Pharmacogenomics of anesthetic drugs in transgenic LQT1 and LQT2 rabbits reveal genotype-specific differential effects on cardiac repolarization

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 295, Issue 6, 2008, Pages

  Odening, Katja E ^a   Hyder, Omar ^a   Chaves, Leonard ^a   Schofield, Lorraine ^a   Brunner, Michael ^b   Kirk, Malcolm ^a   Zehender, Manfred ^b   Peng, Xuwen ^c   Koren, Gideon ^a,d  

^a BROWN UNIVERSITY   (United States)

^b UNIVERSITY OF FREIBURG   (Germany)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

^d RHODE ISLAND HOSPITAL   (United States)

Author keywords

Long QT syndrome types 1 and 2; Repolarization reserve; Sudden cardiac death; Ventricular fibrillation

Indexed keywords

DELAYED RECTIFIER POTASSIUM CHANNEL; ISOFLURANE; KETAMINE; MIDAZOLAM; POTASSIUM CHANNEL BLOCKING AGENT; PROPOFOL; THIOPENTAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ELECTROCARDIOGRAM; FEMALE; GENOTYPE; HEART DEATH; HEART REPOLARIZATION; LONG QT SYNDROME; LONG QT SYNDROME TYPE 1; LONG QT SYNDROME TYPE 2; MALE; NONHUMAN; PHARMACOGENOMICS; POLYMORPHIC VENTRICULAR TACHYCARDIA; PRIORITY JOURNAL; RABBIT; TRANSGENIC ANIMAL;

ACTION POTENTIALS; ANESTHETICS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; ETHER-A-GO-GO POTASSIUM CHANNELS; GENOTYPE; HEART CONDUCTION SYSTEM; HEART RATE; HUMANS; KCNQ1 POTASSIUM CHANNEL; LONG QT SYNDROME; MALE; PHARMACOGENETICS; PHENOTYPE; POTASSIUM CHANNEL BLOCKERS; RABBITS; RISK ASSESSMENT; ROMANO-WARD SYNDROME; TACHYCARDIA, VENTRICULAR; TIME FACTORS;

EID: 57349112336     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00680.2008     Document Type: Article

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