Circulating microRNAs as biomarkers of alzheimer's disease: A systematic review

Journal of Alzheimer's Disease

Volumn 49, Issue 3, 2015, Pages 755-766

  Wu, Helen Zong Ying ^a   Ong, Kwok Leung ^b   Seeher, Katrin ^a   Armstrong, Nicola J ^a,c   Thalamuthu, Anbupalam ^a   Brodaty, Henry ^a   Sachdev, Perminder ^a   Mather, Karen ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c MURDOCH UNIVERSITY   (Australia)

Author keywords

Alzheimer's disease; Biomarkers; Dementia; microRNAs; Mild cognitive impairment

Indexed keywords

MICRORNA; MICRORNA 101; MICRORNA 106A 5P; MICRORNA 106B 5P; MICRORNA 107; MICRORNA 125B; MICRORNA 1306 5P; MICRORNA 132; MICRORNA 143; MICRORNA 143 3P; MICRORNA 146A; MICRORNA 15A; MICRORNA 181C; MICRORNA 18B 5P; MICRORNA 200A; MICRORNA 20A; MICRORNA 210; MICRORNA 29A; MICRORNA 29B; MICRORNA 30E 5P; MICRORNA 31; MICRORNA 335 5P; MICRORNA 34A; MICRORNA 34C; MICRORNA 384; MICRORNA 582 5P; MICRORNA 9; MICRORNA 93; MICRORNA 93 5P; MICRORNA 98 5P; UNCLASSIFIED DRUG; BIOLOGICAL MARKER;

ALZHEIMER DISEASE; AREA UNDER THE CURVE; ARTICLE; AUTOPSY; DAILY LIFE ACTIVITY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DOWN REGULATION; HUMAN; MENTAL DISEASE; MILD COGNITIVE IMPAIRMENT; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY; SYSTEMATIC REVIEW; UPREGULATION; BIBLIOGRAPHIC DATABASE; BLOOD; STATISTICS AND NUMERICAL DATA;

ALZHEIMER DISEASE; BIOMARKERS; DATABASES, BIBLIOGRAPHIC; HUMANS; MICRORNAS;

EID: 84949941091     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-150619     Document Type: Article

References (61)

1. Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP (2013) The global prevalence of dementia: A systematic review and metaanalysis. Alzheimers Dement 9, 63-75.e62.
2. Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, Huang Y, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M (2005) Global prevalence of dementia: A Delphi consensus study. Lancet 366, 2112-2117.
3. Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, Aisen PS, Ghetti B, Klunk WE, McDade E, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Schofield PR, Sperling RA, Salloway S, Morris JC (2012) Clinical and biomarker changes in dominantly inherited Alzheimer's disease. N Engl J Med 367, 795-804.
4. Jack CR Jr, Knopman DS, Jagust WJ, Shaw LM, Aisen PS, Weiner MW, Petersen RC, Trojanowski JQ (2010) Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol 9, 119-128.
5. Sheinerman KS, Umansky SR (2013) Circulating cell-free microRNA as biomarkers for screening, diagnosis and monitoring of neurodegenerative diseases and other neurologic pathologies. Front Cell Neurosci 7, 150.
6. Bekris LM, Lutz F, Montine TJ, Yu CE, Tsuang D, Peskind ER, Leverenz JB (2013) MicroRNA in Alzheimer's disease: An exploratory studyin brain, cerebrospinal fluid and plasma. Biomarkers 18, 455-466.
7. Kroh EM, Parkin RK, Mitchell PS, Tewari M (2010) Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR). Methods 50, 298-301.
8. Cheng L, Quek CY, Sun X, Bellingham SA, Hill AF (2013) The detection of microRNA associated with Alzheimer's disease in biological fluids using next-generation sequencing technologies. Front Genet 4, 150.
9. Kumar P, Dezso Z, MacKenzie C, Oestreicher J, Agoulnik 5, Byrne M, Bernier F, Yanagimachi M, Aoshima K, Oda Y (2013) Circulating miRNA biomarkers for Alzheimer's disease. PLoS One 8, e69807.
10. Haqqani AS, Delaney CE, Tremblay TL, Sodja C, Sandhu JK, Stanimirovic DB (2013) Method for isolation and molecular characterization of extracellular microvesicles released from brain endothelial cells. Fluids Barriers CNS 10, 4.
11. Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, Guo J, Zhang Y, Chen J, Guo X, Li Q, Li X, Wang W, Zhang Y, Wang J, Jiang X, Xiang Y, Xu C, Zheng P, Zhang J, Li R, Zhang H, Shang X, Gong T, Ning G, Wang J, Zen K, Zhang J, Zhang CY (2008) Characterization of microRNAs in serum: A novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18, 997-1006.
12. Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, Tewari M (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 105, 10513-10518.
13. Turchinovich A, Weiz L, Langheinz A, Burwinkel B (2011) Characterization of extracellular circulating microRNA. Nucleic Acids Res 39, 7223-7233.
14. Cogswell JP, Ward J, Taylor IA, Waters M, Shi Y, Cannon B, Kelnar K, Kemppainen J, Brown D, Chen C, Prinjha RK, Richardson JC, Saunders AM, Roses AD, Richards CA (2008) Identification of miRNA changesin Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis 14, 27-41.
15. Delay C, Mandemakers W, Hebert SS (2012) MicroRNAs in Alzheimer's disease. Neurobiol Dis 46, 285-290.
16. Zafari S, Backes C, Meese E, Keller A (2015) Circulating biomarker panels in Alzheimer's disease. Gerontology, doi: 10.1159-000375236
17. Goodall EF, Heath PR, Bandmann O, Kirby J, Shaw PJ (2013) Neuronal dark matter: The emerging role of microRNAs in neurodegeneration. Front Cell Neurosci 7, 178.
18. Femminella GD, Ferrara N, Rengo G (2015) The emerging role of microRNAs in Alzheimer's disease. Front Physiol 6, 40.
19. Lau P, Frigerio CS, De Strooper B(2014) Variance inthe identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: The need of larger datasets. Ageing Res Rev 17, 43-53.
20. Danborg PB, Simonsen AH, Waldemar G, Heegaard NH (2014) The potential of microRNAs as biofluid markers of neurodegenerative diseases - A systematic review. Biomarkers 19, 259-268.
21. Whiting PF, Rutjes AW, Westwood ME, Mallett S, Deeks JJ, Reitsma JB, Leeflang MM, Sterne JA, Bossuyt PM (2011) QUADAS-2: A revised tool for the quality assessment of diagnostic accuracy studies. Ann Intern Med 155, 529-536.
22. Galimberti D, Villa C, Fenoglio C, Serpente M, Ghezzi L, Cioffi SM, Arighi A, Fumagalli G, Scarpini E (2014) Circulating miRNAs as potential biomarkers in Alzheimer's disease. J Alzheimers Dis 42, 1261-1267.
23. Folstein MF, Folstein SE, McHugh PR (1975) Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12, 189-198.
24. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM (1984) Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939-944.
25. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E (1999) Mild cognitive impairment: Clinical characterization and outcome. Arch Neurol 56, 303-308.
26. Xie B, Zhou H, Zhang R, Song M, Yu L, Wang L, Liu Z, Zhang Q, Cui D, Wang X, Xu S (2015) Serum miR-206 and miR-132 as potential circulating biomarkers for mild cognitive impairment. J Alzheimers Dis 45, 721-731.
27. Wang T, Chen K, Li H, Dong S, Su N, Liu Y, Cheng Y, Dai J, Yang C, Xiao S (2015) The feasibility of utilizing plasma miRNA107 and BACE1 messenger RNA gene expression for clinical diagnosis of amnestic mild cognitive impairment. J Clin Psychiatry 76, 135-141.
28. Zhu Y, Li C, Sun A, Wang Y, Zhou S (2015) Quantification of microRNA-210 in the cerebrospinal fluid and serum: Implications for Alzheimer's disease. Exp Ther Med 9, 1013-1017.
29. Liu CG, Wang JL, Li L, Wang PC (2014) MicroRNA-384 regulates both amyloid precursor protein and beta-secretase expression and is a potential biomarker for Alzheimer's disease. Int J Mol Med 34, 160-166.
30. Tan L, Yu JT, Liu QY, Tan MS, Zhang W, Hu N, Wang YL, Sun L, Jiang T, Tan L (2014) Circulating miR-125b as a biomarker of Alzheimer's disease. J Neurol Sci 336, 52-56.
31. Kiko T, Nakagawa K, Tsuduki T, Furukawa K, Arai H, Miyazawa T (2014) MicroRNAs in plasma and cere-brospinal fluid as potential markers for Alzheimer's disease. J Alzheimers Dis 39, 253-259.
32. Bhatnagar S, Chertkow H, Schipper HM, Yuan Z, Shetty V, Jenkins S, Jones T, Wang E (2014) Increased microRNA-34c abundance in Alzheimer's disease circulating blood plasma. Front Mol Neurosci 7, 2.
33. Villa C, Ridolfi E, Fenoglio C, Ghezzi L, Vimercati R, Clerici F, Marcone A, Gallone S, Serpente M, Cantoni C, Bonsi R, Cioffi S, Cappa S, Franceschi M, Rainero I, Mariani C, Scarpini E, Galimberti D (2013) Expression of the transcription factor Sp1 and its regulatory hsa-miR-29b in peripheral blood mononuclear cells from patients with Alzheimer's disease. J Alzheimers Dis 35, 487-494.
34. Sheinerman KS, Tsivinsky VG, Crawford F, Mullan MJ, Abdullah L, Umansky SR (2012) Plasma microRNA biomarkers for detection of mild cognitive impairment. Aging (Albany NY) 4, 590-605.
35. Sheinerman KS, Tsivinsky VG, Abdullah L, Crawford F, Umansky SR (2013) Plasma microRNA biomarkers for detec-tion of mild cognitive impairment: Biomarker validation study. Aging (Albany NY) 5, 925-938.
36. Geekiyanage H, Jicha GA, Nelson PT, Chan C (2012) Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease. Exp Neurol 235, 491-496.
37. Villa C, Fenoglio C, De Riz M, Clerici F, Marcone A, Benussi L, Ghidoni R, Gallone S, Cortini F, Serpente M, Cantoni C, Fumagalli G, Martinelli Boneschi F, Cappa S, Binetti G, Franceschi M, Rainero I, Giordana MT, Mariani C, Bresolin N, Scarpini E, Galimberti D (2011) Role of hnRNP-A1 and miR-590-3p in neuronal death: Genetics and expression analysis in patients with Alzheimer disease and frontotemporal lobar degeneration. Rejuvenation Res 14, 275-281.
38. Dong H, Li J, Huang L, Chen X, Li D, Wang T, Hu C, Xu J, Zhang C, Zen K, Xiao S, Yan Q, Wang C, Zhang C-Y (2015) Serum microRNA profiles serve as novel biomarkers for the diagnosis of Alzheimer's disease. Dis Markers 2015, 625659.
39. Tan L, Yu JT, Tan MS, Liu QY, Wang HF, Zhang W, Jiang T, Tan L (2014) Genome-wide serum microRNA expression profiling identifies serum biomarkers for Alzheimer's disease. J Alzheimers Dis 40, 1017-1027.
40. Cheng L, Doecke JD, Sharples RA, Villemagne VL, Fowler CJ, Rembach A, Martins RN, Rowe CC, Macaulay SL, Masters CL, Hill AF (2014) Prognostic serum miRNA biomarkers associated with Alzheimer's disease shows concordance with neuropsychological and neuroimaging assessment. Mol Psychiatry 20, 1188-1196.
41. Leidinger P, Backes C, Deutscher S, Schmitt K, Mueller SC, Frese K, Haas J, Ruprecht K, Paul F, Stahler C, Lang CJ, Meder B, Bartfai T, Meese E, Keller A (2013) A blood based 12-miRNA signature of Alzheimer disease patients. Genome Biol 14, R78.
42. Schipper HM, Maes OC, Chertkow HM, Wang E (2007) MicroRNA expressioninAlzheimerblood mononuclear cells. Gene Regul Syst Bio 1, 263-274.
43. Zhang S, Smailagic N, Hyde C, Noel-Storr AH, Takwoingi Y, McShane R, Feng J (2014) (11)C-PIB-PET for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev 7, Cd010386.
44. Mulder C, Verwey NA, van der Flier WM, Bouwman FH, Kok A, van Elk EJ, Scheltens P, Blankenstein MA (2010) Amyloid-beta(1-42), total tau, and phosphorylated tau as cerebrospinal fluid biomarkers for the diagnosis of Alzheimer disease. Clin Chem 56, 248-253.
45. Burgos K, Malenica I, Metpally R, Courtright A, Rakela B, Beach T, Shill H, Adler C, Sabbagh M, Villa S, Tembe W, Craig D, Van Keuren-Jensen K (2014) Profilesof extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology. PLoS One 9, e94839.
46. Alexandrov PN, Dua P, Hill JM, Bhattacharjee S, Zhao Y, Lukiw WJ (2012) microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF). Int J Biochem Mol Biol 3, 365-373.
47. Lukiw WJ (2007) Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus. Neuroreport 18, 297-300.
48. Hebert SS, Horre K, Nicolai L, Papadopoulou AS, Mande-makers W, Silahtaroglu AN, Kauppinen S, Delacourte A, De Strooper B (2008) Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci USA 105, 6415-6420.
49. Sethi P, Lukiw WJ (2009) Micro-RNA abundance and stability in human brain: Specific alterationsin Alzheimer's disease temporal lobe neocortex. Neurosci Lett 459, 100-104.
50. Lukiw WJ (2012) NF-small ka, Cyrillic B-regulated micro RNAs (miRNAs) in primary human brain cells. Exp Neurol 235, 484-490.
51. Tiberio P, Callari M, Angeloni V, Daidone MG, Appierto V (2015) Challenges in using circulating miRNAs as cancer biomarkers. Biomed Res Int 2015, 731479.
52. Wang K, Yuan Y, Cho JH, McClarty S, Baxter D, Galas DJ (2012) Comparing the MicroRNA spectrum between serum and plasma. PLoS One 7, e41561.
53. Cheng L, Sharples RA, Scicluna BJ, Hill AF (2014) Exo-somes provide a protective and enriched source of miRNA for biomarker profiling comparedto intracellular and cell-free blood. J Extracell Vesicle 3, 23743.
54. Satoh J-i, Kino Y, Niida S (2015) MicroRNA-Seq data analysis pipeline to identify blood biomarkers for Alzheimer's disease from public data. Biomarker Insights 10, 21-31.
55. Nagy Z, Esiri MM, Hindley NJ, Joachim C, Morris JH, King EM, McDonald B, Litchfield S, Barnetson L, Jobst KA, Smith AD (1998) Accuracyofclinical operational diagnostic criteria for Alzheimer's disease in relation to different pathological diagnostic protocols. Dement Geriatr Cogn Disord 9, 219-226.
56. Nunez-Iglesias J, Liu CC, Morgan TE, Finch CE, Zhou XJ (2010) Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation. PLoS One 5, e8898.
57. Geekiyanage H, Chan C (2011) MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid beta, novel targets in sporadic Alzheimer's disease. J Neurosci 31, 14820-14830.
58. Lukiw WJ, Zhao Y, Cui JG (2008) An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J Biol Chem 283, 31315-31322.
59. Nelson PT, Wang WX (2010) MiR-107 is reduced in Alzheimer's disease brain neocortex: Validation study. J Alzheimers Dis 21, 75-79.
60. Wang WX, Huang Q, Hu Y, Stromberg AJ, Nelson PT (2011) Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: White matter versus gray matter. Acta Neuropathol 121, 193-205.
61. Hebert SS, Wang WX, Zhu Q, Nelson PT (2013) A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls. J Alzheimers Dis 35, 335-348.