메뉴 건너뛰기




Volumn 25, Issue 10, 2015, Pages 601-610

The Whereabouts of microRNA Actions: Cytoplasm and Beyond

Author keywords

Argonaute; Circulating miRNAs; Localization; MiRNA; Organelle; Post translational modification

Indexed keywords

ARGONAUTE PROTEIN; BINDING PROTEIN; MICRORNA; MESSENGER RNA;

EID: 84942087859     PISSN: 09628924     EISSN: 18793088     Source Type: Journal    
DOI: 10.1016/j.tcb.2015.07.005     Document Type: Review
Times cited : (150)

References (96)
  • 1
    • 84904985459 scopus 로고    scopus 로고
    • Regulation of microRNA biogenesis
    • Ha M., Kim V.N. Regulation of microRNA biogenesis. Nat. Rev. Mol. Cell Biol. 2014, 15:509-524.
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 509-524
    • Ha, M.1    Kim, V.N.2
  • 2
    • 84922422451 scopus 로고    scopus 로고
    • In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA
    • La Rocca G., et al. In vivo, Argonaute-bound microRNAs exist predominantly in a reservoir of low molecular weight complexes not associated with mRNA. Proc. Natl. Acad. Sci. U.S.A. 2015, 112:767-772.
    • (2015) Proc. Natl. Acad. Sci. U.S.A. , vol.112 , pp. 767-772
    • La Rocca, G.1
  • 3
    • 56649122127 scopus 로고    scopus 로고
    • Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells
    • Ohrt T., et al. Fluorescence correlation spectroscopy and fluorescence cross-correlation spectroscopy reveal the cytoplasmic origination of loaded nuclear RISC in vivo in human cells. Nucleic Acids Res. 2008, 36:6439-6449.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 6439-6449
    • Ohrt, T.1
  • 4
    • 35748932681 scopus 로고    scopus 로고
    • Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells
    • Höck J., et al. Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells. EMBO Rep. 2007, 8:1052-1060.
    • (2007) EMBO Rep. , vol.8 , pp. 1052-1060
    • Höck, J.1
  • 5
    • 22144478256 scopus 로고    scopus 로고
    • MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
    • Liu J., et al. MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat. Cell Biol. 2005, 7:719-723.
    • (2005) Nat. Cell Biol. , vol.7 , pp. 719-723
    • Liu, J.1
  • 6
    • 20444427566 scopus 로고    scopus 로고
    • Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies
    • Sen G.L., Blau H.M. Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. Nat. Cell Biol. 2005, 7:633-636.
    • (2005) Nat. Cell Biol. , vol.7 , pp. 633-636
    • Sen, G.L.1    Blau, H.M.2
  • 7
    • 84873560641 scopus 로고    scopus 로고
    • Quantifying Argonaute proteins in and out of GW/P-bodies: implications in microRNA activities
    • Leung A.K.L., Sharp P.A. Quantifying Argonaute proteins in and out of GW/P-bodies: implications in microRNA activities. Adv. Exp. Med. Biol. 2013, 768:165-182.
    • (2013) Adv. Exp. Med. Biol. , vol.768 , pp. 165-182
    • Leung, A.K.L.1    Sharp, P.A.2
  • 8
    • 2442566370 scopus 로고    scopus 로고
    • Cytoplasmic foci are sites of mRNA decay in human cells
    • Cougot N., et al. Cytoplasmic foci are sites of mRNA decay in human cells. J. Cell Biol. 2004, 165:31-40.
    • (2004) J. Cell Biol. , vol.165 , pp. 31-40
    • Cougot, N.1
  • 9
    • 33845295461 scopus 로고    scopus 로고
    • Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules
    • Leung A.K.L., et al. Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:18125-18130.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 18125-18130
    • Leung, A.K.L.1
  • 10
    • 34347335707 scopus 로고    scopus 로고
    • P-body formation is a consequence, not the cause, of RNA-mediated gene silencing
    • Eulalio A., et al. P-body formation is a consequence, not the cause, of RNA-mediated gene silencing. Mol. Cell. Biol. 2007, 27:3970-3981.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 3970-3981
    • Eulalio, A.1
  • 11
    • 33744973775 scopus 로고    scopus 로고
    • Relief of microRNA-mediated translational repression in human cells subjected to stress
    • Bhattacharyya S.N., et al. Relief of microRNA-mediated translational repression in human cells subjected to stress. Cell 2006, 125:1111-1124.
    • (2006) Cell , vol.125 , pp. 1111-1124
    • Bhattacharyya, S.N.1
  • 12
    • 84918594125 scopus 로고    scopus 로고
    • Quantifying mRNA targeting to P-bodies in living human cells reveals their dual role in mRNA decay and storage
    • Aizer A., et al. Quantifying mRNA targeting to P-bodies in living human cells reveals their dual role in mRNA decay and storage. J. Cell Sci. 2014, 127:4443-4456.
    • (2014) J. Cell Sci. , vol.127 , pp. 4443-4456
    • Aizer, A.1
  • 13
    • 27144515901 scopus 로고    scopus 로고
    • Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies
    • Brengues M., et al. Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies. Science 2005, 310:486-489.
    • (2005) Science , vol.310 , pp. 486-489
    • Brengues, M.1
  • 14
    • 83455225621 scopus 로고    scopus 로고
    • Reconsidering movement of eukaryotic mRNAs between polysomes and P bodies
    • Arribere J.A., et al. Reconsidering movement of eukaryotic mRNAs between polysomes and P bodies. Mol. Cell 2011, 44:745-758.
    • (2011) Mol. Cell , vol.44 , pp. 745-758
    • Arribere, J.A.1
  • 15
    • 58149401820 scopus 로고    scopus 로고
    • Dendrites of mammalian neurons contain specialized P-body-like structures that respond to neuronal activation
    • Cougot N., et al. Dendrites of mammalian neurons contain specialized P-body-like structures that respond to neuronal activation. J. Neurosci. 2008, 28:13793-13804.
    • (2008) J. Neurosci. , vol.28 , pp. 13793-13804
    • Cougot, N.1
  • 16
    • 77951234253 scopus 로고    scopus 로고
    • A role for huntington disease protein in dendritic RNA granules
    • Savas J.N., et al. A role for huntington disease protein in dendritic RNA granules. J. Biol Chem. 2010, 285:13142-13153.
    • (2010) J. Biol Chem. , vol.285 , pp. 13142-13153
    • Savas, J.N.1
  • 17
    • 84899785408 scopus 로고    scopus 로고
    • Traffic into silence: endomembranes and post-transcriptional RNA silencing
    • Kim Y.J., et al. Traffic into silence: endomembranes and post-transcriptional RNA silencing. EMBO J. 2014, 33:968-980.
    • (2014) EMBO J. , vol.33 , pp. 968-980
    • Kim, Y.J.1
  • 18
    • 0032879978 scopus 로고    scopus 로고
    • GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation
    • Cikaluk D.E., et al. GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation. Mol. Biol. Cell 1999, 10:3357-3372.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 3357-3372
    • Cikaluk, D.E.1
  • 19
    • 84857136721 scopus 로고    scopus 로고
    • Isoprenoid biosynthesis is required for miRNA function and affects membrane association of ARGONAUTE 1 in Arabidopsis
    • Brodersen P., et al. Isoprenoid biosynthesis is required for miRNA function and affects membrane association of ARGONAUTE 1 in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:1778-1783.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 1778-1783
    • Brodersen, P.1
  • 20
    • 84858669745 scopus 로고    scopus 로고
    • The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans
    • Shi Z., Ruvkun G. The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:4568-4573.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 4568-4573
    • Shi, Z.1    Ruvkun, G.2
  • 21
    • 84876416274 scopus 로고    scopus 로고
    • The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing
    • Stalder L., et al. The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing. EMBO J. 2013, 32:1115-1127.
    • (2013) EMBO J. , vol.32 , pp. 1115-1127
    • Stalder, L.1
  • 22
    • 84876918219 scopus 로고    scopus 로고
    • MicroRNAs inhibit the translation of target mRNAs on the endoplasmic reticulum in Arabidopsis
    • Li S., et al. MicroRNAs inhibit the translation of target mRNAs on the endoplasmic reticulum in Arabidopsis. Cell 2013, 153:562-574.
    • (2013) Cell , vol.153 , pp. 562-574
    • Li, S.1
  • 23
    • 84885351670 scopus 로고    scopus 로고
    • Functionally diverse microRNA effector complexes are regulated by extracellular signaling
    • Wu P-H., et al. Functionally diverse microRNA effector complexes are regulated by extracellular signaling. Mol. Cell 2013, 52:113-123.
    • (2013) Mol. Cell , vol.52 , pp. 113-123
    • Wu, P.-H.1
  • 24
    • 84857253794 scopus 로고    scopus 로고
    • Primary role for endoplasmic reticulum-bound ribosomes in cellular translation identified by ribosome profiling
    • Reid D.W., Nicchitta C.V. Primary role for endoplasmic reticulum-bound ribosomes in cellular translation identified by ribosome profiling. J. Biol. Chem. 2012, 287:5518-5527.
    • (2012) J. Biol. Chem. , vol.287 , pp. 5518-5527
    • Reid, D.W.1    Nicchitta, C.V.2
  • 25
    • 84909607974 scopus 로고    scopus 로고
    • Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling
    • Jan C.H., et al. Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling. Science 2014, 346:716.
    • (2014) Science , vol.346 , pp. 716
    • Jan, C.H.1
  • 26
    • 69949185018 scopus 로고    scopus 로고
    • Silencing by small RNAs is linked to endosomal trafficking
    • Lee Y.S., et al. Silencing by small RNAs is linked to endosomal trafficking. Nat. Cell Biol. 2009, 11:1150-1156.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1150-1156
    • Lee, Y.S.1
  • 27
    • 69949117622 scopus 로고    scopus 로고
    • Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity
    • Gibbings D.J., et al. Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity. Nat. Cell Biol. 2009, 11:1143-1149.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1143-1149
    • Gibbings, D.J.1
  • 28
    • 79961025970 scopus 로고    scopus 로고
    • MicroRNAs in body fluids: the mix of hormones and biomarkers
    • Cortez M.A., et al. MicroRNAs in body fluids: the mix of hormones and biomarkers. Nat. Rev. Clin. Oncol. 2011, 8:467-477.
    • (2011) Nat. Rev. Clin. Oncol. , vol.8 , pp. 467-477
    • Cortez, M.A.1
  • 29
    • 84922527336 scopus 로고    scopus 로고
    • Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells
    • Squadrito M.L., et al. Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells. Cell Rep. 2014, 8:1432-1446.
    • (2014) Cell Rep. , vol.8 , pp. 1432-1446
    • Squadrito, M.L.1
  • 30
    • 84903763537 scopus 로고    scopus 로고
    • Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells
    • Ono M., et al. Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells. Sci. Signal. 2014, 7:ra63.
    • (2014) Sci. Signal. , vol.7 , pp. ra63
    • Ono, M.1
  • 31
    • 84874833693 scopus 로고    scopus 로고
    • Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1
    • Morel L., et al. Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1. J. Biol. Chem. 2013, 288:7105-7116.
    • (2013) J. Biol. Chem. , vol.288 , pp. 7105-7116
    • Morel, L.1
  • 32
    • 84924943735 scopus 로고    scopus 로고
    • Polysome arrest restricts miRNA turnover by preventing their exosomal export in growth retarded mammalian cells
    • Ghosh S., et al. Polysome arrest restricts miRNA turnover by preventing their exosomal export in growth retarded mammalian cells. Mol. Biol. Cell 2015, 26:1072-1083.
    • (2015) Mol. Biol. Cell , vol.26 , pp. 1072-1083
    • Ghosh, S.1
  • 33
    • 84873541811 scopus 로고    scopus 로고
    • The role of GW182 proteins in miRNA-mediated gene silencing
    • Braun J.E., et al. The role of GW182 proteins in miRNA-mediated gene silencing. Adv. Exp. Med. Biol. 2013, 768:147-163.
    • (2013) Adv. Exp. Med. Biol. , vol.768 , pp. 147-163
    • Braun, J.E.1
  • 34
    • 67649373353 scopus 로고    scopus 로고
    • Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway
    • Miyoshi K., et al. Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway. RNA 2009, 15:1282-1291.
    • (2009) RNA , vol.15 , pp. 1282-1291
    • Miyoshi, K.1
  • 35
    • 84869237206 scopus 로고    scopus 로고
    • Dicer-dependent and -independent Argonaute2 protein interaction networks in mammalian cells
    • Frohn A., et al. Dicer-dependent and -independent Argonaute2 protein interaction networks in mammalian cells. Mol. Cell. Proteomics 2012, 11:1442-1456.
    • (2012) Mol. Cell. Proteomics , vol.11 , pp. 1442-1456
    • Frohn, A.1
  • 36
    • 33947262696 scopus 로고    scopus 로고
    • AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2
    • Vasudevan S., Steitz J.A. AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2. Cell 2007, 128:1105-1118.
    • (2007) Cell , vol.128 , pp. 1105-1118
    • Vasudevan, S.1    Steitz, J.A.2
  • 37
    • 84860755078 scopus 로고    scopus 로고
    • Human prion protein binds Argonaute and promotes accumulation of microRNA effector complexes
    • Gibbings D., et al. Human prion protein binds Argonaute and promotes accumulation of microRNA effector complexes. Nat. Struct. Mol. Biol. 2012, 19:517-524.
    • (2012) Nat. Struct. Mol. Biol. , vol.19 , pp. 517-524
    • Gibbings, D.1
  • 38
    • 84871959206 scopus 로고    scopus 로고
    • Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses
    • Olejniczak S.H., et al. Long-lived microRNA-Argonaute complexes in quiescent cells can be activated to regulate mitogenic responses. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:157-162.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 157-162
    • Olejniczak, S.H.1
  • 39
    • 84898993533 scopus 로고    scopus 로고
    • Differential RISC association of endogenous human microRNAs predicts their inhibitory potential
    • Flores O., et al. Differential RISC association of endogenous human microRNAs predicts their inhibitory potential. Nucleic Acids Res. 2014, 42:4629-4639.
    • (2014) Nucleic Acids Res. , vol.42 , pp. 4629-4639
    • Flores, O.1
  • 40
    • 84867690270 scopus 로고    scopus 로고
    • Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins
    • Janas M.M., et al. Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins. RNA 2012, 18:2041-2055.
    • (2012) RNA , vol.18 , pp. 2041-2055
    • Janas, M.M.1
  • 41
    • 77649133970 scopus 로고    scopus 로고
    • MiR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts
    • Eiring A.M., et al. miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell 2010, 140:652-665.
    • (2010) Cell , vol.140 , pp. 652-665
    • Eiring, A.M.1
  • 42
    • 84901006597 scopus 로고    scopus 로고
    • The RNA-binding protein TDP-43 selectively disrupts microRNA-1/206 incorporation into the RNA-induced silencing complex
    • King I.N., et al. The RNA-binding protein TDP-43 selectively disrupts microRNA-1/206 incorporation into the RNA-induced silencing complex. J. Biol. Chem. 2014, 289:14263-14271.
    • (2014) J. Biol. Chem. , vol.289 , pp. 14263-14271
    • King, I.N.1
  • 43
    • 84864503916 scopus 로고    scopus 로고
    • MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
    • Fabbri M., et al. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:E2110-E2116.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. E2110-E2116
    • Fabbri, M.1
  • 44
    • 84903743538 scopus 로고    scopus 로고
    • MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production
    • Chen A.K., et al. MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:E2676-E2683.
    • (2014) Proc. Natl. Acad. Sci. U.S.A. , vol.111 , pp. E2676-E2683
    • Chen, A.K.1
  • 45
    • 84896859718 scopus 로고    scopus 로고
    • Argonaute-bound small RNAs from promoter-proximal RNA polymerase II
    • Zamudio J.R., et al. Argonaute-bound small RNAs from promoter-proximal RNA polymerase II. Cell 2014, 156:920-934.
    • (2014) Cell , vol.156 , pp. 920-934
    • Zamudio, J.R.1
  • 46
    • 81255176919 scopus 로고    scopus 로고
    • Argonaute proteins regulate microRNA stability: increased microRNA abundance by Argonaute proteins is due to microRNA stabilization
    • Winter J., Diederichs S. Argonaute proteins regulate microRNA stability: increased microRNA abundance by Argonaute proteins is due to microRNA stabilization. RNA Biol. 2011, 8:1149-1157.
    • (2011) RNA Biol. , vol.8 , pp. 1149-1157
    • Winter, J.1    Diederichs, S.2
  • 47
    • 84880158954 scopus 로고    scopus 로고
    • Homeostatic control of Argonaute stability by microRNA availability
    • Smibert P., et al. Homeostatic control of Argonaute stability by microRNA availability. Nat. Struct. Mol. Biol. 2013, 20:789-795.
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 789-795
    • Smibert, P.1
  • 48
    • 84876532060 scopus 로고    scopus 로고
    • Argonaute2 expression is post-transcriptionally coupled to microRNA abundance
    • Martinez N.J., Gregory R.I. Argonaute2 expression is post-transcriptionally coupled to microRNA abundance. RNA 2013, 19:605-612.
    • (2013) RNA , vol.19 , pp. 605-612
    • Martinez, N.J.1    Gregory, R.I.2
  • 49
    • 79551647673 scopus 로고    scopus 로고
    • Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs
    • Leung A.K.L., et al. Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs. Nat. Struct. Mol. Biol. 2011, 18:237-244.
    • (2011) Nat. Struct. Mol. Biol. , vol.18 , pp. 237-244
    • Leung, A.K.L.1
  • 50
    • 84880447792 scopus 로고    scopus 로고
    • Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates
    • Karginov F.V., Hannon G.J. Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates. Genes Dev. 2013, 27:1624-1632.
    • (2013) Genes Dev. , vol.27 , pp. 1624-1632
    • Karginov, F.V.1    Hannon, G.J.2
  • 51
    • 84906936068 scopus 로고    scopus 로고
    • Alteration of miRNA activity via context-specific modifications of Argonaute proteins
    • Jee D., Lai E.C. Alteration of miRNA activity via context-specific modifications of Argonaute proteins. Trends Cell Biol. 2014, 24:546-553.
    • (2014) Trends Cell Biol. , vol.24 , pp. 546-553
    • Jee, D.1    Lai, E.C.2
  • 52
    • 84879531857 scopus 로고    scopus 로고
    • Akt-mediated phosphorylation of Argonaute 2 downregulates cleavage and upregulates translational repression of microRNA targets
    • Horman S.R., et al. Akt-mediated phosphorylation of Argonaute 2 downregulates cleavage and upregulates translational repression of microRNA targets. Mol. Cell 2013, 50:356-3567.
    • (2013) Mol. Cell , vol.50 , pp. 356-3567
    • Horman, S.R.1
  • 53
    • 79955957616 scopus 로고    scopus 로고
    • Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm
    • Leung A.K.L., et al. Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Mol. Cell 2011, 42:489-499.
    • (2011) Mol. Cell , vol.42 , pp. 489-499
    • Leung, A.K.L.1
  • 54
    • 84885995929 scopus 로고    scopus 로고
    • Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells
    • Seo G.J., et al. Reciprocal inhibition between intracellular antiviral signaling and the RNAi machinery in mammalian cells. Cell Host Microbe 2013, 14:435-445.
    • (2013) Cell Host Microbe , vol.14 , pp. 435-445
    • Seo, G.J.1
  • 55
    • 83255192187 scopus 로고    scopus 로고
    • Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2
    • Wu C., et al. Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2. Mol. Cell. Biol 2011, 31:4760-4774.
    • (2011) Mol. Cell. Biol , vol.31 , pp. 4760-4774
    • Wu, C.1
  • 56
    • 84874573555 scopus 로고    scopus 로고
    • T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire
    • Bronevetsky Y., et al. T cell activation induces proteasomal degradation of Argonaute and rapid remodeling of the microRNA repertoire. J. Exp. Med. 2013, 210:417-432.
    • (2013) J. Exp. Med. , vol.210 , pp. 417-432
    • Bronevetsky, Y.1
  • 57
    • 84904479804 scopus 로고    scopus 로고
    • Sumoylation of human argonaute 2 at lysine-402 regulates its stability
    • Sahin U., et al. Sumoylation of human argonaute 2 at lysine-402 regulates its stability. PLoS ONE 2014, 9:e102957.
    • (2014) PLoS ONE , vol.9 , pp. e102957
    • Sahin, U.1
  • 58
    • 84887117139 scopus 로고    scopus 로고
    • A transient reversal of miRNA-mediated repression controls macrophage activation
    • Mazumder A., et al. A transient reversal of miRNA-mediated repression controls macrophage activation. EMBO Rep. 2013, 14:1008-1016.
    • (2013) EMBO Rep. , vol.14 , pp. 1008-1016
    • Mazumder, A.1
  • 59
    • 84878108145 scopus 로고    scopus 로고
    • EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2
    • Shen J., et al. EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature 2013, 497:383-387.
    • (2013) Nature , vol.497 , pp. 383-387
    • Shen, J.1
  • 60
    • 84906258538 scopus 로고    scopus 로고
    • Aberrant regulation and function of microRNAs in cancer
    • Adams B.D., et al. Aberrant regulation and function of microRNAs in cancer. Curr. Biol. 2014, 24:R762-R776.
    • (2014) Curr. Biol. , vol.24 , pp. R762-R776
    • Adams, B.D.1
  • 61
    • 3242736704 scopus 로고    scopus 로고
    • Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs
    • Meister G., et al. Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol. Cell 2004, 15:185-197.
    • (2004) Mol. Cell , vol.15 , pp. 185-197
    • Meister, G.1
  • 62
    • 33846699083 scopus 로고    scopus 로고
    • A hexanucleotide element directs microRNA nuclear import
    • Hwang H-W., et al. A hexanucleotide element directs microRNA nuclear import. Science 2007, 315:97-100.
    • (2007) Science , vol.315 , pp. 97-100
    • Hwang, H.-W.1
  • 63
    • 77956278708 scopus 로고    scopus 로고
    • Deep sequencing of human nuclear and cytoplasmic small RNAs reveals an unexpectedly complex subcellular distribution of miRNAs and tRNA 3' trailers
    • Liao J-Y., et al. Deep sequencing of human nuclear and cytoplasmic small RNAs reveals an unexpectedly complex subcellular distribution of miRNAs and tRNA 3' trailers. PLoS ONE 2010, 5:e10563.
    • (2010) PLoS ONE , vol.5 , pp. e10563
    • Liao, J.-Y.1
  • 64
    • 78649357109 scopus 로고    scopus 로고
    • Mature microRNAs identified in highly purified nuclei from HCT116 colon cancer cells
    • Park C.W., et al. Mature microRNAs identified in highly purified nuclei from HCT116 colon cancer cells. RNA Biol. 2010, 7:606-614.
    • (2010) RNA Biol. , vol.7 , pp. 606-614
    • Park, C.W.1
  • 65
    • 79953003549 scopus 로고    scopus 로고
    • Nuclear and cytoplasmic localization of neural stem cell microRNAs
    • Jeffries C.D., et al. Nuclear and cytoplasmic localization of neural stem cell microRNAs. RNA 2011, 17:675-686.
    • (2011) RNA , vol.17 , pp. 675-686
    • Jeffries, C.D.1
  • 66
    • 84892544892 scopus 로고    scopus 로고
    • RNAi factors are present and active in human cell nuclei
    • Gagnon K.T., et al. RNAi factors are present and active in human cell nuclei. Cell Rep. 2014, 6:211-221.
    • (2014) Cell Rep. , vol.6 , pp. 211-221
    • Gagnon, K.T.1
  • 67
    • 84907332153 scopus 로고    scopus 로고
    • The microRNA biology of the mammalian nucleus
    • Roberts T.C. The microRNA biology of the mammalian nucleus. Mol. Ther. Nucleic Acids 2014, 3:e188.
    • (2014) Mol. Ther. Nucleic Acids , vol.3 , pp. e188
    • Roberts, T.C.1
  • 68
    • 15544363403 scopus 로고    scopus 로고
    • Specific and potent RNAi in the nucleus of human cells
    • Robb G.B., et al. Specific and potent RNAi in the nucleus of human cells. Nat. Struct. Mol. Biol. 2005, 12:133-137.
    • (2005) Nat. Struct. Mol. Biol. , vol.12 , pp. 133-137
    • Robb, G.B.1
  • 69
    • 59349087552 scopus 로고    scopus 로고
    • Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs
    • Weinmann L., et al. Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. Cell 2009, 136:496-507.
    • (2009) Cell , vol.136 , pp. 496-507
    • Weinmann, L.1
  • 70
    • 84902096048 scopus 로고    scopus 로고
    • Development and applications of CRISPR-Cas9 for genome engineering
    • Hsu P.D., et al. Development and applications of CRISPR-Cas9 for genome engineering. Cell 2014, 157:1262-1278.
    • (2014) Cell , vol.157 , pp. 1262-1278
    • Hsu, P.D.1
  • 71
    • 78649336111 scopus 로고    scopus 로고
    • The nucleolus under stress
    • Boulon S., et al. The nucleolus under stress. Mol. Cell 2010, 40:216-227.
    • (2010) Mol. Cell , vol.40 , pp. 216-227
    • Boulon, S.1
  • 72
    • 35548971658 scopus 로고    scopus 로고
    • MicroRNA-206 colocalizes with ribosome-rich regions in both the nucleolus and cytoplasm of rat myogenic cells
    • Politz J.C.R., et al. MicroRNA-206 colocalizes with ribosome-rich regions in both the nucleolus and cytoplasm of rat myogenic cells. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:18957-18962.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 18957-18962
    • Politz, J.C.R.1
  • 73
    • 40349090024 scopus 로고    scopus 로고
    • MiRNA and piRNA localization in the male mammalian meiotic nucleus
    • Marcon E., et al. miRNA and piRNA localization in the male mammalian meiotic nucleus. Chromosome Res. 2008, 16:243-260.
    • (2008) Chromosome Res. , vol.16 , pp. 243-260
    • Marcon, E.1
  • 74
    • 69049118109 scopus 로고    scopus 로고
    • MicroRNAs with a nucleolar location
    • Politz J.C.R., et al. MicroRNAs with a nucleolar location. RNA 2009, 15:1705-1715.
    • (2009) RNA , vol.15 , pp. 1705-1715
    • Politz, J.C.R.1
  • 75
    • 84881133452 scopus 로고    scopus 로고
    • Dynamic localisation of mature microRNAs in Human nucleoli is influenced by exogenous genetic materials
    • Li Z.F., et al. Dynamic localisation of mature microRNAs in Human nucleoli is influenced by exogenous genetic materials. PLoS ONE 2013, 8:e70869.
    • (2013) PLoS ONE , vol.8 , pp. e70869
    • Li, Z.F.1
  • 76
    • 84901243830 scopus 로고    scopus 로고
    • Small RNA expression and deep sequencing analyses of the nucleolus reveal the presence of nucleolus-associated microRNAs
    • Bai B., et al. Small RNA expression and deep sequencing analyses of the nucleolus reveal the presence of nucleolus-associated microRNAs. FEBS Open Bio 2014, 4:441-449.
    • (2014) FEBS Open Bio , vol.4 , pp. 441-449
    • Bai, B.1
  • 77
    • 76049099302 scopus 로고    scopus 로고
    • CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs
    • Castanotto D., et al. CRM1 mediates nuclear-cytoplasmic shuttling of mature microRNAs. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:21655-21659.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 21655-21659
    • Castanotto, D.1
  • 78
    • 84921931286 scopus 로고    scopus 로고
    • A mRNA and cognate microRNAs localize in the nucleolus
    • Reyes-Gutierrez P., et al. A mRNA and cognate microRNAs localize in the nucleolus. Nucleus 2014, 5:636-642.
    • (2014) Nucleus , vol.5 , pp. 636-642
    • Reyes-Gutierrez, P.1
  • 79
    • 77953871736 scopus 로고    scopus 로고
    • Human mitochondrial mRNAs: like members of all families, similar but different
    • Temperley R.J., et al. Human mitochondrial mRNAs: like members of all families, similar but different. Biochim. Biophys. Acta 2010, 1797:1081-1085.
    • (2010) Biochim. Biophys. Acta , vol.1797 , pp. 1081-1085
    • Temperley, R.J.1
  • 80
    • 79958737573 scopus 로고    scopus 로고
    • Nuclear outsourcing of RNA interference components to human mitochondria
    • Bandiera S., et al. Nuclear outsourcing of RNA interference components to human mitochondria. PLoS ONE 2011, 6:e20746.
    • (2011) PLoS ONE , vol.6 , pp. e20746
    • Bandiera, S.1
  • 81
    • 33748544977 scopus 로고    scopus 로고
    • Identification of small non-coding RNAs from mitochondria and chloroplasts
    • Lung B., et al. Identification of small non-coding RNAs from mitochondria and chloroplasts. Nucleic Acids Res. 2006, 34:3842-3852.
    • (2006) Nucleic Acids Res. , vol.34 , pp. 3842-3852
    • Lung, B.1
  • 82
    • 62549157379 scopus 로고    scopus 로고
    • MicroRNAs identified in highly purified liver-derived mitochondria may play a role in apoptosis
    • Kren B.T., et al. MicroRNAs identified in highly purified liver-derived mitochondria may play a role in apoptosis. RNA Biol. 2009, 6:65-72.
    • (2009) RNA Biol. , vol.6 , pp. 65-72
    • Kren, B.T.1
  • 83
    • 77956343851 scopus 로고    scopus 로고
    • Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions
    • Bian Z., et al. Identification of mouse liver mitochondria-associated miRNAs and their potential biological functions. Cell Res. 2010, 20:1076-1078.
    • (2010) Cell Res. , vol.20 , pp. 1076-1078
    • Bian, Z.1
  • 84
    • 79957575344 scopus 로고    scopus 로고
    • Pre-microRNA and mature microRNA in human mitochondria
    • Barrey E., et al. Pre-microRNA and mature microRNA in human mitochondria. PLoS ONE 2011, 6:e20220.
    • (2011) PLoS ONE , vol.6 , pp. e20220
    • Barrey, E.1
  • 85
    • 84862279805 scopus 로고    scopus 로고
    • Nuclear miRNA regulates the mitochondrial genome in the heart
    • Das S., et al. Nuclear miRNA regulates the mitochondrial genome in the heart. Circ. Res. 2012, 110:1596-1603.
    • (2012) Circ. Res. , vol.110 , pp. 1596-1603
    • Das, S.1
  • 86
    • 84866300155 scopus 로고    scopus 로고
    • Systematic analysis of small RNAs associated with human mitochondria by deep sequencing: detailed analysis of mitochondrial associated miRNA
    • Sripada L., et al. Systematic analysis of small RNAs associated with human mitochondria by deep sequencing: detailed analysis of mitochondrial associated miRNA. PLoS ONE 2012, 7:e44873.
    • (2012) PLoS ONE , vol.7 , pp. e44873
    • Sripada, L.1
  • 87
    • 84905389814 scopus 로고    scopus 로고
    • MicroRNA directly enhances mitochondrial translation during muscle differentiation
    • Zhang X., et al. MicroRNA directly enhances mitochondrial translation during muscle differentiation. Cell 2014, 158:607-619.
    • (2014) Cell , vol.158 , pp. 607-619
    • Zhang, X.1
  • 88
    • 84901020290 scopus 로고    scopus 로고
    • MiR-181c regulates the mitochondrial genome, bioenergetics, and propensity for heart failure in vivo
    • Das S., et al. miR-181c regulates the mitochondrial genome, bioenergetics, and propensity for heart failure in vivo. PLoS ONE 2014, 9:e96820.
    • (2014) PLoS ONE , vol.9 , pp. e96820
    • Das, S.1
  • 89
    • 84860270506 scopus 로고    scopus 로고
    • A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells
    • Roux K.J., et al. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. J. Cell Biol. 2012, 196:801-810.
    • (2012) J. Cell Biol. , vol.196 , pp. 801-810
    • Roux, K.J.1
  • 90
    • 84874956967 scopus 로고    scopus 로고
    • Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging
    • Rhee H-W., et al. Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging. Science 2013, 339:1328-1331.
    • (2013) Science , vol.339 , pp. 1328-1331
    • Rhee, H.-W.1
  • 91
    • 84909606778 scopus 로고    scopus 로고
    • Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling
    • Williams C.C., et al. Targeting and plasticity of mitochondrial proteins revealed by proximity-specific ribosome profiling. Science 2014, 346:748-751.
    • (2014) Science , vol.346 , pp. 748-751
    • Williams, C.C.1
  • 92
    • 84921959250 scopus 로고    scopus 로고
    • Regulation of microRNA-mediated gene silencing by microRNA precursors
    • Roy-Chaudhuri B., et al. Regulation of microRNA-mediated gene silencing by microRNA precursors. Nat. Struct. Mol. Biol. 2014, 21:825-832.
    • (2014) Nat. Struct. Mol. Biol. , vol.21 , pp. 825-832
    • Roy-Chaudhuri, B.1
  • 93
    • 0034711308 scopus 로고    scopus 로고
    • Human RNase III is a 160-kDa protein involved in preribosomal RNA processing
    • Wu H., et al. Human RNase III is a 160-kDa protein involved in preribosomal RNA processing. J. Biol. Chem. 2000, 275:36957-36965.
    • (2000) J. Biol. Chem. , vol.275 , pp. 36957-36965
    • Wu, H.1
  • 94
    • 36048958883 scopus 로고    scopus 로고
    • Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins
    • Shiohama A., et al. Nucleolar localization of DGCR8 and identification of eleven DGCR8-associated proteins. Exp. Cell Res. 2007, 313:4196-4207.
    • (2007) Exp. Cell Res. , vol.313 , pp. 4196-4207
    • Shiohama, A.1
  • 95
    • 84922418997 scopus 로고    scopus 로고
    • Endogenous miRNA and target concentrations determine susceptibility to potential ceRNA competition
    • Bosson A.D., et al. Endogenous miRNA and target concentrations determine susceptibility to potential ceRNA competition. Mol. Cell 2014, 56:347-359.
    • (2014) Mol. Cell , vol.56 , pp. 347-359
    • Bosson, A.D.1
  • 96
    • 84901838697 scopus 로고    scopus 로고
    • Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance
    • Denzler R., et al. Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance. Mol. Cell 2014, 54:766-776.
    • (2014) Mol. Cell , vol.54 , pp. 766-776
    • Denzler, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.