Increase in NF-κB-sensitive miRNA-146a and miRNA-155 in multiple sclerosis (MS) and pro-inflammatory neurodegeneration

Frontiers in Molecular Neuroscience

Volumn 8, Issue MAR, 2015, Pages 1-5

  Devier, Deidre J ^a   Lovera, Jesus F ^a   Lukiw, Walter J ^a,b  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Autoimmunity; Degeneration; Inflammation; MicroRNA (miRNA); MiRNA 146a; MiRNA 155; Multiple sclerosis; NF kB (p50 p65)

Indexed keywords

ACICLOVIR; ANTIINFLAMMATORY AGENT; BIOLOGICAL MARKER; CD47 ANTIGEN; COMPLEMENT FACTOR H; FUMARIC ACID DIMETHYL ESTER; GAMMA INTERFERON; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MICRORNA 146A; MICRORNA 155; OLIGONUCLEOTIDE; STEROID;

3' UNTRANSLATED REGION; ARTICLE; AUTOIMMUNITY; BLOOD BRAIN BARRIER; DEGENERATIVE DISEASE; DISEASE ASSESSMENT; DISEASE COURSE; ENCEPHALOMYELITIS; ENVIRONMENTAL FACTOR; GENE EXPRESSION; HERPES SIMPLEX VIRUS 1; HUMAN; IMMUNOPATHOLOGY; INNATE IMMUNITY; MAJOR HISTOCOMPATIBILITY COMPLEX; MICRORNA REGULATION; MULTIPLE SCLEROSIS; NERVE DEGENERATION; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SYMPTOM ASSESSMENT; VIRUS INFECTION;

EID: 84925115552     PISSN: 16625099     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnmol.2015.00005     Document Type: Article

References (51)

1. Alexandrov, P. N., Dua, P., and Lukiw, W. J. (2014). Up-Regulation of miRNA-146a in progressive, age-related inflammatory neurodegenerative disorders of the human CNS. Front. Neurol. 5:181. doi: 10.3389/fneur.2014.00181
2. Baranzini, S. E. (2014). Symposium 2-1 the autoimmunome: similarities and differences among genetic susceptibility to common immune-related diseases. Nihon Rinsho Meneki. Gakkai Kaishi. 37:261. doi: 10.2177/jsci.37.261
3. Cui, J. G., Li, Y. Y., Zhao, Y., Bhattacharjee, S., and Lukiw, W. J. (2010). Differential regulation of interleukin-1 receptor-associated kinase-1 and IRAK-2 by miRNA-146a & NF-kB in human astroglial cells & in Alzheimer disease.J. Biol. Chem. 285, 38951-38960. doi: 10.1074/jbc.M110.178848
4. Danborg, P. B., Simonsen, A. H., Waldemar, G., and Heegaard, N. H. (2014). The potential of microRNAs as biofluid markers of neurodegenerative diseases-a systematic review. Biomarkers 19, 259-268. doi: 10.3109/1354750X.2014.904001
5. Gibson, N. W. (2014). Engineered miRNA therapeutics. J. R. Coll. Physicians Edinb. 44, 196-200. doi: 10.4997/JRCPE.2014.302
6. Gilden, D. H. (2005). Infectious causes of multiple sclerosis. Lancet Neurol. 4, 195-202. doi: 10.1016/S1474-4422(05)01017-3
7. Gilmore, T. D., and Herscovitch, M. (2006). Inhibitors of NF-kB signaling: 785 and counting. Oncogene 25, 6887-6899. doi: 10.1038/sj.onc.1209982
8. Gotovac, K., Hajnšek, S., Pašiæ, M. B., Pivac, N., and Boroveèki, F. (2014). Personalized medicine in neurodegenerative diseases: how far away? Mol. Diagn. Ther. 18, 17-24. doi: 10.1007/s40291-013-0058-z
9. Gourraud, P. A., Henry, R. G., Cree, B. A., Crane, J. C., Lizee, A., Olson, M. P., et al. (2014). Precision medicine in chronic disease management: the multiple sclerosis BioScreen. Ann. Neurol. 76, 633-642. doi: 10.1002/ana.24282
10. Guo, H., Ingolia, N. T., Weissman, J. S., and Bartel, D. P. (2010). Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466, 835-840. doi: 10.1038/nature09267
11. Guo, J., Cheng, C., Yan, W., Xu, G., Feng, J., Wang, T., et al. (2014). Systematic review of clinical practice guidelines related to multiple sclerosis. PLoS ONE 9:e106762. doi: 10.1371/journal.pone.0106762
12. Haghikia, A., Haghikia, A., Hellwig, K., Baraniskin, A., Holzmann, A., Décard, B. F., et al. (2012). Regulated microRNAs in the CSF of patients with multiple sclerosis: a case-control study. Neurology 79, 2166-2170. doi: 10.1212/WNL.0b013e3182759621
13. Harris, V. K., and Sadiq, S. A. (2014). Biomarkers of therapeutic response in multiple sclerosis: current status. Mol. Diagn. Ther. 18, 605-617. doi: 10.1007/s40291-014-0117-0
14. Hill, J. M., Zhao, Y., Clement, C., Neumann, D. M., and Lukiw, W. J. (2009). HSV-1 infection of human brain cells induces miRNA-146a and Alzheimer-type inflammatory signaling. Neuroreport 20, 1500-1505. doi: 10.1097/WNR.0b013e3283329c05
15. Høglund, R. A., and Maghazachi, A. A. (2014). Multiple sclerosis and the role of immune cells. World J. Exp. Med. 4, 27-37. doi: 10.5493/wjem.v4.i3.27
16. Ingram, G., Loveless, S., Howell, O. W., Hakobyan, S., Dancey, B., Harris, C. L., et al. (2014). Complement activation in multiple sclerosis plaques: an immunohistochemical analysis. Acta Neuropathol Commun. 2:53. doi: 10.1186/2051-5960-2-53
17. Junker, A. (2011). Pathophysiology of translational regulation by microRNAs in multiple sclerosis. FEBS Lett. 585, 3738-3746. doi: 10.1016/j.febslet.2011.03.052
18. Junker, A., Krumbholz, M., Eisele, S., Mohan, H., Augstein, F., Bittner, R., et al. (2009). MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain 132, 3342-3352. doi: 10.1093/brain/awp300
19. Kamphuis, W. W., Troletti, C. D., Reijerkerk, A., Romero, I. A., and de Vries, H. E. (2015). The blood-brain barrier in multiple sclerosis: microRNAs as key regulators. CNS Neurol. Disord. Drug Targets. [Epub ahead of print].
20. Kroesen, B. J., Teteloshvili, N., Smigielska-Czepiel, K., Brouwer, E., Boots, A. M., van den Berg, A., et al. (2015). Immuno-miRs: critical regulators of T-cell development, function and ageing. Immunology 144, 1-10. doi: 10.1111/imm.12367
21. Küçükali, C. I., Kürtüncü, M., Coban, A., Cebi, M., and Tüzün, E. (2014). Epigenetics of multiple sclerosis: an updated review. Neuromolecular Med. doi: 10.1007/s12017-014-8298-6. [Epub ahead of print].
22. Kutty, R. K., Nagineni, C. N., Samuel, W., Vijayasarathy, C., Jaworski, C., Duncan, T., et al. (2013). Differential regulation of miRNA-146a and miRNA-146b-5p in human retinal pigment epithelial cells by IL-1β, tumor necrosis factor-α, and interferon-γ. Mol. Vis. 19, 737-750.
23. Latta, C. H., Brothers, H. M., and Wilcock, D. M. (2014). Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy. Neuroscience. doi: 10.1016/j.neuroscience.2014.09.061. [Epub ahead of print].
24. Leng, R. X., Pan, H. F., Qin, W. Z., Chen, G. M., and Ye, D. Q. (2011). Role of microRNA-155 in autoimmunity.Cytokine Growth Factor Rev. 22, 141-147. doi: 10.1016/j.cytogfr.2011.05.002
25. Li, Y. Y., Alexandrov, P. N., Pogue, A. I., Zhao, Y., Bhattacharjee, S., and Lukiw, W. J. (2012). miRNA-155 upregulation and complement factor H deficits in Down's syndrome. Neuroreport 23, 168-173. doi: 10.1097/WNR.0b013e32834f4eb4
26. Li, Y. Y., Cui, J. G., Dua, P., Pogue, A. I., Bhattacharjee, S., and Lukiw, W. J. (2011). Differential expression of miRNA-146a-regulated inflammatory genes in human primary neural, astroglial and microglial cells. Neurosci. Lett. 499, 109-113. doi: 10.1016/j.neulet.2011.05.044
27. Lopez-Ramirez, M. A., Wu, D., Pryce, G., Simpson, J. E., Reijerkerk, A., King-Robson, J., et al. (2014). MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation. FASEB J. 28, 2551-2565. doi: 10.1096/fj.13-248880
28. Lu, F., Weidmer, A., Liu, C. G., Volinia, S., Croce, C. M., and Lieberman, P. M. (2008). Epstein-Barr virus-induced miR-155 attenuates NF-κB signaling and stabilizes latent virus persistence. J. Virol. 82, 10436-10443. doi: 10.1128/JVI.00752-08
29. Lu, H. E., Yang, Y. C., Chen, S. M., Su, H. L., Huang, P. C., Tsai, M. S., et al. (2013). Modeling neurogenesis impairment in Down syndrome with induced pluripotent stem cells from Trisomy 21 amniotic fluid cells. Exp. Cell Res. 319, 498-505. doi: 10.1016/j.yexcr.2012.09.017
30. Lukiw, W. J. (2012a). NF-êB-regulated micro RNAs (miRNAs) in primary human brain cells. Exp. Neurol. 235, 484-490. doi: 10.1016/j.expneurol.2011.11.022
31. Lukiw, W. J. (2012b). NF-κB-regulated, proinflammatory miRNAs in Alzheimer's disease. Alzheimers. Res. Ther. 4, 47. doi: 10.1186/alzrt150
32. Lukiw, W. J. (2013). Antagonism of NF-κB-up-regulated micro RNAs (miRNAs) in sporadic Alzheimer's disease (AD)-anti-NF-κB vs. anti-miRNA strategies. Front. Genet. 4:77. doi: 10.3389/fgene.2013.00077
33. Lukiw, W. J., and Bazan, N. G. (1998). Strong nuclear factor-κB-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic Alzheimer's disease superior temporal lobe neocortex. J. Neurosci. Res. 53, 583-592.
34. Lukiw, W. J., Cui, J. G., Yuan, L. Y., Bhattacharjee, P. S., Corkern, M., Clement, C., et al. (2010). Acyclovir or Aβ42 peptides attenuate HSV-1-induced miRNA-146a levels in human primary brain cells. Neuroreport 21, 922-927. doi: 10.1097/WNR.0b013e32833da51a
35. Lukiw, W. J., Surjyadipta, B., Dua, P., and Alexandrov, P. N. (2012). Common micro RNAs (miRNAs) target complement factor H (CFH) regulation in Alzheimer's disease (AD) and in age-related macular degeneration (AMD).Int. J. Biochem. Mol. Biol. 3, 105-116.
36. Lukiw, W. J., Zhao, Y., and Cui, J. G. (2008). An NF-kB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J. Biol. Chem. 283, 31315-31322. doi: 10.1074/jbc.M805371200
37. Ma, X., Zhou, J., Zhong, Y., Jiang, L., Mu, P., Li, Y., et al. (2014). Expression, regulation and function of microRNAs in multiple sclerosis. Int. J. Med. Sci. 11, 810-818. doi: 10.7150/ijms.8647
38. Meinl, E., and Meister, G. (2012). MicroRNAs in the CSF: macro-advance in MS? Neurology 79, 2162-2163. doi: 10.1212/WNL.0b013e31827597d1
39. Melcon, M. O., Correale, J., and Melcon, C. M. (2014). Is it time for a new global classification of multiple sclerosis?J. Neurol. Sci. 344, 171-181. doi: 10.1016/j.jns.2014.06.051
40. Murugaiyan, G., Beynon, V., Mittal, A., Joller, N., and Weiner, H. L. (2011). Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis. J. Immunol. 187, 2213-2221. doi: 10.4049/jimmunol.1003952
41. O'Connell, R. M., Kahn, D., Gibson, W. S., Round, J. L., Scholz, R. L., Chaudhuri, A. A., et al. (2010). MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity 33, 607-619. doi: 10.1016/j.immuni.2010.09.009
42. Pogue, A. I., Li, Y. Y., Cui, J. G., Zhao, Y., Kruck, T. P., Percy, M. E., et al. (2009). Characterization of an NF-kB-regulated, miRNA-146a-mediated down-regulation of CFH in metal-sulfate-stressed human brain cells. J. Inorg. Biochem. 103, 1591-1595. doi: 10.1016/j.jinorgbio.2009.05.012
43. Saba, R., Gushue, S., Huzarewich, R. L., Manguiat, K., Medina, S., Robertson, C., et al. (2012). miRNA-146a is over-expressed during prion disease and modulates the innate immune response and the microglial activation state.PLoS ONE 7:e30832. doi: 10.1371/journal.pone.0030832
44. Seddiki, N., Brezar, V., Ruffin, N., Lévy, Y., and Swaminathan, S. (2014). Role of miR-155 in the regulation of lymphocyte immune function and disease. Immunology 142, 32-38. doi: 10.1111/imm.12227
45. Sethi, P., and Lukiw, W. J. (2009). Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex. Neurosci. Lett. 459, 100-104. doi: 10.1016/j.neulet.2009.04.052
46. Sturm, D., Gurevitz, S. L., and Turner, A. (2014). Multiple sclerosis: a review of the disease and treatment options.Consult. Pharm. 29, 469-479. doi: 10.4140/TCP.n.2014.469
47. Stürner, K. H., Verse, N., Yousef, S., Martin, R., and Sospedra, M. (2014). Boswellic acids reduce Th17 differentiation via blockade of IL-1β-mediated IRAK1 signaling. Eur. J. Immunol. 44, 1200-1212. doi: 10.1002/eji.201343629
48. Taganov, K. D., Boldin, M. P., Chang, K. J., and Baltimore, D. (2006). NF-kB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl. Acad. Sci. U.S.A. 103, 12481-12486. doi: 10.1073/pnas.0605298103
49. Thamilarasan, M., Koczan, D., Hecker, M., Paap, B., and Zettl, U. K. (2012). MicroRNAs in multiple sclerosis and experimental autoimmune encephalomyelitis. Autoimmun. Rev. 11, 174-179. doi: 10.1016/j.autrev.2011.05.009
50. Zhang, J., Cheng, Y., Cui, W., Li, M., Li, B., and Guo, L. (2014). MiRNA-155 modulates Th1 and Th17 cell differentiation and is associated with MS and EAE. J. Neuroimmunol. 266, 56-63. doi: 10.1016/j.jneuroim.2013.09.019
51. Zhao, Y., Bhattacharjee, S., Jones, B. M., Hill, J., Dua, P., and Lukiw, W. J. (2014). Regulation of neurotropic signaling by the inducible, NF-kB-sensitive miRNA-125b in Alzheimer's disease (AD) and in primary human neuronal-glial (HNG) cells. Mol. Neurobiol. 50, 97-106. doi: 10.1007/s12035-013-8595-3