Anti-microRNAs as novel therapeutic agents in the clinical management of Alzheimer's disease

Frontiers in Neuroscience

Volumn 10, Issue FEB, 2016, Pages

  Zhao, Yuhai ^a   Alexandrov, Peter N ^b   Lukiw, Walter J ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

Author keywords

Aging; Alzheimer's disease; Anti microRNA (AM); Human genetic heterogeneity; Inflammation; MicroRNA (miRNA); NF kB; Non coding RNA

Indexed keywords

MICRORNA; RIBONUCLEOTIDE; RNA POLYMERASE II; UNTRANSLATED RNA;

ALZHEIMER DISEASE; ARTICLE; CENTRAL NERVOUS SYSTEM; COGNITIVE DEFECT; DOWN REGULATION; GENE EXPRESSION; HEALTH CARE; HIPPOCAMPAL CA1 REGION; HUMAN; INTELLECTUAL IMPAIRMENT; NEUROPATHOLOGY; NUCLEOTIDE SEQUENCE; PERSONALIZED MEDICINE; RNA SEQUENCE; SOCIOECONOMICS; UPREGULATION;

EID: 84964328782     PISSN: 16624548     EISSN: 1662453X     Source Type: Journal    
DOI: 10.3389/fnins.2016.00059     Document Type: Article

References (69)

1. Alzheimer, A. (1991). A contribution concerning the pathological anatomy of mental disturbances in old age 1899. Alzheimer Dis. Assoc. Disord. 5, 69-70. doi: 10.1097/00002093-199100520-00003
2. Alzheimer, A., Förstl, H., and Levy, R. (1991). On certain peculiar diseases of old age. Hist. Psychiatry 2, 71-101. doi: 10.1177/0957154X9100200505
3. Alzheimer, A., Stelzmann, R. A., Schnitzlein, H. N., and Murtagh, F. R. (1995). An English translation of Alzheimer's 1907 paper, "Uber eine eigenartige Erkankung der Hirnrinde". Clin. Anat. 8, 429-431. doi: 10.1002/ca.980080612
4. Ambros, V. (2004). The functions of animal microRNAs. Nature 431, 350-355. doi: 10.1038/nature02871
5. Ambros, V., Bartel, B., Bartel, D. P., Burge, C. B., Carrington, J. C., Chen, X., et al. (2003). A uniform system for microRNA annotation. RNA 9, 277-279. doi: 10.1261/rna.2183803
6. Barnes, J., Dickerson, B. C., Frost, C., Jiskoot, L. C., Wolk, D., and van der Flier, W. M. (2015). Alzheimer's disease first symptoms are age dependent: evidence from the NACC dataset. Alzheimers Dement. 11, 1349-1357. doi: 10.1016/j.jalz.2014.12.007
7. Bartel, D. P. (2009). MicroRNAs: target recognition and regulatory functions. Cell 136, 215-233. doi: 10.1016/j.cell.2009.01.002
8. Baumgart, M., Snyder, H. M., Carrillo, M. C., Fazio, S., Kim, H., and Johns, H. (2015). Summary of the evidence on modifiable risk factors for cognitive decline and dementia: a population-based perspective. Alzheimers Dement. 11, 718-726. doi: 10.1016/j.jalz.2015.05.016
9. Blennow, K., Dubois, B., Fagan, A. M., Lewczuk, P., de Leon, M. J., and Hampel, H. (2015). Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease. Alzheimers Dement. 11, 58-69. doi: 10.1016/j.jalz.2014.02.004
10. Brites, D., and Fernandes, A. (2015). Neuroinflammation and depression: microglia activation, extracellular microvesicles and microRNA dysregulation. Front. Cell Neurosci. 9:476. doi: 10.3389/fncel.2015.00476
11. Burmistrova, O. A., Goltsov, A. Y., Abramova, L. I., Kaleda, V. G., Orlova, V. A., and Rogaev, E. I. (2007). MicroRNA in schizophrenia: genetic and expression analysis of miR-130b (22q11). Biochemistry 72, 578-582. doi: 10.1134/s0006297907050161
12. Cogswell, J. P., Ward, J., Taylor, I. A., Waters, M., Shi, Y., Cannon, B., et al. (2008). Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J. Alzheimers Dis. 14, 27-41
13. Colangelo, V., Schurr, J., Ball, M. J., Pelaez, R. P., Bazan, N. G., and Lukiw, W. J. (2002). Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1. J. Neurosci. Res. 70, 462-473. doi: 10.1002/jnr.10351
14. Cui, J. G., Li, Y. Y., Zhao, Y., Bhattacharjee, S., and Lukiw, W. J. (2010). Differential regulation of interleukin-1 receptor-associated kinase-1 (IRAK-1) and IRAK-2 by microRNA-146a and NF-kB in stressed human astroglial cells and in Alzheimer's disease. J. Biol. Chem. 285, 38951-38960. doi: 10.1074/jbc. M110.178848
15. Denzler, R., and Stoffel, M. (2015). The long, the short, and the unstructured: a unifying model of miRNA biogenesis. Mol. Cell 60, 4-6. doi: 10.1016/j.molcel.2015.09.014
16. Devier, D. J., Lovera, J. F., and Lukiw, W. J. (2015). Increase in NF-κB-sensitive miRNA-146a and miRNA-155 in multiple sclerosis (MS) and pro-inflammatory neurodegeneration. Front. Mol. Neurosci. 8, 5-10. doi: 10.3389/fnmol.2015.00005
17. Fang, W., and Bartel, D. P. (2015). The menu of features that define primary microRNAs and enable de novo design of microRNA genes. Mol. Cell 60, 131-145. doi: 10.1016/j.molcel.2015.08.015
18. Femminella, G. D., Ferrara, N., and Rengo, G. (2015). The emerging role of microRNAs in Alzheimer's disease. Front. Physiol. 6:40. doi: 10.3389/fphys.2015.00040
19. Gabriely, G., Yi, M., Narayan, R. S., Niers, J. M., Wurdinger, T., Imitola, J., et al. (2011). Human glioma growth is controlled by microRNA-10b. Cancer Res. 71, 3563-3572. doi: 10.1158/0008-5472.CAN-10-3568
20. Ginsberg, S. D., Alldred, M. J., and Che, S. (2012). Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease. Neurobiol. Dis. 45, 99-107. doi: 10.1016/j.nbd.2011.07.013
21. Guerreiro, R. J., Gustafson, D. R., and Hardy, J. (2012). The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE. Neurobiol. Aging 33, 437-456. doi: 10.1016/j.neurobiolaging.2010.03.025
22. Gui, Y. X., Liu, H., Zhang, L. S., Lv, W., and Hu, X. Y. (2015). Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease. Oncotarget 6, 37043-37053. doi: 10.18632/oncotarget.6158
23. Guo, H., Ingolia, N. T., Weissman, J. S., and Bartel, D. P. (2010). Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466, 835-840. doi: 10.1038/nature09267
24. Hill, J. M., Clement, C., Zhao, Y., and Lukiw, W. J. (2015a). Induction of the pro-inflammatory NF-kB-sensitive miRNA-146a by human neurotrophic viruses. Front. Microbiol. 6:43. doi: 10.3389/fmicb.2015.00043
25. Hill, J. M., and Lukiw, W. J. (2015). microRNA (miRNA)-mediated pathogenetic signaling in Alzheimer's disease (AD). Neurochem Res. doi: 10.1007/s11064-015-1734-7. [Epub ahead of print]
26. Hill, J. M., Pogue, A. I., and Lukiw, W. J. (2015b). Pathogenic microRNAs common to brain and retinal degeneration; recent observations in Alzheimer's disease and age-related macular degeneration. Front. Neurol. 6:232. doi: 10.3389/fneur.2015.00232
27. Janssen, H. L. A., Reesink, H. W., Lawitz, E. J., Zeuzem, S., Rodriguez-Torres, M., Patel, K., et al. (2013). Treatment of HCV infection by targeting microRNA. N. Engl. J. Med. 368, 1685-1694. doi: 10.1056/NEJMoa1209026
28. Jiang, T., Yu, J. T., Tian, Y., and Tan, L. (2013). Epidemiology and etiology of Alzheimer's disease: from genetic to non-genetic factors. Curr. Alzheimer Res. 10, 852-867. doi: 10.2174/15672050113109990155
29. Kang, L., Gao, Z., Huang, W., Jin, M., and Wang, Q. (2015). Nanocarrier-mediated co-delivery of chemotherapeutic drugs and gene agents for cancer treatment. Acta Pharm. Sin. B 5, 169-175. doi: 10.1016/j.apsb.2015.03.001
30. Karnati, H. K., Panigrahi, M. K., Gutti, R. K., Greig, N. H., and Tamargo, I. A. (2015). miRNAs: key players in neurodegenerative disorders and epilepsy. J. Alzheimers Dis. 48, 563-580. doi: 10.3233/JAD-150395
31. Kaur, U., Banerjee, P., Bir, A., Sinha, M., Biswas, A., and Chakrabarti, S. (2015). Reactive oxygen species, redox signaling and neuroinflammation in Alzheimer's disease: the NFκB connection. Curr. Top Med. Chem. 15, 446-457. doi: 10.2174/1568026615666150114160543
32. Lau, P., Frigerio, C. S., and De Strooper, B. (2014). Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: the need of larger datasets. Ageing Res. Rev. 17, 43-53. doi: 10.1016/j.arr.2014.02.006
33. Leung, A. K. (2015). The whereabouts of microRNA actions: cytoplasm and beyond. Trends Cell Biol. 25, 601-610. doi: 10.1016/j.tcb.2015.07.005
34. Loring, J. F., Wen, X., Lee, J. M., Seilhamer, J., and Somogyi, R. (2001). A gene expression profile of Alzheimer's disease. DNA Cell Biol. 20, 683-695. doi: 10.1089/10445490152717541
35. Lukiw, W. J. (2004). Gene expression profiling in fetal, aged, and Alzheimer hippocampus: a continuum of stress-related signaling. Neurochem. Res. 29, 1287-1297. doi: 10.1023/B:NERE.0000023615.89699.63
36. Lukiw, W. J. (2007). MiRNA speciation in fetal, adult and Alzheimer's disease hippocampus. Neuroreport 18, 297-300. doi: 10.1097/WNR.0b013e3280148e8b
37. Lukiw, W. J. (2012). Evolution and complexity of microRNA in the human brain. Front. Genet. 3, 166-170. doi: 10.3389/fgene.2012.00166
38. Lukiw, W. J. (2012a). NF-κB-regulated, proinflammatory miRNAs in Alzheimer's disease. Alzheimers Res. Ther. 4, 47. doi: 10.1186/alzrt150
39. Lukiw, W. J. (2012b). NF-κB-regulated micro RNAs in primary human brain cells. Exp. Neurol. 235, 484-490. doi: 10.1016/j.expneurol.2011.11.022
40. Lukiw, W. J. (2013a). Antagonism of NF-κB-up-regulated micro RNAs (miRNAs) in sporadic Alzheimer's disease (AD)-anti-NF-κB vs. anti-miRNA strategies. Front. Genet. 4:77. doi: 10.3389/fgene.2013.00077
41. Lukiw, W. J. (2013b). Variability in micro RNA (miRNA) abundance, speciation and complexity amongst different human populations and potential relevance to Alzheimer's disease (AD). Front. Cell. Neurosci. 7:133. doi: 10.3389/fncel.2013.00133
42. Lukiw, W. J., and Bazan, N. G. (1998). Strong nuclear factor-kB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex. J. Neurosci. Res. 53, 583-592
43. Lukiw, W. J., Andreeva, T. V., Grigorenko, A. P., and Rogaev, E. I. (2013). Studying microRNA function and dysfunction in Alzheimer's disease. Front. Genet. 3:327. doi: 10.3389/fgene.2012.00327
44. Lukiw, W. J., Handley, P., Wong, L., and Crapper McLachlan, D. R. (1992). BC200 RNA in normal human neocortex, non-Alzheimer dementia, and senile dementia of the Alzheimer type. Neurochem. Res. 17, 591-597. doi: 10.1007/BF00968788
45. Lukiw, W. J., Zhao, Y., and Cui, J. G. (2008). An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J. Biol. Chem. 283, 31315-31322. doi: 10.1074/jbc. M805371200
46. Monteys, A. M., Spengler, R. M., Dufour, B. D., Wilson, M. S., Oakley, C. K., Sowada, M. J., et al. (2014). Single nucleotide seed modification restores in vivo tolerability of a toxic artificial miRNA sequence in the mouse brain. Nucleic Acids Res. 42, 13315-13327. doi: 10.1093/nar/gku979
47. Østergaard, S. D., Mukherjee, S., Sharp, S. J., Proitsi, P., Lotta, L. A., Day, F., et al. (2015). Associations between potentially modifiable risk factors and Alzheimer disease. PLoS Med. 12:e1001841. doi: 10.1371/journal.pmed.1001841
48. Pogue, A. I., Hill, J. M., and Lukiw, W. J. (2014). MicroRNA (miRNA): sequence and stability, viroid-like properties, and disease association in the CNS. Brain Res. 1584, 73-79. doi: 10.1016/j.brainres.2014.03.042
49. Properzi, F., Ferroni, E., Poleggi, A., and Vinci, R. (2015). The regulation of exosome function in the CNS: implications for neurodegeneration. Swiss Med. Wkly. 145:w14204. doi: 10.4414/smw.2015.14204
50. Qiu, L., Zhang, W., Tan, E. K., and Zeng, L. (2014). Deciphering the function and regulation of microRNAs in Alzheimer's disease and Parkinson's disease. ACS Chem. Neurosci. 5, 884-894. doi: 10.1021/cn500149w
51. Ramsingh, G., Koboldt, D. C., Trissal, M., Chiappinelli, K. B., Wylie, T., Koul, S., et al. (2010). Complete characterization of the microRNAome in a patient with acute myeloid leukemia. Blood 116, 5316-5326. doi: 10.1182/blood-2010-05-285395
52. Roth, W., Hecker, D., and Fava, E. (2016). Systems biology approaches to the study of biological networks underlying Alzheimer's disease: role of miRNAs. Methods Mol. Biol. 1303, 349-377. doi: 10.1007/978-1-4939-2627-5_21
53. Sanei, M., and Chen, X. (2015). Mechanisms of microRNA turnover. Curr. Opin. Plant Biol. 27, 199-206. doi: 10.1016/j.pbi.2015.07.008
54. Schipper, H. M., Maes, O. C., Chertkow, H. M., and Wang, E. (2007). MicroRNA expression in Alzheimer blood mononuclear cells. Gene Regul. Syst. Biol. 1, 263-274
55. Sethi, P., and Lukiw, W. J. (2009). Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex. Neurosci. Lett. 459, 100-104. doi: 10.1016/j.neulet.2009.04.052
56. Shi, J. (2015). Regulatory networks between neurotrophins and miRNAs in brain diseases and cancers. Acta Pharmacol. Sin. 36, 149-157. doi: 10.1038/aps.2014.135
57. Srinivasan, M., and Lahiri, D. K. (2015). Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer's disease and multiple sclerosis. Expert Opin. Ther. Targets 19, 471-487. doi: 10.1517/14728222.2014.989834
58. Srivastava, A., Filant, J., Moxley, K. M., Sood, A., McMeekin, S., and Ramesh, R. (2015). Exosomes: a role for naturally occurring nanovesicles in cancer growth, diagnosis and treatment. Curr. Gene Ther. 15, 182-192. doi: 10.2174/1566523214666141224100612
59. Teplyuk, N. M., Mollenhauer, B., Gabriely, G., Giese, A., Kim, E., Smolsky, M., et al. (2012). MicroRNAs in cerebrospinal fluid identify glioblastoma and metastatic brain cancers and reflect disease activity. Neuro Oncol. 14, 689-700. doi: 10.1093/neuonc/nos074
60. van der Pol, E., Böing, A. N., Gool, E. L., and Nieuwland, R. (2016). Recent developments in the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles. J. Thromb. Haemost. 14, 48-56. doi: 10.1111/jth.13190
61. van Harten, A. C., Mulders, J., Scheltens, P., van der Flier, W. M., and Oudejans, C. B. (2015). Differential expression of microRNA in cerebrospinal fluid as a potential novel biomarker for Alzheimer's disease. J. Alzheimers Dis. 47, 243-252. doi: 10.3233/JAD-140075
62. Verhülsdonk, S., Hellen, F., Höft, B., Supprian, T., and Lange-Asschenfeldt, C. (2015). Attention and CERAD test performances in cognitively impaired elderly subjects. Acta Neurol. Scand. 131, 364-371. doi: 10.1111/ane.12346
63. Walhovd, K. B., Fjell, A. M., and Espeseth, T. (2014). Cognitive decline and brain pathology in aging-need for a dimensional, lifespan and systems vulnerability view. Scand. J. Psychol. 55, 244-254. doi: 10.1111/sjop.12120
64. Wang, H., Jiang, Y., Peng, H., Chen, Y., Zhu, P., and Huang, Y. (2015). Recent progress in microRNA delivery for cancer therapy by non-viral synthetic vectors. Adv. Drug Deliv Rev. 81, 142-160. doi: 10.1016/j.addr.2014.10.031
65. Wang, Z., Wang, J., Zhang, H., Mchugh, R., Sun, X., Li, K., et al. (2015). Interhemispheric functional and structural disconnection in Alzheimer's disease: a combined resting-state fMRI and DTI Study. PLoS ONE 10:e0126310. doi: 10.1371/journal.pone.0126310
66. Wu, H. Z., Ong, K. L., Seeher, K., Armstrong, N. J., Thalamuthu, A., Brodaty, H., et al. (2015). Circulating microRNAs as biomarkers of Alzheimer's disease: a systematic review. J. Alzheimers Dis. 49, 755-766. doi: 10.3233/JAD-150619
67. Yuan, Y., Tong, L., and Wu, S. (2015). microRNA and NF-kappa B. Adv. Exp. Med. Biol. 887, 157-170. doi: 10.1007/978-3-319-22380-3_9
68. Zhang, Y., Wang, Z., and Gemeinhart, R. A. (2013). Progress in microRNA delivery. J. Control. Release 172, 962-974. doi: 10.1016/j.jconrel.2013.09.015
69. Zhao, Y., Bhattacharjee, S., Dua, P., Alexandrov, P. N., and Lukiw, W. J. (2015). microRNA-based biomarkers and the diagnosis of Alzheimer's disease. Front. Neurol. 6:162. doi: 10.3389/fneur.2015.00162