Beat-to-beat repolarization lability identifies patients at risk for sudden cardiac death

Journal of Cardiovascular Electrophysiology

Volumn 9, Issue 9, 1998, Pages 899-908

  Atiga, Walter L ^a   Calkins, Hugh ^a   Lawrence, John H ^a   Tomaselli, Gordon F ^a   Smith, Joseph M ^b   Berger, Ronald D ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

QT interval; Repolarization; Sudden death

Indexed keywords

ADULT; AGED; ARRHYTHMOGENESIS; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; FOLLOW UP; HEART REPOLARIZATION; HEART VENTRICLE ARRHYTHMIA; HIGH RISK POPULATION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PATIENT CODING; PRIORITY JOURNAL; QT INTERVAL; STATISTICAL ANALYSIS; SUDDEN DEATH;

EID: 0031662390     PISSN: 10453873     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1540-8167.1998.tb00130.x     Document Type: Article

References (39)

1. Holmes DR, Davis K, Gersh BJ, et al: Risk factor profiles of patients with sudden cardiac death and death from other cardiac causes: A report from the Coronary Artery Surgery Study (CASS). J Am Coll Cardiol 1989;13:524-530.
2. Kannel WB, Schatzkin A: Sudden death: Lessons from subsets in population studies. J Am Coll Cardiol 1985; 4:141B-149B.
3. Myerburg RJ, Castellanos A: Cardiac arrest and sudden cardiac death. In Braunwald E, ed: Heart Disease, Fifth Edition. WB Saunders, Philadelphia, 1992, pp. 742-779.
4. Bayes de Luna A, Coumel P, Leclercq JF: Ambulatory sudden cardiac death: Mechanisms of production of fatal arrhythmia on the basis of data from 157 cases. Am Heart J 1989;117:151-159.
5. Kempf FCJ, Josephson ME: Cardiac arrest recorded on ambulatory electrocardiograms. Am J Cardiol 1984;53: 1577-1582.
6. Bigger JT, Fleiss JL, Kleiger R, et al: The relationship among ventricular arrhythmias, left ventricular dysfunction, and mortality in the 2 years after myocardial infarction. Circulation 1983;69:250-258.
7. Simson MB: Noninvasive identification of patients at high risk for sudden cardiac death: Signal-averaged electrocardiography. Circulation 1992;85(Suppl I):I-145-I-151.
8. Steinberg JS, Berbari EJ: The signal-averaged electrocardiogram: Update on clinical applications. J Cardiovasc Electrophysiol 1996;7:972-988.
9. Wilber DJ, Garan H, Finkelstein D, et al: Out-of-hospital cardiac arrest: Use of electrophysiologic testing in the prediction of long-term outcome. N Engl J Med 1988;318:19-24.
10. Deniss AR, Richards DA, Cody DV, et al: Prognostic significance of ventricular tachycardia and fibrillation induced at programmed stimulation and delayed potentials detected on the signal-averaged electrograms of survivors of acute myocardial infarction. Circulation 1986;74:731-745.
11. Schwartz PJ, La Rovere MT, Vanoli E: Autonomic nervous system and sudden cardiac death: Experimental basis and clinical observations for post-myocardial infarction risk stratification. Circulation 1992;85:177-191.
12. La Rovere M, Specchia G, Mortara A, et al: Baroreflex sensitivity, clinical correlates, and cardiovascular mortality among patients with a first myocardial infarction: A prospective study. Circulation 1988;78:816-824.
13. Farrell TG, Paul V, Cripps TR, et al: Baroreflex sensitivity and electrophysiological correlates in patients after acute myocardial infarction. Circulation 1991;83:945-952.
14. Kleiger RE, Miller JP, Bigger JT, et al: Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 1987;59:256-262.
15. Saul JP, Arai Y, Berger RD, et al: Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis. Am J Cardiol 1988;61: 1292-1299.
16. Nguyen PT, Scheinmann MM, Seger J: Polymorphous ventricular tachycardia: Clinical characterization, therapy and the QT interval. Circulation 1986;74:340-349.
17. Binah O, Rosen M: Mechanisms of ventricular arrhythmias. Circulation 1992;85(Suppl I):I-25-I-31.
18. Tomaselli GF, Beuckelmann DJ, Calkins HG, et al: Sudden cardiac death in heart failure: The role of abnormal repolarization. Circulation 1994;90:2534-2539.
19. Pye M, Quinn AC, Cobbe SM: QT interval dispersion: A non-invasive marker of susceptibility to arrhythmia in patients with sustained ventricular arrhythmias? Br Heart J 1994;71:511-514.
20. Barr CS, Naas A, Freeman M, et al: QT dispersion and sudden unexpected death in chronic heart failure. Lancet 1994;343:327-329.
21. Surawicz B: Will QT dispersion play a role in clinical decision-making? J Cardiovasc Electrophysiol 1996; 7:777-784.
22. Smith JM, Clancy EA, Valeri R, et al: Electrical alternans and cardiac electrical instability. Circulation 1988;77:110-121.
23. Rosenbaum DS, Jackson LE, Smith JM, et al: Electrical alternans and vulnerability to ventricular arrhythmias. N Engl J Med 1994;330:235-241.
24. Rosenbaum DS, Albrecht P, Cohen RJ: Predicting sudden cardiac death from T wave alternans of the surface electrocardiogram: Promise and pitfalls. J Cardiovasc Electrophysiol 1996;7:1095-1111.
25. Berger RD, Kasper EK, Baughman KL, et al: Beat-to-beat QT interval variability: Novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy. Circulation 1997;96:1557-1565.
26. Day CP, McComb JM, Campbell RWF: QT dispersion: An indication of arrhythmia risk in patients with long QT intervals. Br Heart J 1990;63:342-344.
27. Statters DJ, Malik M, Ward DE, et al: QT dispersion: Problems of methodology and clinical significance. J Cardiovasc Electrophysiol 1994;5:672-685.
28. Berger RD, Tomaselli G, Calkins H: Dilated cardiomyopathy leads to inappropriate fluctuations in QT interval. (Abstract) PACE 1995;18:849.
29. Berger RD, Tomaselli G, Calkins H, et al: QT interval variability quantifies repolarization lability in patients with dilated cardiomyopathy. (Abstract) Circulation 1994;90:I-662.
30. Berger RD, Akselrod S, Gordon D, et al: An efficient algorithm for spectral analysis of heart rate variability. IEEE Trans Biomed Eng 1986;BME-33:900-904.
31. Saul JP, Arai Y, Berger RD, et al: Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis. Am J Cardiol 1988;61: 1292-1299.
32. Metz CD: Basic principles of ROC analysis. Semin Nucl Med 1978;8:283-298.
33. Kuo C, Munakata K, Reddy CP, et al: Characteristics and possible mechanisms of ventricular arrhythmia dependent on the dispersion of action potential durations. Circulation 1983;67:1356-1367.
34. Steinbigler P, Spiegl A, Nespithal K, et al: T-wave-spectral-variance: A new method to determine inhomogenous repolarisation by T-wave beat-to-beat variability in patients prone to ventricular arrhythmias. (Abstract) Circulation. 1996;94(Suppl I):I-504.
35. Berul CI, Wang PJ, Hill SL, et al: Electrical T-wave alternans is superior to QT or JT dispersion as predicitive marker of ventricular arrhythmias. Circulation 1996;94(Suppl I):I-624.
36. Jackman WM, Szabo B, Friday KJ, et al: Ventricular tachyarrhythmias related to early afterdepolarizations and triggered firing: Relationship to QT interval prolongation and potential therapeutic role for calcium channel blocking agents. J Cardiovasc Electrophysiol 1990;1:170-195.
37. Sarma JSM, Singh N, Schoenbaum MP, et al: Circadian and power spectral changes of RR and QT intervals during treatment of patients with angina pectoris with nadolol providing evidence for differential autonomic modulation of heart rate and ventricular repolarization. Am J Cardiol 1994;74:131-136.
38. Myerburg RJ, Kessler KM, Castellanos A: Sudden cardiac death: Structure, function and time-dependence of risk. Circulation 1992;85(Suppl I):I-2-I-10.
39. Furukawa T, Rozanski JJ, Nogami A, et al: Time-dependent risk of and predictors for cardiac arrest recurrence in survivors of out-of-hospital cardiac arrest with chronic coronary artery disease. Circulation 1989;80: 599-608.