A novel transgenic rabbit model with reduced repolarization reserve: Long QT syndrome caused by a dominant-negative mutation of the KCNE1 gene

British Journal of Pharmacology

Volumn 173, Issue 12, 2016, Pages 2046-2061

  Major, Péter ^a   Baczkó, István ^b   Hiripi, László ^a   Odening, Katja E ^c   Juhász, Viktor ^b   Kohajda, Zsófia ^b   Horváth, András ^b   Seprényi, György ^b   Kovács, Mária ^b   Virág, László ^b   Jost, Norbert ^b,d   Prorok, János ^b   Ördög, Balázs ^b   Doleschall, Zoltán ^e   Nattel, Stanley ^f,g,h   Varró, András ^b,d   Bõsze, Zsuzsanna ^a  

^a SZENT ISTVÁN UNIVERSITY   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

^c UNIVERSITY OF FREIBURG   (Germany)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^e NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

^f MONTREAL HEART INSTITUTE   (Canada)

^g MCGILL UNIVERSITY   (Canada)

^h UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DELAYED RECTIFIER POTASSIUM CHANNEL; POTASSIUM CHANNEL KCNE1; KCNE1 PROTEIN, HUMAN; VOLTAGE GATED POTASSIUM CHANNEL;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC MUSCLE CELL; CONTROLLED STUDY; DEACTIVATION TIME CONSTANT; DISEASE PREDISPOSITION; ELECTROCARDIOGRAM; EMBRYO; FEMALE; GENE MUTATION; GENE OVEREXPRESSION; HEART REPOLARIZATION; HUMAN; HUMAN TISSUE; IN VIVO STUDY; KCNE1 GENE; LONG QT SYNDROME 5; MALE; NEW ZEALAND WHITE (RABBIT); NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; QT INTERVAL; TORSADE DES POINTES; YOUNG ADULT; ANIMAL; DISEASE MODEL; DOMINANT GENE; GENETICS; LEPORIDAE; LONG QT SYNDROME; MUTATION; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; FEMALE; GENES, DOMINANT; HUMANS; LONG QT SYNDROME; MALE; MUTATION; POTASSIUM CHANNELS, VOLTAGE-GATED; RABBITS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84964520176     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.13500     Document Type: Article

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