Comparison of the chronic and acute effects of amiodarone on the calcium and potassium currents in rabbit isolated cardiac myocytes

British Journal of Pharmacology

Volumn 117, Issue 6, 1996, Pages 1181-1186

  Varró, András ^a   Virág, László ^a   Papp, Julius Gy ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Amiodarone; Chronic treatment; I(Ca); I(K); I(kl); I(to); Rabbit ventricular myocytes

Indexed keywords

AMIODARONE; ANTIARRHYTHMIC AGENT; CALCIUM ION; POTASSIUM ION;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; COMPARATIVE STUDY; CONTROLLED STUDY; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART VENTRICLE WALL; LONG TERM CARE; MEMBRANE CURRENT; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RABBIT;

EID: 0030008036     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb16713.x     Document Type: Article

References (33)

1. BALSER, J.R., BENNETT, P.B., HONDEGHEM, L.M. & RODEN, D.M. (1991). Suppression of time-dependent outward current in guinea pig ventricular myocytes. Actions of quinidine and amiodarone. Circ. Res., 69, 519-529.
2. CARLSSON, L., ABRAHAMSSON, C., ANDERSSON, B., DUKER, G. & SCHILLER-LINHARDT, G. (1993). Proarrhythmic effects of the class III agent almokalant: importance of infusion rate, QT dispersion, and early afterdepolarization. Cardiovasc. Res., 27, 2186-2193.
3. + current in rabbit ventricular myocytes. Cardiovasc. Drugs Ther., 7, (Suppl 3), 599-604.
4. Kr by amiodarone in rabbit ventricular myocytes. J. Mol. Cell. Cardiol., 26, LVI (abstract).
5. DEBBAS, N.M., DUCAILAR, C., BEXTON, R.S., DEMAILLE, J.G., CAMM, A.J. & PUECH, P. (1984). The QT interval: a predictor of the plasma and myocardial concentrations of amiodarone. Br. Heart J., 51, 316-320.
6. FOLLMER, C.H., AOMINE, M., YEH, J.Z. & SINGER, D.H. (1987). Amiodarone-induced block of sodium current in isolatd cardiac cells. J. Pharmacol. Exp. Ther., 243, 187-194.
7. GALLAGHER, J.D., BIANCHI, J. & GESSMAN, L.J. (1989). A comparison of the electrophysiologic effects of acute and chronic amiodarone administration on canine Purkinje fibers. J. Cardiovasc. Pharmacol., 13, 723-729.
8. IKEDA, N., NADEMANEE, K., KANNAN, R. & SINGH, B.N. (1984). Electrophysiologic effects of amiodarone: Experimental and clinical observation relative to serum and tissue drug concentrations. Am. Heart J., 108, 890-898.
9. KADOYA, M., KONISHI, T., TAMAMURA, T., IKEGUCHI, S., HASHIMOTO, D. & KAWAI, C. (1985). Electrophysiological effects of amiodarone on isolated rabbit heart muscles. J. Cardiovasc. Pharmacol., 7, 643-648.
10. KATO, R., VENKATESH, N., KAMIYA, K., YABEK, S., KANNAN, R. & SINGH, B.N. (1988). Electrophysiologic effects of desethylamiodarone, an active metabolite of amiodarone: Comparison with amiodarone during chronic administration in rabbits. Am. Heart J., 115, 351-359.
11. KODAMA, I., SUZUKI, R., KAMIYA, K., IWATA, H. & TOYAMA, J. (1992). Effects of long-term oral administration of amiodarone on the electrochemical performance of rabbit ventricular muscle. Br. J. Pharmacol., 107, 502-509.
12. LATHAM, K.R., SELLITTI, D.F. & GOLDSTEIN, R.E. (1987). Interaction of amiodarone and desethylamiodarone with solubilized nuclear thyroid hormone receptors. J. Am. Coll. Cardiol., 9, 872-876.
13. MASON, J.W., HODENGHEM, L.M. & KATZUNG, B.G. (1984). Block of inactivated sodium channels and of depolarization-induced automaticity in guinea pig papillary muscle by amiodarone. Circ. Res., 55, 277-285.
14. NATTEL, S., TALAJIC, M., QUANTZ, M. & DEROODE, M. (1987). Frequency-dependent effects of amiodarone on atrioventricular nodal function and slow-channel action potentials: evidence for calcium channel-blocking activity. Circulation, 76, 442-449.
15. NISHIMURA, M., FOLLMER, C.H. & SINGER D.H. (1989). Amiodarone blocks calcium current in single guinea pig ventricular myocytes. J. Pharmacol. Exp. Ther., 251, 650-659.
16. NORTHOVER, B.J. (1984). Alteration to the electrical activity of atrial muscle isolated from the rat heart, produced by exposure in vitro to amiodarone. Br. J. Pharmacol., 82, 191-197.
17. PAPP, J.G.Y. (1978). Regional repolarization within the ventricle as affected by arrhythmogenic factors and antidysrhythmic agents. In Modern Electrocardiology. ed. Antaloczy, Z. pp. 29-39. Budapest, Amsterdam: Akadémiai Kiadó, Excerpta Medica.
18. PFISTERER, M., KIOWSKI, W., BURCKHARDT, D., FOLLATH, F. & BURKART, F. (1992). Beneficial effect of amiodarone on cardiac mortality in patients with asymptomatic complex ventricular arrhythmias after acute myocardial infarction and preserved but not impaired left ventricular function. Am. J. Cardiol., 69, 1399-1402.
19. PLOMP, T.A., VANROSSUM, J.M., ROBLES DE MEDINA, E.O., VANLIER, T. & MAES, R.A.A. (1984). Pharmacokinetics and body distribution of amiodarone in man. Arzneim-Forsch./Drug Res., 34, 513-520.
20. POLSTER, P. & BROEKHUYSEN, J. (1976). The adrenergic antagonism of amiodarone. Biochem. Pharmacol., 25, 131-134.
21. SATO, R., KOUMI, S-I., SINGER, D.H., HISATOME, I., JIA, H., EAGER, S. & WASSERSTROM, J.W. (1994). Amioradone blocks the inward rectifier potassium channel in isolated guinea pig ventricular cells. J. Pharmacol. Exp. Ther., 269, 1213-1219.
22. SINGH, B.N. & VAUGHAN-WILLIAMS, E.M. (1970). The effect of amiodarone, a new anti-anginal drug, on cardiac muscle. Br. J. Pharmacol., 39, 657.
23. TALAJIC, M., NATTEL, S., DAVIES, M. & MCCANS, J. (1987). Attenuation of class 3 and sinus node effects of amiodarone by experimental hypothyroidism. J. Cardiovasc. Pharmacol., 13, 447-450.
24. THE CASCADE INVESIGATORS. (1993). Randomized antiarrhythmic drug therapy in survivors of cardiac arrest (the CASCADE Study). Am. J. Cardiol., 72, 280-287.
25. THE CAST INVESTIGATORS. (1989). Preliminary report: effect of encainide and flecainide on mortality in randomized trial arrhythmia supression after myocardial infarction. N. Engl. J. Med., 321, 406-412.
26. THE SWORD INVESTIGATORS. (1994). Problems for BMS' D-sotalol. SCRIP, No 1973,23.
27. TOYAMA, J., KAMIYA, K., CHENG, J., KODAMA, I. & YAMADA, K. (1994). Acute and chronic effects of amiodarone on action potential and ionic currents in single rabbit ventricular myocytes. Eur. Heart J., 15, 192.(abstract).
28. VALENZUELA, C. & BENNETT, P.B. (1991). Voltage- and use-dependent modulation of calcium channel current in guinea pig ventricular cells by amiodarone and des-oxo-amiodarone. J. Cardiovasc. Pharmacol., 17, 894-902.
29. max in cardiac Pukinje and ventricular muscle fibers. Eur. J. Pharmacol., 112, 419-422.
30. VARRO, A., NAKAYA, Y., ELHARRAR, V. & SURAWICZ, B. (1988). The effects of amiodarone on repolarization and refractoriness of cardiac fibers. Eur. J. Pharmacol., 154, 11-18.
31. VAUGHAN WILLIAMS, E.M. (1975). Classification of anti-dysrhythmic drugs. Pharmacol. Ther., 1, 115-138.
32. WELLENS, H.J.J., BRUGADA, P., ABDOLLAH, H. & DASSEN, W.R. (1984). A comparison of the electrophysiologic effects of intravenous and oral amiodarone in the same patient. Circulation, 69, 120-124.
33. YABEK, S., KATO, R. & SINGH, B.N. (1986). Effects of amiodarone and its metabolite, desethylamiodarone, on the electrophysiologic properties of isolated cardiac muscle. J. Cardiovasc. Pharmacol., 8, 197-207.