Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

PLoS Medicine

Volumn 12, Issue 6, 2015, Pages

  Østergaard, Søren D ^a,b   Mukherjee, Shubhabrata ^c   Sharp, Stephen J ^d   Proitsi, Petroula ^e   Lotta, Luca A ^d   Day, Felix ^d   Perry, John R B ^d   Boehme, Kevin L ^f   Walter, Stefan ^g   Kauwe, John S ^f   Gibbons, Laura E ^c   Larson, Eric B ^c,h   Powell, John F ^e   Langenberg, Claudia ^d   Crane, Paul K ^c   Wareham, Nicholas J ^d   Scott, Robert A ^d   Albert, Marilyn S ⁱ   Albin, Roger L ^j,k,l   Apostolova, Liana G ^m   Arnold, Steven E ⁿ   Asthana, Sanjay ^o,p   Atwood, Craig S ^o,p   Baldwin, Clinton T ^q   Barber, Robert C ^r   Barmada, Michael M ^s   Barnes, Lisa L ^t   Beach, Thomas G ^u   Becker, James T ^v   Beecham, Gary W ^w   Beekly, Duane ^x   Bigio, Eileen H ^y   Bird, Thomas D ^x,z   Blacker, Deborah ^aa,ab   Boeve, Bradley F ^ac   Bowen, James D ^ad   Boxer, Adam ^ae   Burke, James R ^af   Buxbaum, Joseph D ^ag   Cairns, Nigel J ^ah   Cantwell, Laura B ⁿ   Cao, Chuanhai ^ai   Carlson, Chris S ^aj   Carlsson, Cynthia M ^p   Carney, Regina M ^w   Carrasquillo, Minerva M ^ak,av   Carroll, Steven L ^al   Chui, Helena C ^am   Clark, David G ^an   Corneveaux, Jason ^ao   Cribbs, David H ^ap   Crocco, Elizabeth A ^w   Cruchaga, Carlos ^ah   De Jager, Philip L ^aq,ar   DeCarli, Charles ^as   Demirci, F Yesim ^s   Dick, Malcolm ^at   Dickson, Dennis W ^ak   Duara, Ranjan ^au   Ertekin Taner, Nilufer ^ak,av   Evans, Denis ^aw   Faber, Kelley M ^ax   Fallon, Kenneth B ^al   Farlow, Martin R ^ax   Farrer, Lindsay A ^q,ay,az   Ferris, Steven ^ba   Foroud, Tatiana M ^ax   Frosch, Matthew P ^ab   Galasko, Douglas R ^bb   Gearing, Marla ^bc,bd   Geschwind, Daniel H ^be   Ghetti, Bernardino ^ax   Gilbert, John R ^w   Glass, Jonathan D ^bc   Goate, Alison M ^ah   Graff Radford, Neill R ^ak,av   Green, Robert C ^aq   Growdon, John H ^ab   Haines, Jonathan L ^bf   Hakonarson, Hakon ^bg   Hamilton, Ronald L ^v   Hamilton Nelson, Kara L ^w   Hardy, John ^bh,ch   Harrell, Lindy E ^an   Head, Elizabeth ^bi   Honig, Lawrence S ^bj   Huebinger, Ryan M ^bk   Huentelman, Matthew J ^ao   Hulette, Christine M ^af   Hyman, Bradley T ^ab   Jarvik, Gail P ^x   Jicha, Gregory A ^bi   Jin, Lee Way ^as   Jun, Gyungah ^q,ay   Kamboh, M Ilyas ^s   Karydas, Anna ^ae   Kaye, Jeffrey A ^bl,bm   Kim, Ronald ^ap   Kowall, Neil W ^q   Kramer, Joel H ^ae   Kukull, Walter A ^x   Kunkle, Brian W ^w   LaFerla, Frank M ^ap   Lah, James J ^bc   Leverenz, James B ^bn   Levey, Allan I ^bc   Li, Ge ^c   Lieberman, Andrew P ^j   Lin, Chiao Feng ⁿ   Lopez, Oscar L ^s   Lunetta, Kathryn L ^ay   Lyketsos, Constantine G ⁱ   Mack, Wendy J ^am   Marson, Daniel C ^an   Martin, Eden R ^w   Martiniuk, Frank ^bo   Mash, Deborah C ^w   Masliah, Eliezer ^bb,bp   Mayeux, Richard ^bj,bq   McCormick, Wayne C ^c   McCurry, Susan M ^x   McDavid, Andrew N ^aj   McKee, Ann C ^q   Mesulam, Marsel ^y   Miller, Bruce L ^ae   Miller, Carol A ^am   Miller, Joshua W ^as   Montine, Thomas J ^x   Morris, John C ^ah,ct   Murrell, Jill R ^ax   Myers, Amanda J ^w   Naj, Adam C ⁿ   Olichney, John M ^as   Pankratz, Vernon S ^ac   Parisi, Joseph E ^ac   Partch, Amanda ⁿ   Paulson, Henry L ^l   Pericak Vance, Margaret A ^w   Perry, William ^w   Peskind, Elaine ^c   Petersen, Ronald C ^ac   Pierce, Aimee ^ap   Poon, Wayne W ^at   Potter, Huntington ^br   Quinn, Joseph F ^bl   Raj, Ashok ^ai   Raskind, Murray ^c   Reiman, Eric M ^ao,bs,bt,bu   Reisberg, Barry ^ba,bo   Reitz, Christiane ^bj,bq   Ringman, John M ^m   Roberson, Erik D ^an   Rogaeva, Ekaterina ^bv   Rosen, Howard J ^ae   Rosenberg, Roger N ^bk   Sager, Mark A ^p   Sano, Mary ^ag   Schellenberg, Gerard D ⁿ   Schneider, Julie A ^t   Schneider, Lon S ^am   Seeley, William W ^ae   Smith, Amanda G ^ai   Sonnen, Joshua A ^x   Spina, Salvatore ^ax   St George Hyslop, Peter ^bv,bw   Stern, Robert A ^q   Tanzi, Rudolph E ^ab   Thornton Wells, Tricia A ^bx   Trojanowski, John Q ⁿ   Troncoso, Juan C ⁱ   Tsuang, Debby W ^c,z   Valladares, Otto ⁿ   VanDeerlin, Vivianna M ⁿ   Van Eldik, Linda J ^bi   Vardarajan, Badri N ^bj,bq   Vinters, Harry V ^m   Vonsattel, Jean Paul ^bj   Wang, Li San ⁿ   Weintraub, Sandra ^y   Welsh Bohmer, Kathleen A ^af   Williamson, Jennifer ^bj   Wishnek, Sarah ^w   Woltjer, Randall L ^bl   Wright, Clinton B ^w   Younkin, Steven G ^ak,av   Yu, Chang En ^c   Yu, Lei ^t   Harold, Denise ^by   Abraham, Richard ^by   Hollingworth, Paul ^by   Sims, Rebecca ^by   Gerrish, Amy ^by   Chapman, Jade ^by   Russo, Giancarlo ^by   Hamshere, Marian ^by   Singh Pahwa, Jaspreet ^by   Escott Price, Valentina ^by   Badarinarayan, Nandini ^by   Dowzell, Kimberley ^by   Williams, Amy ^by   Jones, Nicola ^by   Thomas, Charlene ^by   Stretton, Alexandra ^by   Morgan, Angharad ^by   Taylor, Sarah ^by   Lovestone, Simon ^e   Lupton, Michelle K ^e   Brayne, Carol ^bz   Rubinsztein, David C ^bw   Gill, Michael ^ca   Lawlor, Brian ^ca   Lynch, Aoibhinn ^ca   Morgan, Kevin ^cb   Brown, Kristelle ^cb   Passmore, Peter ^cc   Craig, David ^cc   McGuinness, Bernadette ^cc   Todd, Stephen ^cc   Johnston, Janet ^cc   Holmes, Clive ^cd   Mann, David ^ce   David Smith, A ^cf   Love, Seth ^cg   Kehoe, Patrick G ^cg   Mead, Simon ^bh   Fox, Nick ^bh   Rossor, Martin ^bh   Collinge, John ^bh   Maier, Wolfgang ^ci   Jessen, Frank ^ci   Heun, Reiner ^ci   Schürmann, Britta ^ci   Ramirez, Alfredo ^ci   Becker, Tim ^bh   Herold, Christine ^bh   Lacour, André ^bh   Drichel, Dmitriy ^bh   van den Bussche, Hendrik ^cj   Heuser, Isabella ^ck   Kornhuber, Johannes ^cl   Wiltfang, Jens ^cm   Dichgans, Martin ^cn   Frölich, Lutz ^co   Hampel, Harald ^cp,cq   Hüll, Michael ^cs   Rujescu, Dan ^cq,cr   Goate, Alison ^ah   Kauwe, John S K ^f   Nowotny, Petra ^ah   Mayo, Kevin ^ct   Livingston, Gill ^cu   Bass, Nicholas J ^cu   Gurling, Hugh ^cu   McQuillin, Andrew ^cv   Gwilliam, Rhian ^cw   Deloukas, Panos ^cw   Al Chalabi, Ammar ^e   Shaw, Christopher E ^e   Singleton, Andrew B ^cx   Guerreiro, Rita ^bh,cx   Mühleisen, Thomas W ^ci   Nöthen, Markus M ^ci   Moebus, Susanne ^cy   Jöckel, Karl Heinz ^cy   Klopp, Norman ^cz   Wichmann, H Erich ^cn,cz,da   Shane Pankratz, V ^ac   Holmans, Peter ^by   Donovan, Michael O ^by   Owen, Michael J ^by   Williams, Julie ^by   Forouhi, Nita G ^d   Kerrison, Nicola D ^d   Sims, Matt ^d   Lucarelli, Debora M E ^d   Barroso, Inês ^cw,db   McCarthy, Mark I ^cf,dc,dd   Arriola, Larraitz ^de,df,dg   Balkau, Beverley ^dh   Barricarte, Aurelio ^dg,di   Boeing, Heiner ^dj   Franks, Paul W ^dk,dl   Gonzalez, Carlos ^dm   Grioni, Sara ^dn   Kaaks, Rudolf ^do   Key, Timothy J ^cf   Navarro, Carmen ^dg,dp,dq   Nilsson, Peter M ^dk   Overvad, Kim ^b,dr   Palli, Domenico ^ds   Panico, Salvatore ^dt   Ramon Quiros J ^du   Rolandsson, Olov ^dl   Sacerdote, Carlotta ^dv,dw   Sánchez, Maria José ^dg,dx,dy   Slimani, Nadia ^dz   Tjonneland, Anne ^ea   Tumino, Rosario ^eb,ec   van der Daphne, A L ^ed   van der Schouw, Yvonne T ^ee   Riboli, Elio ^ef   more..

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d MRC EPIDEMIOLOGY UNIT   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f BRIGHAM YOUNG UNIVERSITY   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h GROUP HEALTH RESEARCH INSTITUTE   (United States)

ⁱ JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^k VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^l UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^m UNIVERSITY OF CALIFORNIA   (United States)

ⁿ UNIVERSITY OF PENNSYLVANIA   (United States)

^o UNIVERSITY OF WISCONSIN MADISON   (United States)

^p UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^q BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^r UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

^s UNIVERSITY OF PITTSBURGH   (United States)

^t RUSH UNIVERSITY MEDICAL CENTER   (United States)

^u SUN HEALTH RESEARCH INSTITUTE   (United States)

^v UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^w UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^x UNIVERSITY OF WASHINGTON   (United States)

^y NORTHWESTERN UNIVERSITY   (United States)

^z VA PUGET SOUND HEALTH CARE SYSTEM   (United States)

^aa HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^ab MASSACHUSETTS GENERAL HOSPITAL   (United States)

^ac MAYO CLINIC   (United States)

^ad SWEDISH MEDICAL CENTER   (United States)

^ae UNIVERSITY OF CALIFORNIA   (United States)

^af DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ag MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^ah WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^ai UNIVERSITY OF SOUTH FLORIDA   (United States)

^aj Fred Hutchinson Cancer Research Center   (United States)

^ak MAYO GRADUATE SCHOOL   (United States)

^al University of Alabama at Birmingham   (United States)

^am UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^an The University of Alabama at Birmingham   (United States)

^ao TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^ap UNIVERSITY OF CALIFORNIA   (United States)

^aq BRIGHAM AND WOMEN S HOSPITAL   (United States)

^ar BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^as UNIVERSITY OF CALIFORNIA   (United States)

^at UNIVERSITY OF CALIFORNIA   (United States)

^au MOUNT SINAI MEDICAL CENTER   (United States)

^av MAYO CLINIC   (United States)

^aw RUSH UNIVERSITY MEDICAL CENTER   (United States)

^ax INDIANA UNIVERSITY   (United States)

^ay BOSTON UNIVERSITY   (United States)

^az BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^ba NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bb UNIVERSITY OF CALIFORNIA   (United States)

^bc EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bd EMORY UNIVERSITY   (United States)

^be UNIVERSITY OF CALIFORNIA   (United States)

^bf CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^bg CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^bh UNIVERSITY COLLEGE LONDON   (United Kingdom)

^bi UNIVERSITY OF KENTUCKY   (United States)

^bj Och Spine at New York Presbyterian Hospitals   (United States)

^bk UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^bl OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^bm PORTLAND VA MEDICAL CENTER   (United States)

^bn LERNER RESEARCH INSTITUTE   (United States)

^bo NEW YORK UNIVERSITY   (United States)

^bp UNIVERSITY OF CALIFORNIA   (United States)

^bq Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^br UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^bs ARIZONA ALZHEIMER S CONSORTIUM   (United States)

^bt UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^bu BANNER ALZHEIMER S INSTITUTE   (United States)

^bv UNIVERSITY OF TORONTO   (Canada)

^bw UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^bx VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^by CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^bz UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^ca ST JAMES S HOSPITAL   (Ireland)

^cb UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^cc QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^cd UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^ce UNIVERSITY OF MANCHESTER   (United Kingdom)

^cf UNIVERSITY OF OXFORD   (United Kingdom)

^cg UNIVERSITY OF BRISTOL   (United Kingdom)

^ch UNIVERSITY COLLEGE LONDON   (United Kingdom)

^ci UNIVERSITY OF BONN   (Germany)

^cj UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^ck CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^cl UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^cm UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^cn LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^co MEDICAL FACULTY MANNHEIM HEIDELBERG UNIVERSITY   (Germany)

^cp TRINITY COLLEGE DUBLIN   (Ireland)

^cq SORBONNE UNIVERSITÉ   (France)

^cr PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^cs UNIVERSITY OF FREIBURG   (Germany)

^ct MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^cu ZNA Middelheim   (Belgium)

^cv UNIVERSITY COLLEGE LONDON   (United Kingdom)

^cw WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^cx NATIONAL INSTITUTE ON AGING   (United States)

^cy UNIVERSITY HOSPITAL ESSEN   (Germany)

^cz INSTITUTE OF EPIDEMIOLOGY   (Germany)

^da UNIVERSITY OF MUNICH   (Germany)

^db UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^dc UNIVERSITY OF OXFORD   (United Kingdom)

^dd NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

^de Basque Government   (Spain)

^df BIODONOSTIA HEALTH RESEARCH INSTITUTE   (Spain)

^dg CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^dh CENTRE FOR RESEARCH IN EPIDEMIOLOGY AND POPULATION HEALTH   (France)

^di INSTITUTO DE SALUD PÚBLICA DE NAVARRA   (Spain)

^dj GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^dk LUND UNIVERSITY   (Sweden)

^dl UMEÅ UNIVERSITY   (Sweden)

^dm CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^dn NATIONAL CANCER INSTITUTE   (Italy)

^do GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^dp DEPARTMENT OF EPIDEMIOLOGY   (Spain)

^dq UNIVERSITY OF MURCIA   (Spain)

^dr AALBORG UNIVERSITY HOSPITAL   (Denmark)

^ds CANCER RESEARCH AND PREVENTION INSTITUTE ISPO   (Italy)

^dt UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^du Cuesta del Observatorio 4 ^*  (Spain)

^dv UNIVERSITY OF TURIN   (Italy)

^dw Human Genetics Foundation (HuGeF)   (Italy)

^dx ANDALUSIAN SCHOOL OF PUBLIC HEALTH   (Spain)

^dy Instituto de Investigación Biosanitaria de Granada ibs GRANADA Granada Health Research Institute ibs GRANADA   (Spain)

^dz INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^ea DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^eb CIVILE M P AREZZO HOSPITAL   (Italy)

^ec Associazone Iblea per la Ricerca Epidemiologica Onlus   (Italy)

^ed NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^ee UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^ef IMPERIAL COLLEGE LONDON   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ALZHEIMER DISEASE; ARTICLE; BLOOD PRESSURE MONITORING; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; ENVIRONMENTAL EXPOSURE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; MENDELIAN RANDOMIZATION ANALYSIS; RISK FACTOR; SBP GENETIC SCORE; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS;

ALZHEIMER DISEASE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MENDELIAN RANDOMIZATION ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS;

EID: 84936961448     PISSN: 15491277     EISSN: 15491676     Source Type: Journal    
DOI: 10.1371/journal.pmed.1001841     Document Type: Article

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