Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective

Alzheimer's and Dementia

Volumn 11, Issue 6, 2015, Pages 718-726

  Baumgart, Matthew ^a   Snyder, Heather M ^a   Carrillo, Maria C ^a   Fazio, Sam ^a   Kim, Hye ^a   Johns, Harry ^a  

^a ALZHEIMER'S ASSOCIATION   (United States)

Author keywords

Alzheimer's Association; Alzheimer's disease; Cardiovascular disease risk factors; Cognitive decline; Cognitive training; Dementia; Diabetes; Diet; Hypertension; Lifelong learning; Lifestyle risk factors; Modifiable risk factors; Obesity; Physical activity; Risk factors; Smoking; World Dementia Council

Indexed keywords

CHOLESTEROL;

ALCOHOL CONSUMPTION; ALZHEIMER DISEASE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COGNITIVE DEFECT; DEMENTIA; DEPRESSION; DIABETES MELLITUS; DIETARY INTAKE; EDUCATIONAL STATUS; EVIDENCE BASED MEDICINE; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; INSOMNIA; LIFELONG LEARNING; MEDITERRANEAN DIET; META ANALYSIS (TOPIC); MILD COGNITIVE IMPAIRMENT; OBESITY; PHYSICAL ACTIVITY; POPULATION; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION; SLEEP DISORDER; SLEEP DISORDERED BREATHING; SMOKING; SOCIAL INTERACTION; SYSTEMATIC REVIEW (TOPIC); TRAINING; TRAUMATIC BRAIN INJURY; UNDERWEIGHT; CARDIOVASCULAR DISEASES; COGNITION DISORDERS; EXERCISE; LIFESTYLE; ORGANIZATION;

CARDIOVASCULAR DISEASES; COGNITION DISORDERS; DEMENTIA; EXERCISE; HUMANS; LIFE STYLE; RISK FACTORS; SOCIETIES;

EID: 84931572221     PISSN: 15525260     EISSN: 15525279     Source Type: Journal    
DOI: 10.1016/j.jalz.2015.05.016     Document Type: Article

References (151)

1. M. Prince, M. Guerchet, and M. Prina The Epidemiology and Impact of Dementia: Current State and Future Trends 2015 World Health Organization Geneva
2. M. Prince, M. Guerchet, M. Prina Alzheimer's Disease International Policy Brief for Heads of Government: The Global Impact of Dementia 2013-2050 2013 Alzheimer's Disease International London
3. G8 Dementia Summit Communique. Available at: www.gov.uk/government/uploads/system/uploads/attachment-data/file/265868/2901669-G8-DementiaSummitCommunique-acc.pdf. Accessed on April 7, 2015.
4. UK Health Forum Promoting brain health: Developing a prevention agenda linking dementia and other non-communicable diseases 2014 UK Health Forum London
5. M. Woodward Dementia Risk Reduction: The Evidence 2007 Alzheimer's Australia Scullin, Australia Paper 13
6. M. Farrow, and E. O'Connor Targeting Brain, Body and Heart for Cognitive Health and Dementia Prevention: Current Evidence and Future Directions 2012 Alzheimer's Australia Canberra, Australia Paper 29
7. M. Prince, E. Albanese, M. Guerchet, and M. Prina Dementia and Risk Reduction: An Analysis of Protective and Modifiable Factors 2014 Alzheimer's Disease International London World Alzheimer's Report 2014
8. D.E. Barnes, and K. Yaffe The projected effect of risk factor reduction on Alzheimer's disease prevalence Lancet Neurol 10 2011 819 828
9. Alzheimer's Association 2014 Alzheimer's Disease Facts and Figures Alzheimers Dement 10 2014 e47 e92
10. L.E. Hebert, J.L. Bienias, N.T. Aggarwal, R.S. Wilson, D.A. Bennett, R.C. Shah et al. Change in risk of Alzheimer disease over time Neurology 75 2010 786 791
11. L.E. Hebert, J. Weuve, P.A. Scherr, and D.A. Evans Alzheimer disease in the United States (2010-2050) estimated using the 2010 census Neurology 80 2013 1778 1783
12. R.C. Green, L.A. Cupples, R. Go, K.S. Benke, T. Edeki, P.A. Griffith, et al. Risk of dementia among white and African American relatives of patients with Alzheimer disease JAMA 287 2002 329 336
13. L. Fratiglioni, A. Ahlbom, M. Viitanen, and B. Winblad Risk factors for late-onset Alzheimer's disease: A population-based, case-control study Ann Neurol 33 1993 258 266
14. R. Mayeux, M. Sano, J. Chen, T. Tatemichi, and Y. Stern Risk of dementia in first-degree relatives of patients with Alzheimer's disease and related disorders Arch Neurol 48 1991 269 273
15. N.T. Lautenschlager, L.A. Cupples, V.S. Rao, S.A. Auerbach, R. Becker, J. Burke, et al. Risk of dementia among relatives of Alzheimer's disease patients in the MIRAGE Study: What is in store for the oldest old? Neurology 46 1996 641 650
16. A.M. Saunders, W.J. Strittmatter, D. Schmechel, P.H. George-Hyslop, M.A. Pericak-Vance, S.H. Joo, et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease Neurology 43 1993 1467 1472
17. L.A. Farrer, L.A. Cupples, J.L. Haines, B. Hyman, W.A. Kukull, R. Mayeux, et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: A meta-analysis JAMA 278 1997 1349 1356
18. National Institutes of Health NIH Consensus Development Conference Statement on Preventing Alzheimer's Disease and Cognitive Decline 2010 National Institutes of Health Bethesda, MD
19. F.P. Lu, K.P. Lin, and H.K. Kuo Diabetes and the risk of multi-system aging phenotypes: A systematic review and meta-analysis PLoS One 4 2009 e4144
20. L.A. Profenno, A.P. Porsteinsson, and S.V. Faraone Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders Biol Psychiatry 67 2010 505 512
21. G.J. Biessels, S. Staekenborg, E. Brunner, C. Brayne, and P. Scheltens Risk of dementia in diabetes mellitus: A systematic review Lancet Neurol 5 2006 64 74
22. R.P. Kloppenborg, E. van den Berg, L.J. Kappelle, and G.J. Biessels Diabetes and other vascular risk factors for dementia: Which factor matters most? A systematic review Eur J Pharmacol 585 2008 97 108
23. G. Cheng, C. Huang, H. Deng, and H. Wang Diabetes as a risk factor for dementia and mild cognitive impairment: A meta-analysis of longitudinal studies Intern Med J 42 2012 484 491
24. K. Gudala, D. Bansal, F. Schifano, and A. Bhansali Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies J Diabetes Investig 4 2013 640 650
25. R.O. Roberts, D.S. Knopman, R.H. Cha, M.M. Mielke, V.S. Pankratz, B.F. Boeve, et al. Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation J Nucl Med 55 2014 759 764
26. B.L. Plassman, J.W. Williams Jr., J.R. Burke, T. Holsinger, and S. Benjamin Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life Ann Intern Med 153 2010 182 193
27. C. Cooper, A. Sommerlad, C.G. Lyketsos, and G. Livingston Modifiable predictors of dementia in mild cognitive impairment: a systematic review and meta-analysis Am J Psychiatry 172 2015 323 334
28. G. Mushtag, J.A. Khan, and M.A. Kamal Biological mechanisms linking Alzheimer's disease and Type-2 Diabetes mellitus CNS Neurol Disord Drug Targets 13 2014 1192 1201
29. F.G. De Felice, and S.T. Ferreira Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease Diabetes 63 2014 2262 2272
30. Y. Yang, and W. Song Molecular links between Alzheimer's disease and diabetes mellitus Neuroscience 250 2013 140 150
31. K.S. Sellbom, and J. Gunstad Cognitive function and decline in obesity J Alzheimers Dis 30 Suppl 2 2012 S89 S95
32. M.A. Beydoun, H.A. Beydoun, and Y. Wang Obesity and central obesity as risk factors for incident dementia and its subtypes: A systematic review and meta-analysis Obes Rev 9 2008 204 218
33. M. Loef, and H. Walach Midlife obesity and dementia: Meta-analysis and adjusted forecast of dementia prevalence in the United States and China Obesity (Silver Spring) 21 2013 E51 E55
34. K.J. Anstey, N. Cherbuin, M. Budge, and J. Young Body mass index in midlife and late-life as a risk factor for dementia: A meta-analysis of prospective studies Obes Rev 12 2011 e426 e437
35. Y. Lee, J.H. Back, J. Kim, S.H. Kim, D.L. Na, H.K. Cheong, et al. Systematic review of health behavioral risks and cognitive health in older adults Int Psychogeriatr 22 2010 174 187
36. D.R. Gustafson, K. Backman, E. Joas, M. Waern, S. Ostling, X. Guo, et al. 37 years of body mass index and dementia: Observations from the prospective population study of women in Gothenburg, Sweden J Alzheimers Dis 28 2012 163 171
37. J.A. Luchsinger, B. Patel, M.X. Tang, N. Schupf, and R. Mayeux Measures of adiposity and dementia risk in elderly persons Arch Neurol 64 2007 392 398
38. A.L. Fitzpatrick, L.H. Kuller, O.L. Lopez, P. Diehr, E.S. O'Meara, W.T. Longstreth Jr. , et al. Midlife and late-life obesity and the risk of dementia: Cardiovascular health study Arch Neurol 66 2009 336 342
39. D.E. Barnes, K.E. Covinsky, R.A. Whitmar, L.H. Kuller, O.L. Lopez, and K. Yaffe Predicting risk of dementia in older adults: the late-life dementia risk index Neurology 73 2009 173 179
40. A.K. Dahl, M. Lopponen, R. Isoaho, S. Berg, and S.L. Kivela Overweight and obesity in old age are not associated with greater dementia risk J Am Geriatr Soc 56 2008 2261 2266
41. D.R. Gustafson, and J.A. Luchsinger High adiposity: Risk factor for dementia and Alzheimer's disease? Alzheimers Res Ther 5 2013 57
42. N. Qizilbash, J. Gregson, M.E. Johnson, N. Pearce, I. Douglas, K. Wing, et al. BMI and risk of dementia in two million people over two decades: a retrospective cohort study Lancet Diabetes Endocrinol 2015 http://dx.doi.org/10.1016/52213-8587(15)00033-9 Epub ahead of print
43. M.C. Power, J. Weuve, J.J. Gagne, M.B. McQueen, A. Viswanathan, and D. Blacker The association between blood pressure and incident Alzheimer disease: A systematic review and meta-analysis Epidemiology 22 2011 646 659
44. B. McGuinness, S. Todd, P. Passmore, and R. Bullock Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia Cochrane Database Syst Rev 4 2009 CD004034
45. K. Shah, S.U. Qureshi, M. Johnson, N. Parikh, P.E. Schulz, and M.E. Kunik Does use of antihypertensive drugs affect the incidence or progression of dementia? A systematic review Am J Geriatr Pharmacother 7 2009 250 261
46. J.W. Guan, C.Q. Huang, Y.H. Li, C.M. Wan, C. You, Z.R. Wang, et al. No association between hypertension and risk for Alzheimer's disease: A meta-analysis of longitudinal studies J Alzheimers Dis 27 2011 799 807
47. S.I. Sharp, D. Aarsland, S. Day, H. Sonnesyn, C. Ballard Alzheimer's Society Vascular Dementia Systematic Review Group Hypertension is a potential risk factor for vascular dementia: Systematic review Int J Geriatr Psychiatry 26 2011 661 669
48. L. Rouch, P. Cestac, O. Hanon, C. Cool, C. Helmer, B. Bouhanick, et al. Antihypertensive drugs, prevention of cognitive decline and dementia: a systematic review of observational studies, randomized controlled trials and meta-analyses, with discussion of potential mechanisms CNS Drugs 29 2015 113 130
49. H. Chang-Quan, W. Hui, W. Chao-Min, W. Zheng-Rong, G. Jun-Wen, L. Yong-Hong, et al. The association of antihypertensive medication use with risk of cognitive decline and dementia: a meta-analysis of longitudinal studies Int J Clin Pract 65 2011 1295 1305
50. S.P. Kennelly, B.A. Lawlor, and R.A. Kenny Blood pressure and the risk for dementia: A double edged sword Ageing Res Rev 8 2009 61 70
51. M. Corrada, K.M. Hayden, S.S. Bullain, A. Paganini-Hill, J. DeMoss, C. Aguirre, et al. Age of onset of hypertension and risk of dementia in the oldest-old: The 90+ study Alzheimers Dement 10 4 Supplement 2014 P501
52. K.J. Anstey, D.M. Lipnicki, and L.F. Low Cholesterol as a risk factor for dementia and cognitive decline: A systematic review of prospective studies with meta-analysis Am J Geriatr Psychiatry 16 2008 343 354
53. M. Kivipelto, and A. Solomon Cholesterol as a risk factor for Alzheimer's disease - epidemiological evidence Acta Neurol Scand Suppl 185 2006 50 57
54. W. Muangpaisan, C. Brayne Alzheimer's Society Vascular Dementia Systematic Review Group Systematic review of statins for the prevention of vascular dementia or dementia Geriatr Gerontol Int 10 2010 199 208
55. A. Beri, N. Sural, and S.B. Mahajan Non-atheroprotective effects of statins: A systematic review Am J Cardiovasc Drugs 9 2009 361 370
56. B. McGuinness, D. Craig, R. Bullock, and P. Passmore Statins for the prevention of dementia Cochrane Database Syst Rev 2 2009 CD003160
57. K. Richardson, M. Schoen, B. French, C.A. Umscheid, M.D. Mitchell, S.E. Arnold, et al. Statins and cognitive function: a systematic review Ann Intern Med 159 2013 688 697
58. S.A. Ligthart, E.P. Moll van Charante, W.A. Van Gool, and E. Richard Treatment of cardiovascular risk factors to prevent cognitive decline and dementia: a systematic review Vasc Health Risk Manag 6 2010 775 785
59. K.J. Anstey, C. von Sanden, A. Salim, and R. O'Kearney Smoking as a risk factor for dementia and cognitive decline: A meta-analysis of prospective studies Am J Epidemiol 166 2007 367 378
60. J.K. Cataldo, J.J. Prochaska, and S.A. Glantz Cigarette smoking is a risk factor for Alzheimer's disease: An analysis controlling for tobacco industry affiliation J Alzheimers Dis 19 2010 465 480
61. R. Peters, R. Poulter, J. Warner, N. Beckett, L. Burch, and C. Bulpitt Smoking, dementia and cognitive decline in the elderly: A systematic review BMC Geriatr 8 2008 36
62. M.A. Beydoun, H.A. Beydoun, A.A. Gamaldo, A. Teel, A.B. Zonderman, and Y. Wang Epidemiologic studies of modifiable factors associated with cognition and dementia: Systematic review and meta-analysis BMC Public Health 14 2014 643
63. J. McKenzie, L. Bhatti, and E. Tursan d'Espaignet WHO Tobacco Knowledge Summaries: Tobacco and Dementia 2014 World Health Organization Geneva
64. G. Zhong, Y. Wang, Y. Zhang, J.J. Guo, and Y. Zhao Smoking is associated with an increased risk of dementia: A meta-analysis of prospective cohort studies with investigation of potential effect modifiers PLoS One 10 2015 e0118333
65. S. Sabia, A. Elbaz, A. Dugravot, J. Head, M. Shipley, G. Hagger-Johnson, et al. Impact of smoking on cognitive decline in early old age: The Whitehall II cohort study Arch Gen Psychiatry 69 2012 627 635
66. M. Rusanen, M. Kivipelto, C.P. Quesenberry Jr., J. Zhou, and R.A. Whitmer Heavy smoking in midlife and long-term risk of Alzheimer disease and vascular dementia Arch Intern Med 171 2011 333 339
67. Y. Rolland, G. Abellan van Kan, and B. Vellas Physical activity and Alzheimer's disease: From prevention to therapeutic perspectives J Am Med Dir Assoc 9 2008 390 405
68. M. Hamer, and Y. Chida Physical activity and risk of neurodegenerative disease: A systematic review of prospective evidence Psychol Med 39 2009 3 11
69. D.H. Paterson, and D.E. Warburton Physical activity and functional limitations in older adults: A systematic review related to Canada's Physical Activity Guidelines Int J Behav Nutr Phys Act 7 2010 38
70. N.T. Lautenschlager, K.L. Cox, L. Flicker, J.K. Foster, F.M. van Bockxmeer, J. Xiao, et al. Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: A randomized trial JAMA 300 2008 1027 1037
71. F. Sofi, D. Valecchi, D. Bacci, R. Abbate, G.F. Gensini, A. Casini, et al. Physical activity and risk of cognitive decline: A meta-analysis of prospective studies J Intern Med 269 2011 107 117
72. S.J. Blondell, R. Hammersley-Mather, and J.L. Veerman Does physical activity prevent cognitive decline and dementia? A systematic review and meta-analysis of longitudinal studies BMC Public Health 14 2014 510
73. J.E. Ahlskog, Y.E. Geda, N.R. Graff-Radford, and R.C. Petersen Physical exercise as a preventive or disease-modifying treatment of dementia and brain aging Mayo Clin Proc 86 2011 876 884
74. S. Colcombe, and A.F. Kramer Fitness effects on the cognitive function of older adults: a meta-analytic study Psychol Sci 14 2003 125 130
75. P.J. Smith, J.A. Blumenthal, B.M. Hoffman, H. Cooper, T.A. Strauman, K. Welsh-Bohmer, et al. Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials Psychosom Med 72 2010 239 252
76. L. Bherer, K.I. Erickson, and T. Liu-Ambrose A review of the effects of physical activity and exercise on cognitive and brain functions in older adults J Aging Res 2013 2013 657508
77. M. Angevaren, G. Aufdemkampe, H.J. Verhaar, A. Aleman, and L. Vanhees Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment Cochrane Database Syst Rev 3 2008 CD005381
78. D.E. Barnes, W. Santos-Modesitt, G. Poelke, A.F. Kramer, C. Castro, L.E. Middleton, et al. The Mental Activity and eXercise (MAX) trial: A randomized controlled trial to enhance cognitive function in older adults JAMA Intern Med 173 2013 797 804
79. I. Lourida, M. Soni, J. Thompson-Coon, N. Purandare, I.A. Lang, O.C. Ukoumunne, et al. Mediterranean diet, cognitive function, and dementia: A systematic review Epidemiology 24 2013 479 489
80. T. Psaltopoulou, T.N. Sergentanis, D.B. Panaqiotakos, I.N. Sergentanis, R. Kosti, and N. Scarmeas Mediterranean diet, stroke, cognitive impairment, and depression: A meta-analysis Ann Neurol 74 2013 580 591
81. M.C. Morris, C.C. Tangney, Y. Wang, F.M. Sacks, D.A. Bennett, and N.T. Aggarwal MIND diet associated with reduced incidence of Alzheimer's disease Alzheimers Dement 2015 http://dx.doi.org/10.1016/j.jalz.2014.11.009 Epub ahead of print
82. K.J. Anstey, H.A. Mack, and N. Cherbuin Alcohol consumption as a risk factor for dementia and cognitive decline: Meta-analysis of prospective studies Am J Geriatr Psychiatry 17 2009 542 555
83. R. Peters, J. Peters, J. Warner, N. Beckett, and C. Bulpitt Alcohol, dementia and cognitive decline in the elderly: A systematic review Age Ageing 37 2008 505 512
84. E.J. Neafsey, and M.A. Collins Moderate alcohol consumption and cognitive risk Neuropsychiatr Dis Treat 7 2011 465 484
85. K.J. Mukamal, M.A. Mittleman, W.T. Longstreth Jr., A.B. Newman, L.P. Fried, and D.S. Siscovick Self-reported alcohol consumption and falls in older adults: Cross-sectional and longitudinal analyses of the Cardiovascular Health Study J Am Geriatr Soc 52 2004 1174 1179
86. M. Stahre, J. Roeber, D. Kanny, R.D. Brewer, and X. Zhang Contribution of excessive alcohol consumption to deaths and years of potential life lost in the United States Prev Chronic Dis 11 2014 E109
87. U.S. Department of Agriculture and U.S. Department of Health and Human Services Dietary Guidelines for Americans, 2010 7th ed. 2010 U.S. Government Printing Office Washington, DC
88. M. Martin, L. Clare, A.M. Altgassen, M.H. Cameron, and F. Zehnder Cognition-based interventions for healthy older people and people with mild cognitive impairment Cochrane Database Syst Rev 1 2011 CD006220
89. C. Stern, and Z. Munn Cognitive leisure activities and their role in preventing dementia: A systematic review Int J Evid Based Healthc 8 2010 2 17
90. M. Valenzuela, and P. Sachdev Can cognitive exercise prevent the onset of dementia? Systematic review of randomized clinical trials with longitudinal follow-up Am J Geriatr Psychiatry 17 2009 179 187
91. L. Fratiglioni, S. Paillard-Borg, and B. Winblad An active and socially integrated lifestyle in late life might protect against dementia Lancet Neurol 3 2004 343 353
92. B.D. James, R.S. Wilson, L.L. Barnes, and D.A. Bennett Late-life social activity and cognitive decline in old age J Int Neuropsychol Soc 17 2011 998 1005
93. T. Noice, H. Noice, and A.F. Kramer Participatory arts for older adults: a review of benefits and challenges Gerontologist 54 2014 741 753
94. K.A. Ertel, M.M. Glymour, and L.F. Berkman Effects of social integration on preserving memory function in a nationally representative US elderly population Am J Public Health 98 2008 1215 1220
95. E.A. Stine-Morrow, J.M. Parisis, D.G. Morrow, and D.C. Park The effects of an engaged lifestyle on cognitive vitality: A field experiment Psychol Aging 23 2008 778 786
96. A. Karp, S. Paillard-Borg, H.X. Wang, M. Silverstein, B. Winblad, and L. Fratiglioni Mental, physical and social components in leisure activities equally contribute to decrease dementia risk Dement Geriatr Cogn Disord 21 2006 65 73
97. L.L. Barnes, C.F. Mendes de Leon, R.S. Wilson, J.L. Bienias, and D.A. Evans Social resources and cognitive decline in a population of older African Americans and whites Neurology 63 2004 2322 2326
98. R.E. Holtzman, G.W. Rebok, J.S. Saczynski, A.C. Kouzis, K. Wilcox Doyle, and W.W. Eaton Social network characteristics and cognition in middle-aged and older adults J Gerontol B Psychol Sci Soc Sci 59 2004 P278 P284
99. N. Scarmeas, G. Levy, M.X. Tang, J. Manly, and Y. Stern Influence of leisure activity on the incidence of Alzheimer's disease Neurology 57 2001 2236 2242
100. V.C. Crooks, J. Lubben, D.B. Petitti, D. Little, and V. Chiu Social network, cognitive function, and dementia incidence among elderly women Am J Public Health 98 2008 1221 1227
101. T.E. Seeman, D.M. Miller-Martinez, S. Stein Merkin, M.E. Lachman, P.A. Tun, and A.S. Karlamangla Histories of social engagement and adult cognition: Midlife in the U.S. study J Gerontol B Psychol Sci Soc Sci 66 Supplement 1 2011 i141 i152
102. C.L. Brown, L.E. Gibbons, R.F. Kennison, A. Robitaille, M. Lindwall, M.B. Mitchell, et al. Social activity and cognitive functioning over time: a coordinated analysis of four longitudinal studies J Aging Res 2012 2012 287438
103. X. Meng, and C. D'Arcy Education and dementia in the context of the cognitive reserve hypothesis: a systematic review with meta-analyses and qualitative analyses PLoS One 7 2012 e38268
104. A.L. Jefferson, L.E. Gibbons, D.M. Rentz, J.O. Carvalho, J. Manly, D.A. Bennett, et al. A life course model of cognitive activities, socioeconomic status, education, reading ability, and cognition J Am Geriatr Soc 59 2011 1403 1411
105. A.L. Fitzpatrick, L.H. Kuller, D.G. Ives, O.L. Lopez, W. Jagust, J.C. Breitner, et al. Incidence and prevalence of dementia in the Cardiovascular Health Study J Am Geriatr Soc 52 2004 195 204
106. W.A. Kukull, R. Higdon, J.D. Bowen, W.C. McCormick, L. Teri, G.D. Schellenberg, et al. Dementia and Alzheimer disease incidence: A prospective cohort study Arch Neurol 59 2002 1737 1746
107. D.A. Evans, D.A. Bennett, R.S. Wilson, J.L. Bienias, M.C. Morris, P.A. Scherr, et al. Incidence of Alzheimer disease in a biracial urban community: Relation to apolipoprotein E allele status Arch Neurol 60 2003 185 189
108. Y. Stern, B. Gurland, T.K. Tatemichi, M.X. Tang, D. Wilder, and R. Mayeux Influence of education and occupation on the incidence of Alzheimer's disease JAMA 271 1994 1004 1010
109. D.A. Evans, L.E. Hebert, L.A. Beckett, P.A. Scherr, M.S. Albert, M.J. Chown, et al. Education and other measures of socioeconomic status and risk of incident Alzheimer disease in a defined population of older persons Arch Neurol 54 1997 1399 1405
110. S.B. Sando, S. Melquist, A. Cannon, M. Hutton, O. Sletvoid, I. Saltvedt, et al. Risk-reducing effect of education in Alzheimer's disease Int J Geriatr Psychiatry 23 2008 1156 1162
111. F. Caamano-Isorna, M. Corral, A. Montes-Martinez, and B. Takkouche Education and dementia: a meta-analytic study Neuroepidemiology 26 2006 226 232
112. T.C. Lye, and E.A. Shores Traumatic brain injury as a risk factor for Alzheimer's disease: A review Neuropsychol Rev 10 2000 115 129
113. B.L. Plassman, R.J. Havlik, D.C. Steffens, M.J. Helms, T.N. Newman, D. Drosdick, et al. Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias Neurology 55 2000 1158 1166
114. D.E. Barnes, A. Kaup, K.A. Kirby, A.L. Byers, R. Diaz-Arrastia, and K. Yaffe Traumatic brain injury and risk of dementia in older veterans Neurology 83 2014 312 319
115. R. Gardner, and K. Yaffe Traumatic brain injury may increase risk of young onset dementia Ann Neurol 75 2014 339 341
116. S. Fleminger, D.L. Oliver, S. Lovestone, S. Rabe-Hesketh, and A. Giora Head injury as a risk factor for Alzheimer's dis-ease: the evidence 10 years on; a partial replication J Neurol Neurosurg Psychiatry 74 2003 857 862
117. S. Shively, A.I. Scher, D.P. Perl, and R. Diaz-Arrastia Dementia resulting from traumatic brain injury: what is the pathology? Arch Neurol 69 2012 1245 1251
118. D.H. Smith, V.E. Johnson, and W. Stewart Chronic neuropathologies of single and repetitive TBI: Substrates of dementia? Nat Rev Neurol 9 2013 211 221
119. K.M. Guskiewicz Association between recurrent concussion and late-life cognitive impairment in retired professional football players Neurosurgery 57 2005 719 726
120. Institute for Social Research National Football League Player Care Foundation Study of NFL Retired Players 2009 University of Michigan Ann Arbor
121. E.J. Lehman, M.J. Hein, S.L. Baron, and C.M. Gersix Neurodegenerative causes of death among retired National Football League players Neurology 79 2012 1970 1974
122. Z. Groswasser, I.I. Reider-Groswasser, K. Schwab, A.K. Ommaya, A. Pridgen, H.R. Brown, et al. Quantitative imaging in late TBI. Part II: Cognition and work after closed and penetrating head injury: A report of the Vietnam Head Injury Study Brain Inj 16 2002 681 690
123. A.M. Salazar, D.L. Warden, K. Schwab, J. Spector, S. Braverman, J. Walter, et al. Cognitive rehabilitation for traumatic brain injury: A randomized trial. Defense and Veterans Head Injury Program (DVHIP) Study Group JAMA 283 2000 3075 3081
124. G.W. Roberts, D. Allsop, and C. Bruton The occult aftermath of boxing J Neurol Neurosurg Psychiatry 53 1990 373 378
125. R.L. Ownby, E. Crocco, A. Acevedo, V. John, and D. Loewenstein Depression and risk for Alzheimer disease: Systematic review, meta-analysis, and metaregression analysis Arch Gen Psychiatry 63 2006 530 538
126. B.S. Diniz, M.A. Butters, S.M. Albert, M.A. Dew, and C.F. Reynolds 3rd Late-life depression and risk of vascular dementia and Alzheimer's disease: Systematic review and meta-analysis of community-based cohort studies Br J Psychiatry 202 2013 329 335
127. D.E. Barnes, K. Yaffe, A.L. Byers, M. McCormick, C. Schaefer, and R.A. Whitmer Midlife vs late-life depressive symptoms and risk of dementia: Differential effects for Alzheimer disease and vascular dementia Arch Gen Psychiatry 69 2012 493 498
128. R.S. Wilson, A.W. Capuano, P.A. Boyle, G.M. Hoganson, L.P. Hizel, R.C. Shah, et al. Clinical-pathologic study of depressive symptoms and cognitive decline in old age Neurology 83 2014 702 709
129. K. Yaffe, A.M. Laffan, S.L. Harrison, S. Redline, A.P. Spira, K.E. Ensrud, et al. Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women JAMA 306 2011 613 619
130. Y.E. Ju, B.P. Lucey, and D.M. Holtzman Sleep and Alzheimer disease pathology - a bidirectional relationship Nat Rev Neurol 10 2014 115 119
131. W.P. Chang, M.E. Liu, W.C. Chang, A.C. Yang, Y.C. Ku, J.T. Pai, et al. Sleep apnea and the risk of dementia: A population-based 5-year follow-up study in Taiwan PLoS One 8 2013 e78655
132. P.L. Chen, W.J. Lee, W.Z. Sun, Y.J. Oyang, and J.L. Fuh Risk of dementia in patients with insomnia and long-term use of hypnotics: A population-based retrospective cohort study PLoS One 7 2012 e49113
133. R. Sterniczuk, O. Theou, B. Rusak, and K. Rockwood Sleep disturbance is associated with incident dementia and mortality Curr Alzheimer Res 10 2013 767 775
134. R.S. Osorio, T. Gumb, E. Pirraglia, A.W. Varga, S.E. Lu, J. Lim, et al. Sleep-disordered breathing advances cognitive decline in the elderly Neurology 84 2015 1964 1971
135. K. Yaffe, C.M. Falvey, and T. Hoang Connections between sleep and cognition in older adults Lancet Neurol 13 2014 1017 1028
136. A.S. Lim, M. Kowgier, L. Yu, A.S. Buchman, and D.A. Bennett Sleep fragmentation and the risk of incident Alzheimer's disease and cognitive decline in older persons Sleep 36 2013 1027 1032
137. O. Potvin, D. Lorrain, H. Forget, M. Dube, S. Grenier, M. Preville, et al. Sleep quality and 1-year incident cognitive impairment in community-dwelling older adults Sleep 35 2012 491 499
138. C.L. Satizabal, A. Beiser, G. Chene, V.A. Chouraki, J.J. Himali, S.R. Preis, et al. Temporal trends in dementia incidence in the Framingham Study Alzheimers Dement 10 4 Supplement 2014 P296
139. E.M. Schrijvers, B.F. Verhaaren, P.J. Koudstaal, A. Hofman, M.A. Ikram, and M.M. Breteler Is dementia incidence declining?: Trends in dementia incidence since 1990 in the Rotterdam Study Neurology 78 2012 1456 1463
140. C. Qiu, E. von Strauss, L. Backman, B. Winblad, and L. Fratiglioni Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden Neurology 80 2013 1888 1894
141. H.H. Dodge, J. Zhu, C.W. Lee, C.C. Chang, and M. Ganguli Cohort effects in age-associated cognitive trajectories J Gerontol A Biol Sci Med Sci 69 2014 687 694
142. G. Doblhammer, A. Fink, and T. Fritze Short-term trends in dementia prevalence in Germany between the years 2007 and 2009 Alzheimers Dement 11 2015 291 299
143. P. Elwood, J. Galante, J. Pickering, S. Palmer, A. Bayer, Y. Ben-Shlomo, et al. Healthy lifestyles reduce the incidence of chronic diseases and dementia: evidence from the Caerphilly cohort study PLoS One 8 2013 e81877
144. E.B. Larson, K. Yaffe, and K.M. Langa New insights into the dementia epidemic N Engl J Med 369 2013 2275 2277
145. L.E. Middleton, and K. Yaffe Targets for the prevention of dementia J Alzheimers Dis 20 2010 915 924
146. R.O. Roberts, R.H. Cha, M.M. Mielke, Y.E. Geda, B.F. Boeve, M.M. Machulda, et al. Risk and protective factors for cognitive impairment in persons aged 85 years and older Neurology 84 2015 1854 1861
147. F. Mangialasche, M. Kivipelto, A. Solomon, and L. Fratiglioni Dementia prevention: current epidemiological evidence and future perspective Alzheimers Res Ther 4 2012 6
148. J.J. Monsuez, A. Gesquiere-Dando, and S. Rivera Cardiovascular prevention of cognitive decline Cardiol Res Pract 2011 2011 250970
149. T. Ngandu, J. Lehtisalo, A. Solomon, E. Levalahti, R.A. Ahtiluoto, L. Backman, et al. A 2-year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial Lancet 2015 http://dx.doi.org/10.1016/S0140-6736(15)60461-5 Epub ahead of print
150. Institute of Medicine Cognitive Aging: Progress in Understanding and Opportunity for Action 2015 The National Academies Press Washington, DC
151. World Dementia Council. WDC Dementia Risk Reduction Statement. Available at: https://s3-eu-west-1.amazonaws.com/media.dh.gov.uk/network/353/files/2015/01/WDC-supportive-statement-on-risk-reduction-FINAL-FOR-PUBLICATION-BRANDED-150128-LM.pdf. Accessed on April 7, 2015.