-
1
-
-
34250007601
-
Synthesis and antibacterial activity of new N-[2-(thiophen-3-yl)ethyl] piperazinyl quinolones
-
(Tokyo)
-
Letafat B, Emami S, Mohammadhosseini N, Faramarzi MA, Samadi N, Shafiee A, Foroumadi A. Synthesis and antibacterial activity of new N-[2-(thiophen-3-yl)ethyl] piperazinyl quinolones. Chem Pharm Bull (Tokyo), 2007; 55:894-898.
-
(2007)
Chem Pharm Bull
, vol.55
, pp. 894-898
-
-
Letafat, B.1
Emami, S.2
Mohammadhosseini, N.3
Faramarzi, M.A.4
Samadi, N.5
Shafiee, A.6
Foroumadi, A.7
-
2
-
-
33947135471
-
Synthesis and antibacterial activity of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine quinolones
-
Srivastava BK, Solanki M, Mishra B, Soni R, Jayadev S, Valani D, Jain M, Patel PR. Synthesis and antibacterial activity of 4,5,6,7-tetrahydrothieno[3,2-c]pyridine quinolones. Bioorg Med Chem Lett, 2007; 17:1924-1929.
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 1924-1929
-
-
Srivastava, B.K.1
Solanki, M.2
Mishra, B.3
Soni, R.4
Jayadev, S.5
Valani, D.6
Jain, M.7
Patel, P.R.8
-
3
-
-
0021891888
-
DNA topoisomerases
-
Wang JC. DNA topoisomerases. Annu Rev Biochem, 1985; 54:665-697.
-
(1985)
Annu Rev Biochem
, vol.54
, pp. 665-697
-
-
Wang, J.C.1
-
4
-
-
43449112181
-
Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: Contribution to reducing in vitro emergence of quinolone-resistant streptococcus pneumoniae
-
Okumura R, Hirata T, Onodera Y, Hoshino K, Otani T, Yamamoto T. Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: Contribution to reducing in vitro emergence of quinolone-resistant streptococcus pneumoniae. J Antimicrob Chemoth, 2008; 62:98-104.
-
(2008)
J Antimicrob Chemoth
, vol.62
, pp. 98-104
-
-
Okumura, R.1
Hirata, T.2
Onodera, Y.3
Hoshino, K.4
Otani, T.5
Yamamoto, T.6
-
5
-
-
0344825065
-
Development of fluoroquinolones as first-line drugs for tuberculosis--at long last
-
O'Brien RJ. Development of fluoroquinolones as first-line drugs for tuberculosis--at long last. Am J Resp Crit Care, 2003; 168:1266-1268.
-
(2003)
Am J Resp Crit Care
, vol.168
, pp. 1266-1268
-
-
O'Brien, R.J.1
-
6
-
-
33847681052
-
Antituberculosis drugs: Ten years of research
-
Janin Y L. Antituberculosis drugs: Ten years of research. Bioorg Med Chem, 2007; 15:2479-2513.
-
(2007)
Bioorg Med Chem
, vol.15
, pp. 2479-2513
-
-
Janin, Y.L.1
-
7
-
-
34547112538
-
Mycobacterium tuberculosis DNA gyrase as a target for drug discovery
-
Mdluli K, Ma Z. Mycobacterium tuberculosis DNA gyrase as a target for drug discovery. Infect Disord Drug Targets, 2007; 7:159-68.
-
(2007)
Infect Disord Drug Targets
, vol.7
, pp. 159-168
-
-
Mdluli, K.1
Ma, Z.2
-
9
-
-
0004944419
-
Cyclization of 2-aminopyridine derivatives. I. substituted ethyl 2-pyridyl amino methylenemalonates
-
Lappin GR. Cyclization of 2-aminopyridine derivatives. I. substituted ethyl 2-pyridyl amino methylenemalonates. J Am Chem Soc, 1948; 70:3348-3350.
-
(1948)
J Am Chem Soc
, vol.70
, pp. 3348-3350
-
-
Lappin, G.R.1
-
10
-
-
84985278773
-
Cycloacylation of Enamines, I.-Synthesis of 4-Quinolone-3-carboxylic Acids
-
Grohe K, Heitzer H. Cycloacylation of Enamines, I.-Synthesis of 4-Quinolone-3-carboxylic Acids. Liebigs Ann Chem, 1987; 1:29-37.
-
(1987)
Liebigs Ann Chem
, vol.1
, pp. 29-37
-
-
Grohe, K.1
Heitzer, H.2
-
11
-
-
0030061794
-
Studies on 6-amino quinolones: Synthesis and antibacterial evaluation of 6-amino-8-methylquinolones
-
Cecchetti V, Fravolini A, Lorenzini MC, Tabarrini O, Terni P, Xin T. Studies on 6-amino quinolones: Synthesis and antibacterial evaluation of 6-amino-8-methylquinolones. J Med Chem, 1996; 39:436-445.
-
(1996)
J Med Chem
, vol.39
, pp. 436-445
-
-
Cecchetti, V.1
Fravolini, A.2
Lorenzini, M.C.3
Tabarrini, O.4
Terni, P.5
Xin, T.6
-
12
-
-
0025608555
-
A direct approach to 2-substituted 1,4 dihydro-4-oxo-quinoline-3-carboxylates by palladium-catalyzed carbonylative cyclization
-
Torii S, Okumoto H, He Xu L. A direct approach to 2-substituted 1,4 dihydro-4-oxo-quinoline-3-carboxylates by palladium-catalyzed carbonylative cyclization. Tetrahedron Lett, 1990; 31: 7175-7178.
-
(1990)
Tetrahedron Lett
, vol.31
, pp. 7175-7178
-
-
Torii, S.1
Okumoto, H.2
He Xu, L.3
-
13
-
-
0028034698
-
The complex of DNA gyrase and quinolone drugs with DNA forms a barrier to transcription by RNA polymerase
-
Willmott C, Critchlow S, Eperon I, Maxwell A. The complex of DNA gyrase and quinolone drugs with DNA forms a barrier to transcription by RNA polymerase. J Mol Biol, 1994; 242:351-363.
-
(1994)
J Mol Biol
, vol.242
, pp. 351-363
-
-
Willmott, C.1
Critchlow, S.2
Eperon, I.3
Maxwell, A.4
-
15
-
-
0034677898
-
Roles of topoisomerases in maintaining steadystate DNA supercoiling in escherichia coli
-
Zechiedrich EL, Khodursky AB, Bachellier S, Schneider R, Chen D, Lilley DM, Cozzarelli NR. Roles of topoisomerases in maintaining steadystate DNA supercoiling in escherichia coli. J Biol Chem, 2000; 275:8103-8113.
-
(2000)
J Biol Chem
, vol.275
, pp. 8103-8113
-
-
Zechiedrich, E.L.1
Khodursky, A.B.2
Bachellier, S.3
Schneider, R.4
Chen, D.5
Lilley, D.M.6
Cozzarelli, N.R.7
-
17
-
-
30144434477
-
Mechanochemical analysis of DNA gyrase using rotor bead tracking
-
Gore J, Bryant Z, Stone MD, Nöllmann M, Cozzarelli NR, Bustamante C. Mechanochemical analysis of DNA gyrase using rotor bead tracking. Nature, 2006; 439:100-104.
-
(2006)
Nature
, vol.439
, pp. 100-104
-
-
Gore, J.1
Bryant, Z.2
Stone, M.D.3
Nöllmann, M.4
Cozzarelli, N.R.5
Bustamante, C.6
-
18
-
-
0004190946
-
-
(Ed. V. T. Andriole), Academic Press, San Diego
-
Gootz, T. D.; Brighty, K. E., In the Quinolones, (Ed. V. T. Andriole), Academic Press, San Diego, 29, 1998.
-
(1998)
In the Quinolones
, vol.29
-
-
Gootz, T.D.1
Brighty, K.E.2
-
19
-
-
0018422012
-
Site-specific cleavage of DNA by E. coli DNA gyrase
-
Morrison A, Cozzarelli NR. Site-specific cleavage of DNA by E. coli DNA gyrase. Cell, 1979; 17:175-184.
-
(1979)
Cell
, vol.17
, pp. 175-184
-
-
Morrison, A.1
Cozzarelli, N.R.2
-
20
-
-
0029922437
-
Using SAR and QSAR analysis to model the activity and structure of the quinolone-DNA complex
-
Llorente B, Leclerc F, Cedergren R. Using SAR and QSAR analysis to model the activity and structure of the quinolone-DNA complex. Bioorg Med Chem, 1996; 4:61-71.
-
(1996)
Bioorg Med Chem
, vol.4
, pp. 61-71
-
-
Llorente, B.1
Leclerc, F.2
Cedergren, R.3
-
21
-
-
0028316927
-
Structure-activity and structure side-effect relationships for the quinolone anti bacterials
-
Domagala JM. Structure-activity and structure side-effect relationships for the quinolone anti bacterials. J Antimicrob Chemother, 1994; 33:685-706.
-
(1994)
J Antimicrob Chemother
, vol.33
, pp. 685-706
-
-
Domagala, J.M.1
-
22
-
-
0029886964
-
Quinolones: Structure-activity relationships and future predictions
-
Tillotson G S. Quinolones: Structure-activity relationships and future predictions. J Med Microbiol, 1996; 44:320-324.
-
(1996)
J Med Microbiol
, vol.44
, pp. 320-324
-
-
Tillotson, G.S.1
-
23
-
-
0029955365
-
Studies on quinolone antibacterials. IV. Structure-activity relationships of antibacterial activity and side effects for 5-or 8-substituted and 5,8-disubstituted-7(3-amino-1-pyrrolidinyl)-1-cyclopropyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids
-
(Tokyo),
-
Yoshida T, Yamamoto Y, Orita H, et al. Studies on quinolone antibacterials. IV. Structure-activity relationships of antibacterial activity and side effects for 5-or 8-substituted and 5,8-disubstituted-7(3-amino-1-pyrrolidinyl)-1-cyclopropyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids. Chem Pharm Bull (Tokyo), 1996; 44:1074-1085.
-
(1996)
Chem Pharm Bull
, vol.44
, pp. 1074-1085
-
-
Yoshida, T.1
Yamamoto, Y.2
Orita, H.3
-
24
-
-
0344936960
-
Novel fluoroquinolone, structure activity, and design of new potent and safe agents
-
In:, (San Francisco). Washington, DC: American Society for Microbiology
-
Ledoussal B, Almstead JK, Flaim CP. Novel fluoroquinolone, structure activity, and design of new potent and safe agents. In: Program and abstracts of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy (San Francisco). Washington, DC: American Society for Microbiology, 1999.
-
(1999)
Program and abstracts of the 39th Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
Ledoussal, B.1
Almstead, J.K.2
Flaim, C.P.3
-
25
-
-
0033533871
-
Synthesis and antimicrobial activity of 4(H)-4-oxoquinolizine derivatives: Consequences of structural modification at the C-8 position
-
Ma Z, Chu DT, Cooper CS, et al. Synthesis and antimicrobial activity of 4(H)-4-oxoquinolizine derivatives: consequences of structural modification at the C-8 position. J Med Chem, 1999; 42: 4202-4213.
-
(1999)
J Med Chem
, vol.42
, pp. 4202-4213
-
-
Ma, Z.1
Chu, D.T.2
Cooper, C.S.3
-
26
-
-
0034671255
-
The complex of DNA gyrase and quinolone drugs on DNA forms a barrier to the T7 DNA polymerase replication complex
-
Wentzell L, Maxwell A. The complex of DNA gyrase and quinolone drugs on DNA forms a barrier to the T7 DNA polymerase replication complex. J Mol Biol, 2000; 304:779-791.
-
(2000)
J Mol Biol
, vol.304
, pp. 779-791
-
-
Wentzell, L.1
Maxwell, A.2
-
27
-
-
0034640525
-
Distinct effects of the UvrD helicase on topoisomerase-quinolone-DNA ternary complexes
-
Shea ME, Hiasa H. Distinct effects of the UvrD helicase on topoisomerase-quinolone-DNA ternary complexes. J Biol Chem, 2000; 275:14649-14658.
-
(2000)
J Biol Chem
, vol.275
, pp. 14649-14658
-
-
Shea, M.E.1
Hiasa, H.2
-
28
-
-
0025282176
-
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli
-
Yoshida H, Bogaki M, Nakamura M, Nakamura S. Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli. Antimicrob Agents Chemother, 1990; 34:1271-2.
-
(1990)
Antimicrob Agents Chemother
, vol.34
, pp. 1271-1272
-
-
Yoshida, H.1
Bogaki, M.2
Nakamura, M.3
Nakamura, S.4
-
29
-
-
0032758083
-
Mechanisms of fluoroquinolone resistance: An update 1994-1998
-
Piddock LJV. Mechanisms of fluoroquinolone resistance: An update 1994-1998. Drugs, 1999; 58:11-18.
-
(1999)
Drugs
, vol.58
, pp. 11-18
-
-
Piddock, L.J.V.1
-
30
-
-
0033736170
-
The interaction of drugs with DNA gyrase: A model for the molecular basis of quinolone action
-
Heddle J, Barnard F, Wentzell L, Maxwell A. The interaction of drugs with DNA gyrase: A model for the molecular basis of quinolone action. Nucleosides, Nucleotides Nucleic Acids, 2000; 19:1249-1264.
-
(2000)
Nucleosides, Nucleotides Nucleic Acids
, vol.19
, pp. 1249-1264
-
-
Heddle, J.1
Barnard, F.2
Wentzell, L.3
Maxwell, A.4
-
31
-
-
0026646102
-
Quinolone binding to DNA is mediated by magnesium ions
-
Palù G, Valisena S, Ciarrocchi G, Gatto B, Palumbo M. Quinolone binding to DNA is mediated by magnesium ions. Proc Natl Acad Sci U. S. A., 1992; 89:9671-9675.
-
(1992)
Proc Natl Acad Sci U. S. A.
, vol.89
, pp. 9671-9675
-
-
Palù, G.1
Valisena, S.2
Ciarrocchi, G.3
Gatto, B.4
Palumbo, M.5
-
32
-
-
0035800671
-
Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions
-
Sissi C, Perdonà E, Domenici E, Feriani A, Howells A, Maxwell A, Palumbo, M. Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions. J Mol Biol, 2001; 311:195-203.
-
(2001)
J Mol Biol
, vol.311
, pp. 195-203
-
-
Sissi, C.1
Perdonà, E.2
Domenici, E.3
Feriani, A.4
Howells, A.5
Maxwell, A.6
Palumbo, M.7
-
33
-
-
2942746909
-
Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: The target of the drugs is DNA
-
Shen, LL, Pernet AG. Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: The target of the drugs is DNA. Proc Natl Acad Sci U. S. A., 1985; 82:307-311.
-
(1985)
Proc Natl Acad Sci U. S. A.
, vol.82
, pp. 307-311
-
-
Shen, L.L.1
Pernet, A.G.2
-
34
-
-
0029904283
-
DNA cleavage is not required for the binding of quinolone drugs to the DNA gyrase-DNA complex
-
Critchlow SE, Maxwell A. DNA cleavage is not required for the binding of quinolone drugs to the DNA gyrase-DNA complex. Biochemistry, 1996; 35:7387-7393.
-
(1996)
Biochemistry
, vol.35
, pp. 7387-7393
-
-
Critchlow, S.E.1
Maxwell, A.2
-
35
-
-
0032575668
-
The DNA gyrasequinolone complex. ATP hydrolysis and the mechanism of DNA cleavage
-
Kampranis SC, Maxwell A. The DNA gyrasequinolone complex. ATP hydrolysis and the mechanism of DNA cleavage. J Biol Chem, 1998; 273:22615-22626.
-
(1998)
J Biol Chem
, vol.273
, pp. 22615-22626
-
-
Kampranis, S.C.1
Maxwell, A.2
-
36
-
-
0021749639
-
Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II
-
Chen GL, Yang L, Rowe TC, Halligan BD, Tewey KM, Liu, LF. Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem, 1984; 259:13560-13566.
-
(1984)
J Biol Chem
, vol.259
, pp. 13560-13566
-
-
Chen, G.L.1
Yang, L.2
Rowe, T.C.3
Halligan, B.D.4
Tewey, K.M.5
Liu, L.F.6
-
37
-
-
0023184331
-
Bacterial evolution
-
Woese CR. Bacterial evolution. Microbiol Rev, 1987; 51:221-271.
-
(1987)
Microbiol Rev
, vol.51
, pp. 221-271
-
-
Woese, C.R.1
-
38
-
-
0022532482
-
Mechanisms of DNA synthesis and topoisomerisation in archaebacteria; reverse gyration in vitro and in vivo
-
Forterre P, Nadal M, Elie C, Mirambeau G, Jaxel C, and Duguet M. Mechanisms of DNA synthesis and topoisomerisation in archaebacteria; reverse gyration in vitro and in vivo. System Appl Microbiol, 1986; 7:67-71.
-
(1986)
System Appl Microbiol
, vol.7
, pp. 67-71
-
-
Forterre, P.1
Nadal, M.2
Elie, C.3
Mirambeau, G.4
Jaxel, C.5
Duguet, M.6
-
39
-
-
0024573337
-
Ciprofloxacin and etoposide (VP16) produce a similar pattern of DNA cleavage in a plasmid of an archaebacterium
-
Sioud M, Forterre P. Ciprofloxacin and etoposide (VP16) produce a similar pattern of DNA cleavage in a plasmid of an archaebacterium. Biochemistry, 1989; 28:3638-3641.
-
(1989)
Biochemistry
, vol.28
, pp. 3638-3641
-
-
Sioud, M.1
Forterre, P.2
-
40
-
-
45749087355
-
Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties of novel indeno[2,1-c]quinolin-7-one and indeno[1,2-c]isoquinolin-5,11-dione derivatives
-
Ryckebusch A, Garcin D, Lansiaux A, Goossens J, Baldeyrou B, Houssin R, Bailly C, Hénichart J. Synthesis, cytotoxicity, DNA interaction, and topoisomerase II inhibition properties of novel indeno[2,1-c]quinolin-7-one and indeno[1,2-c]isoquinolin-5,11-dione derivatives. J Med Chem, 2008; 51:3617-3629.
-
(2008)
J Med Chem
, vol.51
, pp. 3617-3629
-
-
Ryckebusch, A.1
Garcin, D.2
Lansiaux, A.3
Goossens, J.4
Baldeyrou, B.5
Houssin, R.6
Bailly, C.7
Hénichart, J.8
-
41
-
-
18244400107
-
Synthesis and in vitro and in vivo antitumor activity of 2-phenylpyrroloquinolin-4-ones
-
Ferlin MG, Chiarelotto G, Gasparotto V, Dalla Via L, Pezzi V, Barzon L, Palù G, Castagliuolo I. Synthesis and in vitro and in vivo antitumor activity of 2-phenylpyrroloquinolin-4-ones. J Med Chem, 2005; 48:3417-3427.
-
(2005)
J Med Chem
, vol.48
, pp. 3417-3427
-
-
Ferlin, M.G.1
Chiarelotto, G.2
Gasparotto, V.3
dalla Via, L.4
Pezzi, V.5
Barzon, L.6
Palù, G.7
Castagliuolo, I.8
-
42
-
-
33645380372
-
Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: A new class of antimitotic agents devoid of aromatase activity
-
Gasparotto V, Castagliuolo I, Chiarelotto G, Pezzi V, Montanaro D, Brun P, Palù G, Viola G, Ferlin MG. Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: A new class of antimitotic agents devoid of aromatase activity. J Med Chem, 2006; 49:1910-1915.
-
(2006)
J Med Chem
, vol.49
, pp. 1910-1915
-
-
Gasparotto, V.1
Castagliuolo, I.2
Chiarelotto, G.3
Pezzi, V.4
Montanaro, D.5
Brun, P.6
Palù, G.7
Viola, G.8
Ferlin, M.G.9
-
43
-
-
0027276902
-
DNA topoisomerase I and II in cancer chemotherapy: Update and perspectives
-
Pommier Y. DNA topoisomerase I and II in cancer chemotherapy: Update and perspectives. Cancer Chemother Pharmacol, 1993; 32:103-108.
-
(1993)
Cancer Chemother Pharmacol
, vol.32
, pp. 103-108
-
-
Pommier, Y.1
-
44
-
-
19644388869
-
HER-2/neu and topoisomerase IIa gene amplification and protein expression in invasive breast carcinomas: Chromogenic in situ hybridization and immunohistochemical analyses
-
Bhargava R, Lal P, Chen B. HER-2/neu and topoisomerase IIa gene amplification and protein expression in invasive breast carcinomas: Chromogenic in situ hybridization and immunohistochemical analyses. Am J Clin Pathol, 2005; 123:889-895.
-
(2005)
Am J Clin Pathol
, vol.123
, pp. 889-895
-
-
Bhargava, R.1
Lal, P.2
Chen, B.3
-
45
-
-
43849086499
-
The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines
-
Schmidt F, Knobbe CB, Frank B, Weller M, Wolburg H. The topoisomerase II inhibitor, genistein, induces G2/M arrest and apoptosis in human malignant glioma cell lines. Oncol Rep, 2008; 19:1061-1066.
-
(2008)
Oncol Rep
, vol.19
, pp. 1061-1066
-
-
Schmidt, F.1
Knobbe, C.B.2
Frank, B.3
Weller, M.4
Wolburg, H.5
-
46
-
-
2942720408
-
Antiviral properties of quinolone-based drugs
-
Richter S, Parolin C, Palumbo M, Palu G. Antiviral properties of quinolone-based drugs. Curr Drug Targets Infect Disord, 2004; 4:111-116.
-
(2004)
Curr Drug Targets Infect Disord
, vol.4
, pp. 111-116
-
-
Richter, S.1
Parolin, C.2
Palumbo, M.3
Palu, G.4
-
48
-
-
0025653684
-
DNA topoisomerases as anticancer drug targets
-
(San Diego, Calif.)
-
Schneider E, Hsiang YH, Liu LF. DNA topoisomerases as anticancer drug targets. Advances in Pharmacology (San Diego, Calif.), 1990; 21:149-183.
-
(1990)
Advances in Pharmacology
, vol.21
, pp. 149-183
-
-
Schneider, E.1
Hsiang, Y.H.2
Liu, L.F.3
-
49
-
-
0024467301
-
Topoisomerase II as a target of antileukemia drugs: A review of controversial areas
-
Zwelling LA. Topoisomerase II as a target of antileukemia drugs: A review of controversial areas. Hematologic Pathology, 1989; 3:101-112.
-
(1989)
Hematologic Pathology
, vol.3
, pp. 101-112
-
-
Zwelling, L.A.1
-
50
-
-
0018628599
-
Escherichia coli mutants thermosensitive for deoxyribonucleic acid gyrase subunit A: Effects on deoxyribonucleic acid replication, transcription, and bacteriophage growth
-
Kreuzer KN, Cozzarelli NR. Escherichia coli mutants thermosensitive for deoxyribonucleic acid gyrase subunit A: Effects on deoxyribonucleic acid replication, transcription, and bacteriophage growth. J Bacteriol, 1979; 140:424-435.
-
(1979)
J Bacteriol
, vol.140
, pp. 424-435
-
-
Kreuzer, K.N.1
Cozzarelli, N.R.2
-
51
-
-
0026178922
-
Catalytic function of DNA topoisomerase II
-
Osheroff N, Zechiedrich EL, Gale, KC. Catalytic function of DNA topoisomerase II. BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology, 1991; 13:269-273.
-
(1991)
BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
, vol.13
, pp. 269-273
-
-
Osheroff, N.1
Zechiedrich, E.L.2
Gale, K.C.3
-
52
-
-
0024278459
-
Inhibitors of DNA topoisomerases
-
Drlica K, Franco RJ. Inhibitors of DNA topoisomerases. Biochemistry, 1988; 27:2253-2259.
-
(1988)
Biochemistry
, vol.27
, pp. 2253-2259
-
-
Drlica, K.1
Franco, R.J.2
-
53
-
-
0026100406
-
Fluoroquinolone antimicrobial agents
-
Hooper DC, Wolfson JS. Fluoroquinolone antimicrobial agents. N Engl J Med, 1991; 324: 384-94.
-
(1991)
N Engl J Med
, vol.324
, pp. 384-394
-
-
Hooper, D.C.1
Wolfson, J.S.2
-
54
-
-
0026720440
-
Antitumor quinolones with mammalian topo isomerase II mediated DNA cleavage activity
-
Yamashita Y, Ashizawa T, Morimoto M., et al. Antitumor quinolones with mammalian topo isomerase II mediated DNA cleavage activity. Cancer Res, 1992; 52:2818-2822.
-
(1992)
Cancer Res
, vol.52
, pp. 2818-2822
-
-
Yamashita, Y.1
Ashizawa, T.2
Morimoto, M.3
-
55
-
-
0022538665
-
Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts
-
Hussy P, Maass G, Tummler B, Grosse F, Schomburg U. Effect of 4-quinolones and novobiocin on calf thymus DNA polymerase alpha primase complex, topoisomerases I and II, and growth of mammalian lymphoblasts. Antimicrob Agents Chemother, 1986; 29:1073-1078.
-
(1986)
Antimicrob Agents Chemother
, vol.29
, pp. 1073-1078
-
-
Hussy, P.1
Maass, G.2
Tummler, B.3
Grosse, F.4
Schomburg, U.5
-
56
-
-
0019295604
-
In vitro antimicrobial activity of rosoxacin against Neisseria gonorrhoeae, Chlamydia trachomatis, and Ureaplasma urealyticum
-
Dobson RA, O'Connor JR, Poulin SA, Kundsin RB, Smith TF, Came PE. In vitro antimicrobial activity of rosoxacin against Neisseria gonorrhoeae, Chlamydia trachomatis, and Ureaplasma urealyticum. Antimicrob Agents Chemother, 1980; 18:738-740.
-
(1980)
Antimicrob Agents Chemother
, vol.18
, pp. 738-740
-
-
Dobson, R.A.1
O'Connor, J.R.2
Poulin, S.A.3
Kundsin, R.B.4
Smith, T.F.5
Came, P.E.6
-
57
-
-
0021719716
-
1-Ethyl-1,4-dihydro-4-oxo-7-(pyridinyl)-3-quinolinecarboxylic acids. II
-
Carabateas PM, Brundage, RP, Gellote MD, Lorenz RR, Opalka CJ, Thielking WH, Williams GL, Lesher GY. 1-Ethyl-1,4-dihydro-4-oxo-7-(pyridinyl)-3-quinolinecarboxylic acids. II. Synthesis J Heterocycl Chem, 1984; 21:1857-1863.
-
(1984)
Synthesis J Heterocycl Chem
, vol.21
, pp. 1857-1863
-
-
Carabateas, P.M.1
Brundage, R.P.2
Gellote, M.D.3
Lorenz, R.R.4
Opalka, C.J.5
Thielking, W.H.6
Williams, G.L.7
Lesher, G.Y.8
-
58
-
-
0027382944
-
Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and related derivatives
-
Wentland MP, Lesher GY, Reuman M, Gruett M D, Singh B, Aldous, S C, et al. Mammalian topoisomerase II inhibitory activity of 1-cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic acid and related derivatives. J Med Chem, 1993; 36:2801-2809.
-
(1993)
J Med Chem
, vol.36
, pp. 2801-2809
-
-
Wentland, M.P.1
Lesher, G.Y.2
Reuman, M.3
Gruett, M.D.4
Singh, B.5
Aldous, S.C.6
-
59
-
-
0029008124
-
3-benzyl-quinolones: Novel, potent inhibitors of mammalian topoisomerase II
-
Eissenstat MA, Kuo G, Weaver JD, Wentland, MP. 3-benzyl-quinolones: Novel, potent inhibitors of mammalian topoisomerase II. Bioorg Med Chem Lett, 1995; 5:1021-1026.
-
(1995)
Bioorg Med Chem Lett
, vol.5
, pp. 1021-1026
-
-
Eissenstat, M.A.1
Kuo, G.2
Weaver, J.D.3
Wentland, M.P.4
-
60
-
-
0026567611
-
Induction of calf thymus topoisomerase II-mediated DNA breakage by the antibacterial isothiazoloquinolones A-65281 and A-65282
-
Kohlbrenner WE, Wideburg N, Weigl D, Saldivar A, Chu, DT. Induction of calf thymus topoisomerase II-mediated DNA breakage by the antibacterial isothiazoloquinolones A-65281 and A-65282. Antimicrob Agents Chemother, 1992; 36:81-86.
-
(1992)
Antimicrob Agents Chemother
, vol.36
, pp. 81-86
-
-
Kohlbrenner, W.E.1
Wideburg, N.2
Weigl, D.3
Saldivar, A.4
Chu, D.T.5
-
61
-
-
0036581843
-
Synthesis, photochemical synthesis and antitumor evaluation of novel derivatives of thieno[3',2':4,5]thieno[2,3-c]quinolones
-
(Tokyo)
-
DoganKoruznjak J, Slade N, Zamola B, Pavelić K, Karminski-Zamola G. Synthesis, photochemical synthesis and antitumor evaluation of novel derivatives of thieno[3',2':4,5]thieno[2,3-c]quinolones. Chem Pharm Bull (Tokyo), 2002; 50:656-660.
-
(2002)
Chem Pharm Bull
, vol.50
, pp. 656-660
-
-
Dogan Koruznjak, J.1
Slade, N.2
Zamola, B.3
Pavelić, K.4
Karminski-Zamola, G.5
-
62
-
-
0026333913
-
Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage
-
Robinson MJ, Martin BA, Gootz TD. Effects of quinolone derivatives on eukaryotic topoisomerase II. A novel mechanism for enhancement of enzyme-mediated DNA cleavage. J Biol Chem, 1991; 266:14585-14592.
-
(1991)
J Biol Chem
, vol.266
, pp. 14585-14592
-
-
Robinson, M.J.1
Martin, B.A.2
Gootz, T.D.3
-
63
-
-
0026568084
-
Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group
-
Robinson MJ, Martin BA, Gootz TD, McGuirk PR, Osheroff N. Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group. Antimicrob Agents Chemother, 1992; 36:751-756.
-
(1992)
Antimicrob Agents Chemother
, vol.36
, pp. 751-756
-
-
Robinson, M.J.1
Martin, B.A.2
Gootz, T.D.3
McGuirk, P.R.4
Osheroff, N.5
-
64
-
-
0027375881
-
Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: Correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential
-
Elsea SH, McGuirk PR, Gootz TD, Moynihan M, Osheroff N. Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: Correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential. Antimicrob Agents Chemother, 1993; 37:2179-2186.
-
(1993)
Antimicrob Agents Chemother
, vol.37
, pp. 2179-2186
-
-
Elsea, S.H.1
McGuirk, P.R.2
Gootz, T.D.3
Moynihan, M.4
Osheroff, N.5
-
65
-
-
0033979885
-
Engineering the specificity of antibacterial fluoroquinolones: Benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target in Streptococcus pneumoniae from topoisomerase IV to gyrase
-
Alovero FL, Pan XS, Morris JE, Manzo RH, Fisher LM. Engineering the specificity of antibacterial fluoroquinolones: Benzenesulfonamide modifications at C-7 of ciprofloxacin change its primary target in Streptococcus pneumoniae from topoisomerase IV to gyrase. Antimicrob Agents Chemother, 2000; 44:320-325.
-
(2000)
Antimicrob Agents Chemother
, vol.44
, pp. 320-325
-
-
Alovero, F.L.1
Pan, X.S.2
Morris, J.E.3
Manzo, R.H.4
Fisher, L.M.5
-
66
-
-
0028125853
-
Placement of alkyl substituents on the C-7 piperazine ring of fluoroquinolones: Dramatic differential effects on mammalian topoisomerase II and DNA gyrase
-
Gootz TD, McGuirk PR, Moynihan MS, Haskell SL. Placement of alkyl substituents on the C-7 piperazine ring of fluoroquinolones: Dramatic differential effects on mammalian topoisomerase II and DNA gyrase. Antimicrob Agents Chemother, 1994; 38:130-133.
-
(1994)
Antimicrob Agents Chemother
, vol.38
, pp. 130-133
-
-
Gootz, T.D.1
McGuirk, P.R.2
Moynihan, M.S.3
Haskell, S.L.4
-
67
-
-
0027070672
-
Fluoroquinolones: Relationships between structural variations, mammalian cell cytotoxicity, and antimicrobial activity
-
Suto MJ, Domagala JM, Roland GE, Mailloux GB, Cohen MA. Fluoroquinolones: Relationships between structural variations, mammalian cell cytotoxicity, and antimicrobial activity. J Med Chem, 1992; 35:4745-4750.
-
(1992)
J Med Chem
, vol.35
, pp. 4745-4750
-
-
Suto, M.J.1
Domagala, J.M.2
Roland, G.E.3
Mailloux, G.B.4
Cohen, M.A.5
-
68
-
-
0024466108
-
Use of in vitro topoisomerase II assays for studying quinolone antibacterial agents
-
Barrett JF, Gootz TD, McGuirk PR, Farrell CA, Sokolowski SA. Use of in vitro topoisomerase II assays for studying quinolone antibacterial agents. Antimicrob Agents Chemother, 1989; 33:1697-1703.
-
(1989)
Antimicrob Agents Chemother
, vol.33
, pp. 1697-1703
-
-
Barrett, J.F.1
Gootz, T.D.2
McGuirk, P.R.3
Farrell, C.A.4
Sokolowski, S.A.5
-
69
-
-
77950631247
-
Voreloxin, a first-in-class anticancer quinolone derivative, in Relapsed/Refractory solid tumors: A report on two dosing schedules
-
Advani RH, Hurwitz HI, Gordon MS, Ebbinghaus SW, Mendelson DS, Wakelee HA, et al. Voreloxin, a first-in-class anticancer quinolone derivative, in Relapsed/Refractory solid tumors: A report on two dosing schedules. Clin Canc Res, 2010; 16:2167-2175.
-
(2010)
Clin Canc Res
, vol.16
, pp. 2167-2175
-
-
Advani, R.H.1
Hurwitz, H.I.2
Gordon, M.S.3
Ebbinghaus, S.W.4
Mendelson, D.S.5
Wakelee, H.A.6
-
70
-
-
84856206437
-
Preparation of thiazoloquinolonecarboxylic acid derivatives and their pharmaceutical compositions as antitumor agents
-
PCT Int. Appl. WO 89 12055 (1990, 113, 6328m)
-
Hosomi J, Asahina Y, Suzue S. PCT Int. Appl. WO 89 12055. Preparation of thiazoloquinolonecarboxylic acid derivatives and their pharmaceutical compositions as antitumor agents (Chem Abstr. 1990, 113, 6328m), 1989.
-
(1989)
Chem. Abstr
-
-
Hosomi, J.1
Asahina, Y.2
Suzue, S.3
-
71
-
-
0141884959
-
The quinolone family: From antibacterial to anticancer agents
-
Sissi C, Palumbo M. The quinolone family: From antibacterial to anticancer agents. Curr Med Chem:Anti-Cancer Agents. 2003; 3:439-450.
-
(2003)
Curr Med Chem:Anti-Cancer Agents
, vol.3
, pp. 439-450
-
-
Sissi, C.1
Palumbo, M.2
-
73
-
-
84855361282
-
Polycyclic quinolones (part1)-thieno [2,3-b] benzo [h] quinoline derivatives: Design, synthesis, preliminary in vitro and in silico studies
-
Submission no. Com-11-12374
-
Ahmed A, Daneshtalab, M. Polycyclic quinolones (part1)-thieno [2,3-b] benzo [h] quinoline derivatives: design, synthesis, preliminary in vitro and in silico studies. Heterocycl. Submission no. Com-11-12374.
-
Heterocycl.
-
-
Ahmed, A.1
Daneshtalab, M.2
-
74
-
-
0034657336
-
The role of STATs in transcriptional control and their impact on cellular function
-
Bromberg J, Darnell JE. The role of STATs in transcriptional control and their impact on cellular function. Oncogene, 2000; 19:2468-2473.
-
(2000)
Oncogene
, vol.19
, pp. 2468-2473
-
-
Bromberg, J.1
Darnell, J.E.2
-
75
-
-
0036731485
-
STATs: Transcriptional control and biological impact
-
Levy DE, Darnell JE. STATs: transcriptional control and biological impact. Nat Rev Mol Cell Biol, 2002; 3: 651-662.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 651-662
-
-
Levy, D.E.1
Darnell, J.E.2
-
76
-
-
33645839013
-
Signal transducers and activators of transcription (STATs): Novel targets of chemopreventive and chemotherapeutic drugs
-
Klampfer L. Signal transducers and activators of transcription (STATs): novel targets of chemopreventive and chemotherapeutic drugs. Curr Cancer Drug Targets, 2006; 6:107-121.
-
(2006)
Curr Cancer Drug Targets
, vol.6
, pp. 107-121
-
-
Klampfer, L.1
-
77
-
-
20944441928
-
Validating STAT3 in cancer therapy
-
Darnell JE. Validating STAT3 in cancer therapy. Nat Med, 2005; 11:595-596.
-
(2005)
Nat Med
, vol.11
, pp. 595-596
-
-
Darnell, J.E.1
-
78
-
-
20844444135
-
Targeting STAT3 in cancer therapy
-
Jing N, Tweardy DJ. Targeting STAT3 in cancer therapy. Anti-Cancer Drugs, 2005; 16:601-607.
-
(2005)
Anti-Cancer Drugs
, vol.16
, pp. 601-607
-
-
Jing, N.1
Tweardy, D.J.2
-
79
-
-
47749107900
-
Inhibition of the signal transducer and activator of transcription-3 (STAT3) signalling pathway by 4-oxo-1-phenyl-1,4-dihydro quinoline-3-carboxylic acid esters
-
Xu J, Cole DC, Chang CPB, Ayyad R, Asselin M, Hao W, Gibbons J, Jelinsky SA, Saraf KA, Park K. Inhibition of the signal transducer and activator of transcription-3 (STAT3) signalling pathway by 4-oxo-1-phenyl-1,4-dihydro quinoline-3-carboxylic acid esters. J Med Chem, 2008; 51: 4115-4121.
-
(2008)
J Med Chem
, vol.51
, pp. 4115-4121
-
-
Xu, J.1
Cole, D.C.2
Chang, C.P.B.3
Ayyad, R.4
Asselin, M.5
Hao, W.6
Gibbons, J.7
Jelinsky, S.A.8
Saraf, K.A.9
Park, K.10
-
80
-
-
33750456981
-
Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2
-
Golub AG, Yakovenko OY, Bdzhola VG, Sapelkin, VM, Zien P, Yarmoluk, SM. Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2. J Med Chem, 2006; 49: 6443-6450.
-
(2006)
J Med Chem
, vol.49
, pp. 6443-6450
-
-
Golub, A.G.1
Yakovenko, O.Y.2
Bdzhola, V.G.3
Sapelkin, V.M.4
Zien, P.5
Yarmoluk, S.M.6
-
81
-
-
0026646102
-
Quinolone binding to DNA is mediated by magnesium ions
-
Palù G, Valisena S, Ciarrocchi G, Gatto B, Palumbo M. Quinolone binding to DNA is mediated by magnesium ions. Proc Natl Acad Sci U. S. A., 1992; 89: 9671-9675.
-
(1992)
Proc Natl Acad Sci U. S. A.
, vol.89
, pp. 9671-9675
-
-
Palù, G.1
Valisena, S.2
Ciarrocchi, G.3
Gatto, B.4
Palumbo, M.5
-
82
-
-
2942746909
-
Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: The target of the drugs is DNA
-
Shen LL, Pernet AG. Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: The target of the drugs is DNA. Proc. Natl. Acad. Sci. U. S. A., 1985; 82:307-311.
-
(1985)
Proc. Natl. Acad. Sci. U. S. A.
, vol.82
, pp. 307-311
-
-
Shen, L.L.1
Pernet, A.G.2
-
83
-
-
0024533317
-
Mechanism of quinolone inhibition of DNA gyrase appearance of unique norfloxacin binding sites in enzyme-DNA complexes
-
2973-2878
-
Shen LL, Kohlbrenner WE, Weigl D, Baranowski J. Mechanism of quinolone inhibition of DNA gyrase appearance of unique norfloxacin binding sites in enzyme-DNA complexes. J Biol Chem, 1989; 264:2973-2878.
-
(1989)
J Biol Chem
, vol.264
-
-
Shen, L.L.1
Kohlbrenner, W.E.2
Weigl, D.3
Baranowski, J.4
-
84
-
-
0024580262
-
Mechanism of inhibition of DNA gyrase by quinolone antibacterials: Specificity and cooperativity of drug binding to DNA
-
Shen LL, Baranowski J, Pernet A G. Mechanism of inhibition of DNA gyrase by quinolone antibacterials: Specificity and cooperativity of drug binding to DNA. Biochemistry, 1989; 28:3879-3885.
-
(1989)
Biochemistry
, vol.28
, pp. 3879-3885
-
-
Shen, L.L.1
Baranowski, J.2
Pernet, A.G.3
-
85
-
-
0024546107
-
Mechanism of inhibition of DNA gyrase by quinolone antibacterials: A cooperative drug--DNA binding model
-
Shen LL, Mitscher LA, Sharma PN, O'Donnell TJ, Chu DW, Cooper CS, et al. Mechanism of inhibition of DNA gyrase by quinolone antibacterials: A cooperative drug--DNA binding model. Biochemistry, 1989; 28:3886-3894.
-
(1989)
Biochemistry
, vol.28
, pp. 3886-3894
-
-
Shen, L.L.1
Mitscher, L.A.2
Sharma, P.N.3
O'Donnell, T.J.4
Chu, D.W.5
Cooper, C.S.6
-
86
-
-
0027321566
-
On the mechanism of action of quinolone drugs
-
Palumbo M, Gatto B, Zagotto G, Palù G. On the mechanism of action of quinolone drugs. Trends Microbiol, 1993; 1:232-5.
-
(1993)
Trends Microbiol
, vol.1
, pp. 232-235
-
-
Palumbo, M.1
Gatto, B.2
Zagotto, G.3
Palù, G.4
-
88
-
-
84856191991
-
WO9602540, Preparation of piperazinoquinolonecarboxylates as antiviral agents
-
DE 4425647 A1 19960125
-
Bender W, Roeben W, Paesens A, Bartel, S. WO9602540, Preparation of piperazinoquinolonecarboxylates as antiviral agents. Ger. Offen. DE 4425647 A1 19960125, 1996.
-
(1996)
Ger. Offen
-
-
Bender, W.1
Roeben, W.2
Paesens, A.3
Bartel, S.4
-
89
-
-
84856184312
-
WO9602532, Preparation of 7-piperazinyl-1,4-dihydro-4-oxo-1-[4-(1H-1,2,4-triazol-1-ylmethyl) phenyl] quinoline-3-carboxylic acids as virucides
-
DE 4425660 A1 19960125
-
Bender W, Roeben W, Paesens A, Bartel S. WO9602532, Preparation of 7-piperazinyl-1,4-dihydro-4-oxo-1-[4-(1H-1,2,4-triazol-1-ylmethyl) phenyl] quinoline-3-carboxylic acids as virucides. Ger. Offen. DE 4425660 A1 19960125, 1996.
-
(1996)
Ger. Offen
-
-
Bender, W.1
Roeben, W.2
Paesens, A.3
Bartel, S.4
-
90
-
-
0025665238
-
Fluoroquinolones protect the human lymphocyte CEM cell line from HIV-1-mediated cytotoxicity
-
Nozaki-Renard J, Iino T, Sato Y, Marumoto Y, Ohta G, Furusawa M. Fluoroquinolones protect the human lymphocyte CEM cell line from HIV-1-mediated cytotoxicity. Cell Structure and Function, 1990; 15:295-299.
-
(1990)
Cell Structure and Function
, vol.15
, pp. 295-299
-
-
Nozaki-Renard, J.1
Iino, T.2
Sato, Y.3
Marumoto, Y.4
Ohta, G.5
Furusawa, M.6
-
91
-
-
0025637564
-
A fluoroquinolone (DR-3355) protects human lymphocyte cell lines from HIV-1-induced cytotoxicity
-
(London, England),
-
Nozaki-Renard J, Iino T, Sato Y, Marumoto Y, Ohta G, Furusawa M. A fluoroquinolone (DR-3355) protects human lymphocyte cell lines from HIV-1-induced cytotoxicity. AIDS (London, England), 1990; 4:1283-1286.
-
(1990)
AIDS
, vol.4
, pp. 1283-1286
-
-
Nozaki-Renard, J.1
Iino, T.2
Sato, Y.3
Marumoto, Y.4
Ohta, G.5
Furusawa, M.6
-
92
-
-
0030995059
-
Potent and selective inhibition of human immunodeficiency virus type 1 transcription by piperazinyloxoquinoline derivatives
-
Baba M, Okamoto M, Makino M, Kimura Y, Ikeuchi T, Sakaguchi T, et al. Potent and selective inhibition of human immunodeficiency virus type 1 transcription by piperazinyloxoquinoline derivatives. Antimicrob Agents Chemother, 1997; 41:1250-1255.
-
(1997)
Antimicrob Agents Chemother
, vol.41
, pp. 1250-1255
-
-
Baba, M.1
Okamoto, M.2
Makino, M.3
Kimura, Y.4
Ikeuchi, T.5
Sakaguchi, T.6
-
93
-
-
0033028772
-
Human immunodeficiency virus gene regulation as a target for antiviral chemotherapy
-
Daelemans D, Vandamme AM, De Clercq E. Human immunodeficiency virus gene regulation as a target for antiviral chemotherapy. Antiviral Chem Chemother, 1999; 10:1-14.
-
(1999)
Antiviral Chem Chemother
, vol.10
, pp. 1-14
-
-
Daelemans, D.1
Vandamme, A.M.2
De Clercq, E.3
-
94
-
-
0037416975
-
New antihuman immunodeficiency virus type 1 6-aminoquinolones: Mechanism of action
-
Parolin C, Gatto B, Del Vecchio C, Pecere T, Tramontano E, Cecchetti V, et al. New antihuman immunodeficiency virus type 1 6-aminoquinolones: Mechanism of action. Antimicrob Agents Chemother, 2003; 47:889-896.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 889-896
-
-
Parolin, C.1
Gatto, B.2
del Vecchio, C.3
Pecere, T.4
Tramontano, E.5
Cecchetti, V.6
-
95
-
-
6044239447
-
Structure modifications of 6-aminoquinolones with potent anti-HIV activity
-
Tabarrini O, Stevens M, Cecchetti V, Sabatini S, Dell'Uomo M, Manfroni G, et al. Structure modifications of 6-aminoquinolones with potent anti-HIV activity. J Med Chem, 2004; 47: 5567-78.
-
(2004)
J Med Chem
, vol.47
, pp. 5567-5578
-
-
Tabarrini, O.1
Stevens, M.2
Cecchetti, V.3
Sabatini, S.4
Dell'Uomo, M.5
Manfroni, G.6
-
96
-
-
51849133134
-
Structure-Activity relationship study on anti-HIV 6-desfluoroquinolones
-
Tabarrini O, Massari S, Daelemans D, Stevens M, Manfroni G, Sabatini S, et al. Structure-Activity relationship study on anti-HIV 6-desfluoroquinolones. J Med Chem 2008; 51:5454-5458.
-
(2008)
J Med Chem
, vol.51
, pp. 5454-5458
-
-
Tabarrini, O.1
Massari, S.2
Daelemans, D.3
Stevens, M.4
Manfroni, G.5
Sabatini, S.6
-
97
-
-
34247140849
-
Novel in vivo model for the study of human immunodeficiency virus type 1 transcription inhibitors: Evaluation of new 6-desfluoroquinolone derivatives
-
Stevens M, Pollicita M, Pannecouque C, Verbeken E, Tabarrini O, Cecchetti V, et al. Novel in vivo model for the study of human immunodeficiency virus type 1 transcription inhibitors: Evaluation of new 6-desfluoroquinolone derivatives. Antimicrob Agents Chemother, 2007; 51:1407-1413.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 1407-1413
-
-
Stevens, M.1
Pollicita, M.2
Pannecouque, C.3
Verbeken, E.4
Tabarrini, O.5
Cecchetti, V.6
-
99
-
-
33748774971
-
Synthesis and HIV-integrase strand transfer inhibition activity of 7-hydroxy[1,3]thiazolo[5,4-b]pyridin-5(4H)-ones
-
Boros EE, Johns BA, Garvey EP, Koble CS, Miller WH. Synthesis and HIV-integrase strand transfer inhibition activity of 7-hydroxy[1,3]thiazolo[5,4-b]pyridin-5(4H)-ones. Bioorg Med Chem Lett, 2006; 16:5668-5672.
-
(2006)
Bioorg Med Chem Lett
, vol.16
, pp. 5668-5672
-
-
Boros, E.E.1
Johns, B.A.2
Garvey, E.P.3
Koble, C.S.4
Miller, W.H.5
-
100
-
-
0034609799
-
6-aminoquinolones as new potential anti-HIV agents
-
Cecchetti V, Parolin C, Moro S, Pecere T, Filipponi E, Calistri A, et al. 6-aminoquinolones as new potential anti-HIV agents. J Med Chem, 2000; 43:3799-802.
-
(2000)
J Med Chem
, vol.43
, pp. 3799-3802
-
-
Cecchetti, V.1
Parolin, C.2
Moro, S.3
Pecere, T.4
Filipponi, E.5
Calistri, A.6
-
101
-
-
33644863638
-
Novel HIV-1 integrase inhibitors derived from quinolone antibiotics
-
Sato M, Motomura T, Aramaki H, Matsuda T, Yamashita M, Ito, Y, et al. Novel HIV-1 integrase inhibitors derived from quinolone antibiotics. J Med Chem, 2006; 49:1506-1508.
-
(2006)
J Med Chem
, vol.49
, pp. 1506-1508
-
-
Sato, M.1
Motomura, T.2
Aramaki, H.3
Matsuda, T.4
Yamashita, M.5
Ito, Y.6
-
102
-
-
29144509688
-
Diketo acid pharmacophore. 2. discovery of structurally diverse inhibitors of HIV-1 integrase
-
Dayam R, Sanchez T, Neamati, N. Diketo acid pharmacophore. 2. discovery of structurally diverse inhibitors of HIV-1 integrase. J Med Chem, 2005; 48:8009-8015.
-
(2005)
J Med Chem
, vol.48
, pp. 8009-8015
-
-
Dayam, R.1
Sanchez, T.2
Neamati, N.3
-
103
-
-
41649096265
-
Quinolone 3-carboxylic acid pharmacophore: Design of second generation HIV-1 integrase inhibitors
-
Dayam R, Al-Mawsawi LQ, Zawahir Z, Witvrouw M, Debyser Z, Neamati N. Quinolone 3-carboxylic acid pharmacophore: Design of second generation HIV-1 integrase inhibitors. J Med Chem, 2008; 51:1136-1144.
-
(2008)
J Med Chem
, vol.51
, pp. 1136-1144
-
-
Dayam, R.1
Al-Mawsawi, L.Q.2
Zawahir, Z.3
Witvrouw, M.4
Debyser, Z.5
Neamati, N.6
-
104
-
-
33645943739
-
Effects of drug resistance on viral load in patients failing antiretroviral therapy
-
Machouf N, Thomas R, Nguyen V K, Trottier B, Boulassel MR, Wainberg MA, et al. Effects of drug resistance on viral load in patients failing antiretroviral therapy. J Med Virol, 2006; 78: 608-613.
-
(2006)
J Med Virol
, vol.78
, pp. 608-613
-
-
McHouf, N.1
Thomas, R.2
Nguyen, V.K.3
Trottier, B.4
Boulassel, M.R.5
Wainberg, M.A.6
-
105
-
-
34147138794
-
Evolution of drug resistance in HIV-infected patients remaining on a virologically failing combination antiretroviral therapy regimen
-
(London, England),
-
Cozzi-Lepri A, Phillips AN, Ruiz L, Clotet B, Loveday C, Kjaer J, et al. Evolution of drug resistance in HIV-infected patients remaining on a virologically failing combination antiretroviral therapy regimen. AIDS (London, England), 2007; 21:721-732.
-
(2007)
AIDS
, vol.21
, pp. 721-732
-
-
Cozzi-Lepri, A.1
Phillips, A.N.2
Ruiz, L.3
Clotet, B.4
Loveday, C.5
Kjaer, J.6
-
106
-
-
34247537169
-
Class of antiretroviral drugs and the risk of myocardial infarction
-
Friis-Møller N, Reiss P, Sabin CA, Weber R, Monforte A, El-Sadr W, et al. Class of antiretroviral drugs and the risk of myocardial infarction. N Engl J Med, 2007; 356:1723-1735.
-
(2007)
N Engl J Med
, vol.356
, pp. 1723-1735
-
-
Friis-Møller, N.1
Reiss, P.2
Sabin, C.A.3
Weber, R.4
Monforte, A.5
El-Sadr, W.6
-
107
-
-
33646468974
-
Genetic analyses reveal structured HIV-1 populations in serially sampled T lymphocytes of patients receiving HAART
-
Potter SJ, Lemey P, Dyer WB, Sullivan JS, Chew CB, Vandamme AM, et al. Genetic analyses reveal structured HIV-1 populations in serially sampled T lymphocytes of patients receiving HAART. Virology, 2006; 348:35-46.
-
(2006)
Virology
, vol.348
, pp. 35-46
-
-
Potter, S.J.1
Lemey, P.2
Dyer, W.B.3
Sullivan, J.S.4
Chew, C.B.5
Vandamme, A.M.6
-
108
-
-
30744447460
-
Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1
-
Fätkenheuer G, Pozniak AL, Johnson MA, Plettenberg A, Staszewski S, Hoepelman AI, et al. Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1. Nat Med, 2005; 11:1170-1172.
-
(2005)
Nat Med
, vol.11
, pp. 1170-1172
-
-
Fätkenheuer, G.1
Pozniak, A.L.2
Johnson, M.A.3
Plettenberg, A.4
Staszewski, S.5
Hoepelman, A.I.6
-
109
-
-
33745218564
-
Monographs-GS-9137-anti-HIV agent, HIV integrase inhibitor
-
Sorbera LA, Serradell N. Monographs-GS-9137-anti-HIV agent, HIV integrase inhibitor. Drugs of the Future, 2006; 31:310-313.
-
(2006)
Drugs of the Future
, vol.31
, pp. 310-313
-
-
Sorbera, L.A.1
Serradell, N.2
-
110
-
-
62949153971
-
Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase
-
Jones GS, Yu F, Zeynalzadegan A, Hesselgesser J, Chen X, Chen, J, et al. Preclinical evaluation of GS-9160, a novel inhibitor of human immunodeficiency virus type 1 integrase. Antimicrob Agents Chemother, 2009; 53:1194-1203.
-
(2009)
Antimicrob Agents Chemother
, vol.53
, pp. 1194-1203
-
-
Jones, G.S.1
Yu, F.2
Zeynalzadegan, A.3
Hesselgesser, J.4
Chen, X.5
Chen, J.6
-
111
-
-
0034723439
-
Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells
-
(New York, N.Y.),
-
Hazuda DJ, Felock P, Witmer M, Wolfe A, Stillmock K, Grobler JA, et al. Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells. Science (New York, N.Y.), 2000; 287:646-50.
-
(2000)
Science
, vol.287
, pp. 646-650
-
-
Hazuda, D.J.1
Felock, P.2
Witmer, M.3
Wolfe, A.4
Stillmock, K.5
Grobler, J.A.6
-
112
-
-
2342561153
-
Rational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: Implication for binding to two metal ions on the active site of integrase
-
Long YQ, Jiang, XH, Dayam R, Sanchez T, Shoemaker R, Sei S, et al. Rational design and synthesis of novel dimeric diketoacid-containing inhibitors of HIV-1 integrase: Implication for binding to two metal ions on the active site of integrase. J Med Chem, 2004; 47:2561-2573.
-
(2004)
J Med Chem
, vol.47
, pp. 2561-2573
-
-
Long, Y.Q.1
Jiang, X.H.2
Dayam, R.3
Sanchez, T.4
Shoemaker, R.5
Sei, S.6
-
113
-
-
0031875905
-
Styrylquinoline derivatives: A new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells
-
Mekouar K, Mouscadet JF, Desmaële D, Subra F, Leh H, Savouré D, et al. Styrylquinoline derivatives: A new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells. J Med Chem, 1998; 41:2846-2857.
-
(1998)
J Med Chem
, vol.41
, pp. 2846-2857
-
-
Mekouar, K.1
Mouscadet, J.F.2
Desmaële, D.3
Subra, F.4
Leh, H.5
Savouré, D.6
-
114
-
-
0037057562
-
Use of the kohonen neural network for rapid screening of ex vivo anti-HIV activity of styrylquinolines
-
Polanski J, Zouhiri F, Jeanson L, Desmaële D, d'Angelo J, Mouscadet JF, et al. Use of the kohonen neural network for rapid screening of ex vivo anti-HIV activity of styrylquinolines. J Med Chem, 2002; 45:4647-54.
-
(2002)
J Med Chem
, vol.45
, pp. 4647-4654
-
-
Polanski, J.1
Zouhiri, F.2
Jeanson, L.3
Desmaële, D.4
D'Angelo, J.5
Mouscadet, J.F.6
-
116
-
-
3843108916
-
A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase
-
Hazuda DJ, Anthony NJ, Gomez RP, Jolly SM, Wai JS, Zhuang L, et al. A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase. Proc Natl Acad Sci U. S. A., 2004; 101:11233-11238.
-
(2004)
Proc Natl Acad Sci U. S. A.
, vol.101
, pp. 11233-11238
-
-
Hazuda, D.J.1
Anthony, N.J.2
Gomez, R.P.3
Jolly, S.M.4
Wai, J.S.5
Zhuang, L.6
-
117
-
-
4844227300
-
Nuclear import of HIV-1 integrase is inhibited in vitro by styrylquinoline derivatives
-
Mousnier A, Leh H, Mouscadet J F, Dargemont C. Nuclear import of HIV-1 integrase is inhibited in vitro by styrylquinoline derivatives. Mol Pharmacol, 2004; 66:783-788.
-
(2004)
Mol Pharmacol
, vol.66
, pp. 783-788
-
-
Mousnier, A.1
Leh, H.2
Mouscadet, J.F.3
Dargemont, C.4
-
118
-
-
0035851335
-
HIV-1 replication inhibitors of the styrylquinoline class: Incorporation of a masked diketo acid pharmacophore
-
Zouhiri F, Desmaele D, d'Angelo J, Ourevitch M, Mouscadet JF, Leh H, et al. HIV-1 replication inhibitors of the styrylquinoline class: Incorporation of a masked diketo acid pharmacophore. Tetrahedron Lett, 2001; 42:8189-8192.
-
(2001)
Tetrahedron Lett
, vol.42
, pp. 8189-8192
-
-
Zouhiri, F.1
Desmaele, D.2
D'Angelo, J.3
Ourevitch, M.4
Mouscadet, J.F.5
Leh, H.6
-
119
-
-
30344486281
-
Intermolecular interactions in the crystal structures of potential HIV-1integrase inhibitors
-
Majerz-Maniecka K, Musiol R, Nitek W, et al. Intermolecular interactions in the crystal structures of potential HIV-1integrase inhibitors. Bioorg Med Chem Lett, 2006; 16:1005-1009.
-
(2006)
Bioorg Med Chem Lett
, vol.16
, pp. 1005-1009
-
-
Majerz-Maniecka, K.1
Musiol, R.2
Nitek, W.3
-
120
-
-
33748919490
-
Microwave-assisted synthesis of fluoroquinolones and their nucleosides as inhibitors of HIV integrase
-
Adam MM, Bats JW, Nikolaus NV, Witvrouw M, Debyser Z, Engels JW. Microwave-assisted synthesis of fluoroquinolones and their nucleosides as inhibitors of HIV integrase. Collect Czech Chem Commun, 2006; 71:978-990.
-
(2006)
Collect Czech Chem Commun
, vol.71
, pp. 978-990
-
-
Adam, M.M.1
Bats, J.W.2
Nikolaus, N.V.3
Witvrouw, M.4
Debyser, Z.5
Engels, J.W.6
-
121
-
-
50249137113
-
Investigations on the 4-quinolone-3-carboxylic acid motif. 1. synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors
-
Pasquini S, Mugnaini C, Tintori C, Botta M, Corelli F, Trejos A, et al. Investigations on the 4-quinolone-3-carboxylic acid motif. 1. synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors. J Med Chem, 2008; 51:5125-5129.
-
(2008)
J Med Chem
, vol.51
, pp. 5125-5129
-
-
Pasquini, S.1
Mugnaini, C.2
Tintori, C.3
Botta, M.4
Corelli, F.5
Trejos, A.6
-
122
-
-
33745656139
-
Binding mode prediction of strand transfer HIV-1 integrase inhibitors using Tn5 transposase as a plausible surrogate model for HIV-1 integrase
-
Barreca ML, De Luca L, Iraci N, Chimirri A. Binding mode prediction of strand transfer HIV-1 integrase inhibitors using Tn5 transposase as a plausible surrogate model for HIV-1 integrase. J Med Chem, 2006; 49:3994-3997.
-
(2006)
J Med Chem
, vol.49
, pp. 3994-3997
-
-
Barreca, M.L.1
De Luca, L.2
Iraci, N.3
Chimirri, A.4
-
123
-
-
43849091636
-
New developments in the discovery of agents to treat Hepatitis C
-
633-562
-
Rönn R, Sandström A. New developments in the discovery of agents to treat Hepatitis C. CurrTopMed Chem, 2008; 8:633-562.
-
(2008)
CurrTopMed Chem
, vol.8
-
-
Rönn, R.1
Sandström, A.2
-
124
-
-
12144267646
-
Expression and characterization of the HCV NS2 protease
-
Reed K E, Rice CM. Expression and characterization of the HCV NS2 protease. Methods in Molecular Medicine, 1999; 19:331-342.
-
(1999)
Methods in Molecular Medicine
, vol.19
, pp. 331-342
-
-
Reed, K.E.1
Rice, C.M.2
-
125
-
-
0034812856
-
Characterization of the hepatitis C virus NS2/3 processing reaction by using a purified precursor protein
-
Pallaoro M, Lahm A, Biasiol G, Brunetti M, Nardella C, Orsatti L, et al. Characterization of the hepatitis C virus NS2/3 processing reaction by using a purified precursor protein. J Virol, 2001; 75:9939-46.
-
(2001)
J Virol
, vol.75
, pp. 9939-9946
-
-
Pallaoro, M.1
Lahm, A.2
Biasiol, G.3
Brunetti, M.4
Nardella, C.5
Orsatti, L.6
-
126
-
-
78650513766
-
Quinolones as HCV NS5B polymerase inhibitors
-
Kumar DV, Rai R, Brameld KA, Somoza JR, Rajagopalan R, Janc JW, et al. Quinolones as HCV NS5B polymerase inhibitors. Bioorg Med Chem Lett, 2011; 21:82-87.
-
(2011)
Bioorg Med Chem Lett
, vol.21
, pp. 82-87
-
-
Kumar, D.V.1
Rai, R.2
Brameld, K.A.3
Somoza, J.R.4
Rajagopalan, R.5
Janc, J.W.6
-
127
-
-
0033920304
-
Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo
-
Kolykhalov AA, Mihalik K, Feinstone SM, Rice CM. Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo. J Virol, 2000; 74:2046-51.
-
(2000)
J Virol
, vol.74
, pp. 2046-2051
-
-
Kolykhalov, A.A.1
Mihalik, K.2
Feinstone, S.M.3
Rice, C.M.4
-
128
-
-
63349109767
-
HCV796: A selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity in vitro, in mice with chimeric human livers, and in humans infected with hepatitis C virus
-
Kneteman NM, Howe AYM, Gao T, Lewis J, Pevear D, Lund G, et al. HCV796: A selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity in vitro, in mice with chimeric human livers, and in humans infected with hepatitis C virus. Hepatology, 2009; 49:745-752.
-
(2009)
Hepatology
, vol.49
, pp. 745-752
-
-
Kneteman, N.M.1
Howe, A.Y.M.2
Gao, T.3
Lewis, J.4
Pevear, D.5
Lund, G.6
-
129
-
-
33646378952
-
N-1-aza-4-hydroxyquinolone benzothiadiazines: Inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase exhibiting replication potency and favorable rat pharmacokinetics
-
(Abstract 1224A)
-
thAnnual Meeting of AASLD. Hepatology 40 (S4), 697A (Abstract 1224a), 2004.
-
(2004)
thAnnual Meeting of AASLD. Hepatology
, vol.40
, Issue.S4
-
-
Pratt, J.K.1
Beno, D.2
Donner, P.3
Jiang, W.4
Kati, W.5
Kempf, D.J.6
Koev, G.7
Liu, D.8
Liu, Y.9
Maring, C.10
Masse, S.11
Middleton, T.12
Mo, H.13
Molla, A.14
Montgomery, D.15
Xie, Q.16
-
130
-
-
2542467813
-
Mutations conferring resistance to a potent hepatitis C virus serine protease inhibitor in vitro
-
Lu L, Pilot-Matias TJ, et al. Mutations conferring resistance to a potent hepatitis C virus serine protease inhibitor in vitro. Antimicrob Agents Chemother, 2004; 48:2260-2266.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 2260-2266
-
-
Lu, L.1
Pilot-Matias, T.J.2
-
131
-
-
25844466713
-
Mutations conferring resistance to a hepatitis C virus (HCV) RNAdependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro
-
Mo H, Lu L, et al. Mutations conferring resistance to a hepatitis C virus (HCV) RNAdependent RNA polymerase inhibitor alone or in combination with an HCV serine protease inhibitor in vitro. Antimicrob Agents Chemother, 2005; 49:4305-4314.
-
(2005)
Antimicrob Agents Chemother
, vol.49
, pp. 4305-4314
-
-
Mo, H.1
Lu, L.2
-
132
-
-
33846131893
-
Antiviral interactions of an HCV polymerase inhibitor with an HCV protease inhibitor or interferon in vitro
-
Koev G, Dekhtyar T, Han L, Yan P, Ng TI, Lin CT, et al. Antiviral interactions of an HCV polymerase inhibitor with an HCV protease inhibitor or interferon in vitro. Antiviral Res, 2007; 73:78-83.
-
(2007)
Antiviral Res
, vol.73
, pp. 78-83
-
-
Koev, G.1
Dekhtyar, T.2
Han, L.3
Yan, P.4
Ng, T.I.5
Lin, C.T.6
|