메뉴 건너뛰기




Volumn 12, Issue 1, 2014, Pages 95-103

Mini-review: Polyamines metabolism, toxicity and potent therapeutical use

Author keywords

Anticancer activity; Antimicrobial activity; Metabolism; Polyamines; Therapeutical use

Indexed keywords

ABC TRANSPORTER; ACYLTRANSFERASE; AMIKACIN; AMOXICILLIN; CLAVULANIC ACID; DEXAMETHASONE; DISINFECTANT AGENT; DIZOCILPINE; ERYTHROMYCIN; IFENPRODIL; NOVOBIOCIN; ORNITHINE DECARBOXYLASE; POLYAMINE DERIVATIVE; POLYAMINE OXIDASE; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN P53; SPERMINE SYNTHASE; SQUALAMINE; STIGMASTEROL; TETRACYCLINE;

EID: 84891822854     PISSN: 22113525     EISSN: 22113533     Source Type: Journal    
DOI: 10.2174/22113525113119990118     Document Type: Review
Times cited : (15)

References (56)
  • 1
    • 40549096043 scopus 로고    scopus 로고
    • Multifaceted role for polyamines in bacterial pathogens
    • Shah, P.; Swiatlo, E.A. multifaceted role for polyamines in bacterial pathogens. Mol. Microbiol., 2008, 68, 4-16.
    • (2008) Mol. Microbiol. , vol.68 , pp. 4-16
    • Shah, P.1    Swiatlo, E.A.2
  • 2
    • 0000029613 scopus 로고
    • De natise semine genitali animalculis
    • Leeuwenhoek, D.A. De natise semine genitali animalculis. Philos. Trans. Roy. Soc., 1677, 12, 1040-1043.
    • (1677) Philos. Trans. Roy. Soc. , vol.12 , pp. 1040-1043
    • Leeuwenhoek, D.A.1
  • 3
    • 79952199559 scopus 로고    scopus 로고
    • The early history of polyamine research
    • Bachrach, U. The early history of polyamine research. Plant Physiol. Biochem., 2010, 48, 490-495.
    • (2010) Plant Physiol. Biochem. , vol.48 , pp. 490-495
    • Bachrach, U.1
  • 5
    • 0028277606 scopus 로고
    • Polyamines inhibit nitric oxide synthase in rat cerebellum
    • Hu, J.; Mahmoud, M.I.; El-Fakahany, E.E. Polyamines inhibit nitric oxide synthase in rat cerebellum. Neurosci. Lett., 1994, 175, 41-45.
    • (1994) Neurosci. Lett. , vol.175 , pp. 41-45
    • Hu, J.1    Mahmoud, M.I.2    El-Fakahany, E.E.3
  • 6
    • 0027749469 scopus 로고
    • Spermidine facilitates PCR amplification of target DNA
    • Wan, C.Y.; Wilkins, T.A. Spermidine facilitates PCR amplification of target DNA. PCR Methods Appl., 1993, 3, 208-210.
    • (1993) PCR Methods Appl. , vol.3 , pp. 208-210
    • Wan, C.Y.1    Wilkins, T.A.2
  • 7
    • 0025246649 scopus 로고
    • Preparation of extracts from prokaryotes
    • Cull, M.; McHenry, C.S. Preparation of extracts from prokaryotes. Methods Enzymol., 1990, 182, 147-153.
    • (1990) Methods Enzymol. , vol.182 , pp. 147-153
    • Cull, M.1    McHenry, C.S.2
  • 8
    • 0014429449 scopus 로고
    • Argenine decarboxylase from Escherichia coli. I. Purification and specificity for substrates and coenzyme
    • Blethen, S.L.; Boeker, E.A.; Snell, E.E. Argenine decarboxylase from Escherichia coli. I. Purification and specificity for substrates and coenzyme. J. Biol. Chem., 1968, 243, 1671-1677.
    • (1968) J. Biol. Chem. , vol.243 , pp. 1671-1677
    • Blethen, S.L.1    Boeker, E.A.2    Snell, E.E.3
  • 9
    • 0015919368 scopus 로고
    • Biosynthetic arginine decarboxylase from Escherichia coli. Subunit interactions and the role of magnesium ion
    • Wu, W.H.; Morris, D.R. Biosynthetic arginine decarboxylase from Escherichia coli. Subunit interactions and the role of magnesium ion. J. Biol. Chem., 1973, 248, 1696-1699.
    • (1973) J. Biol. Chem. , vol.248 , pp. 1696-1699
    • Wu, W.H.1    Morris, D.R.2
  • 11
    • 0023070460 scopus 로고
    • First-strand cDNA synthesis primed with oligo (dT)
    • Krug, M.S.; Berger, S.L. First-strand cDNA synthesis primed with oligo (dT). Methods Enzymol., 1987, 152, 316-325.
    • (1987) Methods Enzymol. , vol.152 , pp. 316-325
    • Krug, M.S.1    Berger, S.L.2
  • 12
    • 0016758335 scopus 로고
    • A DNA polymerase from embryos of Drosophila melanogaster. Purification and properties
    • Karkas, J.D.; Margulies, L.; Chargaff, E. A DNA polymerase from embryos of Drosophila melanogaster. Purification and properties. J. Biol. Chem., 1975, 250, 8657-8663.
    • (1975) J. Biol. Chem. , vol.250 , pp. 8657-8663
    • Karkas, J.D.1    Margulies, L.2    Chargaff, E.3
  • 13
    • 0019881429 scopus 로고
    • The effect of spermidine on endonuclease inhibition by agarose contaminants
    • Bouche, J.P. The effect of spermidine on endonuclease inhibition by agarose contaminants. Anal. Biochem., 1981, 115, 42-45.
    • (1981) Anal. Biochem. , vol.115 , pp. 42-45
    • Bouche, J.P.1
  • 15
    • 77953072049 scopus 로고    scopus 로고
    • The polyamine transport system as a target for anticancer drug development
    • Palmer, A.J.; Wallace, H.M. The polyamine transport system as a target for anticancer drug development. Amino Acids, 2010, 38, 415-422.
    • (2010) Amino Acids , vol.38 , pp. 415-422
    • Palmer, A.J.1    Wallace, H.M.2
  • 17
    • 78649869949 scopus 로고    scopus 로고
    • Characteristics of cellular polyamine transport in prokaryotes and eukaryotes
    • Igarashi, K.; Kashiwagi, K. Characteristics of cellular polyamine transport in prokaryotes and eukaryotes. Plant Physiol. Biochem., 2010, 48, 506-512.
    • (2010) Plant Physiol. Biochem. , vol.48 , pp. 506-512
    • Igarashi, K.1    Kashiwagi, K.2
  • 19
    • 0029258072 scopus 로고
    • The prospects of treatment failure in the chemotherapy of infectious diseases in the 1990s
    • Armstrong, D.; Neu, H.; Peterson, L.R.; Tomasz, A. The prospects of treatment failure in the chemotherapy of infectious diseases in the 1990s. Microb. Drug Resist, 1995, 1, 1-4.
    • (1995) Microb. Drug Resist , vol.1 , pp. 1-4
    • Armstrong, D.1    Neu, H.2    Peterson, L.R.3    Tomasz, A.4
  • 20
    • 0141633535 scopus 로고    scopus 로고
    • Thirty years of polyamine-related approaches to cancer therapy. Retrospect. and prospect. Part 1. Selective enzyme inhibitors
    • Seiler, N. Thirty years of polyamine-related approaches to cancer therapy. Retrospect. and prospect. Part 1. Selective enzyme inhibitors. Curr. Drug Targets, 2003, 4, 537-564.
    • (2003) Curr. Drug Targets , vol.4 , pp. 537-564
    • Seiler, N.1
  • 21
    • 84863516635 scopus 로고    scopus 로고
    • Apoptosis polyamine: Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis
    • Zou, T.; Rao, J.N.; Liu, L.; Xiao, L.; Cui, Y.H.; Jiang, Z.; Ouyang, M.; Donahue, J.M.; Wang, J.Y. Apoptosis polyamine: Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis. Am. J. Physiol. Cell Physiol., 2012, 303, C102-C111.
    • (2012) Am. J. Physiol. Cell Physiol. , vol.303
    • Zou, T.1    Rao, J.N.2    Liu, L.3    Xiao, L.4    Cui, Y.H.5    Jiang, Z.6    Ouyang, M.7    Donahue, J.M.8    Wang, J.Y.9
  • 22
    • 0032861554 scopus 로고    scopus 로고
    • Stimulation of transcription: Role of polyamines in mediating malignant transformation and oncogene expression
    • Tabib, A.; Bachrach, U. Stimulation of transcription: Role of polyamines in mediating malignant transformation and oncogene expression. Int. J. Biochem. Cell Biol., 1999, 31, 1289-1295.
    • (1999) Int. J. Biochem. Cell Biol. , vol.31 , pp. 1289-1295
    • Tabib, A.1    Bachrach, U.2
  • 25
    • 0032910232 scopus 로고    scopus 로고
    • In vitro cytotoxicity of poly (amidoamine) s, relevance to DNA delivery
    • Hill, I.R.; Garnett, M.C.; Bignotti, F.; Davis, S.S. In vitro cytotoxicity of poly (amidoamine) s, relevance to DNA delivery. Biochim. Biophys. Acta, 1999, 1427, 161-174.
    • (1999) Biochim. Biophys. Acta , vol.1427 , pp. 161-174
    • Hill, I.R.1    Garnett, M.C.2    Bignotti, F.3    Davis, S.S.4
  • 26
    • 0031262221 scopus 로고    scopus 로고
    • Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells
    • Sparapani, M.; Dall'Olio, R.; Gandolfi, O.; Ciani, E.; Contestabile, A. Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells. Exp. Neurol., 1997, 148, 157-166.
    • (1997) Exp. Neurol. , vol.148 , pp. 157-166
    • Sparapani, M.1    Dall'Olio, R.2    Gandolfi, O.3    Ciani, E.4    Contestabile, A.5
  • 27
    • 40549089913 scopus 로고    scopus 로고
    • Spermine induces cell death in cultured human embryonic cerebral cortical neurons through N-methyl-D-aspartate receptor activation
    • de Verra, N.; Martinez, E.; Sanfeliu, C. Spermine induces cell death in cultured human embryonic cerebral cortical neurons through N-methyl-D-aspartate receptor activation. J. Neurosci. Res., 2008, 86, 861-872.
    • (2008) J. Neurosci. Res. , vol.86 , pp. 861-872
    • de Verra, N.1    Martinez, E.2    Sanfeliu, C.3
  • 29
    • 0015292664 scopus 로고
    • Effect of oxidized spermine and other aldehydes on the infectivity of vaccinia virus
    • Bachrach, U.; Rosenkovitch, E. Effect of oxidized spermine and other aldehydes on the infectivity of vaccinia virus. Appl. Microbiol., 1972, 23, 232-235.
    • (1972) Appl. Microbiol. , vol.23 , pp. 232-235
    • Bachrach, U.1    Rosenkovitch, E.2
  • 30
    • 34547662510 scopus 로고    scopus 로고
    • Antiviral activity of oxidized polyamines
    • Bachrach, U. Antiviral activity of oxidized polyamines. Amino Acids, 2007, 33, 267-272.
    • (2007) Amino Acids , vol.33 , pp. 267-272
    • Bachrach, U.1
  • 31
    • 46749135648 scopus 로고    scopus 로고
    • Synthesis and antiviral activities of N-mono-and/or N, N'-dicarbamoyl and acyl derivatives of symmetrical diamines
    • Mibu, N.; Yokomizo, K.; Oishi, M.; Miyata, M.T.; Sumoto, K. Synthesis and antiviral activities of N-mono-and/or N, N'-dicarbamoyl and acyl derivatives of symmetrical diamines. Chem. Pharm. Bull., 2008, 56, 1052-1058.
    • (2008) Chem. Pharm. Bull. , vol.56 , pp. 1052-1058
    • Mibu, N.1    Yokomizo, K.2    Oishi, M.3    Miyata, M.T.4    Sumoto, K.5
  • 33
    • 77950030227 scopus 로고    scopus 로고
    • Design, synthesis and antimalarial/ anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines
    • Chadwick, J.; Jones, M.; Mercer, A.E.; Stocks, P.A.; Ward, S.A.; Park, B.K.; O'Neill, P.M. Design, synthesis and antimalarial/ anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines. Bioorg. Med. Chem., 2010, 18, 2586-2597.
    • (2010) Bioorg. Med. Chem. , vol.18 , pp. 2586-2597
    • Chadwick, J.1    Jones, M.2    Mercer, A.E.3    Stocks, P.A.4    Ward, S.A.5    Park, B.K.6    O'Neill, P.M.7
  • 34
    • 62249091718 scopus 로고    scopus 로고
    • 3-Aminosterol Compounds as a New Class of Anti-Malarial Agents against Chloroquine-Susceptible and-Resistant Plasmodium falciparum
    • Salmi, C.; Loncle, C.; Vidal, N.; Rogier, C.; Letourneux, Y.; Pradines, B.; Brunel, J.M. 3-Aminosterol Compounds as a New Class of Anti-Malarial Agents against Chloroquine-Susceptible and-Resistant Plasmodium falciparum. Lett. Drug Design Discov., 2009, 6, 163-166.
    • (2009) Lett. Drug Design Discov. , vol.6 , pp. 163-166
    • Salmi, C.1    Loncle, C.2    Vidal, N.3    Rogier, C.4    Letourneux, Y.5    Pradines, B.6    Brunel, J.M.7
  • 36
    • 77953554146 scopus 로고    scopus 로고
    • In vitro antifungal activity of aminosterols against moulds isolated from cystic fibrosis patients
    • Alhanout, K.; Brunel, J.M.; Ranque, S.; Rolain, J.M. In vitro antifungal activity of aminosterols against moulds isolated from cystic fibrosis patients. J. Antimicrob. Chemother., 2010, 65, 1307-1309.
    • (2010) J. Antimicrob. Chemother. , vol.65 , pp. 1307-1309
    • Alhanout, K.1    Brunel, J.M.2    Ranque, S.3    Rolain, J.M.4
  • 37
    • 78751520932 scopus 로고    scopus 로고
    • In vitro activity of aminosterols against yeasts involved in blood stream infections
    • Alhanout, K.; Djouhri, L.; Vidal, N.; Brunel, J.M.; Piarroux, R.; Ranque, S. In vitro activity of aminosterols against yeasts involved in blood stream infections. Med. Mycol., 2011, 49, 121-125.
    • (2011) Med. Mycol. , vol.49 , pp. 121-125
    • Alhanout, K.1    Djouhri, L.2    Vidal, N.3    Brunel, J.M.4    Piarroux, R.5    Ranque, S.6
  • 39
    • 0036174272 scopus 로고    scopus 로고
    • The synthesis of spermine analogs of the shark aminosterol squalamine
    • Shu, Y.; Jones, S.R.; Kinney, W.A.; Selinsky, B.S. The synthesis of spermine analogs of the shark aminosterol squalamine. Steroids, 2002, 67, 291-304.
    • (2002) Steroids , vol.67 , pp. 291-304
    • Shu, Y.1    Jones, S.R.2    Kinney, W.A.3    Selinsky, B.S.4
  • 40
    • 41849148651 scopus 로고    scopus 로고
    • Synthesis and antimicrobial activity of 7 alpha-amino-23, 24-bisnor-5 alpha-cholan-22-ol derivatives
    • Khan, S.N.; Jung, Y.M.; Kim, B.J.; Cho, H.; Lee, J.; Kim, H.S. Synthesis and antimicrobial activity of 7 alpha-amino-23, 24-bisnor-5 alpha-cholan-22-ol derivatives. Bioorg. Med. Chem. Lett., 2008, 18, 2558-2561.
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 2558-2561
    • Khan, S.N.1    Jung, Y.M.2    Kim, B.J.3    Cho, H.4    Lee, J.5    Kim, H.S.6
  • 41
    • 70349131567 scopus 로고    scopus 로고
    • Synthesis and biological activities of 3-polyamino-5-beta cholane-7 alpha, 24 diols
    • Khan, S.N.; Kim, H.S. Synthesis and biological activities of 3-polyamino-5-beta cholane-7 alpha, 24 diols. J. Indus. Eng. Chem., 2009, 15, 561-565.
    • (2009) J. Indus. Eng. Chem. , vol.15 , pp. 561-565
    • Khan, S.N.1    Kim, H.S.2
  • 42
    • 79958760217 scopus 로고    scopus 로고
    • A concise synthesis and antimicrobial activities of 3-polyamino-23, 24-bisnorcholanes as steroid-polyamine conjugates
    • Kim, H.S.; Khan, S.N.; Jadhav, J.R.; Jeong, J.W.; Jung, K.; Kwak, J.H. A concise synthesis and antimicrobial activities of 3-polyamino-23, 24-bisnorcholanes as steroid-polyamine conjugates. Bioorg. Med. Chem. Lett., 2011, 21, 3861-3865.
    • (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 3861-3865
    • Kim, H.S.1    Khan, S.N.2    Jadhav, J.R.3    Jeong, J.W.4    Jung, K.5    Kwak, J.H.6
  • 44
    • 36148972065 scopus 로고    scopus 로고
    • Synthesis of new 7-aminosterol squalamine analogues with high antimicrobila activities through a stereoselective titanium reductive amination reaction
    • Loncle, C.; Salmi, C.; Letourneux, Y.; Brunel, J.M. Synthesis of new 7-aminosterol squalamine analogues with high antimicrobila activities through a stereoselective titanium reductive amination reaction. Tetrahedron, 2007, 63, 12968-12974.
    • (2007) Tetrahedron , vol.63 , pp. 12968-12974
    • Loncle, C.1    Salmi, C.2    Letourneux, Y.3    Brunel, J.M.4
  • 45
    • 40249098265 scopus 로고    scopus 로고
    • New stereoselective titanium reductive amination synthesis of 3-amino and polyaminosterol derivatives possessing antimicrobial activities
    • Salmi, C.; Loncle, C.; Vidal, N.; Letourneux, Y.; Brunel, J.M. New stereoselective titanium reductive amination synthesis of 3-amino and polyaminosterol derivatives possessing antimicrobial activities. Eur. J. Med. Chem., 2008, 43, 540-547.
    • (2008) Eur. J. Med. Chem. , vol.43 , pp. 540-547
    • Salmi, C.1    Loncle, C.2    Vidal, N.3    Letourneux, Y.4    Brunel, J.M.5
  • 46
    • 70349462581 scopus 로고    scopus 로고
    • In vitro antibacterial activity of aminosterols against multidrug-resistant bacteria from patients with cystic fibrosis
    • Alhanout, K.; Brunel, J.M.; Raoult, D.; Rolain, J.M. In vitro antibacterial activity of aminosterols against multidrug-resistant bacteria from patients with cystic fibrosis. J. Antimicrob. Chemother., 2009, 64, 810-814.
    • (2009) J. Antimicrob. Chemother. , vol.64 , pp. 810-814
    • Alhanout, K.1    Brunel, J.M.2    Raoult, D.3    Rolain, J.M.4
  • 49
    • 74349088909 scopus 로고    scopus 로고
    • Biophysical studies of the interaction of squalamine and other cationic amphiphilic molecules with bacterial and eukaryotic membranes, importance of the distribution coefficient in membrane selectivity
    • Di pasquale, E.; Salmi-Smail, C.; Brunel, J.M.; Sanchez, P.; Fantini, J.; Maresca, M. Biophysical studies of the interaction of squalamine and other cationic amphiphilic molecules with bacterial and eukaryotic membranes, importance of the distribution coefficient in membrane selectivity. Chem. Phys. Lipids, 2010, 163, 131-140.
    • (2010) Chem. Phys. Lipids , vol.163 , pp. 131-140
    • Di pasquale, E.1    Salmi-Smail, C.2    Brunel, J.M.3    Sanchez, P.4    Fantini, J.5    Maresca, M.6
  • 50
    • 3042644686 scopus 로고    scopus 로고
    • Mode of action of novel polyamines increasing the permeability of bacterial outer membrane
    • Yasuda, K.; Ohmizo, C.; Katsu, T. Mode of action of novel polyamines increasing the permeability of bacterial outer membrane. Int. J. Antimicrob. Agents, 2004, 24, 67-71.
    • (2004) Int. J. Antimicrob. Agents , vol.24 , pp. 67-71
    • Yasuda, K.1    Ohmizo, C.2    Katsu, T.3
  • 51
    • 77952572015 scopus 로고    scopus 로고
    • Squalamine, an original chemosensitizer to combat antibiotic-resistant gramnegative bacteria
    • Lavigne, J.P.; Brunel, J.M.; Chevalier, J.; Pages, J.M. Squalamine, an original chemosensitizer to combat antibiotic-resistant gramnegative bacteria. J. Antimicrob. Chemother., 2010, 65, 799-801.
    • (2010) J. Antimicrob. Chemother. , vol.65 , pp. 799-801
    • Lavigne, J.P.1    Brunel, J.M.2    Chevalier, J.3    Pages, J.M.4
  • 52
    • 33644668576 scopus 로고    scopus 로고
    • Structural correlates of antibacterial and membrane-permeabilizing activities in acylpolyamines
    • Balakrishna, R.; Wood, S.J.; Nguyen, T.B. Structural correlates of antibacterial and membrane-permeabilizing activities in acylpolyamines. Antimicrob. Agents Chemother., 2006, 50, 852-861.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 852-861
    • Balakrishna, R.1    Wood, S.J.2    Nguyen, T.B.3
  • 54
    • 77952667208 scopus 로고    scopus 로고
    • Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasonespermine conjugate
    • Bucki, R.; Leszczynska, K.; Byfield, F.J. Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasonespermine conjugate. Antimicrob. Agents Chemother., 2010, 54, 2525-2533.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 2525-2533
    • Bucki, R.1    Leszczynska, K.2    Byfield, F.J.3
  • 55
    • 0032926818 scopus 로고    scopus 로고
    • Antiseptics and disinfectants, activity, action, and resistance
    • McDonnell, G.; Russell, A.D. Antiseptics and disinfectants, activity, action, and resistance. Clin. Microbiol. Rev., 1999, 12, 147-179.
    • (1999) Clin. Microbiol. Rev. , vol.12 , pp. 147-179
    • McDonnell, G.1    Russell, A.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.