress enhance the barrier properties of human brain microvascular endothelial cells. Brain Res. 2007;1147:39-50.
    • (2007) Brain Res , vol.1147 , pp. 39-50
    • Siddharthan, V.1    Kim, Y.V.2    Liu, S.3    Kim, K.S.4
  • 135
    • 84856587379 scopus 로고    scopus 로고
    • CXCL12-induced monocyte-endothelial interactions promote lymphocyte transmigration across an in vitro blood-brain barrier
    • 3710123 22301555
    • Man S, Tucky B, Cotleur A, Drazba J, Takeshita Y, Ransohoff RM. CXCL12-induced monocyte-endothelial interactions promote lymphocyte transmigration across an in vitro blood-brain barrier. Sci Transl Med. 2012;4:119ra14.
    • (2012) Sci Transl Med , vol.4 , pp. 119ra14
    • Man, S.1    Tucky, B.2    Cotleur, A.3    Drazba, J.4    Takeshita, Y.5    Ransohoff, R.M.6
  • 137
    • 84905695712 scopus 로고    scopus 로고
    • Effects of grinding method, particle size, and physical form of the diet on gastrointestinal morphology and jejunal glucose transport in laying hens
    • 1:STN:280:DC%2BC2cjpsVGgtQ%3D%3D 24902702
    • Rohe I, Ruhnke I, Knorr F, Mader A, Boroojeni FG, Lowe R, et al. Effects of grinding method, particle size, and physical form of the diet on gastrointestinal morphology and jejunal glucose transport in laying hens. Poult Sci. 2014;93(8):2060-8.
    • (2014) Poult Sci , vol.93 , Issue.8 , pp. 2060-2068
    • Rohe, I.1    Ruhnke, I.2    Knorr, F.3    Mader, A.4    Boroojeni, F.G.5    Lowe, R.6
  • 138
    • 67049146675 scopus 로고    scopus 로고
    • A guide to Ussing chamber studies of mouse intestine
    • 1:CAS:528:DC%2BD1MXnsVCltbk%3D 2697950 19342508
    • Clarke LL. A guide to Ussing chamber studies of mouse intestine. Am J Physiol Gastrointest Liver Physiol. 2009;296:G1151-66.
    • (2009) Am J Physiol Gastrointest Liver Physiol , vol.296 , pp. 1151-G1166
    • Clarke, L.L.1
  • 139
    • 0028949154 scopus 로고
    • Adhesion and differentiation of endothelial cells by exposure to chronic shear stress: A vascular graft model
    • 1:STN:280:DyaK2MzksVKiuw%3D%3D 7619384
    • Ballermann BJ, Ott MJ. Adhesion and differentiation of endothelial cells by exposure to chronic shear stress: a vascular graft model. Blood Purif. 1995;13:125-34.
    • (1995) Blood Purif , vol.13 , pp. 125-134
    • Ballermann, B.J.1    Ott, M.J.2
  • 140
    • 73249122034 scopus 로고    scopus 로고
    • Vascular mechanobiology: Endothelial cell responses to fluid shear stress
    • 1:CAS:528:DC%2BD1MXhsVKgsb%2FP 19801852
    • Ando J, Yamamoto K. Vascular mechanobiology: endothelial cell responses to fluid shear stress. Circ J. 2009;73:1983-92.
    • (2009) Circ J , vol.73 , pp. 1983-1992
    • Ando, J.1    Yamamoto, K.2
  • 141
    • 77953639636 scopus 로고    scopus 로고
    • Mechanotransduction by endothelial cells is locally generated, direction-dependent, and ligand-specific
    • 1:CAS:528:DC%2BC3cXmslWitLk%3D 20432432
    • Chretien ML, Zhang M, Jackson MR, Kapus A, Langille BL. Mechanotransduction by endothelial cells is locally generated, direction-dependent, and ligand-specific. J Cell Physiol. 2010;224:352-61.
    • (2010) J Cell Physiol , vol.224 , pp. 352-361
    • Chretien, M.L.1    Zhang, M.2    Jackson, M.R.3    Kapus, A.4    Langille, B.L.5
  • 142
    • 0022380016 scopus 로고
    • Prostacyclin production by cultured endothelial cell monolayers exposed to step increases in shear stress
    • 1:CAS:528:DyaL2MXptVGlsA%3D%3D 3918129
    • Grabowski EF, Jaffe EA, Weksler BB. Prostacyclin production by cultured endothelial cell monolayers exposed to step increases in shear stress. J Lab Clin Med. 1985;105:36-43.
    • (1985) J Lab Clin Med , vol.105 , pp. 36-43
    • Grabowski, E.F.1    Jaffe, E.A.2    Weksler, B.B.3
  • 143
    • 77649090069 scopus 로고    scopus 로고
    • Laminar shear stress modulates phosphorylation and localization of RNA polymerase II on the endothelial nitric oxide synthase gene
    • 1:CAS:528:DC%2BC3cXitlSgur0%3D 2948754 20167666
    • Moore JP, Weber M, Searles CD. Laminar shear stress modulates phosphorylation and localization of RNA polymerase II on the endothelial nitric oxide synthase gene. Arterioscler Thromb Vasc Biol. 2010;30:561-7.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 561-567
    • Moore, J.P.1    Weber, M.2    Searles, C.D.3
  • 144
    • 0026032652 scopus 로고
    • Shear stress-induced release of nitric oxide from endothelial cells grown on beads
    • 1:CAS:528:DyaK3MXhsVSmu7g%3D 1991651
    • Buga GM, Gold ME, Fukuto JM, Ignarro LJ. Shear stress-induced release of nitric oxide from endothelial cells grown on beads. Hypertension. 1991;17:187-93.
    • (1991) Hypertension , vol.17 , pp. 187-193
    • Buga, G.M.1    Gold, M.E.2    Fukuto, J.M.3    Ignarro, L.J.4
  • 145
    • 0028950622 scopus 로고
    • Shear stress-conditioned, endothelial cell-seeded vascular grafts: Improved cell adherence in response to in vitro shear stress
    • 1:STN:280:DyaK2M7osVSrug%3D%3D 7878541
    • Ott MJ, Ballermann BJ. Shear stress-conditioned, endothelial cell-seeded vascular grafts: improved cell adherence in response to in vitro shear stress. Surgery. 1995;117:334-9.
    • (1995) Surgery , vol.117 , pp. 334-339
    • Ott, M.J.1    Ballermann, B.J.2
  • 146
    • 80051931770 scopus 로고    scopus 로고
    • Stabilization of Brain Microvascular Endothelial Barrier Function by Shear Stress Involves VE-cadherin Signaling Leading to Modulation of pTyr-Occludin Levels
    • 1:CAS:528:DC%2BC3MXhtVKksrjK 21302304
    • Walsh TG, Murphy RP, Fitzpatrick P, Rochfort KD, Guinan AF, Murphy A, et al. Stabilization of Brain Microvascular Endothelial Barrier Function by Shear Stress Involves VE-cadherin Signaling Leading to Modulation of pTyr-Occludin Levels. J Cell Physiol. 2011;226(11):3053-63.
    • (2011) J Cell Physiol , vol.226 , Issue.11 , pp. 3053-3063
    • Walsh, T.G.1    Murphy, R.P.2    Fitzpatrick, P.3    Rochfort, K.D.4    Guinan, A.F.5    Murphy, A.6
  • 147
    • 34447539769 scopus 로고    scopus 로고
    • Regulation of bovine brain microvascular endothelial tight junction assembly and barrier function by laminar shear stress
    • 1:CAS:528:DC%2BD2sXmvF2ksbY%3D 17308001
    • Colgan OC, Ferguson G, Collins NT, Murphy RP, Meade G, Cahill PA, et al. Regulation of bovine brain microvascular endothelial tight junction assembly and barrier function by laminar shear stress. Am J Physiol Heart Circ Physiol. 2007;292:H3190-7.
    • (2007) Am J Physiol Heart Circ Physiol , vol.292 , pp. 3190-H3197
    • Colgan, O.C.1    Ferguson, G.2    Collins, N.T.3    Murphy, R.P.4    Meade, G.5    Cahill, P.A.6
  • 148
    • 77954341974 scopus 로고    scopus 로고
    • Shear stress and the endothelial transport barrier
    • 1:CAS:528:DC%2BC3cXotlChtb8%3D 2915475 20543206
    • Tarbell JM. Shear stress and the endothelial transport barrier. Cardiovasc Res. 2010;87:320-30.
    • (2010) Cardiovasc Res , vol.87 , pp. 320-330
    • Tarbell, J.M.1
  • 149
    • 0019355002 scopus 로고
    • The dynamic response of vascular endothelial cells to fluid shear stress
    • 7278196
    • Dewey Jr CF, Bussolari SR, Gimbrone Jr MA, Davies PF. The dynamic response of vascular endothelial cells to fluid shear stress. J Biomech Eng. 1981;103:177-85.
    • (1981) J Biomech Eng , vol.103 , pp. 177-185
    • Dewey, C.F.1    Bussolari, S.R.2    Gimbrone, M.A.3    Davies, P.F.4
  • 150
    • 0020464724 scopus 로고
    • Apparatus for subjecting living cells to fluid shear stress
    • 1:STN:280:DyaL3s7hvFKntw%3D%3D 7156852
    • Bussolari SR, Dewey Jr CF, Gimbrone Jr MA. Apparatus for subjecting living cells to fluid shear stress. Rev Sci Instrum. 1982;53:1851-4.
    • (1982) Rev Sci Instrum , vol.53 , pp. 1851-1854
    • Bussolari, S.R.1    Dewey, C.F.2    Gimbrone, M.A.3
  • 151
    • 84893676358 scopus 로고    scopus 로고
    • Roles for GP IIb/IIIa and alphavbeta3 integrins in MDA-MB-231 cell invasion and shear flow-induced cancer cell mechanotransduction
    • 1:CAS:528:DC%2BC3sXhslGls7jI 24176823
    • Zhao F, Li L, Guan L, Yang H, Wu C, Liu Y. Roles for GP IIb/IIIa and alphavbeta3 integrins in MDA-MB-231 cell invasion and shear flow-induced cancer cell mechanotransduction. Cancer Lett. 2014;344:62-73.
    • (2014) Cancer Lett , vol.344 , pp. 62-73
    • Zhao, F.1    Li, L.2    Guan, L.3    Yang, H.4    Wu, C.5    Liu, Y.6
  • 152
    • 80055114178 scopus 로고    scopus 로고
    • Analysis of physiologic E-selectin-mediated leukocyte rolling on microvascular endothelium
    • Wiese G, Barthel SR, Dimitroff CJ. Analysis of physiologic E-selectin-mediated leukocyte rolling on microvascular endothelium. J Vis Exp 2009.
    • (2009) J Vis Exp
    • Wiese, G.1    Barthel, S.R.2    Dimitroff, C.J.3
  • 154
    • 84878932988 scopus 로고    scopus 로고
    • Hypo- and hyperglycemia impair endothelial cell actin alignment and nitric oxide synthase activation in response to shear stress
    • 1:CAS:528:DC%2BC3sXhtVanu77K 3680428 23776627
    • Kemeny SF, Figueroa DS, Clyne AM. Hypo- and hyperglycemia impair endothelial cell actin alignment and nitric oxide synthase activation in response to shear stress. PLoS ONE. 2013;8:e66176.
    • (2013) PLoS ONE , vol.8 , pp. 66176
    • Kemeny, S.F.1    Figueroa, D.S.2    Clyne, A.M.3
  • 155
    • 84877025122 scopus 로고    scopus 로고
    • A potential model for drug screening by simulating the effect of shear stress in vivo on endothelium
    • 1:CAS:528:DC%2BC3sXms1WhtL0%3D 23619151
    • Xu Y, Wang B, Deng J, Liu Z, Zhu L. A potential model for drug screening by simulating the effect of shear stress in vivo on endothelium. Biorheology. 2013;50:33-43.
    • (2013) Biorheology , vol.50 , pp. 33-43
    • Xu, Y.1    Wang, B.2    Deng, J.3    Liu, Z.4    Zhu, L.5
  • 156
    • 84887414300 scopus 로고    scopus 로고
    • Development and application of a volume penalization immersed boundary method for the computation of blood flow and shear stresses in cerebral vessels and aneurysms
    • 23192329
    • Mikhal J, Geurts BJ. Development and application of a volume penalization immersed boundary method for the computation of blood flow and shear stresses in cerebral vessels and aneurysms. J Math Biol. 2013;67:1847-75.
    • (2013) J Math Biol , vol.67 , pp. 1847-1875
    • Mikhal, J.1    Geurts, B.J.2
  • 157
    • 85061174032 scopus 로고    scopus 로고
    • High-speed particle image velocimetry near surfaces
    • L. Lu and V. Sick. High-speed particle image velocimetry near surfaces. J Vis Exp 2013.
    • (2013) J Vis Exp
    • Lu, L.1    Sick, V.2
  • 158
    • 0029759938 scopus 로고    scopus 로고
    • A dynamic model of the blood-brain barrier "in vitro"
    • 1:CAS:528:DyaK28Xltl2ktLo%3D 8856743
    • Stanness KA, Guatteo E, Janigro D. A dynamic model of the blood-brain barrier "in vitro". Neurotoxicology. 1996;17:481-96.
    • (1996) Neurotoxicology , vol.17 , pp. 481-496
    • Stanness, K.A.1    Guatteo, E.2    Janigro, D.3
  • 159
    • 84873255363 scopus 로고    scopus 로고
    • A new dynamic in vitro modular capillaries-venules modular system: Cerebrovascular physiology in a box
    • 3598202 23388041
    • Cucullo L, Hossain M, Tierney W, Janigro D. A new dynamic in vitro modular capillaries-venules modular system: cerebrovascular physiology in a box. BMC Neurosci. 2013;14:18.
    • (2013) BMC Neurosci , vol.14 , pp. 18
    • Cucullo, L.1    Hossain, M.2    Tierney, W.3    Janigro, D.4
  • 160
    • 0037019919 scopus 로고    scopus 로고
    • A new dynamic in vitro model for the multidimensional study of astrocyte-endothelial cell interactions at the blood-brain barrier
    • 1:CAS:528:DC%2BD38Xnt1ajur0%3D 12270503
    • Cucullo L, McAllister MS, Kight K, Krizanac-Bengez L, Marroni M, Mayberg MR, et al. A new dynamic in vitro model for the multidimensional study of astrocyte-endothelial cell interactions at the blood-brain barrier. Brain Res. 2002;951:243-54.
    • (2002) Brain Res , vol.951 , pp. 243-254
    • Cucullo, L.1    McAllister, M.S.2    Kight, K.3    Krizanac-Bengez, L.4    Marroni, M.5    Mayberg, M.R.6
  • 161
    • 58149119716 scopus 로고    scopus 로고
    • Volume flow and wall shear stress quantification in the human conjunctival capillaries and post-capillary venules in vivo
    • 18401076
    • Koutsiaris AG, Tachmitzi SV, Batis N, Kotoula MG, Karabatsas CH, Tsironi E, et al. Volume flow and wall shear stress quantification in the human conjunctival capillaries and post-capillary venules in vivo. Biorheology. 2007;44:375-86.
    • (2007) Biorheology , vol.44 , pp. 375-386
    • Koutsiaris, A.G.1    Tachmitzi, S.V.2    Batis, N.3    Kotoula, M.G.4    Karabatsas, C.H.5    Tsironi, E.6
  • 162
    • 79551646674 scopus 로고    scopus 로고
    • A dynamic in vitro BBB model for the study of immune cell trafficking into the central nervous system
    • 1:CAS:528:DC%2BC3MXhsVOmsbY%3D 3049530 20842162
    • Cucullo L, Marchi N, Hossain M, Janigro D. A dynamic in vitro BBB model for the study of immune cell trafficking into the central nervous system. J Cereb Blood Flow Metab. 2011;31:767-77.
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 767-777
    • Cucullo, L.1    Marchi, N.2    Hossain, M.3    Janigro, D.4
  • 164
    • 84939905410 scopus 로고    scopus 로고
    • Loss of shear stress induces leukocyte-mediated cytokine release and blood-brain barrier failure in dynamic in vitro blood-brain barrier model
    • Krizanac-Bengez L, Mayberg MR, Cunningham E, Hossain M, Ponnampalam S, Parkinson FE, et al. Loss of shear stress induces leukocyte-mediated cytokine release and blood-brain barrier failure in dynamic in vitro blood-brain barrier model. J Cell Physiol. 2005;291(4):C740-9.
    • (2005) J Cell Physiol , vol.291 , Issue.4 , pp. 740-749
    • Krizanac-Bengez, L.1    Mayberg, M.R.2    Cunningham, E.3    Hossain, M.4    Ponnampalam, S.5    Parkinson, F.E.6
  • 165
    • 84873415685 scopus 로고    scopus 로고
    • Impedance-based cell monitoring: Barrier properties and beyond
    • 3560213 23305242
    • Benson K, Cramer S, Galla HJ. Impedance-based cell monitoring: barrier properties and beyond. Fluids Barriers CNS. 2013;10:5.
    • (2013) Fluids Barriers CNS , vol.10 , pp. 5
    • Benson, K.1    Cramer, S.2    Galla, H.J.3
  • 166
    • 84860366574 scopus 로고    scopus 로고
    • Characterization of a microfluidic in vitro model of the blood-brain barrier (muBBB)
    • 1:CAS:528:DC%2BC38XlvFGrsL0%3D 22422217
    • Booth R, Kim H. Characterization of a microfluidic in vitro model of the blood-brain barrier (muBBB). Lab Chip. 2012;12:1784-92.
    • (2012) Lab Chip , vol.12 , pp. 1784-1792
    • Booth, R.1    Kim, H.2
  • 167
    • 53249138093 scopus 로고    scopus 로고
    • Brain endothelial cell-cell junctions: How to "open" the blood brain barrier
    • 1:CAS:528:DC%2BD1cXht1amurvE 2687937 19506719
    • Stamatovic SM, Keep RF, Andjelkovic AV. Brain endothelial cell-cell junctions: how to "open" the blood brain barrier. Curr Neuropharmacol. 2008;6:179-92.
    • (2008) Curr Neuropharmacol , vol.6 , pp. 179-192
    • Stamatovic, S.M.1    Keep, R.F.2    Andjelkovic, A.V.3
  • 168
    • 84872610509 scopus 로고    scopus 로고
    • W.B.de, P.M.ter Braak, B.B. Weksler, I.A. Romero, P.O. Couraud, I. Vermes, A.D.van der Meer, and A.van den Berg. BBB on chip: Microfluidic platform to mechanically and biochemically modulate blood-brain barrier function
    • 1:CAS:528:DC%2BC3sXptlWrtA%3D%3D 22955726
    • Griep LM, Wolbers F. W.B.de, P.M.ter Braak, B.B. Weksler, I.A. Romero, P.O. Couraud, I. Vermes, A.D.van der Meer, and A.van den Berg. BBB on chip: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function. Biomed Microdevices. 2013;15:145-50.
    • (2013) Biomed Microdevices , vol.15 , pp. 145-150
    • Griep, L.M.1    Wolbers, F.2
  • 171
    • 33645409846 scopus 로고    scopus 로고
    • Flow-induced deformation of shallow microfluidic channels
    • 1:CAS:528:DC%2BD28XivFWhu78%3D 16572212
    • Gervais T, El-Ali J, Gunther A, Jensen KF. Flow-induced deformation of shallow microfluidic channels. Lab Chip. 2006;6:500-7.
    • (2006) Lab Chip , vol.6 , pp. 500-507
    • Gervais, T.1    El-Ali, J.2    Gunther, A.3    Jensen, K.F.4
  • 172
    • 84871150286 scopus 로고    scopus 로고
    • Development of polydimethylsiloxane substrates with tunable elastic modulus to study cell mechanobiology in muscle and nerve
    • 1:CAS:528:DC%2BC38XhvFSksLrF 3519875 23240031
    • Palchesko RN, Zhang L, Sun Y, Feinberg AW. Development of polydimethylsiloxane substrates with tunable elastic modulus to study cell mechanobiology in muscle and nerve. PLoS ONE. 2012;7:e51499.
    • (2012) PLoS ONE , vol.7 , pp. 51499
    • Palchesko, R.N.1    Zhang, L.2    Sun, Y.3    Feinberg, A.W.4
  • 173
    • 59549094629 scopus 로고    scopus 로고
    • Effect of P-glycoprotein inhibitor, verapamil, on oral bioavailability and pharmacokinetics of irinotecan in rats
    • 1:CAS:528:DC%2BD1MXhs1aqurk%3D 19135530
    • Bansal T, Mishra G, Jaggi M, Khar RK, Talegaonkar S. Effect of P-glycoprotein inhibitor, verapamil, on oral bioavailability and pharmacokinetics of irinotecan in rats. Eur J Pharm Sci. 2009;36:580-90.
    • (2009) Eur J Pharm Sci , vol.36 , pp. 580-590
    • Bansal, T.1    Mishra, G.2    Jaggi, M.3    Khar, R.K.4    Talegaonkar, S.5
  • 174
    • 78650062139 scopus 로고    scopus 로고
    • A review of three-dimensional in vitro tissue models for drug discovery and transport studies
    • 1:CAS:528:DC%2BC3cXhsFegsbbF 20533556
    • Elliott NT, Yuan F. A review of three-dimensional in vitro tissue models for drug discovery and transport studies. J Pharm Sci. 2011;100:59-74.
    • (2011) J Pharm Sci , vol.100 , pp. 59-74
    • Elliott, N.T.1    Yuan, F.2
  • 175
    • 32944481839 scopus 로고    scopus 로고
    • Proliferation and differentiation of human embryonic germ cell derivatives in bioactive polymeric fibrous scaffold
    • 1:CAS:528:DC%2BD2MXhtFGkt7bO 16268248
    • Yim EK, Leong KW. Proliferation and differentiation of human embryonic germ cell derivatives in bioactive polymeric fibrous scaffold. J Biomater Sci Polym Ed. 2005;16:1193-217.
    • (2005) J Biomater Sci Polym Ed , vol.16 , pp. 1193-1217
    • Yim, E.K.1    Leong, K.W.2
  • 176
    • 14644400268 scopus 로고    scopus 로고
    • Chondrogenic differentiation of murine embryonic stem cells: Effects of culture conditions and dexamethasone
    • 1:CAS:528:DC%2BD2cXosVyqsrg%3D 15372628
    • Tanaka H, Murphy CL, Murphy C, Kimura M, Kawai S, Polak JM. Chondrogenic differentiation of murine embryonic stem cells: effects of culture conditions and dexamethasone. J Cell Biochem. 2004;93:454-62.
    • (2004) J Cell Biochem , vol.93 , pp. 454-462
    • Tanaka, H.1    Murphy, C.L.2    Murphy, C.3    Kimura, M.4    Kawai, S.5    Polak, J.M.6
  • 177
    • 84901608764 scopus 로고    scopus 로고
    • Modeling the tumor extracellular matrix: Tissue engineering tools repurposed towards new frontiers in cancer biology
    • 24300038
    • Gill BJ, West JL. Modeling the tumor extracellular matrix: Tissue engineering tools repurposed towards new frontiers in cancer biology. J Biomech. 2013;47(9):1969-78.
    • (2013) J Biomech , vol.47 , Issue.9 , pp. 1969-1978
    • Gill, B.J.1    West, J.L.2
  • 179
    • 56549121176 scopus 로고    scopus 로고
    • Cell-matrix interactions improve beta-cell survival and insulin secretion in three-dimensional culture
    • 1:CAS:528:DC%2BD1cXhsVSjsbrO 2992396 18724831
    • Weber LM, Hayda KN, Anseth KS. Cell-matrix interactions improve beta-cell survival and insulin secretion in three-dimensional culture. Tissue Eng Part A. 2008;14:1959-68.
    • (2008) Tissue Eng Part A , vol.14 , pp. 1959-1968
    • Weber, L.M.1    Hayda, K.N.2    Anseth, K.S.3
  • 180
    • 33847356130 scopus 로고    scopus 로고
    • A novel 3D mammalian cell perfusion-culture system in microfluidic channels
    • 1:CAS:528:DC%2BD2sXit12ktLc%3D 17330160
    • Toh YC, Zhang C, Zhang J, Khong YM, Chang S, Samper VD, et al. A novel 3D mammalian cell perfusion-culture system in microfluidic channels. Lab Chip. 2007;7:302-9.
    • (2007) Lab Chip , vol.7 , pp. 302-309
    • Toh, Y.C.1    Zhang, C.2    Zhang, J.3    Khong, Y.M.4    Chang, S.5    Samper, V.D.6
  • 181
    • 84891742591 scopus 로고    scopus 로고
    • A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone
    • 1:CAS:528:DC%2BC2cXms1yn 24388382
    • Bersini S, Jeon JS, Dubini G, Arrigoni C, Chung S, Charest JL, et al. A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone. Biomaterials. 2014;35:2454-61.
    • (2014) Biomaterials , vol.35 , pp. 2454-2461
    • Bersini, S.1    Jeon, J.S.2    Dubini, G.3    Arrigoni, C.4    Chung, S.5    Charest, J.L.6
  • 182
    • 84878623615 scopus 로고    scopus 로고
    • Measuring collective cell movement and extracellular matrix interactions using magnetic resonance imaging
    • 3662010 23698816
    • Chen Y, Dodd SJ, Tangrea MA, Emmert-Buck MR, Koretsky AP. Measuring collective cell movement and extracellular matrix interactions using magnetic resonance imaging. Sci Rep. 2013;3:1879.
    • (2013) Sci Rep , vol.3 , pp. 1879
    • Chen, Y.1    Dodd, S.J.2    Tangrea, M.A.3    Emmert-Buck, M.R.4    Koretsky, A.P.5
  • 183
    • 24644459023 scopus 로고    scopus 로고
    • Cell migration in 3D matrix
    • 1:CAS:528:DC%2BD2MXhtVWnsb7I 16112853
    • Even-Ram S, Yamada KM. Cell migration in 3D matrix. Curr Opin Cell Biol. 2005;17:524-32.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 524-532
    • Even-Ram, S.1    Yamada, K.M.2
  • 184
    • 49049121594 scopus 로고    scopus 로고
    • Mechanotransduction from the ECM to the genome: Are the pieces now in place?
    • 1:CAS:528:DC%2BD1cXps1Ohsrk%3D 17546585
    • Gieni RS, Hendzel MJ. Mechanotransduction from the ECM to the genome: are the pieces now in place? J Cell Biochem. 2008;104:1964-87.
    • (2008) J Cell Biochem , vol.104 , pp. 1964-1987
    • Gieni, R.S.1    Hendzel, M.J.2
  • 186
    • 84865115966 scopus 로고    scopus 로고
    • Quantitative analysis of molecular absorption into PDMS microfluidic channels
    • 22484830
    • Wang JD, Douville NJ, Takayama S, ElSayed M. Quantitative analysis of molecular absorption into PDMS microfluidic channels. Ann Biomed Eng. 2012;40:1862-73.
    • (2012) Ann Biomed Eng , vol.40 , pp. 1862-1873
    • Wang, J.D.1    Douville, N.J.2    Takayama, S.3    Elsayed, M.4
  • 187
    • 84884255934 scopus 로고    scopus 로고
    • Human-on-chip for therapy development and fundamental science
    • Luni C, Serena E, Elvassore N. Human-on-chip for therapy development and fundamental science. Curr Opin Biotechnol. 2014;25C:45-50.
    • (2014) Curr Opin Biotechnol , vol.25 , pp. 45-50
    • Luni, C.1    Serena, E.2    Elvassore, N.3
  • 188
    • 79960527448 scopus 로고    scopus 로고
    • The role of body-on-a-chip devices in drug and toxicity studies
    • 1:CAS:528:DC%2BC3MXhtFCit7zK 21513459
    • Esch MB, King TL, Shuler ML. The role of body-on-a-chip devices in drug and toxicity studies. Annu Rev Biomed Eng. 2011;13:55-72.
    • (2011) Annu Rev Biomed Eng , vol.13 , pp. 55-72
    • Esch, M.B.1    King, T.L.2    Shuler, M.L.3
  • 189
    • 84898899012 scopus 로고    scopus 로고
    • Microfluidics-based in Vivo mimetic systems for the study of cellular biology
    • 1:CAS:528:DC%2BC2cXivFWgsrs%3D 24555566
    • Kim D, Wu X, Young AT, Haynes CL. Microfluidics-based in Vivo mimetic systems for the study of cellular biology. Acc Chem Res. 2014;47(4):1165-73.
    • (2014) Acc Chem Res , vol.47 , Issue.4 , pp. 1165-1173
    • Kim, D.1    Wu, X.2    Young, A.T.3    Haynes, C.L.4


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