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Volumn 7, Issue , 2013, Pages 753-766

Open-source approaches for the repurposing of existing or failed candidate drugs: Learning from and applying the lessons across diseases

Author keywords

Human capacity development; Models of collaboration; Neglected tropical diseases; Open source; Rare diseases; Repurposing

Indexed keywords

AMPHOTERICIN B; ASTEMIZOLE; AVERMECTIN; CHLOROQUINE; EFLORNITHINE; MILTEFOSINE; NEW DRUG; PHOSPHODIESTERASE INHIBITOR; TAMOXIFEN;

EID: 84881303961     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S46289     Document Type: Review
Times cited : (79)

References (72)
  • 1
    • 84867445885 scopus 로고    scopus 로고
    • NCATS launches drug repurposing program
    • Alison M. NCATS launches drug repurposing program. Nat Biotechnol. 2012;30(7):571-572.
    • (2012) Nat Biotechnol , vol.30 , Issue.7 , pp. 571-572
    • Alison, M.1
  • 2
    • 84881291575 scopus 로고    scopus 로고
    • National Center for Advancing Translational Sciences. Available from:. Accessed March 21
    • National Center for Advancing Translational Sciences. Rescuing and repurposing drugs. Available from: http://www.ncats.nih.gov/research/reengineering/rescue-repurpose/rescue-repurpose.html. Accessed March 21, 2013.
    • (2013) Rescuing and repurposing drugs
  • 3
    • 84881283337 scopus 로고    scopus 로고
    • Available from:. Accessed June 16 2013
    • Philippidis A. NCATS, MRC take aim at teaching old drug new tricks. 2012. Available from: http://www.genengnews.com/insight-and-intelligenceand153/ncats-mrc-take-aim-at-teaching-old-drugs-new-tricks/77899618. Accessed June 16, 2013.
    • (2012) NCATS, MRC take aim at teaching old drug new tricks
    • Philippidis, A.1
  • 5
    • 80052218993 scopus 로고    scopus 로고
    • Drug repositioning: Re-investigating existing drugs for new therapeutic indications
    • Padhy BM, Gupta YK. Drug repositioning: re-investigating existing drugs for new therapeutic indications. J Postgrad Med. 2011;57(2): 153-160.
    • (2011) J Postgrad Med , vol.57 , Issue.2 , pp. 153-160
    • Padhy, B.M.1    Gupta, Y.K.2
  • 6
    • 0037007645 scopus 로고    scopus 로고
    • Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
    • Zhu S, Stavrovskaya IG, Drozda M, et al. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature. 2002;417(6684):74-78.
    • (2002) Nature , vol.417 , Issue.6684 , pp. 74-78
    • Zhu, S.1    Stavrovskaya, I.G.2    Drozda, M.3
  • 7
    • 40549130652 scopus 로고    scopus 로고
    • PDTD: A web-accessible protein database for drug target identification
    • Gao Z, Li H, Zhang H, et al. PDTD: a web-accessible protein database for drug target identification. BMC Bioinformatics. 2008;9:104.
    • (2008) BMC Bioinformatics. , vol.9 , pp. 104
    • Gao, Z.1    Li, H.2    Zhang, H.3
  • 8
    • 38549182474 scopus 로고    scopus 로고
    • SuperTarget and Matador: Resources for exploring drug-target relationships
    • Database issue
    • Günther S, Kuhn M, Dunkel M, et al. SuperTarget and Matador: resources for exploring drug-target relationships. Nucleic Acids Res. 2008;36(Database issue):D919-D922.
    • (2008) Nucleic Acids Res , vol.36
    • Günther, S.1    Kuhn, M.2    Dunkel, M.3
  • 9
    • 78651287426 scopus 로고    scopus 로고
    • DrugBank 3.0: A comprehensive resource for 'omics' research on drugs
    • Database issue
    • Knox C, Law V, Jewison T, et al. DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011; 39(Database issue):D1035-D1041.
    • (2011) Nucleic Acids Res , vol.39
    • Knox, C.1    Law, V.2    Jewison, T.3
  • 10
    • 4344668661 scopus 로고    scopus 로고
    • Drug repositioning: Identifying and developing new uses for existing drugs
    • Ashburn TT, Thor KB. Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov. 2004;3(8): 673-683.
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.8 , pp. 673-683
    • Ashburn, T.T.1    Thor, K.B.2
  • 11
    • 34250777249 scopus 로고    scopus 로고
    • Network analysis of FDA approved drugs and their targets
    • Ma'ayan A, Jenkins SL, Goldfarb J, Iyengar R. Network analysis of FDA approved drugs and their targets. Mt Sinai J Med. 2007;74(1):27-32.
    • (2007) Mt Sinai J Med , vol.74 , Issue.1 , pp. 27-32
    • Ma'ayan, A.1    Jenkins, S.L.2    Goldfarb, J.3    Iyengar, R.4
  • 12
    • 84881278337 scopus 로고    scopus 로고
    • Available from:. Accessed July 19, 2013
    • Poh A. Breathing new life into old drugs. 2008. Available from: http://www.bio-itworld.com/issues/2008/nov-dec/chantest.html. Accessed July 19, 2013.
    • (2008) Breathing new life into old drugs
    • Poh, A.1
  • 13
    • 44349084276 scopus 로고    scopus 로고
    • IDMap: Facilitating the detection of potential leads with therapeutic targets
    • Ha S, Seo YJ, Kwon MS, Chang BH, Han CK, Yoon JH. IDMap: facilitating the detection of potential leads with therapeutic targets. Bioinformatics. 2008;24(11):1413-1415.
    • (2008) Bioinformatics , vol.24 , Issue.11 , pp. 1413-1415
    • Ha, S.1    Seo, Y.J.2    Kwon, M.S.3    Chang, B.H.4    Han, C.K.5    Yoon, J.H.6
  • 14
    • 84881273982 scopus 로고    scopus 로고
    • [website on the Internet]. Available from:. Accessed March 21
    • Open PHACTS [website on the Internet]. Available from: http://www.openphacts.org. Accessed March 21, 2013.
    • (2013) Open PHACTS
  • 15
    • 84877743291 scopus 로고    scopus 로고
    • Network-based drug repositioning
    • Wu Z, Wang Y, Chen L. Network-based drug repositioning. Mol Biosyst. 2013;9(6):1268-1281.
    • (2013) Mol Biosyst , vol.9 , Issue.6 , pp. 1268-1281
    • Wu, Z.1    Wang, Y.2    Chen, L.3
  • 16
    • 84875963165 scopus 로고    scopus 로고
    • Drug target prediction and repositioning using an integrated network-based approach
    • Emig D, Ivliev A, Pustovalova O, et al. Drug target prediction and repositioning using an integrated network-based approach. PLoS One. 2013;8(4):e60618.
    • (2013) PLoS One , vol.8 , Issue.4
    • Emig, D.1    Ivliev, A.2    Pustovalova, O.3
  • 18
    • 77951672406 scopus 로고    scopus 로고
    • High-throughput screening and small animal models, where are we?
    • Giacomotto J, Ségalat L. High-throughput screening and small animal models, where are we? Br J Pharmacol. 2010;160(2):204-216.
    • (2010) Br J Pharmacol , vol.160 , Issue.2 , pp. 204-216
    • Giacomotto, J.1    Ségalat, L.2
  • 19
    • 84881295149 scopus 로고    scopus 로고
    • National Institutes of Health. [press release]. Bethesda (MD): NIH; 2012 [Mar 13]. Available from:. Accessed March 21
    • National Institutes of Health. NIH and Lilly to generate public resource of approved and investigational medicines [press release]. Bethesda (MD): NIH; 2012 [Mar 13]. Available from: http://www.nih.gov/news/health/mar2012/ncats-13.htm. Accessed March 21, 2013.
    • (2013) NIH and Lilly to generate public resource of approved and investigational medicines
  • 20
    • 84867191656 scopus 로고    scopus 로고
    • Drug repurposing
    • Thayer AM. Drug repurposing. Chem Eng News. 2012;90(40):15-25.
    • (2012) Chem Eng News , vol.90 , Issue.40 , pp. 15-25
    • Thayer, A.M.1
  • 21
    • 84881302781 scopus 로고    scopus 로고
    • Genetic Engineering and Biotechnology News
    • Available from:. Accessed June 16, 2013
    • Genetic Engineering and Biotechnology News. Roche, Broad Institute seek new uses for old drugs. 2012. Available from: http://www.genengnews.com/gen-news-highlights/roche-broad-institute-seek-new-uses-for-old-drugs/81247689. Accessed June 16, 2013.
    • (2012) Roche, Broad Institute seek new uses for old drugs
  • 22
    • 33746381549 scopus 로고    scopus 로고
    • A clinical drug library screen identifies astemizole as an antimalarial agent
    • Chong CR, Chen X, Shi L, Liu OJ, Sullivan DJ Jr. A clinical drug library screen identifies astemizole as an antimalarial agent. Nat Chem Biol. 2006;2(8):415-416.
    • (2006) Nat Chem Biol , vol.2 , Issue.8 , pp. 415-416
    • Chong, C.R.1    Chen, X.2    Shi, L.3    Liu, O.J.4    Sullivan Jr., D.J.5
  • 23
    • 79955428497 scopus 로고    scopus 로고
    • The NCGC Pharmaceutical Collection: A comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics
    • Huang R, Southall N, Wang Y, et al. The NCGC Pharmaceutical Collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. Sci Transl Med. 2011;3(80):80ps16.
    • (2011) Sci Transl Med , vol.3 , Issue.80
    • Huang, R.1    Southall, N.2    Wang, Y.3
  • 24
    • 84862165688 scopus 로고    scopus 로고
    • Orphan/rare drug discovery through drug repositioning
    • Muthyala R. Orphan/rare drug discovery through drug repositioning. Drug Discov Today Ther Strateg. 2011;8(3-4):71-76.
    • (2011) Drug Discov Today Ther Strateg , vol.8 , Issue.3-4 , pp. 71-76
    • Muthyala, R.1
  • 25
    • 84881272039 scopus 로고    scopus 로고
    • [website on the Internet]. Available from:. Accessed March 21
    • International Rare Diseases Research Consortium [website on the Internet]. Available from: http://www.irdirc.org. Accessed March 21, 2013.
    • (2013) International Rare Diseases Research Consortium
  • 26
    • 79960830371 scopus 로고    scopus 로고
    • Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases
    • Xu K, Coté TR. Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases. Brief Bioinform. 2011;12(4):341-345.
    • (2011) Brief Bioinform , vol.12 , Issue.4 , pp. 341-345
    • Xu, K.1    Coté, T.R.2
  • 27
    • 84864145020 scopus 로고    scopus 로고
    • US Food and Drug Administration. Available from:. Accessed March 21, 2013
    • US Food and Drug Administration. A valuable resource for drug developers: the Rare Disease Repurposing Database (RDRD). 2011. Available from: http://www.fda.gov/ForIndustry/DevelopingProductsforRareDiseasesConditions/HowtoapplyforOrphanProductDesignation/ucm216147.htm. Accessed March 21, 2013.
    • (2011) A valuable resource for drug developers: The Rare Disease Repurposing Database (RDRD)
  • 28
    • 84862156580 scopus 로고    scopus 로고
    • The CTSA Pharmaceutical Assets Portal-a public-private partnership model for drug repositioning
    • Marusina K, Welsch DJ, Lynn R, Brock D, Bahr N. The CTSA Pharmaceutical Assets Portal-a public-private partnership model for drug repositioning. Drug Discov Today Ther Strateg. 2011;8(3-4):77-83.
    • (2011) Drug Discov Today Ther Strateg , vol.8 , Issue.3-4 , pp. 77-83
    • Marusina, K.1    Welsch, D.J.2    Lynn, R.3    Brock, D.4    Bahr, N.5
  • 29
    • 84881270784 scopus 로고    scopus 로고
    • [website on the Internet]. Available from:. Accessed March 21
    • World Intellectual Property Organization Re:Search [website on the Internet]. Available from: http://www.wipo.int/research/en. Accessed March 21, 2013.
    • (2013) World Intellectual Property Organization Re:Search
  • 30
    • 84881295443 scopus 로고    scopus 로고
    • [website on the Internet]. Available from:. Accessed March 21
    • Johns Hopkins Clinical Compound Screening Initiative [website on the Internet]. Available from: http://www.jhccsi.org/background.html. Accessed March 21, 2013.
    • (2013) Johns Hopkins Clinical Compound Screening Initiative
  • 31
    • 84881269587 scopus 로고    scopus 로고
    • [website on the Internet]. Available from:. Accessed March 21
    • Cures Within Reach [website on the Internet]. Available from: http://www.cureswithinreach.org/about-us. Accessed March 21, 2013.
    • (2013) Cures Within Reach
  • 32
    • 84857720818 scopus 로고    scopus 로고
    • Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnerships
    • Weir SJ, DeGennaro LJ, Austin CP. Repurposing approved and abandoned drugs for the treatment and prevention of cancer through public-private partnerships. Cancer Res. 2012;72(5):1055-1058.
    • (2012) Cancer Res , vol.72 , Issue.5 , pp. 1055-1058
    • Weir, S.J.1    DeGennaro, L.J.2    Austin, C.P.3
  • 34
    • 84881307438 scopus 로고    scopus 로고
    • Washington University, Available from:. Accessed June 16, 2013
    • Arbanas C. Washington University, Pfizer announce groundbreaking research collaboration. 2010. Available from: http://news.wustl.edu/news/Pages/20770.aspx. Accessed June 16, 2013.
    • (2010) Pfizer announce groundbreaking research collaboration
    • Arbanas, C.1
  • 37
    • 77950937284 scopus 로고    scopus 로고
    • The US Orphan Drug Act: Rare disease research stimulator or commercial opportunity?
    • Wellman-Labadie O, Zhou Y. The US Orphan Drug Act: rare disease research stimulator or commercial opportunity? Health Policy. 2010;95(2-3):216-228.
    • (2010) Health Policy , vol.95 , Issue.2-3 , pp. 216-228
    • Wellman-Labadie, O.1    Zhou, Y.2
  • 38
    • 78649700786 scopus 로고    scopus 로고
    • Rare diseases, orphan drugs and their regulation: Questions and misconceptions
    • Tambuyzer E. Rare diseases, orphan drugs and their regulation: questions and misconceptions. Nat Rev Drug Discov. 2010;9(12):921-929.
    • (2010) Nat Rev Drug Discov , vol.9 , Issue.12 , pp. 921-929
    • Tambuyzer, E.1
  • 39
    • 0028788896 scopus 로고
    • The economics of orphan drug policy in the US. Can the legislation be improved?
    • Peabody JW, Ruby A, Cannon P. The economics of orphan drug policy in the US. Can the legislation be improved? Pharmacoeconomics. 1995;8(5):374-384.
    • (1995) Pharmacoeconomics , vol.8 , Issue.5 , pp. 374-384
    • Peabody, J.W.1    Ruby, A.2    Cannon, P.3
  • 41
    • 84987613894 scopus 로고    scopus 로고
    • Available from:. Accessed June 16, 2013
    • Agres T. New life for old drugs. 2011. Available from: http://www.dddmag.com/articles/2011/07/new-life-old-drugs. Accessed June 16, 2013.
    • (2011) New life for old drugs
    • Agres, T.1
  • 43
    • 84862165688 scopus 로고    scopus 로고
    • Orphan/rare drug discovery through drug repositioning
    • Muthyala R. Orphan/rare drug discovery through drug repositioning. Drug Discovery Today. 2011; 8(3-4): 71-76.
    • (2011) Drug Discovery Today , vol.8 , Issue.3-4 , pp. 71-76
    • Muthyala, R.1
  • 45
    • 84881297161 scopus 로고    scopus 로고
    • Indiana University-Purdue University Indianapolis. Available from:. Accessed June 16, 2013
    • Indiana University-Purdue University Indianapolis. Molecules made by IUPUI students may have potential to cure diseases. 2011. Available from: http://newscenter.iupui.edu/4997/Molecules-Made-by-IUPUI-Students-May-Have-Potential-To-Cure-Diseases110124. Accessed June 16, 2013.
    • (2011) Molecules made by IUPUI students may have potential to cure diseases
  • 46
    • 84881308569 scopus 로고    scopus 로고
    • American Type Culture Collection
    • Available from:. Accessed June 16
    • American Type Culture Collection. What we offer. Available from: http://www.atcc.org/About/About_ATCC/What_We_Offer.aspx. Accessed June 16, 2013.
    • (2013) What we offer
  • 47
    • 0242303583 scopus 로고    scopus 로고
    • The Malaria Research and Reference Reagent Resource (MR4) Center-creating African opportunities
    • Wu Y, Fairfield AS, Oduola A, Cypess RH. The Malaria Research and Reference Reagent Resource (MR4) Center-creating African opportunities. Afr J Med Sci. 2001;30 Suppl:52-54.
    • (2001) Afr J Med Sci , vol.30 , Issue.SUPPL , pp. 52-54
    • Wu, Y.1    Fairfield, A.S.2    Oduola, A.3    Cypess, R.H.4
  • 48
    • 84864352043 scopus 로고    scopus 로고
    • Understanding and creating value from open source drug discovery for neglected tropical diseases
    • Allarakhia M, Ajuwon L. Understanding and creating value from open source drug discovery for neglected tropical diseases. Expert Opin Drug Discov. 2012;7(8):643-657.
    • (2012) Expert Opin Drug Discov , vol.7 , Issue.8 , pp. 643-657
    • Allarakhia, M.1    Ajuwon, L.2
  • 49
    • 77954805871 scopus 로고    scopus 로고
    • Developing a framework for understanding and enabling open source drug discovery
    • Allarakhia M. Developing a framework for understanding and enabling open source drug discovery. Expert Opin Drug Discov. 2010;5(8): 709-714.
    • (2010) Expert Opin Drug Discov , vol.5 , Issue.8 , pp. 709-714
    • Allarakhia, M.1
  • 50
    • 68249144628 scopus 로고    scopus 로고
    • Drug discovery using chemical systems biology: Repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis
    • Kinnings SL, Liu N, Buchmeier N, Tonge PJ, Xie L, Bourne PE. Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis. PLoS Comput Biol. 2009;5:e1000423.
    • (2009) PLoS Comput Biol. , vol.5
    • Kinnings, S.L.1    Liu, N.2    Buchmeier, N.3    Tonge, P.J.4    Xie, L.5    Bourne, P.E.6
  • 51
    • 77649268555 scopus 로고    scopus 로고
    • Repositioning of an existing drug for the neglected tropical disease onchocerciasis
    • Gloeckner C, Garner AL, Mersha F, et al. Repositioning of an existing drug for the neglected tropical disease onchocerciasis. Proc Natl Acad Sci U S A. 2010;107(8):3424-3429.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.8 , pp. 3424-3429
    • Gloeckner, C.1    Garner, A.L.2    Mersha, F.3
  • 54
    • 34548136191 scopus 로고    scopus 로고
    • Tamoxifen is effective against Leishmania and induces a rapid alkalinization of parasitophorous vacuoles harbouring Leishmania (Leishmania) amazonensis amastigotes
    • Miguel DC, Yokoyama-Yasunaka JK, Andreoli WK, Mortara RA, Uliana SR. Tamoxifen is effective against Leishmania and induces a rapid alkalinization of parasitophorous vacuoles harbouring Leishmania (Leishmania) amazonensis amastigotes. J Antimicrob Chemother. 2007;60(3):526-534.
    • (2007) J Antimicrob Chemother , vol.60 , Issue.3 , pp. 526-534
    • Miguel, D.C.1    Yokoyama-Yasunaka, J.K.2    Andreoli, W.K.3    Mortara, R.A.4    Uliana, S.R.5
  • 56
    • 30744459609 scopus 로고    scopus 로고
    • One world problem, one world solution?
    • No authors listed
    • [No authors listed]. One world problem, one world solution? Nature Rev Drug Discov. 2005;4:701.
    • (2005) Nature Rev Drug Discov. , vol.4 , pp. 701
  • 58
    • 82555161767 scopus 로고    scopus 로고
    • Target repurposing for neglected diseases
    • Pollastri MP, Campbell RK. Target repurposing for neglected diseases. Future Med Chem. 2011;3(10):1307-1315.
    • (2011) Future Med Chem , vol.3 , Issue.10 , pp. 1307-1315
    • Pollastri, M.P.1    Campbell, R.K.2
  • 59
    • 84856397064 scopus 로고    scopus 로고
    • Drug discovery for neglected tropical diseases at the Sandler Center
    • Robertson SA, Renslo AR. Drug discovery for neglected tropical diseases at the Sandler Center. Future Med Chem. 2011;3(10):1279-1288.
    • (2011) Future Med Chem , vol.3 , Issue.10 , pp. 1279-1288
    • Robertson, S.A.1    Renslo, A.R.2
  • 60
    • 80052698379 scopus 로고    scopus 로고
    • Open source drug discovery-a new paradigm of collaborative research in tuberculosis drug development
    • Bhardwaj A, Scaria V, Raghava GP, et al. Open source drug discovery-a new paradigm of collaborative research in tuberculosis drug development. Tuberculosis (Edinb). 2011;91(5):479-486.
    • (2011) Tuberculosis (Edinb) , vol.91 , Issue.5 , pp. 479-486
    • Bhardwaj, A.1    Scaria, V.2    Raghava, G.P.3
  • 61
    • 84881294635 scopus 로고    scopus 로고
    • [website on the Internet]. Available from:. Accessed February 15
    • Open Source Drug Discovery [website on the Internet]. Available from: http://www.osdd.net. Accessed February 15, 2012.
    • (2012) Open Source Drug Discovery
  • 62
    • 84881308188 scopus 로고    scopus 로고
    • Available from:. Accessed June 16, 2013
    • Sreelata M. Open source TB megaproject yields first fruits. 2010. Available from: http://www.scidev.net/en/news/open-source-tb-megaproject-yields-first-fruits.html. Accessed June 16, 2013.
    • (2010) Open source TB megaproject yields first fruits
    • Sreelata, M.1
  • 65
    • 84864116400 scopus 로고    scopus 로고
    • The role of academic institutions in the development of drugs for rare and neglected diseases
    • Coles LD, Cloyd JC. The role of academic institutions in the development of drugs for rare and neglected diseases. Clin Pharmacol Ther. 2012;92(2):193-202.
    • (2012) Clin Pharmacol Ther , vol.92 , Issue.2 , pp. 193-202
    • Coles, L.D.1    Cloyd, J.C.2
  • 66
    • 79953695916 scopus 로고    scopus 로고
    • In silico repositioning of approved drugs for rare and neglected diseases
    • Ekins S, Williams AJ, Krasowski MD, Freundlich JS. In silico repositioning of approved drugs for rare and neglected diseases. Drug Discov Today. 2011;16(7-8):298-310.
    • (2011) Drug Discov Today , vol.16 , Issue.7-8 , pp. 298-310
    • Ekins, S.1    Williams, A.J.2    Krasowski, M.D.3    Freundlich, J.S.4
  • 68
    • 78751643946 scopus 로고    scopus 로고
    • Managing knowledge assets under conditions of radical change: The case of the pharmaceutical industry
    • Allarakhia M, Walsh S. Managing knowledge assets under conditions of radical change: The case of the pharmaceutical industry. Technovation. 2011;31(2):105-117.
    • (2011) Technovation , vol.31 , Issue.2 , pp. 105-117
    • Allarakhia, M.1    Walsh, S.2
  • 69
    • 0002006014 scopus 로고
    • The economic foundations of technology policy: Equilibrium and evolutionary perspectives
    • In: Stoneman P, editor. Oxford: Blackwell
    • Metcalfe S. The economic foundations of technology policy: equilibrium and evolutionary perspectives. In: Stoneman P, editor. Handbook of the Economics of Innovation and Technological Change. Oxford: Blackwell; 1995.
    • (1995) Handbook of the Economics of Innovation and Technological Change
    • Metcalfe, S.1
  • 71
    • 0004104876 scopus 로고    scopus 로고
    • Organisation for Economic Co-operation and Development. Available from:. Accessed March 21 2013
    • Organisation for Economic Co-operation and Development. National systems of innovation. 1997. Available from: http://www.oecd.org/science/inno/2101733.pdf. Accessed March 21, 2013.
    • (1997) National systems of innovation
  • 72
    • 84881291446 scopus 로고    scopus 로고
    • PR Newswire. Available from:. Accessed April 2, 2013
    • PR Newswire. Transparency Life Sciences launches Indication Finder crowdsourcing tool for drug repurposing. 2012. Available from: http://www.prnewswire.com/news-releases/transparency-life-sciences-launches-indication-finder-crowdsourcing-tool-for-drug-repurposing-175572351.html. Accessed April 2, 2013.
    • (2012) Transparency Life Sciences launches Indication Finder crowdsourcing tool for drug repurposing


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