Elimination of microglia improves functional outcomes following extensive neuronal loss in the hippocampus

Journal of Neuroscience

Volumn 35, Issue 27, 2015, Pages 9977-9989

  Rice, Rachel A ^a   Spangenberg, Elizabeth E ^a   Yamate Morgan, Hana ^a   Lee, Rafael J ^a   Arora, Rajan P S ^a   Hernandez, Michael X ^a   Tenner, Andrea J ^a   West, Brian L ^b   Green, Kim N ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PLEXXIKON INC   (United States)

Author keywords

Behavior; Glia; Inflammation; Lesion; Spines; Synapse

Indexed keywords

B7 ANTIGEN; BETA 2 MICROGLOBULIN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR2; COMPLEMENTARY DNA; DIPHTHERIA TOXIN; DOXYCYCLINE; INTERLEUKIN 15; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN BAX; PROTEIN TYROSINE KINASE INHIBITOR; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE; SIALOADHESIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; SYNAPTOPHYSIN; 5-((5-CHLORO-1H-PYRROLO(2,3-B)PYRIDIN-3-YL)METHYL)-N-((6-(TRIFLUOROMETHYL)PYRIDIN-3-YL)METHYL)PYRIDIN-2-AMINE; AMINOPYRIDINE DERIVATIVE; ENOLASE; PYRROLE DERIVATIVE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN DAMAGE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DENDRITIC SPINE; ELEVATED PLUS MAZE TEST; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENE MUTATION; HIPPOCAMPUS; MALE; MICROGLIA; MORRIS WATER MAZE TEST; MOUSE; NERVE CELL DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STEREOLOGY; ANIMAL; BEHAVIOR; BRAIN INJURIES; COGNITION DISORDERS; COMPLICATION; CONVALESCENCE; DISEASE MODEL; DRUG EFFECTS; MAZE TEST; METABOLISM; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

AMINOPYRIDINES; ANIMALS; BEHAVIORAL SYMPTOMS; BLOOD-BRAIN BARRIER; BRAIN INJURIES; COGNITION DISORDERS; DENDRITIC SPINES; DISEASE MODELS, ANIMAL; DOXYCYCLINE; FEMALE; HIPPOCAMPUS; MALE; MAZE LEARNING; MICE; MICE, TRANSGENIC; MICROGLIA; NEURONS; PHOSPHOPYRUVATE HYDRATASE; PYRROLES; RECOVERY OF FUNCTION; SYNAPTOPHYSIN;

EID: 84936869193     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0336-15.2015     Document Type: Article

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