-
1
-
-
57749107808
-
Bad bugs, no drugs: No ESKAPE! An update from the Infectious Diseases Society of America
-
Boucher HW, Talbot GH, Bradley JS, et al. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis 2009; 8: 1-12.
-
(2009)
Clin Infect Dis
, vol.8
, pp. 1-12
-
-
Boucher, H.W.1
Talbot, G.H.2
Bradley, J.S.3
-
2
-
-
84875262522
-
A call for antibiotic alternatives research
-
Stanton TB. A call for antibiotic alternatives research. Trends Microbiol 2013; 21:111-13.
-
(2013)
Trends Microbiol
, vol.21
, pp. 111-113
-
-
Stanton, T.B.1
-
3
-
-
84906938796
-
Gross underinvestment in antibacterial research
-
Head M G. Gross underinvestment in antibacterial research. Lancet Infect Dis 2014;14:788-9.
-
(2014)
Lancet Infect Dis
, vol.14
, pp. 788-789
-
-
Head, M.G.1
-
4
-
-
80053095983
-
Resistance drives antibacterial drug development
-
Theuretzbacher U. Resistance drives antibacterial drug development. Curr Opin Pharmacol 2011; 11: 433-8.
-
(2011)
Curr Opin Pharmacol
, vol.11
, pp. 433-438
-
-
Theuretzbacher, U.1
-
6
-
-
84887627398
-
Antibiotic resistance - the need for global solutions
-
Laxminarayan R, Duse A, Chand W, et al. Antibiotic resistance - the need for global solutions. Lancet Infect Dis 2013; 13:1057-98.
-
(2013)
Lancet Infect Dis
, vol.13
, pp. 1057-1098
-
-
Laxminarayan, R.1
Duse, A.2
Chand, W.3
-
8
-
-
84897603328
-
Potential impact of antimicrobial resistance in wildlife, environment, and human health
-
Radhouani H, Silva N, Poeta P, et al. Potential impact of antimicrobial resistance in wildlife, environment, and human health. Front Microbiol 2014; 5: 23.
-
(2014)
Front Microbiol
, vol.5
, pp. 23
-
-
Radhouani, H.1
Silva, N.2
Poeta, P.3
-
9
-
-
84904761947
-
Global antibiotic consumption 2000 to 2010: An analysis of national pharmaceutical sales data
-
Van Boeckel TP, Gandra S, Ashok A, et al. Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. Lancet Infect Dis 2014; 14: 742-50.
-
(2014)
Lancet Infect Dis
, vol.14
, pp. 742-750
-
-
Van Boeckel, T.P.1
Gandra, S.2
Ashok, A.3
-
10
-
-
62549092624
-
Antibiotic resistance in bacteria isolated from the deep terrestrial subsurface
-
Brown MG, Balkwill DL. Antibiotic resistance in bacteria isolated from the deep terrestrial subsurface. Microb Ecol 2009; 57: 484-93.
-
(2009)
Microb Ecol
, vol.57
, pp. 484-493
-
-
Brown, M.G.1
Balkwill, D.L.2
-
11
-
-
80053130409
-
Antibiotic resistance is ancient
-
D’Costa VM, King CE, Kalan L, et al. Antibiotic resistance is ancient. Nature 2011; 477: 457-61.
-
(2011)
Nature
, vol.477
, pp. 457-461
-
-
D’Costa, V.M.1
King, C.E.2
Kalan, L.3
-
12
-
-
84859270554
-
Antibiotic resistance is ancient: Implications for drug discovery
-
Wright DG, Poinar H. Antibiotic resistance is ancient: implications for drug discovery. Trends Microbiol 2012; 20: 157-9.
-
(2012)
Trends Microbiol
, vol.20
, pp. 157-159
-
-
Wright, D.G.1
Poinar, H.2
-
13
-
-
80051703609
-
On behalf of the British Society for Antimicrobial Chemotherapy Working Party on The Urgent Need: Regenerating antibacterial drug discovery and development
-
Livermore RM on behalf of the British Society for Antimicrobial Chemotherapy Working Party on The Urgent Need: regenerating antibacterial drug discovery and development. J Antimicrob Chemother 2011; 66: 1941-4.
-
(2011)
J Antimicrob Chemother
, vol.66
, pp. 1941-1944
-
-
Livermore, R.M.1
-
14
-
-
4344668661
-
Drug repositioning. Identifying and developing new uses for existing drugs
-
Ashburn T T, Thor K B. Drug repositioning. Identifying and developing new uses for existing drugs. Nature Rev Drug Discov 2004; 3: 673-83.
-
(2004)
Nature Rev Drug Discov
, vol.3
, pp. 673-683
-
-
Ashburn, T.T.1
Thor, K.B.2
-
15
-
-
34547770279
-
New uses for old drugs
-
Chong CR, Sullivan DJ. New uses for old drugs. Nature 2007; 448: 645-6.
-
(2007)
Nature
, vol.448
, pp. 645-646
-
-
Chong, C.R.1
Sullivan, D.J.2
-
16
-
-
84872420439
-
Is repositioning drugs a viable alternative in the treatment of tuberculosis?
-
Palomino JC, Martin A. Is repositioning drugs a viable alternative in the treatment of tuberculosis? J Antimicrob Chemother 2013; 68: 275-83.
-
(2013)
J Antimicrob Chemother
, vol.68
, pp. 275-283
-
-
Palomino, J.C.1
Martin, A.2
-
17
-
-
84887953273
-
Editorial: New therapeutic bearings for drug repositioning
-
Clark K B. Editorial: new therapeutic bearings for drug repositioning. Curr Top Med Chem 2013; 13: 2281-2.
-
(2013)
Curr Top Med Chem
, vol.13
, pp. 2281-2282
-
-
Clark, K.B.1
-
18
-
-
84887938416
-
Calcium antagonists: A ready prescription for treating infectious diseases?
-
Clark KB, Eisenstein EM, Krahl SE. Calcium antagonists: a ready prescription for treating infectious diseases? Curr Topics Medic Chem 2013; 13: 2291-305.
-
(2013)
Curr Topics Medic Chem
, vol.13
, pp. 2291-2305
-
-
Clark, K.B.1
Eisenstein, E.M.2
Krahl, S.E.3
-
19
-
-
84884248559
-
The mating judgments of microbes
-
In: Clark K B, Ed., Hauppauge, NY: Nova Science Publishers Inc
-
Clark K B. “The mating judgments of microbes,” In: Clark K B, Ed. Social Learning Theory: Phylogenetic Considerations across Animal, Plant, and Microbial Taxa. Hauppauge, NY: Nova Science Publishers Inc 2013; pp.173-200.
-
(2013)
Social Learning Theory: Phylogenetic Considerations across Animal, Plant, and Microbial Taxa
, pp. 173-200
-
-
Clark, K.B.1
-
20
-
-
33745738994
-
Non-antibiotics: Alternative therapy for the management of MDRTB and MRSA in economically disadvantaged countries
-
Amaral L, Viveiros M, Kristiansen JE. ‘Non-antibiotics’: alternative therapy for the management of MDRTB and MRSA in economically disadvantaged countries. Curr Drug Targets 2006; 7: 887-91.
-
(2006)
Curr Drug Targets
, vol.7
, pp. 887-891
-
-
Amaral, L.1
Viveiros, M.2
Kristiansen, J.E.3
-
21
-
-
35248895271
-
Thioridazine: Resurrection as an antimicrobial agent?
-
Thanacoody HKR. Thioridazine: resurrection as an antimicrobial agent? Br J Clin Pharmacol 2007; 64: 566-74.
-
(2007)
Br J Clin Pharmacol
, vol.64
, pp. 566-574
-
-
Thanacoody, H.K.R.1
-
22
-
-
19944427226
-
Clinical concentrations of thioridazine enhance the killing of intracellular methicillinresistant Staphylococcus aureus: An in vivo, ex vivo and electron microscopy study
-
Martins M B W, Marko A, Ordway D, et al. Clinical concentrations of thioridazine enhance the killing of intracellular methicillinresistant Staphylococcus aureus: an in vivo, ex vivo and electron microscopy study. In Vivo 2004; 18: 787-94.
-
(2004)
In Vivo
, vol.18
, pp. 787-794
-
-
Martins, M.1
Marko, A.2
Ordway, D.3
-
23
-
-
0026942088
-
Antitubercular activity of trifluoperazine, a calmodulin antagonist
-
Ratnakar P, Murthy PS. Antitubercular activity of trifluoperazine, a calmodulin antagonist. FEMS Microbiol Lett 1992; 76: 73-6.
-
(1992)
FEMS Microbiol Lett
, vol.76
, pp. 73-76
-
-
Ratnakar, P.1
Murthy, P.S.2
-
24
-
-
20144385739
-
Inhibitors of type II NADH:Menaquinone oxidoreductase represent a class of antitubercular drugs
-
Weinstein EA, Yano T, Li LS, et al. Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs. Proc Natl Acad Sci USA 2005; 102: 4548-53.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 4548-4553
-
-
Weinstein, E.A.1
Yano, T.2
Li, L.S.3
-
25
-
-
33748506876
-
Trypanosoma cruzi dihydrolipoamide dehydrogenase as target for phenothiazine cationic radicals. Effect of antioxidants
-
Gutierrez-Correa J. Trypanosoma cruzi dihydrolipoamide dehydrogenase as target for phenothiazine cationic radicals. Effect of antioxidants. Curr Drug Targets 2006; 7: 1155-79.
-
(2006)
Curr Drug Targets
, vol.7
, pp. 1155-1179
-
-
Gutierrez-Correa, J.1
-
26
-
-
0036302735
-
Trypanosoma cruzi trypanothione reductase inhibitors: Phenothiazines and related compounds modify experimental Chagas' disease evolution
-
Rivarola HW, Paglini-Oliva PA. Trypanosoma cruzi trypanothione reductase inhibitors: phenothiazines and related compounds modify experimental Chagas' disease evolution. Curr Drug Targets Cardiovasc Haematol Disord 2002; 2: 43-52.
-
(2002)
Curr Drug Targets Cardiovasc Haematol Disord
, vol.2
, pp. 43-52
-
-
Rivarola, H.W.1
Paglini-Oliva, P.A.2
-
27
-
-
0021279835
-
Antileishmanial activity of chlorpromazine
-
Pearson RD, Manian AA, Hall D, Harcus JL, Hewlett EL. Antileishmanial activity of chlorpromazine. Antimicrob Agents Chemother 1984; 25: 571-4.
-
(1984)
Antimicrob Agents Chemother
, vol.25
, pp. 571-574
-
-
Pearson, R.D.1
Manian, A.A.2
Hall, D.3
Harcus, J.L.4
Hewlett, E.L.5
-
28
-
-
0042834382
-
Since phenothiazines alter antibiotic susceptibility of microorganisms by inhibiting efflux pumps, are these agents useful for evaluating similar pumps in phenothiazine-sensitive parasites?
-
Gracio MA, Gracio AJ, Viveiros M, Amaral L. Since phenothiazines alter antibiotic susceptibility of microorganisms by inhibiting efflux pumps, are these agents useful for evaluating similar pumps in phenothiazine-sensitive parasites? Int J Antimicrob Agents 2003; 22: 347-51.
-
(2003)
Int J Antimicrob Agents
, vol.22
, pp. 347-351
-
-
Gracio, M.A.1
Gracio, A.J.2
Viveiros, M.3
Amaral, L.4
-
30
-
-
0000601329
-
Chemotherapeutics: Scientific principles, methods, and results
-
Ehrlich P. Chemotherapeutics: scientific principles, methods, and results. Lancet 1913; 2: 445-51.
-
(1913)
Lancet
, Issue.2
, pp. 445-451
-
-
Ehrlich, P.1
-
31
-
-
0035657318
-
Phenothiazines: Potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries
-
Amaral L, Viveiros M, Kristiansen JE. Phenothiazines: potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries. Trop Med Int Health 2001; 6: 1016-22.
-
(2001)
Trop Med Int Health
, vol.6
, pp. 1016-1022
-
-
Amaral, L.1
Viveiros, M.2
Kristiansen, J.E.3
-
32
-
-
34447547640
-
Reversal of resistance in microorganisms by help of non-antibiotics
-
Kristiansen JE, Hendricks O, Delvin T, et al. Reversal of resistance in microorganisms by help of non-antibiotics. J Antimicrob Chemother 2007; 59: 1271-9.
-
(2007)
J Antimicrob Chemother
, vol.59
, pp. 1271-1279
-
-
Kristiansen, J.E.1
Hendricks, O.2
Delvin, T.3
-
33
-
-
84903821429
-
Ketanserin, an antidepressant, exerts its antileishmanial action via inhibition of 3- hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) enzyme of Leishmania donovani
-
Singh S, Dinesh N, Kaur PK, Shamiulla B. Ketanserin, an antidepressant, exerts its antileishmanial action via inhibition of 3- hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) enzyme of Leishmania donovani. Parasitol Res 2014; 113: 2161-216.
-
(2014)
Parasitol Res
, vol.113
, pp. 2161-2216
-
-
Singh, S.1
Dinesh, N.2
Kaur, P.K.3
Shamiulla, B.4
-
34
-
-
76749134217
-
Anticancer agents against malaria: Time to revisit?
-
Nzila A, Okombo J, Becker RP, Chilengi R, Lang T, Niehues T: Anticancer agents against malaria: time to revisit? Trends Parasitol 2010; 26: 125-9.
-
(2010)
Trends Parasitol
, vol.26
, pp. 125-129
-
-
Nzila, A.1
Okombo, J.2
Becker, R.P.3
Chilengi, R.4
Lang, T.5
Niehues, T.6
-
37
-
-
68449086364
-
New anti-tuberculosis drugs: Strategies, sources and new molecules
-
Palomino JC, Ramos DF, da Silva PA. New anti-tuberculosis drugs: strategies, sources and new molecules. Curr Med Chem 2009; 16: 1898-904.
-
(2009)
Curr Med Chem
, vol.16
, pp. 1898-1904
-
-
Palomino, J.C.1
Ramos, D.F.2
Da Silva, P.A.3
-
38
-
-
84866953429
-
Antifungal drug discovery: Something old and something new
-
Butts A, Krysan D J. Antifungal drug discovery: something old and something new. PLoS Pathog 2012, 8, e1002870.
-
(2012)
Plos Pathog
, vol.8
-
-
Butts, A.1
Krysan, D.J.2
-
39
-
-
79959299426
-
Expanding the antimalarial drug arsenal-now, but how?
-
Grimberg BT, Mehlotra R K. Expanding the antimalarial drug arsenal-now, but how? Pharmaceuticals 2011; 4: 681-712.
-
(2011)
Pharmaceuticals
, vol.4
, pp. 681-712
-
-
Grimberg, B.T.1
Mehlotra, R.K.2
-
40
-
-
84858308226
-
Natural products as sources of new drugs over the 30 years from 1981 to 2010
-
Newman D J, Cragg GM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 2012; 75: 311-35.
-
(2012)
J Nat Prod
, vol.75
, pp. 311-335
-
-
Newman, D.J.1
Cragg, G.M.2
-
41
-
-
0033110869
-
Malarone (Atovaquone and proguanil hydrochloride): A review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group
-
Looareesuwan S, Chulay J D, Canfield JC, Hutchinson DBA. Malarone (atovaquone and proguanil hydrochloride): a review of its clinical development for treatment of malaria. Malarone Clinical Trials Study Group. Am J Trop Med Hyg 1999; 60: 533-41.
-
(1999)
Am J Trop Med Hyg
, vol.60
, pp. 533-541
-
-
Looareesuwan, S.1
Chulay, J.D.2
Canfield, J.C.3
Hutchinson, D.B.A.4
-
42
-
-
0014847819
-
Geldanamycin, a new antibiotic
-
DeBoer C, Meulman P A, Wnuk R J, Peterson D H. Geldanamycin, a new antibiotic. J. Antibiot 1970; 23: 442-7.
-
(1970)
J. Antibiot
, vol.23
, pp. 442-447
-
-
Deboer, C.1
Meulman, P.A.2
Wnuk, R.J.3
Peterson, D.H.4
-
43
-
-
0028064940
-
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
-
Whitesell L, Mimnaugh EG, De Costa B, Myers C E, Neckers L M. Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci USA 1994; 91: 8324-8.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 8324-8328
-
-
Whitesell, L.1
Mimnaugh, E.G.2
De Costa, B.3
Myers, C.E.4
Neckers, L.M.5
-
44
-
-
84876725385
-
Heat shock protein 90 inhibitors as broad spectrum anti- infectives
-
Rochani A K, Singh M, Tatu U. Heat shock protein 90 inhibitors as broad spectrum anti- infectives. Curr Pharm Des 2013; 19: 377-86.
-
(2013)
Curr Pharm Des
, vol.19
, pp. 377-386
-
-
Rochani, A.K.1
Singh, M.2
Tatu, U.3
-
45
-
-
84884138930
-
TMC207 becames bedaquiline, a new anti- TB drug
-
Palomino JC, Martin A. TMC207 becames bedaquiline, a new anti- TB drug. Future Microbiol 2013; 8: 1071-80.
-
(2013)
Future Microbiol
, vol.8
, pp. 1071-1080
-
-
Palomino, J.C.1
Martin, A.2
-
46
-
-
84883436933
-
Tuberculosis clinical trial update and the current anti-tuberculosis drug portfolio
-
Palomino JC, Martin A. Tuberculosis clinical trial update and the current anti-tuberculosis drug portfolio. Curr Med Chem 2013; 20: 3785-96.
-
(2013)
Curr Med Chem
, vol.20
, pp. 3785-3796
-
-
Palomino, J.C.1
Martin, A.2
-
47
-
-
77049136734
-
New antiniotic, pyridomycin
-
Maeda K, Kosaka H, Okami Y, Umezawa H. A new antiniotic, pyridomycin. J. Antibiot 1953, 6, 140.
-
(1953)
J. Antibiot
, vol.6
, pp. 140
-
-
Maeda, K.1
Kosaka, H.2
Okami, Y.3
Umezawa, H.A.4
-
48
-
-
84867067622
-
Towards a new tuberculosis drug: Pyridomycin- nature’s isoniazid
-
Hartkoorn RC, Sala C, Neres J, et al. Towards a new tuberculosis drug: pyridomycin- nature’s isoniazid. EMBO Mol Med 2012; 4: 1032-42.
-
(2012)
EMBO Mol Med
, vol.4
, pp. 1032-1042
-
-
Hartkoorn, R.C.1
Sala, C.2
Neres, J.3
-
49
-
-
84867055243
-
Back to the future: A new ‘old’ lead for tuberculosis
-
Wright G D. Back to the future: a new ‘old’ lead for tuberculosis. EMBO Mol Chem 2012; 4: 1029-31.
-
(2012)
EMBO Mol Chem
, vol.4
, pp. 1029-1031
-
-
Wright, G.D.1
-
50
-
-
79958005979
-
Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517
-
Huang T, Wang Y, Yin J, et al. Identification and characterization of the pyridomycin biosynthetic gene cluster of Streptomyces pyridomyceticus NRRL B-2517. J Biol Chem 2011; 286: 20648-57.
-
(2011)
J Biol Chem
, vol.286
, pp. 20648-20657
-
-
Huang, T.1
Wang, Y.2
Yin, J.3
-
51
-
-
77649268555
-
Repositioning of an existing drug for the neglected tropical disease onchocerciasis
-
Gloeckner C, Garner AL, Mersha F, et al. Repositioning of an existing drug for the neglected tropical disease onchocerciasis. Proc Natl Acad Sci USA 2010; 107: 3424-9.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 3424-3429
-
-
Gloeckner, C.1
Garner, A.L.2
Mersha, F.3
-
52
-
-
84872842061
-
Anthelmintic avermectins kill Mycobacterium tuberculosis, including multidrug-resistant clinical strains
-
Lim LE, Vilchèze C, Ng C, et al. Anthelmintic avermectins kill Mycobacterium tuberculosis, including multidrug-resistant clinical strains. Antimicrob Agents Chemother 2013; 57: 1040-6.
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 1040-1046
-
-
Lim, L.E.1
Vilchèze, C.2
Ng, C.3
-
53
-
-
33746280567
-
Design, synthesis, and SAR studies of mefloquine-based ligands as potential antituberculosis agents
-
Jayaprakash S, Iso Y, Wan B et al. Design, synthesis, and SAR studies of mefloquine-based ligands as potential antituberculosis agents. Chem Med Chem 2006; 1: 593-7.
-
(2006)
Chem Med Chem
, vol.1
, pp. 593-597
-
-
Jayaprakash, S.1
Iso, Y.2
Wan, B.3
-
54
-
-
84861140844
-
Randomized pilot trial of eight weeks of bedaquiline (TMC207) treatment for multidrugresistant tuberculosis: Long-term outcome, tolerability, and effect on emergence of drug resistance
-
Diacon AH, Donald PR, Pym A, et al. Randomized pilot trial of eight weeks of bedaquiline (TMC207) treatment for multidrugresistant tuberculosis: long-term outcome, tolerability, and effect on emergence of drug resistance. Antimicrob Agents Chemother 2012; 56: 3271-6.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 3271-3276
-
-
Diacon, A.H.1
Donald, P.R.2
Pym, A.3
-
55
-
-
68249144628
-
Drug discovery using chemical systems biology: Repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis
-
Kinnings SL, Liu N, Buchmeier N, Tonge PJ, Xie L, Bourne PE. Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis. PLoS Comput Biol 2009; 5: e1000423.
-
(2009)
Plos Comput Biol
, vol.5
-
-
Kinnings, S.L.1
Liu, N.2
Buchmeier, N.3
Tonge, P.J.4
Xie, L.5
Bourne, P.E.6
-
57
-
-
84890976055
-
Inspiration from old dyes: Tris(stilbene) compounds as potent Gram-positive antibacterial agents
-
Boulos RA, Man NYT, Lengkeek NA. et al. Inspiration from old dyes: tris(stilbene) compounds as potent Gram-positive antibacterial agents. Chem Eur J 2013; 19: 17980-8.
-
(2013)
Chem Eur J
, vol.19
, pp. 17980-17988
-
-
Boulos, R.A.1
Man, N.2
Lengkeek, N.A.3
-
58
-
-
77955923752
-
Potential role of the cardiovascular non-antibiotic (Helper compound) amlodipine in the treatment of microbial infections: Scope and hope for the future
-
Mazumdar K, Kumar KA, Dutta NK. Potential role of the cardiovascular non-antibiotic (helper compound) amlodipine in the treatment of microbial infections: scope and hope for the future. Intern J Antimicrob Agents 2010; 36: 295-302.
-
(2010)
Intern J Antimicrob Agents
, vol.36
, pp. 295-302
-
-
Mazumdar, K.1
Kumar, K.A.2
Dutta, N.K.3
-
59
-
-
85027930731
-
Reversal of meticillin resi stance in Staphylococcus aureus by the anthelmintic avermectin
-
Guo H, Ren B, Dai H. et al. Reversal of meticillin resi stance in Staphylococcus aureus by the anthelmintic avermectin. Int J Antimicrob Agents 2014; 44: 274-6.
-
(2014)
Int J Antimicrob Agents
, vol.44
, pp. 274-276
-
-
Guo, H.1
Ren, B.2
Dai, H.3
-
60
-
-
84884940960
-
Antibacterial activity and mode of action of tert- butylhydroquinone (TBHQ) and its oxidative product, tert-butylbenzoquinone (TBBQ)
-
Ooi N, Chopra I, Eady EA. et al. Antibacterial activity and mode of action of tert- butylhydroquinone (TBHQ) and its oxidative product, tert-butylbenzoquinone (TBBQ). J Antimicrob Chemother 2013; 68: 1297-304.
-
(2013)
J Antimicrob Chemother
, vol.68
, pp. 1297-1304
-
-
Ooi, N.1
Chopra, I.2
Eady, E.A.3
-
61
-
-
84963993830
-
Redox-active compounds with a history of human use: Antistaphylococcal action and potential for repurposing as topical antibiofilm agent
-
PMID 25368206
-
Ooi N, Eady EA, Cave JH, O’Neill AJ. Redox-active compounds with a history of human use: antistaphylococcal action and potential for repurposing as topical antibiofilm agent. J Antimicrob Chemother 2014; PMID 25368206.
-
(2014)
J Antimicrob Chemother
-
-
Ooi, N.1
Eady, E.A.2
Cave, J.H.3
O’Neill, A.J.4
-
62
-
-
84865574615
-
Repurposing screens identify rifamycins as potential broad-spectrum therapy for multi-drug-resistant Acinetobacter baumannii and select agent microorganisms
-
Chromy BA, Elsheikh M, Christensen TL, et al. Repurposing screens identify rifamycins as potential broad-spectrum therapy for multi-drug-resistant Acinetobacter baumannii and select agent microorganisms. Future Microbiol 2012; 7: 1011-20.
-
(2012)
Future Microbiol
, vol.7
, pp. 1011-1020
-
-
Chromy, B.A.1
Elsheikh, M.2
Christensen, T.L.3
-
63
-
-
84880707604
-
Toward repurposing ciclopirox as an antibiotic against drug-resistant Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae
-
Carlson-Banning KM, Chou A, Liu Z, et al. Toward repurposing ciclopirox as an antibiotic against drug-resistant Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae. PLoS One 2013; 8: e69646.
-
(2013)
Plos One
, vol.8
-
-
Carlson-Banning, K.M.1
Chou, A.2
Liu, Z.3
-
64
-
-
84892973953
-
Gallium-based antiinfectives: Targeting microbial iron-uptake mechanisms
-
Kelson AB, Carnevall M, Truong-Le V. Gallium-based antiinfectives: targeting microbial iron-uptake mechanisms. Curr Opin Pharmacol 2013; 13: 707-18.
-
(2013)
Curr Opin Pharmacol
, vol.13
, pp. 707-718
-
-
Kelson, A.B.1
Carnevall, M.2
Truong-Le, V.3
-
65
-
-
84899503151
-
Promises and failures of gallium as an antibacterial agent
-
Minandri F, Bonchi C, Frangipani F, Imperi F, Visca P. Promises and failures of gallium as an antibacterial agent. Future Microbiol 2014; 9: 379-97.
-
(2014)
Future Microbiol
, vol.9
, pp. 379-397
-
-
Minandri, F.1
Bonchi, C.2
Frangipani, F.3
Imperi, F.4
Visca, P.5
-
66
-
-
84906074895
-
Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa
-
Frangipani E, Bonchi C, Minandri F, Imperi F, Visca P. Pyochelin potentiates the inhibitory activity of gallium on Pseudomonas aeruginosa. Antim Agents Chemother 2014; 58: 5572-5.
-
(2014)
Antim Agents Chemother
, vol.58
, pp. 5572-5575
-
-
Frangipani, E.1
Bonchi, C.2
Minandri, F.3
Imperi, F.4
Visca, P.5
-
67
-
-
84912127744
-
A drug-repositioning screening identifies pentetic acid as a potential therapeutic agent suppressing the elastase-mediated virulence of Pseudomonas aeruginosa
-
Gi M, Jeong J, Lee K. et al. A drug-repositioning screening identifies pentetic acid as a potential therapeutic agent suppressing the elastase-mediated virulence of Pseudomonas aeruginosa. Antim Agents Chemother 2014; 58: 7205-14.
-
(2014)
Antim Agents Chemother
, vol.58
, pp. 7205-7214
-
-
Gi, M.1
Jeong, J.2
Lee, K.3
-
68
-
-
84872874295
-
New life fora n old drug: The anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa quorum sensing
-
Imperi F, Massai F, Ramachandran Pillai C, et al. New life fora n old drug: the anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa quorum sensing. Antimicrob Agents Chemother 2013; 57: 996-1005.
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 996-1005
-
-
Imperi, F.1
Massai, F.2
Ramachandran Pillai, C.3
-
69
-
-
84876936620
-
Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity
-
Imperi F, Massai F, Facchini M, et al. Repurposing the antimycotic drug flucytosine for suppression of Pseudomonas aeruginosa pathogenicity. PNAS 2013; 110: 7458-63.
-
(2013)
PNAS
, vol.110
, pp. 7458-7463
-
-
Imperi, F.1
Massai, F.2
Facchini, M.3
-
70
-
-
84896467050
-
Repurposing as a means to increase the activity of amphotericin B and caspofungin against Candida albicans biofilma
-
Delattin N, De Brucher K, Vandamme K, et al. Repurposing as a means to increase the activity of amphotericin B and caspofungin against Candida albicans biofilma. J Antimicrob Chemother 2014; 69: 1035-44.
-
(2014)
J Antimicrob Chemother
, vol.69
, pp. 1035-1044
-
-
Delattin, N.1
De Brucher, K.2
Vandamme, K.3
-
71
-
-
84907442986
-
Neglected tropical diseases: Now more than just ‘other diseases’- the post- 2015 Agenda
-
Molyneux DH. Neglected tropical diseases: now more than just ‘other diseases’- the post- 2015 Agenda. Int Health 2014; 6: 172-80.
-
(2014)
Int Health
, vol.6
, pp. 172-180
-
-
Molyneux, D.H.1
-
72
-
-
84881303961
-
Open-source approached for the repurposing of existing or failed candidate drugs: Learning from and applying the lesson across diseases
-
Allarakhia M. Open-source approached for the repurposing of existing or failed candidate drugs: learning from and applying the lesson across diseases. Drug Des Devel Ther 2013; 7: 753-66.
-
(2013)
Drug Des Devel Ther
, vol.7
, pp. 753-766
-
-
Allarakhia, M.1
-
73
-
-
80052698379
-
Open source drug discovery a new paradigm of collaborative research in tuberculosis drug development
-
Bhardwaj A, Scaria V, Raghava GP, et al. Open source drug discovery a new paradigm of collaborative research in tuberculosis drug development. Tuberculosis (Edinburg) 2011; 91: 479-86.
-
(2011)
Tuberculosis (Edinburg)
, vol.91
, pp. 479-486
-
-
Bhardwaj, A.1
Scaria, V.2
Raghava, G.P.3
-
75
-
-
33749363878
-
Oral miltefosine for the treatment of Indian visceral leishmaniasis
-
Sundar S, Jha TK, Thakur CP, Bhattacharya SK, Rai M. Oral miltefosine for the treatment of Indian visceral leishmaniasis. Trans R Soc Trop Med Hyg 2006; 100 (1): S26-S33.
-
(2006)
Trans R Soc Trop Med Hyg
, vol.100
, Issue.1
, pp. S26-S33
-
-
Sundar, S.1
Jha, T.K.2
Thakur, C.P.3
Bhattacharya, S.K.4
Rai, M.5
-
76
-
-
34548136191
-
Tamoxifen is effective against Leishmania and induces a rapid alkalinization of parasitophorous vacuoles harbouring Leishmania (Leishmania) amazonensis amastigotes
-
Miguel DC, Yokoyama-Yasunaka JK, Andreoli WK, Mortara RA, Uliana SR. Tamoxifen is effective against Leishmania and induces a rapid alkalinization of parasitophorous vacuoles harbouring Leishmania (Leishmania) amazonensis amastigotes. J Antimicrob Chemother 2007; 60: 526-34.
-
(2007)
J Antimicrob Chemother
, vol.60
, pp. 526-534
-
-
Miguel, D.C.1
Yokoyama-Yasunaka, J.K.2
Reoli, W.K.3
Mortara, R.A.4
Uliana, S.R.5
-
77
-
-
84902461096
-
Activity of anti-cancer protein kinase inhibitors against Leishmania spp
-
Sanderson L, Yardley V, Croft SL. Activity of anti-cancer protein kinase inhibitors against Leishmania spp. J Antimicrob Chemother 2014; 69: 1888-91.
-
(2014)
J Antimicrob Chemother
, vol.69
, pp. 1888-1891
-
-
Sanderson, L.1
Yardley, V.2
Croft, S.L.3
-
78
-
-
84861468840
-
Visceral leishmaniasis treatment: What do we have, what do we need and how to deliver it?
-
Freitas-Junior LH, Chatelain E, Kim HA, Siqueira-Neto JL. Visceral leishmaniasis treatment: what do we have, what do we need and how to deliver it? Int J Parasitol Drugs Drug Resist 2012; 2: 11-9.
-
(2012)
Int J Parasitol Drugs Drug Resist
, vol.2
, pp. 11-19
-
-
Freitas-Junior, L.H.1
Chatelain, E.2
Kim, H.A.3
Siqueira-Neto, J.L.4
-
79
-
-
30744459609
-
One world problem, one world solution?
-
No authors listed
-
No authors listed.. One world problem, one world solution? Nature Rev Drug Discov 2005; 4: 701.
-
(2005)
Nature Rev Drug Discov
, vol.4
-
-
-
80
-
-
79960775459
-
Drug repositioning for orphan diseases
-
Sardana D, Zhu C, Zhang M, et al. Drug repositioning for orphan diseases. Brief Bioinform 2011; 12: 346-56.
-
(2011)
Brief Bioinform
, vol.12
, pp. 346-356
-
-
Sardana, D.1
Zhu, C.2
Zhang, M.3
-
81
-
-
82555161767
-
Target repurposing for neglected diseases
-
Pollastri MP, Campbell RK. Target repurposing for neglected diseases. Future Med Chem 2011; 3: 1307-15.
-
(2011)
Future Med Chem
, vol.3
, pp. 1307-1315
-
-
Pollastri, M.P.1
Campbell, R.K.2
-
82
-
-
84856397064
-
Drug discovery for neglected tropical diseases at the Sandler Center
-
Robertson SA, Renslo AR. Drug discovery for neglected tropical diseases at the Sandler Center. Future Med Chem 2011; 3: 1279-88.
-
(2011)
Future Med Chem
, vol.3
, pp. 1279-1288
-
-
Robertson, S.A.1
Renslo, A.R.2
-
83
-
-
84905487382
-
Synergy testing of FDAapproved drugs identifies potent drug combinations against Trypanosoma cruzi
-
Planer JD, Hulverson MA, Arif JA, et al. Synergy testing of FDAapproved drugs identifies potent drug combinations against Trypanosoma cruzi. PLoS Negl Trop Dis. 2014; 8: e2977.
-
(2014)
Plos Negl Trop Dis
, vol.8
-
-
Planer, J.D.1
Hulverson, M.A.2
Arif, J.A.3
-
84
-
-
84896874963
-
Identification of levothyroxine antichagasic activity through computer-aided drug repurposing
-
Bellera CL, Balcazar DE, Alberca L, et al. Identification of levothyroxine antichagasic activity through computer-aided drug repurposing. Scientific World Journal 2014; 279618.
-
(2014)
Scientific World Journal
-
-
Bellera, C.L.1
Balcazar, D.E.2
Alberca, L.3
-
85
-
-
84885147970
-
Drug repositioning as a route to anti-malarial drug discovery: Preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate
-
Matthews H, Usman-Idris M, Khan F, Read M, Nirmalan N. Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate. Malaria J 2013; 12: 359.
-
(2013)
Malaria J
, vol.12
-
-
Matthews, H.1
Usman-Idris, M.2
Khan, F.3
Read, M.4
Nirmalan, N.5
-
86
-
-
84908458930
-
The potential of quinoline derivatives for the treatment of Toxoplasma gondii infection
-
Kadri D, Crater AK, Lee H, Solomon VR, Ananvoranich S. The potential of quinoline derivatives for the treatment of Toxoplasma gondii infection. Exp Parasitol 2014; 145: 135-44.
-
(2014)
Exp Parasitol
, vol.145
, pp. 135-144
-
-
Kadri, D.1
Crater, A.K.2
Lee, H.3
Solomon, V.R.4
Ananvoranich, S.5
-
87
-
-
84907260954
-
Repurposing the Open Access Malaria Box to discover potent inhibitors of Toxoplasma gondii and Entamoeba histolytica
-
Boyom FF, Fokou PVT, Tchokouaha LRY, et al. Repurposing the Open Access Malaria Box to discover potent inhibitors of Toxoplasma gondii and Entamoeba histolytica. Antimicrob Agents Chemother 2014; 58: 5848-54.
-
(2014)
Antimicrob Agents Chemother
, vol.58
, pp. 5848-5854
-
-
Boyom, F.F.1
Fokou, P.2
Tchokouaha, L.3
-
88
-
-
79958051292
-
Use of minocycline in viral infections
-
Dutta K, Basu A. Use of minocycline in viral infections. Indian J Med Res 2011; 133: 467-70.
-
(2011)
Indian J Med Res
, vol.133
, pp. 467-470
-
-
Dutta, K.1
Basu, A.2
-
89
-
-
84856190901
-
Nonclassical biological activities of quinolone derivatives
-
Ahmed A, Daneshtalab M. Nonclassical biological activities of quinolone derivatives. J Pharm Pharm Sci 2012; 15: 52-72.
-
(2012)
J Pharm Pharm Sci
, vol.15
, pp. 52-72
-
-
Ahmed, A.1
Daneshtalab, M.2
-
90
-
-
84870607167
-
Identification of old drugs as potential inhibitors of HIV-1 integrase- human LEDGF/p75 interaction via molecular docking
-
Hu G, Li X, Sun X, et al. Identification of old drugs as potential inhibitors of HIV-1 integrase- human LEDGF/p75 interaction via molecular docking. J Mol Model 2012; 18: 4995-5003.
-
(2012)
J Mol Model
, vol.18
, pp. 4995-5003
-
-
Hu, G.1
Li, X.2
Sun, X.3
-
91
-
-
84864523421
-
Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: New prospects for an old drug
-
Mastrangelo E, Pezzullo M, De Burghgraeve T, et al. Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug. J Antimicrob Agents 2012; 67: 1884-94.
-
(2012)
J Antimicrob Agents
, vol.67
, pp. 1884-1894
-
-
Mastrangelo, E.1
Pezzullo, M.2
De Burghgraeve, T.3
-
92
-
-
84875965830
-
A systematic screen of DNA-approved drugs for inhibitors of biological threat agents
-
Madrid PB, Chopra S, Manger ID, et al. A systematic screen of DNA-approved drugs for inhibitors of biological threat agents. PLoS One 2013; 8: e60579.
-
(2013)
Plos One
, vol.8
-
-
Madrid, P.B.1
Chopra, S.2
Manger, I.D.3
-
93
-
-
84899507401
-
Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity
-
Boonyasuppayakorn S, Reichert ED, Manzano M, Nagarajan K, Padmanabhan R. Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity. Antiviral Res 2014; 106: 125-34.
-
(2014)
Antiviral Res
, vol.106
, pp. 125-134
-
-
Boonyasuppayakorn, S.1
Reichert, E.D.2
Manzano, M.3
Nagarajan, K.4
Padmanabhan, R.5
-
94
-
-
84880544466
-
FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection
-
Johansen LM, Brannan JM, Delos SE, et al. FDA-approved selective estrogen receptor modulators inhibit Ebola virus infection. Sci Transl Med 2013; 5: 190ra79.
-
(2013)
Sci Transl Med
, vol.5
-
-
Johansen, L.M.1
Brannan, J.M.2
Delos, S.E.3
-
95
-
-
84902176510
-
Repurposing of clinically developed drugs for treatment of Middle East Respiratory Syndrome Coronavirus infection
-
Dyall J, Coleman CM, Hart BJ, et al. Repurposing of clinically developed drugs for treatment of Middle East Respiratory Syndrome Coronavirus infection. Antimicrob Agents Chemother 2014; 58: 4885-93.
-
(2014)
Antimicrob Agents Chemother
, vol.58
, pp. 4885-4893
-
-
Dyall, J.1
Coleman, C.M.2
Hart, B.J.3
-
96
-
-
84921693765
-
Antiviral effects of inhibiting host gene expression
-
Tripp RA, Mark Tomkins S. Antiviral effects of inhibiting host gene expression. Curr Top Microbiol Immunol 2015; 386: 459-77.
-
(2015)
Curr Top Microbiol Immunol
, vol.386
, pp. 459-477
-
-
Tripp, R.A.1
Mark Tomkins, S.2
-
98
-
-
84906241587
-
Repurposing Cryptosporidium Inosine 5_- Monophosphate Dehydrogenase Inhibitors as Potential Antibacterial Agents
-
Mandapati K, Gorla SK, House AL, et al. Repurposing Cryptosporidium Inosine 5_- Monophosphate Dehydrogenase Inhibitors as Potential Antibacterial Agents. ACS Med Chem 2014; 5: 846-50.
-
(2014)
ACS Med Chem
, vol.5
, pp. 846-850
-
-
Mandapati, K.1
Gorla, S.K.2
House, A.L.3
-
100
-
-
84908388258
-
Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus
-
Perlmutter JI, Forbes LT, Krysan DJ, et al. Repurposing the antihistamine terfenadine for antimicrobial activity against Staphylococcus aureus. J Med Chem 2014; 57: 8540-62.
-
(2014)
J Med Chem
, vol.57
, pp. 8540-8562
-
-
Perlmutter, J.I.1
Forbes, L.T.2
Krysan, D.J.3
-
101
-
-
0141633535
-
Thirty years of polyamine-related approaches to cancer therapy. Retrospect. and prospect. Part I. Selective enzyme inhibitors
-
Seiler, N. Thirty years of polyamine-related approaches to cancer therapy. Retrospect. and prospect. Part I. Selective enzyme inhibitors. Curr Drug Targets 2003; 4: 537-64.
-
(2003)
Curr Drug Targets
, vol.4
, pp. 537-564
-
-
Seiler, N.1
-
103
-
-
77950030227
-
Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines
-
Chadwick J, Jones M, Mercer AE, et al. Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines. Bioorg Med Chem 2010; 18: 2586-97.
-
(2010)
Bioorg Med Chem
, vol.18
, pp. 2586-2597
-
-
Chadwick, J.1
Jones, M.2
Mercer, A.E.3
-
104
-
-
40549096043
-
Multifaceted role for polyamines in bacterial pathogens
-
Shah P, Swiatlo EA. Multifaceted role for polyamines in bacterial pathogens. Mol Microbiol 2008; 68: 4-16.
-
(2008)
Mol Microbiol
, vol.68
, pp. 4-16
-
-
Shah, P.1
Swiatlo, E.A.2
-
105
-
-
77953554146
-
Rolain JM. In vitro antifungal activity of aminosterols against moulds isolated from cystic fibrosis patients
-
Alhanout K, Brunel JM, Ranque S, Rolain JM. In vitro antifungal activity of aminosterols against moulds isolated from cystic fibrosis patients. J Antimicrob Chemother 2010; 65: 1307-9.
-
(2010)
J Antimicrob Chemother
, vol.65
, pp. 1307-1309
-
-
Alhanout, K.1
Brunel, J.M.2
Ranque, S.3
-
106
-
-
34547662510
-
Antiviral activity of oxidized polyamines
-
Bachrach U. Antiviral activity of oxidized polyamines. Amino Acids 2007; 33: 267-72.
-
(2007)
Amino Acids
, vol.33
, pp. 267-272
-
-
Bachrach, U.1
-
107
-
-
80053145985
-
Squalamine as a broadspectrum systemic antiviral agent with therapeutic potential
-
Zasloff M, Adams AP, Beckerman B, et al. Squalamine as a broadspectrum systemic antiviral agent with therapeutic potential. Proc Natl Acad Sci USA 2011; 108: 15978-83.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 15978-15983
-
-
Zasloff, M.1
Adams, A.P.2
Beckerman, B.3
-
108
-
-
84891822854
-
Mini-Review: Polyamines metabolism, toxicity and potent therapeutical use
-
Djouhri-Bouktab, Rolain JM, Brunel JM. Mini-Review: polyamines metabolism, toxicity and potent therapeutical use. Anti- Infective Agents 2014; 12: 95-103.
-
(2014)
Anti- Infective Agents
, vol.12
, pp. 95-103
-
-
Djouhri-Bouktab, R.J.1
Brunel, J.M.2
-
109
-
-
84910091759
-
A new strategy to fight antimicrobial resistance: the revival of old antibiotics
-
Cassir N, Rolain J-M, Broqui P. A new strategy to fight antimicrobial resistance: the revival of old antibiotics. Front Microbiol 2014; 5: 551.
-
(2014)
Front Microbiol
, vol.5
-
-
Cassir, N.1
Rolain, J.-M.2
Broqui, P.3
|