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Volumn 58, Issue 10, 2014, Pages 5848-5854

Repurposing the open access malaria box to discover potent inhibitors of Toxoplasma gondii and Entamoeba histolytica

Author keywords

[No Author keywords available]

Indexed keywords

ACETAMIDE DERIVATIVE; ANTIAMEBIC AGENT; ANTIMALARIAL AGENT; COCCIDIOSTATIC AGENT; METRONIDAZOLE; MMV 006704; MMV 006861; MMV 007363; MMV 007791; MMV 020548; MMV 085203; MMV 666095; MMV 666600; PIPERAZINE DERIVATIVE; PYRIMETHAMINE; SULFADIAZINE; UNCLASSIFIED DRUG; ANTIPROTOZOAL AGENT; PIPERAZINE;

EID: 84907260954     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02541-14     Document Type: Article
Times cited : (56)

References (55)
  • 1
    • 80155186278 scopus 로고    scopus 로고
    • Drug development to protozoan diseases
    • Monzote L, Siddiq A. 2011. Drug development to protozoan diseases. Open Med. Chem. J. 5: 1-3. http://dx.doi.org/10.2174/1874104501105010001.
    • (2011) Open Med. Chem. J. , vol.5 , pp. 1-3
    • Monzote, L.1    Siddiq, A.2
  • 3
    • 0036941286 scopus 로고    scopus 로고
    • Toxoplasmosis, an overview with emphasis on ocular involvement
    • Klaren VN, Kijlstra A. 2002. Toxoplasmosis, an overview with emphasis on ocular involvement. Ocul. Immunol. Inflamm. 10: 1-26. http://dx.doi .org/10.1076/ocii.10.1.1.10330.
    • (2002) Ocul. Immunol. Inflamm. , vol.10 , pp. 1-26
    • Klaren, V.N.1    Kijlstra, A.2
  • 6
    • 67649989063 scopus 로고    scopus 로고
    • Seroprevalence of Toxoplasma gondii infection and characteristics of seropositive patients in general hospitals in Daejeon, Korea
    • Shin DW, Cha DY, Hua QJ, Cha GH, Lee YH. 2009. Seroprevalence of Toxoplasma gondii infection and characteristics of seropositive patients in general hospitals in Daejeon, Korea. Korean J. Parasitol. 47: 125-130. http://dx.doi.org/10.3347/kjp.2009.47.2.125.
    • (2009) Korean J. Parasitol. , vol.47 , pp. 125-130
    • Shin, D.W.1    Cha, D.Y.2    Hua, Q.J.3    Cha, G.H.4    Lee, Y.H.5
  • 7
    • 0023795206 scopus 로고
    • Acquired toxoplasmic infection as the cause of toxoplasmic retinochoroiditis in families
    • Silveira C, Belfort R, Jr, Burnier M, Jr, Nussenblatt R. 1988. Acquired toxoplasmic infection as the cause of toxoplasmic retinochoroiditis in families. Am. J. Ophthalmol. 106: 362-364. http://dx.doi.org/10.1016 /0002-9394(88)90382-0.
    • (1988) Am. J. Ophthalmol. , vol.106 , pp. 362-364
    • Silveira, C.1    Belfort, R.2    Burnier, M.3    Nussenblatt, R.4
  • 8
    • 77949821126 scopus 로고    scopus 로고
    • Annual burden of ocular toxoplasmosis in the United States
    • Jones JL, Holland GN. 2010. Annual burden of ocular toxoplasmosis in the United States. Am. J. Trop. Med. Hyg. 82: 464-465. http://dx.doi.org /10.4269/ajtmh.2010.09-0664.
    • (2010) Am. J. Trop. Med. Hyg. , vol.82 , pp. 464-465
    • Jones, J.L.1    Holland, G.N.2
  • 11
    • 0036605892 scopus 로고    scopus 로고
    • The molecular basis of sulfonamide resistance in Toxoplasma gondii and implications for the clinical management of toxoplasmosis
    • Aspinall TV, Joynson DH, Guy E, Hyde JE, Sims PF. 2002. The molecular basis of sulfonamide resistance in Toxoplasma gondii and implications for the clinical management of toxoplasmosis. J. Infect. Dis. 185: 1637-1643. http://dx.doi.org/10.1086/340577.
    • (2002) J. Infect. Dis. , vol.185 , pp. 1637-1643
    • Aspinall, T.V.1    Joynson, D.H.2    Guy, E.3    Hyde, J.E.4    Sims, P.F.5
  • 12
    • 33745154817 scopus 로고    scopus 로고
    • Reactivation of Toxoplasma retinochoroiditis under atovaquone therapy in an immunocompetent patient
    • Baatz H, Mirshahi A, Puchta J, Gumbel H, Hattenbach LO. 2006. Reactivation of Toxoplasma retinochoroiditis under atovaquone therapy in an immunocompetent patient. Ocul. Immunol. Inflamm. 14: 185-187. http://dx.doi.org/10.1080/09273940600659740.
    • (2006) Ocul. Immunol. Inflamm. , vol.14 , pp. 185-187
    • Baatz, H.1    Mirshahi, A.2    Puchta, J.3    Gumbel, H.4    Hattenbach, L.O.5
  • 13
    • 70449587557 scopus 로고    scopus 로고
    • Reassessment of the epidemiology of amebiasis: State of the art
    • Ximénez C, Morän P, Rojas L, Valadez A, Gómez A. 2009. Reassessment of the epidemiology of amebiasis: state of the art. Infect. Genet. Evol. 9: 1023-1032. http://dx.doi.org/10.1016/j.meegid.2009.06.008.
    • (2009) Infect. Genet. Evol. , vol.9 , pp. 1023-1032
    • Ximénez, C.1    Morän, P.2    Rojas, L.3    Valadez, A.4    Gómez, A.5
  • 16
    • 0037460789 scopus 로고    scopus 로고
    • Amoebiasis
    • Stanley SL, Jr. 2003. Amoebiasis. Lancet 361: 1025-1034. http://dx.doi .org/10.1016/S0140-6736(03)12830-9.
    • (2003) Lancet , vol.361 , pp. 1025-1034
    • Stanley, S.L.1
  • 17
    • 33645058068 scopus 로고    scopus 로고
    • Entamoeba histolytica (amoebiasis)
    • Mandell GL, Bennett JE, Dolin R (ed) Churchill Livingstone, Philadelphia, PA
    • Ravdin JI, Stauffer WM. 2005. Entamoeba histolytica (amoebiasis), p 3097-3111. In Mandell GL, Bennett JE, Dolin R (ed), Principles and practice of infectious diseases, vol 2. Churchill Livingstone, Philadelphia, PA.
    • (2005) Principles and Practice of Infectious Diseases , vol.2 , pp. 3097-3111
    • Ravdin, J.I.1    Stauffer, W.M.2
  • 18
    • 0031087498 scopus 로고    scopus 로고
    • WHO/PAHO/UNESCO report: A consultation with experts on amoebiasis. Mexico City Mexico 28-29 January 1997
    • WHO
    • WHO. 1997. WHO/PAHO/UNESCO report: a consultation with experts on amoebiasis. Mexico City, Mexico 28-29 January 1997. Epidemiol. Bull. 18: 13-14.
    • (1997) Epidemiol. Bull. , vol.18 , pp. 13-14
  • 21
    • 77949449167 scopus 로고    scopus 로고
    • Seroprevalence of Entamoeba histolytica in the context of HIV and AIDS: The case of the Vhembe district, in South Africa's Limpopo province
    • Samie A, Barrett LJ, Bessong PO, Ramalivhana JN, Mavhandu LG, Njayou M, Gurreant RL. 2010. Seroprevalence of Entamoeba histolytica in the context of HIV and AIDS: the case of the Vhembe district, in South Africa's Limpopo province. Ann. Trop. Med. Parasitol. 104: 55-63. http://dx.doi.org/10.1179/136485910X12607012373911.
    • (2010) Ann. Trop. Med. Parasitol. , vol.104 , pp. 55-63
    • Samie, A.1    Barrett, L.J.2    Bessong, P.O.3    Ramalivhana, J.N.4    Mavhandu, L.G.5    Njayou, M.6    Gurreant, R.L.7
  • 22
    • 80053442804 scopus 로고    scopus 로고
    • Amebiasis in HIV-1-infected Japanese men: Clinical features and response to therapy
    • Watanabe K, Gatanaga H, Escueta-de Cadiz A, Tanuma J, Nozaki T, Oka S. 2011. Amebiasis in HIV-1-infected Japanese men: clinical features and response to therapy. PLoS Negl. Trop. Dis. 5: e1318. http://dx.doi.org /10.1371/journal.pntd.0001318.
    • (2011) PLoS Negl. Trop. Dis. , vol.5 , pp. e1318
    • Watanabe, K.1    Gatanaga, H.2    Escueta-De Cadiz, A.3    Tanuma, J.4    Nozaki, T.5    Oka, S.6
  • 23
    • 84872679301 scopus 로고    scopus 로고
    • Current pharmacotherapy of amebiasis, advances in new drugs, and design of a vaccine
    • (In Spanish.)
    • Chacïn-Bonilla L. 2012. Current pharmacotherapy of amebiasis, advances in new drugs, and design of a vaccine. Invest. Clin. 53: 301-314. (In Spanish.)
    • (2012) Invest. Clin. , vol.53 , pp. 301-314
    • Chacïn-Bonilla, L.1
  • 24
    • 84879189895 scopus 로고    scopus 로고
    • The open access Malaria Box: A drug discovery catalyst for neglected diseases
    • Spangenberg T, Burrows JN, Kowalczyk P, McDonald S, Wells TNC, Willis P. 2013. The open access Malaria Box: a drug discovery catalyst for neglected diseases. PLoS One 8: e62906. http://dx.doi.org/10.1371/journal .pone.0062906.
    • (2013) PLoS One , vol.8 , pp. e62906
    • Spangenberg, T.1    Burrows, J.N.2    Kowalczyk, P.3    McDonald, S.4    Wells, T.N.C.5    Willis, P.6
  • 25
    • 26044468809 scopus 로고    scopus 로고
    • Opportunities and challenges in antiparasitic drug discovery
    • Pink R, Hudson A, Mouriès MA, Bendig M. 2005. Opportunities and challenges in antiparasitic drug discovery. Nat. Rev. Drug Discov. 4: 727-740. http://dx.doi.org/10.1038/nrd1824.
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 727-740
    • Pink, R.1    Hudson, A.2    Mouriès, M.A.3    Bendig, M.4
  • 26
    • 0242406992 scopus 로고    scopus 로고
    • Antimalarial drug discovery: Old and new approaches
    • Rosenthal PJ. 2003. Antimalarial drug discovery: old and new approaches. J. Exp. Biol. 206: 3735-3744. http://dx.doi.org/10.1242/jeb.00589.
    • (2003) J. Exp. Biol. , vol.206 , pp. 3735-3744
    • Rosenthal, P.J.1
  • 27
    • 0032895561 scopus 로고    scopus 로고
    • Current strategies in the search for novel antiparasitic agents
    • Witty M. 1999. Current strategies in the search for novel antiparasitic agents. Int. J. Parasitol. 29: 95-103. http://dx.doi.org/10.1016/S0020-7519 (98)00193-3.
    • (1999) Int. J. Parasitol. , vol.29 , pp. 95-103
    • Witty, M.1
  • 28
    • 9444230640 scopus 로고    scopus 로고
    • The life and times of ivermectin - A success story
    • Omura S, Crump A. 2004. The life and times of ivermectin-a success story. Nat. Rev. Microbiol. 2: 984-989. http://dx.doi.org/10.1038 /nrmicro1048.
    • (2004) Nat. Rev. Microbiol. , vol.2 , pp. 984-989
    • Omura, S.1    Crump, A.2
  • 29
    • 10944233987 scopus 로고    scopus 로고
    • Research on infectious diseases requires better coordination
    • Ridley RG. 2004. Research on infectious diseases requires better coordination. Nat. Med. 10: S137-S140. http://dx.doi.org/10.1038/nm1153.
    • (2004) Nat. Med. , vol.10 , pp. S137-S140
    • Ridley, R.G.1
  • 30
    • 30744457206 scopus 로고    scopus 로고
    • Drug development for tropical diseases-present situation, future perspectives
    • Horton J. 2003. Drug development for tropical diseases-present situation, future perspectives. Trends Parasitol. 19: P06.
    • (2003) Trends Parasitol. , vol.19 , pp. P06
    • Horton, J.1
  • 31
    • 84887357069 scopus 로고
    • Toxoplasmic encephalitis in children
    • Sabin AB. 1941. Toxoplasmic encephalitis in children. JAMA 116: 801-807.
    • (1941) JAMA , vol.116 , pp. 801-807
    • Sabin, A.B.1
  • 32
    • 0017653908 scopus 로고
    • Experimental amebiasis. II. Hepatic amebiasis in the newborn hamster
    • Mattern CF, Keister DB. 1977. Experimental amebiasis. II. Hepatic amebiasis in the newborn hamster. Am. J. Trop. Med. Hyg. 26: 402-411.
    • (1977) Am. J. Trop. Med. Hyg. , vol.26 , pp. 402-411
    • Mattern, C.F.1    Keister, D.B.2
  • 33
    • 57949103535 scopus 로고    scopus 로고
    • Toxoplasma gondii: A simple high-throughput assay for drug screening in vitro
    • Jin C, Kaewintajuk K, Jiang J, Jeong W, Kamata M, Kim HS, Wataya Y, Park H. 2009. Toxoplasma gondii: a simple high-throughput assay for drug screening in vitro. Exp. Parasitol. 121: 132-136. http://dx.doi.org/10 .1016/j.exppara.2008.10.006.
    • (2009) Exp. Parasitol. , vol.121 , pp. 132-136
    • Jin, C.1    Kaewintajuk, K.2    Jiang, J.3    Jeong, W.4    Kamata, M.5    Kim, H.S.6    Wataya, Y.7    Park, H.8
  • 34
    • 0035010668 scopus 로고    scopus 로고
    • Drug susceptibility testing of anaerobic protozoa
    • Upcroft JA, Upcroft P. 2001. Drug susceptibility testing of anaerobic protozoa. Antimicrob. Agents Chemother. 45: 1810-1814. http://dx.doi .org/10.1128/AAC.45.6.1810-1814.2001.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 1810-1814
    • Upcroft, J.A.1    Upcroft, P.2
  • 36
    • 12244279339 scopus 로고    scopus 로고
    • Efficacy of atovaquone combined with clindamycin against murine infection with a cystogenic (Me49) strain of Toxoplasma gondii
    • Djurković-Djaković O, Milenković V, Nikolić A, Bobić B, Grujić J. 2002. Efficacy of atovaquone combined with clindamycin against murine infection with a cystogenic (Me49) strain of Toxoplasma gondii. J. Antimicrob. Chemother. 50: 981-987. http://dx.doi.org/10.1093/jac/dkf251.
    • (2002) J. Antimicrob. Chemother. , vol.50 , pp. 981-987
    • Djurković-Djaković, O.1    Milenković, V.2    Nikolić, A.3    Bobić, B.4    Grujić, J.5
  • 40
    • 84863159115 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 2-(3-fluoro-4-nitro phenoxy)-N-phenylacetamide derivatives as novel potential affordable antitubercular agents
    • Ang W, Lin YN, Tao Y, Yang JZ, Pi WY, Yang YH, Luo YF, Deng Y, Wei YQ. 2012. Synthesis and biological evaluation of 2-(3-fluoro-4-nitro phenoxy)- N-phenylacetamide derivatives as novel potential affordable antitubercular agents. Molecules 17: 2248-2258. http://dx.doi.org/10.3390 /molecules17022248.
    • (2012) Molecules , vol.17 , pp. 2248-2258
    • Ang, W.1    Lin, Y.N.2    Tao, Y.3    Yang, J.Z.4    Pi, W.Y.5    Yang, Y.H.6    Luo, Y.F.7    Deng, Y.8    Wei, Y.Q.9
  • 41
    • 80054986171 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of phenoxy-N-phenylacetamide derivatives as novel P-glycoprotein inhibitors
    • Lee K, Roh SH, Xia Y, Kang KW. 2011. Synthesis and biological evaluation of phenoxy-N-phenylacetamide derivatives as novel P-glycoprotein inhibitors. Bull. Korean Chem. Soc. 32: 3666-3674. http://dx.doi.org/10 .5012/bkcs.2011.32.10.3666.
    • (2011) Bull. Korean Chem. Soc. , vol.32 , pp. 3666-3674
    • Lee, K.1    Roh, S.H.2    Xia, Y.3    Kang, K.W.4
  • 42
    • 84898650563 scopus 로고    scopus 로고
    • Identification of Cryptosporidium parvum active chemical series by repurposing the open access Malaria Box
    • Bessoff K, Spangenberg T, Foderaro JE, Jumani RS, Ward GE, Huston CD. 2014. Identification of Cryptosporidium parvum active chemical series by repurposing the open access Malaria Box. Antimicrob. Agents Chemother. 58: 2731-2739. http://dx.doi.org/10.1128/AAC.02641-13.
    • (2014) Antimicrob. Agents Chemother. , vol.58 , pp. 2731-2739
    • Bessoff, K.1    Spangenberg, T.2    Foderaro, J.E.3    Jumani, R.S.4    Ward, G.E.5    Huston, C.D.6
  • 43
    • 34748867173 scopus 로고    scopus 로고
    • Intravitreal clindamycin for toxoplasmic retinochoroiditis
    • Sobrin L, Kump LI, Foster CS. 2007. Intravitreal clindamycin for toxoplasmic retinochoroiditis. Retina 27: 952-957. http://dx.doi.org/10.1097 /IAE.0b013e31804b3f0d.
    • (2007) Retina , vol.27 , pp. 952-957
    • Sobrin, L.1    Kump, L.I.2    Foster, C.S.3
  • 44
    • 78650846839 scopus 로고    scopus 로고
    • Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosis
    • Soheilian M, Ramezani A, Azimzadeh A, Sadoughi MM, Dehghan MH, Shahghadami R, Yaseri M, Peyman GA. 2011. Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosis. Ophthalmology 118: 134-141. http://dx.doi.org/10.1016/j.ophtha.2010.04.020.
    • (2011) Ophthalmology , vol.118 , pp. 134-141
    • Soheilian, M.1    Ramezani, A.2    Azimzadeh, A.3    Sadoughi, M.M.4    Dehghan, M.H.5    Shahghadami, R.6    Yaseri, M.7    Peyman, G.A.8
  • 45
    • 27644587827 scopus 로고    scopus 로고
    • Prospective randomized trial of trimethoprim/sulfamethoxazole versus pyrimethamine and sulfadiazine in the treatment of ocular toxoplasmosis
    • Soheilian M, Sadoughi MM, Ghajarnia M, Dehghan MH, Yazdani S, Behboudi H, Anisian A, Peyman GA. 2005. Prospective randomized trial of trimethoprim/sulfamethoxazole versus pyrimethamine and sulfadiazine in the treatment of ocular toxoplasmosis. Ophthalmology 112: 1876-1882. http://dx.doi.org/10.1016/j.ophtha.2005.05.025.
    • (2005) Ophthalmology , vol.112 , pp. 1876-1882
    • Soheilian, M.1    Sadoughi, M.M.2    Ghajarnia, M.3    Dehghan, M.H.4    Yazdani, S.5    Behboudi, H.6    Anisian, A.7    Peyman, G.A.8
  • 46
    • 84893487091 scopus 로고    scopus 로고
    • Anti-apicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the Malaria Box
    • Bowman JD, Merino EF, Brooks CF, Striepen B, Carlier PR, Cassera MB. 2014. Anti-apicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the Malaria Box. Antimicrob. Agents Chemother. 58: 811-819. http://dx.doi.org/10.1128/AAC.01500-13.
    • (2014) Antimicrob. Agents Chemother. , vol.58 , pp. 811-819
    • Bowman, J.D.1    Merino, E.F.2    Brooks, C.F.3    Striepen, B.4    Carlier, P.R.5    Cassera, M.B.6
  • 47
    • 84879502018 scopus 로고    scopus 로고
    • Evaluating anti-Toxoplasma gondii activity of new series of phenylsemicarbazone and phenylthiosemicarbazones in vitro
    • Gomes MAGB, Carvalho LP, Rocha BS, Oliveira RR, de Melo EJT, Maria EJ. 2013. Evaluating anti-Toxoplasma gondii activity of new series of phenylsemicarbazone and phenylthiosemicarbazones in vitro. Med. Chem. Res. 22: 3574-3580. http://dx.doi.org/10.1007/s00044-012-0347-9.
    • (2013) Med. Chem. Res. , vol.22 , pp. 3574-3580
    • Gomes, M.A.G.B.1    Carvalho, L.P.2    Rocha, B.S.3    Oliveira, R.R.4    De Melo, E.J.T.5    Maria, E.J.6
  • 48
    • 0033840638 scopus 로고    scopus 로고
    • Anti-Toxoplasma activities of antiretroviral drugs and interactions with pyrimethamine and sulfadiazine in vitro
    • Derouin F, Santillana-Hayat M. 2000. Anti-Toxoplasma activities of antiretroviral drugs and interactions with pyrimethamine and sulfadiazine in vitro. Antimicrob. Agents Chemother. 44: 2575-2577. http://dx.doi.org /10.1128/AAC.44.9.2575-2577.2000.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 2575-2577
    • Derouin, F.1    Santillana-Hayat, M.2
  • 49
    • 84887224619 scopus 로고    scopus 로고
    • Fusidic acid is an effective treatment against Toxoplasma gondii and Listeria monocytogenes in vitro, but not in mice
    • Payne AJ, Neal LM, Knoll LJ. 2013. Fusidic acid is an effective treatment against Toxoplasma gondii and Listeria monocytogenes in vitro, but not in mice. Parasitol. Res. 112: 3859-3863. http://dx.doi.org/10.1007/s00436 -013-3574-1.
    • (2013) Parasitol. Res. , vol.112 , pp. 3859-3863
    • Payne, A.J.1    Neal, L.M.2    Knoll, L.J.3
  • 50
    • 34247142732 scopus 로고    scopus 로고
    • Growth inhibition of Toxoplasma gondii and Plasmodium falciparum by nanomolar concentrations of 1-hydroxy-2-dodecyl-4(1H)quinolone, a highaffinity inhibitor of alternative (type II) NADH dehydrogenases
    • Saleh A, Friesen J, Baumeister S, Gross U, Bohne W. 2007. Growth inhibition of Toxoplasma gondii and Plasmodium falciparum by nanomolar concentrations of 1-hydroxy-2-dodecyl-4(1H)quinolone, a highaffinity inhibitor of alternative (type II) NADH dehydrogenases. Antimicrob. Agents Chemother. 51: 1217-1222. http://dx.doi.org/10.1128/AAC .00895-06.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 1217-1222
    • Saleh, A.1    Friesen, J.2    Baumeister, S.3    Gross, U.4    Bohne, W.5
  • 51
    • 73849094311 scopus 로고    scopus 로고
    • In vitro and in vivo activities of 1-hydroxy-2-alkyl-4(1H)quinolone derivatives against Toxoplasma gondii
    • Bajohr LL, Ma L, Platte C, Liesenfeld O, Tietze LF, Groß U, Bohne W. 2010. In vitro and in vivo activities of 1-hydroxy-2-alkyl-4(1H)quinolone derivatives against Toxoplasma gondii. Antimicrob. Agents Chemother. 54: 517-521. http://dx.doi.org/10.1128/AAC.01001-09.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 517-521
    • Bajohr, L.L.1    Ma, L.2    Platte, C.3    Liesenfeld, O.4    Tietze, L.F.5    Groß, U.6    Bohne, W.7
  • 52
    • 34848872528 scopus 로고    scopus 로고
    • Experience with intravenous metronidazole to treat moderate-to-severe amebiasis in Japan
    • Kimura M, Nakamura T, Nawa Y. 2007. Experience with intravenous metronidazole to treat moderate-to-severe amebiasis in Japan. Am. J. Trop. Med. Hyg. 77: 381-385.
    • (2007) Am. J. Trop. Med. Hyg. , vol.77 , pp. 381-385
    • Kimura, M.1    Nakamura, T.2    Nawa, Y.3
  • 53
    • 19544362922 scopus 로고    scopus 로고
    • Antiparasitic therapy in children
    • Moon TD, Oberhelman RA. 2005. Antiparasitic therapy in children. Pediatr. Clin. North Am. 52: 917-948. http://dx.doi.org/10.1016/j.pcl.2005.02.012.
    • (2005) Pediatr. Clin. North Am. , vol.52 , pp. 917-948
    • Moon, T.D.1    Oberhelman, R.A.2
  • 54
    • 84889686091 scopus 로고    scopus 로고
    • Recent highlights in antiprotozoan drug development and resistance research
    • Buckner FS, Waters NC, Avery VM. 2012. Recent highlights in antiprotozoan drug development and resistance research. Int. J. Parasitol. Drugs Drug Resist. 2: 230-270. http://dx.doi.org/10.1016/j.ijpddr.2012.05 .002.
    • (2012) Int. J. Parasitol. Drugs Drug Resist. , vol.2 , pp. 230-270
    • Buckner, F.S.1    Waters, N.C.2    Avery, V.M.3


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