A drug-repositioning screening identifies pentetic acid as a potential therapeutic agent for suppressing the elastase-mediated virulence of Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 12, 2014, Pages 7205-7214

  Gi, Mia ^a   Jeong, Junhui ^a   Lee, Keehoon ^a   Lee, Kang Mu ^a   Toyofuku, Masanori ^b   Yong, Dong Eun ^a   Yoon, Sang Sun ^a   Jae, Young ^a   Choia, ^a  

^a Yonsei University College of Medicine   (South Korea)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ELASTASE; MANGANESE; PENTETIC ACID; ZINC ION; 2-HEPTYL-3-HYDROXY-4-QUINOLONE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; DIVALENT CATION; ENZYME INHIBITOR; IRON CHELATING AGENT; METALLOPROTEINASE; MOLECULAR LIBRARY; PSEUDOLYSIN, PSEUDOMONAS AERUGINOSA; QUINOLONE DERIVATIVE; ZINC;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; CELL VIABILITY; CHELATION; COLONY FORMING UNIT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; DRUG REPOSITIONING; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LASB GENE; MALE; MOUSE; NONHUMAN; PSEUDOMONAS AERUGINOSA; QUORUM SENSING; RESPIRATORY TRACT INFECTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOFILM; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GROWTH, DEVELOPMENT AND AGING; INTRANASAL DRUG ADMINISTRATION; METABOLISM; MICROBIOLOGY; MOLECULAR LIBRARY; PATHOGENICITY; PHARMACOLOGY; PSEUDOMONAS INFECTIONS; TUMOR CELL LINE; VIRULENCE;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOFILMS; CATIONS, DIVALENT; CELL LINE, TUMOR; DRUG REPOSITIONING; ENZYME INHIBITORS; HUMANS; IRON CHELATING AGENTS; MALE; MANGANESE; METALLOENDOPEPTIDASES; MICE; PENTETIC ACID; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; QUINOLONES; QUORUM SENSING; SMALL MOLECULE LIBRARIES; VIRULENCE; ZINC;

EID: 84912127744     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.03063-14     Document Type: Article

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