-
1
-
-
6344240461
-
Plasma membrane localization of multidrug resistance-associated protein (MRP) homologues in brain capillary endothelial cells
-
Zhang Y, Schuetz JD, Elmquist WF, Miller DW. Plasma membrane localization of multidrug resistance-associated protein (MRP) homologues in brain capillary endothelial cells. J Pharmacol Exp Ther 311: 449-455, 2004.
-
(2004)
J Pharmacol Exp Ther
, vol.311
, pp. 449-455
-
-
Zhang, Y.1
Schuetz, J.D.2
Elmquist, W.F.3
Miller, D.W.4
-
2
-
-
0034623293
-
Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells
-
Zhang Y, Han H, Elmquist WF, Miller DW. Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells. Brain Res 876:148-153, 2000.
-
(2000)
Brain Res
, vol.876
, pp. 148-153
-
-
Zhang, Y.1
Han, H.2
Elmquist, W.F.3
Miller, D.W.4
-
3
-
-
0141894132
-
Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood-brain barrier model for drug uptake and transport studies
-
Omidi Y, Campbell L, Barar J, Connell D, Akhtar S, Gumbleton M. Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood-brain barrier model for drug uptake and transport studies. Brain Res 990:95-112, 2003.
-
(2003)
Brain Res
, vol.990
, pp. 95-112
-
-
Omidi, Y.1
Campbell, L.2
Barar, J.3
Connell, D.4
Akhtar, S.5
Gumbleton, M.6
-
5
-
-
0033975098
-
Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
-
Wijnholds J, deLange EC, Scheffer GL, van den Berg DJ, Mol CA, van der Valk M, Schinkel AH, Scheper RJ, Breimer DD, Borst P. Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J Clin Invest 105:279-285, 2000.
-
(2000)
J Clin Invest
, vol.105
, pp. 279-285
-
-
Wijnholds, J.1
Delange, E.C.2
Scheffer, G.L.3
Van Den Berg, D.J.4
Mol, C.A.5
Van Der Valk, M.6
Schinkel, A.H.7
Scheper, R.J.8
Breimer, D.D.9
Borst, P.10
-
6
-
-
0032859340
-
Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain
-
Gao B, Stieger B, Noe B, Fritschy JM, Meier PJ. Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain. J Histochem Cytochem 47:1255-1264, 1999.
-
(1999)
J Histochem Cytochem
, vol.47
, pp. 1255-1264
-
-
Gao, B.1
Stieger, B.2
Noe, B.3
Fritschy, J.M.4
Meier, P.J.5
-
7
-
-
0036788234
-
Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: Its involvement in neurotransmitter metabolite clearance from the brain
-
Ohtsuki S, Asaba H, Takanaga H, Deguchi T, Hosoya K, Otagiri M, Terasaki T. Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J Neurochem 83:57-66, 2002.
-
(2002)
J Neurochem
, vol.83
, pp. 57-66
-
-
Ohtsuki, S.1
Asaba, H.2
Takanaga, H.3
Deguchi, T.4
Hosoya, K.5
Otagiri, M.6
Terasaki, T.7
-
8
-
-
0032900953
-
Biochemical, cellular, and pharmacological aspects of the multidrug transporter
-
Ambudkar SV, Dey S, Hrycyna CA, Ramachandra M, Pastan I, Gottesman MM. Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol 39:361-398, 1999.
-
(1999)
Annu Rev Pharmacol Toxicol
, vol.39
, pp. 361-398
-
-
Ambudkar, S.V.1
Dey, S.2
Hrycyna, C.A.3
Ramachandra, M.4
Pastan, I.5
Gottesman, M.M.6
-
10
-
-
0032542358
-
Crystal structure of the ATP-binding subunit of an ABC transporter
-
Hung LW, Wang IX, Nikaido K, Liu PQ, Ames GF, Kim SH. Crystal structure of the ATP-binding subunit of an ABC transporter. Nature 396:703-707, 1998.
-
(1998)
Nature
, vol.396
, pp. 703-707
-
-
Hung, L.W.1
Wang, I.X.2
Nikaido, K.3
Liu, P.Q.4
Ames, G.F.5
Kim, S.H.6
-
11
-
-
3242785620
-
Importance of P-glycoprotein at blood-tissue barriers
-
Fromm MF. Importance of P-glycoprotein at blood-tissue barriers. Trends Pharmacol Sci 25:423-429, 2004.
-
(2004)
Trends Pharmacol Sci
, vol.25
, pp. 423-429
-
-
Fromm, M.F.1
-
12
-
-
0034953105
-
The human ATP-binding cassette (ABC) transporter superfamily
-
Dean M, Hamon Y, Chimini G. The human ATP-binding cassette (ABC) transporter superfamily. J Lipid Res 42:1007-1017, 2001.
-
(2001)
J Lipid Res
, vol.42
, pp. 1007-1017
-
-
Dean, M.1
Hamon, Y.2
Chimini, G.3
-
13
-
-
33645830172
-
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
-
Juliano RL, Ling V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 455:152-162, 1976.
-
(1976)
Biochim Biophys Acta
, vol.455
, pp. 152-162
-
-
Juliano, R.L.1
Ling, V.2
-
14
-
-
0024576304
-
Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: Evidence for localization in brain capillaries and cross reactivity of one antibody with a muscle protein
-
Thiebaut F, Tsuruo T, Hamada H, Gottesman MM, Pastan I, Willingham MC. Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and cross reactivity of one antibody with a muscle protein. J Histochem Cytochem 37:159-164, 1989.
-
(1989)
J Histochem Cytochem
, vol.37
, pp. 159-164
-
-
Thiebaut, F.1
Tsuruo, T.2
Hamada, H.3
Gottesman, M.M.4
Pastan, I.5
Willingham, M.C.6
-
15
-
-
0025071180
-
Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues
-
Cordon-Cardo C, O'Brien JP, Boccia J, Casals D, Bertino JR, Melamed MR. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues. J Histochem Cytochem 38:1277-1287, 1990.
-
(1990)
J Histochem Cytochem
, vol.38
, pp. 1277-1287
-
-
Cordon-Cardo, C.1
O'Brien, J.P.2
Boccia, J.3
Casals, D.4
Bertino, J.R.5
Melamed, M.R.6
-
16
-
-
0025362517
-
Structural analysis of the mouse mdrla (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant 1774.2 cells
-
Hsu SI, Cohen D, Kirschner LS, Lothstein L, Hartstein M, Horwitz SB. Structural analysis of the mouse mdrla (P-glycoprotein) promoter reveals the basis for differential transcript heterogeneity in multidrug-resistant 1774.2 cells. Mol Cell Biol 10:3596-3606, 1990.
-
(1990)
Mol Cell Biol
, vol.10
, pp. 3596-3606
-
-
Hsu, S.I.1
Cohen, D.2
Kirschner, L.S.3
Lothstein, L.4
Hartstein, M.5
Horwitz, S.B.6
-
17
-
-
0024414605
-
Structure and expression of the human MDR (P-glycoprotein) gene family
-
Chin JE, Soffir R, Noonan KE, Choi K, Roninson IB. Structure and expression of the human MDR (P-glycoprotein) gene family. Mol Cell Biol 9:3808-3820, 1989.
-
(1989)
Mol Cell Biol
, vol.9
, pp. 3808-3820
-
-
Chin, J.E.1
Soffir, R.2
Noonan, K.E.3
Choi, K.4
Roninson, I.B.5
-
18
-
-
0027363563
-
Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease
-
Smit JJ, Schinkel AH, Oude Elferink RP, Groen AK, Wagenaar E, van Deemter L, Mol CA, Ottenhoff R, van der Lugt NM, van Roon MA, van der Valk MA, Offerhaus GJA, Berns AJM, Borst P. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 75:451-462, 1993.
-
(1993)
Cell
, vol.75
, pp. 451-462
-
-
Smit, J.J.1
Schinkel, A.H.2
Oude Elferink, R.P.3
Groen, A.K.4
Wagenaar, E.5
Van Deemter, L.6
Mol, C.A.7
Ottenhoff, R.8
Van Der Lugt, N.M.9
Van Roon, M.A.10
Van Der Valk, M.A.11
Offerhaus, G.J.A.12
Berns, A.J.M.13
Borst, P.14
-
19
-
-
0024267730
-
Sequence of mdr3 cDNA encoding a human P-glycoprotein
-
van der Bliek AM, Kooiman PM, Schneider C, Borst P. Sequence of mdr3 cDNA encoding a human P-glycoprotein. Gene 71:401-411, 1988.
-
(1988)
Gene
, vol.71
, pp. 401-411
-
-
Van Der Bliek, A.M.1
Kooiman, P.M.2
Schneider, C.3
Borst, P.4
-
20
-
-
0031964966
-
Restoration of TNF-alpha-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833
-
Bezombes C, Maestre N, Laurent G, Levade T, Bettaieb A, Jaffrezou JP. Restoration of TNF-alpha-induced ceramide generation and apoptosis in resistant human leukemia KG1a cells by the P-glycoprotein blocker PSC833. FASEB J 12:101-109, 1998.
-
(1998)
FASEB J
, vol.12
, pp. 101-109
-
-
Bezombes, C.1
Maestre, N.2
Laurent, G.3
Levade, T.4
Bettaieb, A.5
Jaffrezou, J.P.6
-
21
-
-
0035849506
-
Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter
-
Romsicki Y, Sharom FJ. Phospholipid flippase activity of the reconstituted P-glycoprotein multidrug transporter. Biochemistry 40:6937-6947, 2001.
-
(2001)
Biochemistry
, vol.40
, pp. 6937-6947
-
-
Romsicki, Y.1
Sharom, F.J.2
-
22
-
-
0035425507
-
Multidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factor
-
Raggers RJ, Vogels I, van Meer G. Multidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factor. Biochem J 357:859-865, 2001.
-
(2001)
Biochem J
, vol.357
, pp. 859-865
-
-
Raggers, R.J.1
Vogels, I.2
Van Meer, G.3
-
23
-
-
0032709624
-
Secretion of platelet-activating factor is mediated by MDR1 P-glycoprotein in cultured human mesangial cells
-
Ernest S, Bello-Reuss E. Secretion of platelet-activating factor is mediated by MDR1 P-glycoprotein in cultured human mesangial cells. J Am Soc Nephrol 10:2306-2313, 1999.
-
(1999)
J Am Soc Nephrol
, vol.10
, pp. 2306-2313
-
-
Ernest, S.1
Bello-Reuss, E.2
-
24
-
-
0033958086
-
Multiple physiological functions for multidrug transporter P-glycoprotein?
-
Johnstone RW, Ruefli AA, Smyth MJ. Multiple physiological functions for multidrug transporter P-glycoprotein? Trends Biochem Sci 25:1-6, 2000.
-
(2000)
Trends Biochem Sci
, vol.25
, pp. 1-6
-
-
Johnstone, R.W.1
Ruefli, A.A.2
Smyth, M.J.3
-
25
-
-
0026536805
-
Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein
-
Valverde MA, Diaz M, Sepulveda FV, Gill DR, Hyde SC, Higgins CF. Volume-regulated chloride channels associated with the human multidrug-resistance P-glycoprotein. Nature 355:830-833, 1992.
-
(1992)
Nature
, vol.355
, pp. 830-833
-
-
Valverde, M.A.1
Diaz, M.2
Sepulveda, F.V.3
Gill, D.R.4
Hyde, S.C.5
Higgins, C.F.6
-
26
-
-
0033548572
-
Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol
-
Luker GD, Nilsson KR, Covey DF, Piwnica-Worms D. Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol. J Biol Chem 274:6979-6991, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 6979-6991
-
-
Luker, G.D.1
Nilsson, K.R.2
Covey, D.F.3
Piwnica-Worms, D.4
-
28
-
-
1942457312
-
P-glycoprotein in autoimmune diseases
-
Richaud-Patin Y, Soto-Vega E, Jakez-Ocampo J, Llorente L. P-glycoprotein in autoimmune diseases. Autoimmun Rev 3:188-192, 2004.
-
(2004)
Autoimmun Rev
, vol.3
, pp. 188-192
-
-
Richaud-Patin, Y.1
Soto-Vega, E.2
Jakez-Ocampo, J.3
Llorente, L.4
-
29
-
-
1642454475
-
ABC transporters and the blood-brain barrier
-
Begley DJ. ABC transporters and the blood-brain barrier. Curr Pharm Des 10:1295-1312, 2004.
-
(2004)
Curr Pharm des
, vol.10
, pp. 1295-1312
-
-
Begley, D.J.1
-
30
-
-
0029892497
-
P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs
-
Schinkel AH, Wagenaar E, Mol CA, van Deemter L. P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest 97:2517-2524, 1996.
-
(1996)
J Clin Invest
, vol.97
, pp. 2517-2524
-
-
Schinkel, A.H.1
Wagenaar, E.2
Mol, C.A.3
Van Deemter, L.4
-
31
-
-
0028229150
-
Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
-
Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CA, van der Valk MA, Robanus-Maandag EC, te Riele HP, Berns AJM, Borst P. Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77:491-502, 1994.
-
(1994)
Cell
, vol.77
, pp. 491-502
-
-
Schinkel, A.H.1
Smit, J.J.2
Van Tellingen, O.3
Beijnen, J.H.4
Wagenaar, E.5
Van Deemter, L.6
Mol, C.A.7
Van Der Valk, M.A.8
Robanus-Maandag, E.C.9
Te Riele, H.P.10
Berns, A.J.M.11
Borst, P.12
-
32
-
-
0035164622
-
Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene
-
Mealey KL, Bentjen SA, Gay JM, Cantor GH. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics 11:727-733, 2001.
-
(2001)
Pharmacogenetics
, vol.11
, pp. 727-733
-
-
Mealey, K.L.1
Bentjen, S.A.2
Gay, J.M.3
Cantor, G.H.4
-
33
-
-
0038106665
-
Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs
-
Sakaeda T, Nakamura T, Okumura K. Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs. Pharmacogenomics 4:397-410, 2003.
-
(2003)
Pharmacogenomics
, vol.4
, pp. 397-410
-
-
Sakaeda, T.1
Nakamura, T.2
Okumura, K.3
-
34
-
-
1942424048
-
Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein
-
Kemper EM, Verheij M, Boogerd W, Beijnen JH, van Tellingen O. Improved penetration of docetaxel into the brain by co-administration of inhibitors of P-glycoprotein. Eur J Cancer 40:1269-1274, 2004.
-
(2004)
Eur J Cancer
, vol.40
, pp. 1269-1274
-
-
Kemper, E.M.1
Verheij, M.2
Boogerd, W.3
Beijnen, J.H.4
Van Tellingen, O.5
-
35
-
-
0037478891
-
Increased penetration of paclitaxel into the brain by inhibition of P-glycoprotein
-
Kemper EM, van Zandbergen AE, Cleypool C, Mos HA, Boogerd W, Beijnen JH, van Tellingen O. Increased penetration of paclitaxel into the brain by inhibition of P-glycoprotein. Clin Cancer Res 9:2849-2855, 2003.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2849-2855
-
-
Kemper, E.M.1
Van Zandbergen, A.E.2
Cleypool, C.3
Mos, H.A.4
Boogerd, W.5
Beijnen, J.H.6
Van Tellingen, O.7
-
36
-
-
0036841686
-
Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo
-
Fellner S, Bauer B, Miller DS, Schaffrik M, Fankhanel M, Spruss T, Bernhardt G, Graeff C, Farber L, Gschaidmeier H, Buschauer A, Fricker G. Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. J Clin Invest 110:1309-1318, 2002.
-
(2002)
J Clin Invest
, vol.110
, pp. 1309-1318
-
-
Fellner, S.1
Bauer, B.2
Miller, D.S.3
Schaffrik, M.4
Fankhanel, M.5
Spruss, T.6
Bernhardt, G.7
Graeff, C.8
Farber, L.9
Gschaidmeier, H.10
Buschauer, A.11
Fricker, G.12
-
39
-
-
0344393071
-
Signalling pathways influencing basal and H(2)O(2)-induced P-glycoprotein expression in endothelial cells derived from the blood-brain barrier
-
Nwaozuzu OM, Sellers LA, Barrand MA. Signalling pathways influencing basal and H(2)O(2)-induced P-glycoprotein expression in endothelial cells derived from the blood-brain barrier. J Neurochem 87:1043-1051, 2003.
-
(2003)
J Neurochem
, vol.87
, pp. 1043-1051
-
-
Nwaozuzu, O.M.1
Sellers, L.A.2
Barrand, M.A.3
-
40
-
-
0347363616
-
Puromycin selectively increases mdrla expression in immortalized rat brain endothelial cell lines
-
Demeuse P, Fragner P, Leroy-Noury C, Mercier C, Payen L, Fardel O, Couraud PO, Roux F. Puromycin selectively increases mdrla expression in immortalized rat brain endothelial cell lines. J Neurochem 88:23-31, 2004.
-
(2004)
J Neurochem
, vol.88
, pp. 23-31
-
-
Demeuse, P.1
Fragner, P.2
Leroy-Noury, C.3
Mercier, C.4
Payen, L.5
Fardel, O.6
Couraud, P.O.7
Roux, F.8
-
41
-
-
0036196904
-
Trafficking of canalicular ABC transporters in hepatocytes
-
Kipp H, Arias IM. Trafficking of canalicular ABC transporters in hepatocytes. Annu Rev Physiol 64:595-608, 2002.
-
(2002)
Annu Rev Physiol
, vol.64
, pp. 595-608
-
-
Kipp, H.1
Arias, I.M.2
-
42
-
-
0033988860
-
Endothelin B receptor-mediated regulation of ATP-driven drug secretion in renal proximal tubule
-
Masereeuw R, Terlouw SA, van Aubel RA, Russel FG, Miller DS. Endothelin B receptor-mediated regulation of ATP-driven drug secretion in renal proximal tubule. Mol Pharmacol 57:59-67, 2000.
-
(2000)
Mol Pharmacol
, vol.57
, pp. 59-67
-
-
Masereeuw, R.1
Terlouw, S.A.2
Van Aubel, R.A.3
Russel, F.G.4
Miller, D.S.5
-
43
-
-
0034990906
-
Nephrotoxicants induce endothelin release and signaling in renal proximal tubules: Effect on drug efflux
-
Terlouw SA, Masereeuw R, Russel FG, Miller DS. Nephrotoxicants induce endothelin release and signaling in renal proximal tubules: effect on drug efflux. Mol Pharmacol 59:1433-1440, 2001.
-
(2001)
Mol Pharmacol
, vol.59
, pp. 1433-1440
-
-
Terlouw, S.A.1
Masereeuw, R.2
Russel, F.G.3
Miller, D.S.4
-
44
-
-
4944230261
-
Rapid regulation of p-glycoprotein at the blood-brain barrier by endothelin-1
-
Hartz AM, Bauer B, Fricker G, Miller DS. Rapid regulation of p-glycoprotein at the blood-brain barrier by endothelin-1. Mol Pharmacol 66:387-394, 2004.
-
(2004)
Mol Pharmacol
, vol.66
, pp. 387-394
-
-
Hartz, A.M.1
Bauer, B.2
Fricker, G.3
Miller, D.S.4
-
45
-
-
1642504354
-
Alkylglycerol opening of the blood-brain barrier to small and large fluorescence markers in normal and C6 glioma-bearing rats and isolated rat brain capillaries
-
Erdlenbruch B, Alipour M, Fricker G, Miller DS, Kugler W, Eibl H, Lakomek M. Alkylglycerol opening of the blood-brain barrier to small and large fluorescence markers in normal and C6 glioma-bearing rats and isolated rat brain capillaries. Br J Pharmacol 140:1201-1210, 2003.
-
(2003)
Br J Pharmacol
, vol.140
, pp. 1201-1210
-
-
Erdlenbruch, B.1
Alipour, M.2
Fricker, G.3
Miller, D.S.4
Kugler, W.5
Eibl, H.6
Lakomek, M.7
-
46
-
-
0037119577
-
Drug targeting. Breaking down barriers
-
Miller G. Drug targeting. Breaking down barriers. Science 297:1116-1118, 2002.
-
(2002)
Science
, vol.297
, pp. 1116-1118
-
-
Miller, G.1
-
47
-
-
0031965788
-
Outwitting the blood-brain barrier for therapeutic purposes: Osmotic opening and other means
-
Kroll RA, Neuwelt EA. Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means. Neurosurgery 42:1083-1100, 1998.
-
(1998)
Neurosurgery
, vol.42
, pp. 1083-1100
-
-
Kroll, R.A.1
Neuwelt, E.A.2
-
48
-
-
0036083728
-
Role of NO in endothelin-regulated drug transport in the renal proximal tubule
-
Notenboom S, Miller DS, Smits P, Russel FG, Masereeuw R. Role of NO in endothelin-regulated drug transport in the renal proximal tubule. Am J Physiol Renal Physiol 282:F458-F464, 2002.
-
(2002)
Am J Physiol Renal Physiol
, vol.282
-
-
Notenboom, S.1
Miller, D.S.2
Smits, P.3
Russel, F.G.4
Masereeuw, R.5
-
49
-
-
0031730608
-
Protein kinase C regulation of p-glycoprotein-mediated xenobiotic secretion in renal proximal tubule
-
Miller DS, Sussman CR, Renfro JL. Protein kinase C regulation of p-glycoprotein-mediated xenobiotic secretion in renal proximal tubule. Am J Physiol 275:F785-F795, 1998.
-
(1998)
Am J Physiol
, vol.275
-
-
Miller, D.S.1
Sussman, C.R.2
Renfro, J.L.3
-
50
-
-
0036019498
-
Xenobiotic export pumps, endothelin signaling, and tubular nephrotoxicants-a case of molecular hijacking
-
Miller DS. Xenobiotic export pumps, endothelin signaling, and tubular nephrotoxicants-a case of molecular hijacking. J Biochem Mol Toxicol 16:121-127, 2002.
-
(2002)
J Biochem Mol Toxicol
, vol.16
, pp. 121-127
-
-
Miller, D.S.1
-
51
-
-
3242670026
-
New invMED1 element cis-activates human multidrug-related MDR1 and MVP genes, involving the LRP.130 protein
-
Labialle S, Dayan G, Gayet L, Rigal D, Gambrelle J, Baggetto LG. New invMED1 element cis-activates human multidrug-related MDR1 and MVP genes, involving the LRP.130 protein. Nucleic Acids Res 32:3864-3876, 2004.
-
(2004)
Nucleic Acids Res
, vol.32
, pp. 3864-3876
-
-
Labialle, S.1
Dayan, G.2
Gayet, L.3
Rigal, D.4
Gambrelle, J.5
Baggetto, L.G.6
-
52
-
-
0036710923
-
Transcriptional regulators of the human multidrug resistance 1 gene: Recent views
-
Labialle S, Gayet L, Marthinet E, Rigal D, Baggetto LG. Transcriptional regulators of the human multidrug resistance 1 gene: recent views. Biochem Pharmacol 64:943-948, 2002.
-
(2002)
Biochem Pharmacol
, vol.64
, pp. 943-948
-
-
Labialle, S.1
Gayet, L.2
Marthinet, E.3
Rigal, D.4
Baggetto, L.G.5
-
53
-
-
0035805536
-
Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin
-
Geick A, Eichelbaum M, Burk O. Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin. J Biol Chem 276:14581-14587, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 14581-14587
-
-
Geick, A.1
Eichelbaum, M.2
Burk, O.3
-
54
-
-
0032498303
-
An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway
-
Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterstrom RH, Perlmann T, Lehmann JM. An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway. Cell 92:73-82, 1998.
-
(1998)
Cell
, vol.92
, pp. 73-82
-
-
Kliewer, S.A.1
Moore, J.T.2
Wade, L.3
Staudinger, J.L.4
Watson, M.A.5
Jones, S.A.6
McKee, D.D.7
Oliver, B.B.8
Willson, T.M.9
Zetterstrom, R.H.10
Perlmann, T.11
Lehmann, J.M.12
-
55
-
-
0032169485
-
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
-
Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, Kliewer SA. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 102:1016-1023, 1998.
-
(1998)
J Clin Invest
, vol.102
, pp. 1016-1023
-
-
Lehmann, J.M.1
McKee, D.D.2
Watson, M.A.3
Willson, T.M.4
Moore, J.T.5
Kliewer, S.A.6
-
56
-
-
0036240393
-
Structural insights into the promiscuity and function of the human pregnane X receptor
-
Watkins RE, Noble SM, Redinbo MR. Structural insights into the promiscuity and function of the human pregnane X receptor. Curr Opin Drug Discov Devel 5:150-158, 2002.
-
(2002)
Curr Opin Drug Discov Devel
, vol.5
, pp. 150-158
-
-
Watkins, R.E.1
Noble, S.M.2
Redinbo, M.R.3
-
57
-
-
0035038386
-
Promiscuous regulator of xenobiotic removal
-
Schuetz E, Strom S. Promiscuous regulator of xenobiotic removal. Nat Med 7:536-537, 2001.
-
(2001)
Nat Med
, vol.7
, pp. 536-537
-
-
Schuetz, E.1
Strom, S.2
-
58
-
-
0036592202
-
The nuclear receptor PXR: A master regulator of "homeland" defense
-
Dussault I, Forman BM. The nuclear receptor PXR: a master regulator of "homeland" defense. Crit Rev Eukaryot Gene Expr 12:53-64, 2002.
-
(2002)
Crit Rev Eukaryot Gene Expr
, vol.12
, pp. 53-64
-
-
Dussault, I.1
Forman, B.M.2
-
59
-
-
0037972688
-
Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor
-
Rosenfeld JM, Vargas R Jr, Xie W, Evans RM. Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor. Mol Endocrinol 17:1268-1282, 2003.
-
(2003)
Mol Endocrinol
, vol.17
, pp. 1268-1282
-
-
Rosenfeld, J.M.1
Vargas Jr., R.2
Xie, W.3
Evans, R.M.4
-
60
-
-
11144357796
-
Activators of the rat pregnane X receptor differentially modulate hepatic and intestinal gene expression
-
Hartley DP, Dai X, He YD, Carlini EJ, Wang B, Huskey SE, Ulrich RG, Rushmore TH, Evers R, Evans DC. Activators of the rat pregnane X receptor differentially modulate hepatic and intestinal gene expression. Mol Pharmacol 65:1159-1171, 2004.
-
(2004)
Mol Pharmacol
, vol.65
, pp. 1159-1171
-
-
Hartley, D.P.1
Dai, X.2
He, Y.D.3
Carlini, E.J.4
Wang, B.5
Huskey, S.E.6
Ulrich, R.G.7
Rushmore, T.H.8
Evers, R.9
Evans, D.C.10
-
61
-
-
0142150021
-
Induction of ABCC3 (MRP3) by pregnane X receptor activators
-
Teng S, Jekerle V, Piquette-Miller M. Induction of ABCC3 (MRP3) by pregnane X receptor activators. Drug Metab Dispos 31:1296-1299, 2003.
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 1296-1299
-
-
Teng, S.1
Jekerle, V.2
Piquette-Miller, M.3
-
62
-
-
17744375160
-
The pregnane X receptor: A promiscuous xenobiotic receptor that has diverged during evolution
-
Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NC, LeCluyse EL, Lambert MH, Willson TM, Kliewer SA, Moore JT. The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol Endocrinol 14:27-39, 2000.
-
(2000)
Mol Endocrinol
, vol.14
, pp. 27-39
-
-
Jones, S.A.1
Moore, L.B.2
Shenk, J.L.3
Wisely, G.B.4
Hamilton, G.A.5
McKee, D.D.6
Tomkinson, N.C.7
Lecluyse, E.L.8
Lambert, M.H.9
Willson, T.M.10
Kliewer, S.A.11
Moore, J.T.12
-
63
-
-
0033178677
-
Rat pregnane X receptor: Molecular cloning, tissue distribution, and xenobiotic regulation
-
Zhang H, LeCulyse E, Liu L, Hu M, Matoney L, Zhu W, Yan B. Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation. Arch Biochem Biophys 368:14-22, 1999.
-
(1999)
Arch Biochem Biophys
, vol.368
, pp. 14-22
-
-
Zhang, H.1
Leculyse, E.2
Liu, L.3
Hu, M.4
Matoney, L.5
Zhu, W.6
Yan, B.7
-
64
-
-
4944230477
-
Pregnane X receptor up-regulation of p-glycoprotein expression and transport function at the blood-brain barrier
-
Bauer B, Hartz AM, Fricker G, Miller DS. Pregnane X receptor up-regulation of p-glycoprotein expression and transport function at the blood-brain barrier. Mol Pharmacol 66:413-419, 2004.
-
(2004)
Mol Pharmacol
, vol.66
, pp. 413-419
-
-
Bauer, B.1
Hartz, A.M.2
Fricker, G.3
Miller, D.S.4
-
65
-
-
0035669389
-
Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy
-
Dombrowski SM, Desai SY, Marroni M, Cucullo L, Goodrich K, Bingaman W, Mayberg MR, Bengez L, Janigro D. Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia 42:1501-1506, 2001.
-
(2001)
Epilepsia
, vol.42
, pp. 1501-1506
-
-
Dombrowski, S.M.1
Desai, S.Y.2
Marroni, M.3
Cucullo, L.4
Goodrich, K.5
Bingaman, W.6
Mayberg, M.R.7
Bengez, L.8
Janigro, D.9
-
66
-
-
1542314451
-
Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats
-
Perloff MD, von Moltke LL, Greenblatt DJ. Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats. Xenobiotica 34:133-150, 2004.
-
(2004)
Xenobiotica
, vol.34
, pp. 133-150
-
-
Perloff, M.D.1
Von Moltke, L.L.2
Greenblatt, D.J.3
-
67
-
-
0345732179
-
Molecular aspects of bile formation and cholestasis
-
Arrese M, Trauner M. Molecular aspects of bile formation and cholestasis. Trends Mol Med 9:558-564, 2003.
-
(2003)
Trends Mol Med
, vol.9
, pp. 558-564
-
-
Arrese, M.1
Trauner, M.2
-
68
-
-
1642579697
-
Suppression of drug-metabolizing enzymes and efflux transporters in the intestine of endotoxin-treated rats
-
Kalitsky-Szirtes J, Shayeganpour A, Brocks DR, Piquette-Miller M. Suppression of drug-metabolizing enzymes and efflux transporters in the intestine of endotoxin-treated rats. Drug Metab Dispos 32:20-27, 2004.
-
(2004)
Drug Metab Dispos
, vol.32
, pp. 20-27
-
-
Kalitsky-Szirtes, J.1
Shayeganpour, A.2
Brocks, D.R.3
Piquette-Miller, M.4
-
69
-
-
0036786429
-
Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia
-
Hartmann G, Cheung AK, Piquette-Miller M. Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther 303:273-281, 2002.
-
(2002)
J Pharmacol Exp Ther
, vol.303
, pp. 273-281
-
-
Hartmann, G.1
Cheung, A.K.2
Piquette-Miller, M.3
-
70
-
-
0034185251
-
Regulation of the multidrug resistance genes by stress signals
-
Sukhai M, Piquette-Miller M. Regulation of the multidrug resistance genes by stress signals. J Pharm Pharm Sci 3:268-280, 2000.
-
(2000)
J Pharm Pharm Sci
, vol.3
, pp. 268-280
-
-
Sukhai, M.1
Piquette-Miller, M.2
-
71
-
-
0037646504
-
Repression of farnesoid X receptor during the acute phase response
-
Kim MS, Shigenaga J, Moser A, Feingold K, Grunfeld C. Repression of farnesoid X receptor during the acute phase response. J Biol Chem 278:8988-8995, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 8988-8995
-
-
Kim, M.S.1
Shigenaga, J.2
Moser, A.3
Feingold, K.4
Grunfeld, C.5
-
72
-
-
0037716531
-
Down-regulation of mdrla expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin
-
Goralski KB, Hartmann G, Piquette-Miller M, Renton KW. Down-regulation of mdrla expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin. Br J Pharmacol 139:35-48, 2003.
-
(2003)
Br J Pharmacol
, vol.139
, pp. 35-48
-
-
Goralski, K.B.1
Hartmann, G.2
Piquette-Miller, M.3
Renton, K.W.4
-
73
-
-
0142071056
-
Influence of tumor necrosis factor-alpha on the expression and function of P-glycoprotein in an immortalised rat brain capillary endothelial cell line, GPNT
-
Theron D, Barraud de Lagerie S, Tardivel S, Pelerin H, Demeuse P, Mercier C, Mabondzo A, Farinotti R, Lacour B, Roux F, Gimenez F. Influence of tumor necrosis factor-alpha on the expression and function of P-glycoprotein in an immortalised rat brain capillary endothelial cell line, GPNT. Biochem Pharmacol 66:579-587, 2003.
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 579-587
-
-
Theron, D.1
Barraud De Lagerie, S.2
Tardivel, S.3
Pelerin, H.4
Demeuse, P.5
Mercier, C.6
Mabondzo, A.7
Farinotti, R.8
Lacour, B.9
Roux, F.10
Gimenez, F.11
-
74
-
-
0037147661
-
Evaluation of the role of P-glycoprotein in inflammation induced blood-brain barrier damage
-
Tan KH, Purcell WM, Heales SJ, McLeod JD, Hurst RD. Evaluation of the role of P-glycoprotein in inflammation induced blood-brain barrier damage. Neuroreport 13:2593-2597, 2002.
-
(2002)
Neuroreport
, vol.13
, pp. 2593-2597
-
-
Tan, K.H.1
Purcell, W.M.2
Heales, S.J.3
McLeod, J.D.4
Hurst, R.D.5
-
75
-
-
0346014856
-
Nephrotoxicity and the proximal tubule. Insights from cadmium
-
Thevenod F. Nephrotoxicity and the proximal tubule. Insights from cadmium. Nephron Physiol 93:87-93, 2003.
-
(2003)
Nephron Physiol
, vol.93
, pp. 87-93
-
-
Thevenod, F.1
-
76
-
-
0034695660
-
Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- And reactive oxygen species-induced apoptosis
-
Thevenod F, Friedmann JM, Katsen AD, Hauser IA. Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis. J Biol Chem 275:1887-1896, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 1887-1896
-
-
Thevenod, F.1
Friedmann, J.M.2
Katsen, A.D.3
Hauser, I.A.4
-
77
-
-
0028277719
-
P-glycoprotein expression in brain capillary endothelial cells after focal ischaemia in the rat
-
Samoto K, Ikezaki K, Yokoyama N, Fukui M. P-glycoprotein expression in brain capillary endothelial cells after focal ischaemia in the rat. Neurol Res 16:217-223, 1994.
-
(1994)
Neurol Res
, vol.16
, pp. 217-223
-
-
Samoto, K.1
Ikezaki, K.2
Yokoyama, N.3
Fukui, M.4
-
78
-
-
0036269538
-
P-glycoprotein expression in rat brain endothelial cells: Evidence for regulation by transient oxidative stress
-
Felix RA, Barrand MA. P-glycoprotein expression in rat brain endothelial cells: evidence for regulation by transient oxidative stress. J Neurochem 80:64-72, 2002.
-
(2002)
J Neurochem
, vol.80
, pp. 64-72
-
-
Felix, R.A.1
Barrand, M.A.2
|