The serotonin system in autism spectrum disorder: From biomarker to animal models

Neuroscience

Volumn 321, Issue , 2016, Pages 24-41

  Muller, C L ^a   Anacker, A M J ^b   Veenstra VanderWeele, J ^b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Genetic; Monoamine; Multisensory; Neurodevelopment; Platelet; Reuptake

Indexed keywords

ALANINE; ARIPIPRAZOLE; GLYCINE; OXYTOCIN; RISPERIDONE; SEROTONIN; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; SEROTONIN UPTAKE INHIBITOR; BIOLOGICAL MARKER;

AUTISM; COGNITION; COMPULSION; DRUG EFFECT; GENE MUTATION; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC VARIABILITY; HERITABILITY; HUMAN; INTERPERSONAL COMMUNICATION; NERVE CELL DIFFERENTIATION; NONHUMAN; PATHOPHYSIOLOGY; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RECURRENCE RISK; REVIEW; SEROTONIN BLOOD LEVEL; SEROTONIN UPTAKE; SEROTONINERGIC SYSTEM; SERT GENE; SLC6A4 GENE; SOCIAL BEHAVIOR; ANIMAL; AUTISM SPECTRUM DISORDER; BRAIN; DISEASE MODEL; FEMALE; GENETIC ASSOCIATION STUDY; GENETICS; MALE; METABOLISM; MUTANT MOUSE STRAIN; SEX DIFFERENCE;

ANIMALS; AUTISM SPECTRUM DISORDER; BIOMARKERS; BRAIN; DISEASE MODELS, ANIMAL; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC LINKAGE; HUMANS; MALE; MICE, MUTANT STRAINS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEX FACTORS;

EID: 84963706421     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.11.010     Document Type: Review

References (234)

1. Abney M., McPeek M.S., Ober C. Broad and narrow heritabilities of quantitative traits in a founder population. Am J Hum Genet 2001, 68:1302-1307.
2. Abramson R.K., Wright H.H., Carpenter R., Brennan W., Lumpuy O., Cole E., Young S.R. Elevated blood serotonin in autistic probands and their first-degree relatives. J Autism Dev Disord 1989, 19:397-407.
3. American Psychiatric Association Diagnostic and statistical manual of mental disorders 2013, American Psychiatric Publishing, Arlington, VA. 5th ed. (DSM-5).
4. Amodeo D.A., Jones J.H., Sweeney J.A., Ragozzino M.E. Risperidone and the 5-HT2A receptor antagonist M100907 improve probabilistic reversal learning in BTBR T + tf/J mice. Autism Res 2014, 7:555-567.
5. Anderson G.M. Measurement of plasma serotonin in autism. Pediatr Neurol 2007, 36:138. author reply 138-139.
6. Anderson G.M., Minderaa R.B., van Benthem P.P., Volkmar F.R., Cohen D.J. Platelet imipramine binding in autistic subjects. Psychiatry Res 1984, 11:133-141.
7. Anderson G.M., Feibel F.C., Cohen D.J. Determination of serotonin in whole blood, platelet-rich plasma, platelet-poor plasma and plasma ultrafiltrate. Life Sci 1987, 40:1063-1070.
8. Anderson G.M., Feibel F.C., Cohen D.J. Determination of serotonin in whole blood, platelet-rich plasma, platelet-poor plasma and plasma ultrafiltrate. Life Sci 1987, 40:1063-1070.
9. Anderson G.M., Freedman D.X., Cohen D.J., Volkmar F.R., Hoder E.L., McPhedran P., Minderaa R.B., Hansen C.R., Young J.G. Whole blood serotonin in autistic and normal subjects. J Child Psychol Psychiatry 1987, 28:885-900.
10. Anderson G.M., Gutknecht L., Cohen D.J., Brailly-Tabard S., Cohen J.H., Ferrari P., Roubertoux P.L., Tordjman S. Serotonin transporter promoter variants in autism: functional effects and relationship to platelet hyperserotonemia. Mol Psychiatry 2002, 7:831-836.
11. Anderson G.M., Hertzig M.E., McBride P.A. Brief report: platelet-poor plasma serotonin in autism. J Autism Dev Disord 2012, 42:1510-1514.
12. Ansorge M.S., Zhou M., Lira A., Hen R., Gingrich J.A. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 2004, 306:879-881.
13. Aoki Y., Yahata N., Watanabe T., Takano Y., Kawakubo Y., Kuwabara H., Iwashiro N., Natsubori T., Inoue H., Suga M., Takao H., Sasaki H., Gonoi W., Kunimatsu A., Kasai K., Yamasue H. Oxytocin improves behavioural and neural deficits in inferring others' social emotions in autism. Brain 2014, 137:3073-3086.
14. Aoki Y., Watanabe T., Abe O., Kuwabara H., Yahata N., Takano Y., Iwashiro N., Natsubori T., Takao H., Kawakubo Y., Kasai K., Yamasue H. Oxytocin's neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism: a randomized controlled trial. Mol Psychiatry 2015, 20:447-453.
15. Atladottir H.O., Henriksen T.B., Schendel D.E., Parner E.T. Autism after infection, febrile episodes, and antibiotic use during pregnancy: an exploratory study. Pediatrics 2012, 130:e1447-1454.
16. Auyeung B., Lombardo M.V., Heinrichs M., Chakrabarti B., Sule A., Deakin J.B., Bethlehem R.A., Dickens L., Mooney N., Sipple J.A., Thiemann P., Baron-Cohen S. Oxytocin increases eye contact during a real-time, naturalistic social interaction in males with and without autism. Transl Psychiatry 2015, 5:e507.
17. Azmitia E.C., Singh J.S., Whitaker-Azmitia P.M. Increased serotonin axons (immunoreactive to 5-HT transporter) in postmortem brains from young autism donors. Neuropharmacology 2011, 60:1347-1354.
18. Baganz N.L., Blakely R.D. A dialogue between the immune system and brain, spoken in the language of serotonin. ACS Chem Neurosci 2013, 4:48-63.
19. Bengel D., Murphy D.L., Andrews A.M., Wichems C.H., Feltner D., Heils A., Mossner R., Westphal H., Lesch K.P. Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter- deficient mice. Mol Pharmacol 1998, 53:649-655.
20. Bennett-Clarke C.A., Leslie M.J., Lane R.D., Rhoades R.W. Effect of serotonin depletion on vibrissa-related patterns of thalamic afferents in the rat's somatosensory cortex. J Neurosci 1994, 14:7594-7607.
21. Bennett-Clarke C.A., Lane R.D., Rhoades R.W. Fenfluramine depletes serotonin from the developing cortex and alters thalamocortical organization. Brain Res 1995, 702:255-260.
22. Blakely R.D., Edwards R.H. Vesicular and plasma membrane transporters for neurotransmitters. Cold Spring Harbor Perspect Biol 2012, 4.
23. Blakely R.D., Berson H.E., Fremeau R.T., Caron M.G., Peek M.M., Prince H.K., Bradley C.C. Cloning and expression of a functional serotonin transporter from rat brain. Nature 1991, 354:66-70.
24. Blakely R.D., Defelice L.J., Galli A. Biogenic amine neurotransmitter transporters: just when you thought you knew them. Physiology 2005, 20:225-231.
25. Boccuto L., Chen C.F., Pittman A.R., Skinner C.D., McCartney H.J., Jones K., Bochner B.R., Stevenson R.E., Schwartz C.E. Decreased tryptophan metabolism in patients with autism spectrum disorders. Mol Autism 2013, 4:16.
26. Bonnin A., Peng W., Hewlett W., Levitt P. Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development. Neuroscience 2006, 141:781-794.
27. Bonnin A., Torii M., Wang L., Rakic P., Levitt P. Serotonin modulates the response of embryonic thalamocortical axons to netrin-1. Nat Neurosci 2007, 10:588-597.
28. Bonnin A., Goeden N., Chen K., Wilson M.L., King J., Shih J.C., Blakely R.D., Deneris E.S., Levitt P. A transient placental source of serotonin for the fetal forebrain. Nature 2011, 472:347-350.
29. Bortolato M., Godar S.C., Alzghoul L., Zhang J., Darling R.D., Simpson K.L., Bini V., Chen K., Wellman C.L., Lin R.C., Shih J.C. Monoamine oxidase A and A/B knockout mice display autistic-like features. Int J Neuropsychopharmacol 2013, 16:869-888.
30. Boulougouris V., Robbins T.W. Enhancement of spatial reversal learning by 5-HT2C receptor antagonism is neuroanatomically specific. J Neurosci 2010, 30:930-938.
31. Brown A.S. Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism. Dev Neurobiol 2012, 72:1272-1276.
32. Burns C.M., Chu H., Rueter S.M., Hutchinson L.K., Canton H., Sanders-Bush E., Emeson R.B. Regulation of serotonin-2C receptor G-protein coupling by RNA editing. Nature 1997, 387:303-308.
33. Carneiro A.M., Cook E.H., Murphy D.L., Blakely R.D. Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. J Clin Invest 2008, 118:1544-1552.
34. Carneiro A.M., Airey D.C., Thompson B., Zhu C.B., Lu L., Chesler E.J., Erikson K.M., Blakely R.D. Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes. Proc Natl Acad Sci USA 2009, 106:2047-2052.
35. Carter M.D., Shah C.R., Muller C.L., Crawley J.N., Carneiro A.M., Veenstra-VanderWeele J. Absence of preference for social novelty and increased grooming in integrin beta3 knockout mice: initial studies and future directions. Autism Res 2011, 4:57-67.
36. Cases O., Vitalis T., Seif I., De Maeyer E., Sotelo C., Gaspar P. Lack of barrels in the somatosensory cortex of monoamine oxidase A-deficient mice: role of a serotonin excess during the critical period. Neuron 1996, 16:297-307.
37. Caspi A., McClay J., Moffitt T.E., Mill J., Martin J., Craig I.W., Taylor A., Poulton R. Role of genotype in the cycle of violence in maltreated children. Science 2002, 297:851-854.
38. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., McClay J., Mill J., Martin J., Braithwaite A., Poulton R. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003, 301:386-389.
39. Chadman K.K. Fluoxetine but not risperidone increases sociability in the BTBR mouse model of autism. Pharmacol Biochem Behav 2011, 97:586-594.
40. Chen X., Ye R., Gargus J.J., Blakely R.D., Dobrenis K., Sze J.Y. Disruption of transient serotonin accumulation by non-serotonin-producing neurons impairs cortical map development. Cell Rep 2015.
41. Chugani D.C., Muzik O., Behen M., Rothermel R., Janisse J.J., Lee J., Chugani H.T. Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children. Ann Neurol 1999, 45:287-295.
42. Clarke H.F., Dalley J.W., Crofts H.S., Robbins T.W., Roberts A.C. Cognitive inflexibility after prefrontal serotonin depletion. Science 2004, 304:878-880.
43. Conrad L.C., Leonard C.M., Pfaff D.W. Connections of the median and dorsal raphe nuclei in the rat: an autoradiographic and degeneration study. J Comp Neurol 1974, 156:179-205.
44. Cook E.H., Leventhal B.L., Freedman D.X. Free serotonin in plasma: autistic children and their first-degree relatives. Biol Psychiatry 1988, 24:488-491.
45. Cook E.H., Leventhal B.L., Freedman D.X. Serotonin and measured intelligence. J Autism Dev Disord 1988, 18:553-559.
46. Cook E.H., Leventhal B.L., Heller W., Metz J., Wainwright M., Freedman D.X. Autistic children and their first-degree relatives: relationships between serotonin and norepinephrine levels and intelligence. J Neuropsychiatry Clin Neurosci 1990, 2:268-274.
47. Cook E., Arora R., Anderson G., Berry-Kravis E., Yan S.-Y., Yeoh H., Sklena P., Charak D., Leventhal B. Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder. Life Sci 1993, 52:2005-2015.
48. Cook E.H., Arora R.C., Anderson G.M., Berry-Kravis E.M., Yan S.Y., Yeoh H.C., Sklena P.J., Charak D.A., Leventhal B.L. Platelet serotonin studies in hyperserotonemic relatives of children with autistic disorder. Life Sci 1993, 52:2005-2015.
49. Cools R., Roberts A.C., Robbins T.W. Serotoninergic regulation of emotional and behavioural control processes. Trends Cogn Sci 2008, 12:31-40.
50. Cote F., Fligny C., Bayard E., Launay J.M., Gershon M.D., Mallet J., Vodjdani G. Maternal serotonin is crucial for murine embryonic development. Proc Natl Acad Sci USA 2007, 104:329-334.
51. Courchesne E., Karns C.M., Davis H.R., Ziccardi R., Carper R.A., Tigue Z.D., Chisum H.J., Moses P., Pierce K., Lord C., Lincoln A.J., Pizzo S., Schreibman L., Haas R.H., Akshoomoff N.A., Courchesne R.Y. Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study. Neurology 2001, 57:245-254.
52. Coutinho A.M., Oliveira G., Morgadinho T., Fesel C., Macedo T.R., Bento C., Marques C., Ataide A., Miguel T., Borges L., Vicente A.M. Variants of the serotonin transporter gene (SLC6A4) significantly contribute to hyperserotonemia in autism. Mol Psychiatry 2004, 9:264-271.
53. Coutinho A.M., Sousa I., Martins M., Correia C., Morgadinho T., Bento C., Marques C., Ataide A., Miguel T.S., Moore J.H., Oliveira G., Vicente A.M. Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. Hum Genet 2007, 121:243-256.
54. Croen L.A., Grether J.K., Yoshida C.K., Odouli R., Hendrick V. Antidepressant use during pregnancy and childhood autism spectrum disorders. Arch Gen Psychiatry 2011, 68:1104-1112.
55. Croonenberghs J., Delmeire L., Verkerk R., Lin A.H., Meskal A., Neels H., Van der Planken M., Scharpe S., Deboutte D., Pison G., Maes M. Peripheral markers of serotonergic and noradrenergic function in post-pubertal, caucasian males with autistic disorder. Neuropsychopharmacology 2000, 22:275-283.
56. Cross S., Kim S.J., Weiss L.A., Delahanty R.J., Sutcliffe J.S., Leventhal B.L., Cook E.H., Veenstra-Vanderweele J. Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism. Neuropsychopharmacology 2008, 33:353-360.
57. D' Eufemia P., Finocchiaro R., Celli M., Viozzi L., Monteleone D., Giardini O. Low serum tryptophan to large neutral amino acids ratio in idiopathic infantile autism. Biomed Pharmacother 1995, 49:288-292.
58. Dahlstroem A., Fuxe K. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol Scand Suppl 1964, 232:231-255.
59. Daly E.M., Deeley Q., Ecker C., Craig M., Hallahan B., Murphy C., Johnston P., Spain D., Gillan N., Brammer M., Giampietro V., Lamar M., Page L., Toal F., Cleare A., Surguladze S., Murphy D.G. Serotonin and the neural processing of facial emotions in adults with autism: an fMRI study using acute tryptophan depletion. Arch Gen Psychiatry 2012, 69:1003-1013.
60. Daly E., Ecker C., Hallahan B., Deeley Q., Craig M., Murphy C., Johnston P., Spain D., Gillan N., Gudbrandsen M., Brammer M., Giampietro V., Lamar M., Page L., Toal F., Schmitz N., Cleare A., Robertson D., Rubia K., Murphy D.G. Response inhibition and serotonin in autism: a functional MRI study using acute tryptophan depletion. Brain 2014, 137:2600-2610.
61. D'Amato R.J., Blue M.E., Largent B.L., Lynch D.R., Ledbetter D.J., Molliver M.E., Snyder S.H. Ontogeny of the serotonergic projection to rat neocortex: transient expression of a dense innervation to primary sensory areas. Proc Natl Acad Sci USA 1987, 84:4322-4326.
62. Dawson N., Ferrington L., Olverman H.J., Harmar A.J., Kelly P.A. Sex influences the effect of a lifelong increase in serotonin transporter function on cerebral metabolism. J Neurosci Res 2009, 87:2375-2385.
63. DeRubeis S., He X., Goldberg A.P., Poultney C.S., Samocha K., Cicek A.E., Kou Y., Liu L., Fromer M., Walker S., Singh T., Klei L., Kosmicki J., Shih-Chen F., Aleksic B., Biscaldi M., Bolton P.F., Brownfeld J.M., Cai J., Campbell N.G., Carracedo A., Chahrour M.H., Chiocchetti A.G., Coon H., Crawford E.L., Curran S.R., Dawson G., Duketis E., Fernandez B.A., Gallagher L., Geller E., Guter S.J., Hill R.S., Ionita-Laza J., JimenzGonzalez P., Kilpinen H., Klauck S.M., Kolevzon A., Lee I., Lei I., Lei J., Lehtimaki T., Lin C.F., Ma'ayan A., Marshall C.R., McInnes A.L., Neale B., Owen M.J., Ozaki N., Parellada M., Parr J.R., Purcell S., Puura K., Rajagopalan D., Rehnstrom K., Reichenberg A., Sabo A., Sachse M., Sanders S.J., Schafer C., Schulte-Ruther M., Skuse D., Stevens C., Szatmari P., Tammimies K., Valladares O., Voran A., Li-San W., Weiss L.A., Willsey A.J., Yu T.W., Yuen R.K., Cook E.H., Freitag C.M., Gill M., Hultman C.M., Lehner T., Palotie A., Schellenberg G.D., Sklar P., State M.W., Sutcliffe J.S., Walsh C.A., Scherer S.W., Zwick M.E., Barett J.C., Cutler D.J., Roeder K., Devlin B., Daly M.J., Buxbaum J.D. Synaptic, transcriptional and chromatin genes disrupted in autism. Nature 2014, 515:209-215. Study DDD, Homozygosity Mapping Collaborative for A, Consortium UK.
64. de Theije C.G., Wopereis H., Ramadan M., van Eijndthoven T., Lambert J., Knol J., Garssen J., Kraneveld A.D., Oozeer R. Altered gut microbiota and activity in a murine model of autism spectrum disorders. Brain Behav Immun 2014, 37:197-206.
65. Del'Guidice T., Lemay F., Lemasson M., Levasseur-Moreau J., Manta S., Etievant A., Escoffier G., Dore F.Y., Roman F.S., Beaulieu J.M. Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation. Neuropsychopharmacology 2014, 39:1125-1134.
66. Developmental Disabilities Monitoring Network (2014) Prevalence of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2010. MMWR Surveill Summ 63:1-21.
67. Devlin B., Cook E.H., Coon H., Dawson G., Grigorenko E.L., McMahon W., Minshew N., Pauls D., Smith M., Spence M.A., Rodier P.M., Stodgell C., Schellenberg G.D., Network C.G. Autism and the serotonin transporter: the long and short of it. Mol Psychiatry 2005, 10:1110-1116.
68. Dolen G. Autism: oxytocin, serotonin, and social reward. Soc Neurosci 2015, 10:450-465.
69. Dölen G., Darvishzadeh A., Huang K.W., Malenka R.C. Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin. Nature 2013, 501:179-184.
70. Dougherty J.D., Maloney S.E., Wozniak D.F., Rieger M.A., Sonnenblick L., Coppola G., Mahieu N.G., Zhang J., Cai J., Patti G.J., Abrahams B.S., Geschwind D.H., Heintz N. The disruption of Celf6, a gene identified by translational profiling of serotonergic neurons, results in autism-related behaviors. J Neurosci 2013, 33:2732-2753.
71. Dufour-Rainfray D., Vourc'h P., Le Guisquet A.M., Garreau L., Ternant D., Bodard S., Jaumain E., Gulhan Z., Belzung C., Andres C.R., Chalon S., Guilloteau D. Behavior and serotonergic disorders in rats exposed prenatally to valproate: a model for autism. Neurosci Lett 2010, 470:55-59.
72. Eaton J.L., Roache L., Nguyen K.N., Cushing B.S., Troyer E., Papademetriou E., Raghanti M.A. Organizational effects of oxytocin on serotonin innervation. Dev Psychobiol 2012, 54:92-97.
73. Edwards D.J., Chugani D.C., Chugani H.T., Chehab J., Malian M., Aranda J.V. Pharmacokinetics of buspirone in autistic children. J Clin Pharmacol 2006, 46:508-514.
74. Esaki T., Cook M., Shimoji K., Murphy D.L., Sokoloff L., Holmes A. Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice. Proc Natl Acad Sci USA 2005, 102:5582-5587.
75. Farook M.F., DeCuypere M., Hyland K., Takumi T., LeDoux M.S., Reiter L.T. Altered serotonin, dopamine and norepinephrine levels in 15q duplication and Angelman syndrome mouse models. PLoS One 2012, 7:e43030.
76. File S.E., Gonzalez L.E., Andrews N. Comparative study of pre- and postsynaptic 5-HT1A receptor modulation of anxiety in two ethological animal tests. J Neurosci 1996, 16:4810-4815.
77. Folk G.E., Long J.P. Serotonin as a neurotransmitter: a review. Comp Biochem Physiol C 1988, 91:251-257.
78. Fujimiya M., Kimura H., Maeda T. Postnatal development of serotonin nerve fibers in the somatosensory cortex of mice studied by immunohistochemistry. J Comp Neurol 1986, 246:191-201.
79. Gabriele S., Sacco R., Persico A.M. Blood serotonin levels in autism spectrum disorder: a systematic review and meta-analysis. Eur Neuropsychopharmacol 2014, 24:919-929.
80. Gaugler T., Klei L., Sanders S.J., Bodea C.A., Goldberg A.P., Lee A.B., Mahajan M., Manaa D., Pawitan Y., Reichert J., Ripke S., Sandin S., Sklar P., Svantesson O., Reichenberg A., Hultman C.M., Devlin B., Roeder K., Buxbaum J.D. Most genetic risk for autism resides with common variation. Nat Genet 2014, 46:881-885.
81. Gershon M.D. 5-Hydroxytryptamine (serotonin) in the gastrointestinal tract. Curr Opin Endocrinol Diabetes Obes 2013, 20:14-21.
82. Girgis R.R., Slifstein M., Xu X., Frankle W.G., Anagnostou E., Wasserman S., Pepa L., Kolevzon A., Abi-Dargham A., Laruelle M., Hollander E. The 5-HT(2A) receptor and serotonin transporter in Asperger's disorder: A PET study with [(1)(1)C]MDL 100907 and [(1)(1)C]DASB. Psychiatry Res 2011, 194:230-234.
83. Gleason G., Liu B., Bruening S., Zupan B., Auerbach A., Mark W., Oh J.E., Gal-Toth J., Lee F., Toth M. The serotonin1A receptor gene as a genetic and prenatal maternal environmental factor in anxiety. Proc Natl Acad Sci USA 2010, 107:7592-7597.
84. Goldberg J., Anderson G.M., Zwaigenbaum L., Hall G.B., Nahmias C., Thompson A., Szatmari P. Cortical serotonin type-2 receptor density in parents of children with autism spectrum disorders. J Autism Dev Disord 2009, 39:97-104.
85. Gordon C., State R., Nelson J., Hamburger S., Rapoport J. A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. Arch Gen Psychiatry 1993, 50:441-447.
86. Gordon I., Vander Wyk B.C., Bennett R.H., Cordeaux C., Lucas M.V., Eilbott J.A., Zagoory-Sharon O., Leckman J.F., Feldman R., Pelphrey K.A. Oxytocin enhances brain function in children with autism. Proc Natl Acad Sci USA 2013, 110:20953-20958.
87. Gorrindo P., Williams K.C., Lee E.B., Walker L.S., McGrew S.G., Levitt P. Gastrointestinal dysfunction in autism: parental report, clinical evaluation, and associated factors. Autism Res 2012, 5:101-108.
88. Gould G.G., Hensler J.G., Burke T.F., Benno R.H., Onaivi E.S., Daws L.C. Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors, and effects of their targeting on BTBR T+tf/J mouse social behavior. J Neurochem 2011, 116:291-303.
89. Gould G.G., Burke T.F., Osorio M.D., Smolik C.M., Zhang W.Q., Onaivi E.S., Gu T.T., DeSilva M.N., Hensler J.G. Enhanced novelty-induced corticosterone spike and upregulated serotonin 5-HT1A and cannabinoid CB1 receptors in adolescent BTBR mice. Psychoneuroendocrinology 2014, 39:158-169.
90. Guastella A.J., Gray K.M., Rinehart N.J., Alvares G.A., Tonge B.J., Hickie I.B., Keating C.M., Cacciotti-Saija C., Einfeld S.L. The effects of a course of intranasal oxytocin on social behaviors in youth diagnosed with autism spectrum disorders: a randomized controlled trial. J Child Psychol Psychiatry 2015, 56:444-452.
91. Hammock E., Veenstra-VanderWeele J., Yan Z., Kerr T.M., Morris M., Anderson G.M., Carter C.S., Cook E.H., Jacob S. Examining autism spectrum disorders by biomarkers: example from the oxytocin and serotonin systems. J Am Acad Child Adolesc Psychiatry 2012, 51(712-721):e711.
92. Hanley H.G., Stahl S.M., Freedman D.X. Hyperserotonemia and amine metabolites in autistic and retarded children. Arch Gen Psychiatry 1977, 34:521-531.
93. Hanna G.L., Yuwiler A., Cantwell D.P. Whole blood serotonin in juvenile obsessive-compulsive disorder. Biol Psychiatry 1991, 29:738-744.
94. Hannon J., Hoyer D. Molecular biology of 5-HT receptors. Behav Brain Res 2008, 195:198-213.
95. Hardebo J.E., Owman C. Barrier mechanisms for neurotransmitter monoamines and their precursors at the blood-brain interface. Ann Neurol 1980, 8:1-31.
96. Hariri A.R., Mattay V.S., Tessitore A., Kolachana B., Fera F., Goldman D., Egan M.F., Weinberger D.R. Serotonin transporter genetic variation and the response of the human amygdala. Science 2002, 297:400-403.
97. Harrington R.A., Lee L.C., Crum R.M., Zimmerman A.W., Hertz-Picciotto I. Serotonin hypothesis of autism: implications for selective serotonin reuptake inhibitor use during pregnancy. Autism Res 2013, 6:149-168.
98. Harrington R.A., Lee L.C., Crum R.M., Zimmerman A.W., Hertz-Picciotto I. Prenatal SSRI use and offspring with autism spectrum disorder or developmental delay. Pediatrics 2014, 133:e1241-1248.
99. Hay-Schmidt A. The evolution of the serotonergic nervous system. Proc Biol Sci 2000, 267:1071-1079.
100. Hollander E., Phillips A., Chaplin W., Zagursky K., Novotny S., Wasserman S., Iyengar R. A placebo controlled crossover trial of liquid fluoxetine on repetitive behaviors in childhood and adolescent autism. Neuropsychopharmacology 2005, 30:582-589.
101. Hollander E., Soorya L., Chaplin W., Anagnostou E., Taylor B.P., Ferretti C.J., Wasserman S., Swanson E., Settipani C. A double-blind placebo-controlled trial of fluoxetine for repetitive behaviors and global severity in adult autism spectrum disorders. Am J Psychiatry 2012, 169:292-299.
102. Hsiao E.Y., McBride S.W., Hsien S., Sharon G., Hyde E.R., McCue T., Codelli J.A., Chow J., Reisman S.E., Petrosino J.F., Patterson P.H., Mazmanian S.K. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 2013, 155:1451-1463.
103. Hunt G.E., McGregor I.S., Cornish J.L., Callaghan P.D. MDMA-induced c-Fos expression in oxytocin-containing neurons is blocked by pretreatment with the 5-HT-1A receptor antagonist WAY 100635. Brain Res Bull 2011, 86:65-73.
104. Hviid A., Melbye M., Pasternak B. Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism. N Engl J Med 2013, 369:2406-2415.
105. A full genome screen for autism with evidence for linkage to a region on chromosome 7q. Hum Mol Genet 1998, 7:571-578. International Molecular Genetic Study of Autism Consortium.
106. Iossifov I., O'Roak B.J., Sanders S.J., Ronemus M., Krumm N., Levy D., Stessman H.A., Witherspoon K.T., Vives L., Patterson K.E., Smith J.D., Paeper B., Nickerson D.A., Dea J., Dong S., Gonzalez L.E., Mandell J.D., Mane S.M., Murtha M.T., Sullivan C.A., Walker M.F., Waqar Z., Wei L., Willsey A.J., Yamrom B., Lee Y.H., Grabowska E., Dalkic E., Wang Z., Marks S., Andrews P., Leotta A., Kendall J., Hakker I., Rosenbaum J., Ma B., Rodgers L., Troge J., Narzisi G., Yoon S., Schatz M.C., Ye K., McCombie W.R., Shendure J., Eichler E.E., State M.W., Wigler M. The contribution of de novo coding mutations to autism spectrum disorder. Nature 2014, 515:216-221.
107. Jacob S., Brune C.W., Carter C.S., Leventhal B.L., Lord C., Cook E.H. Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism. Neurosci Lett 2007, 417:6-9.
108. Jacobs B.L., Azmitia E.C. Structure and function of the brain serotonin system. Physiol Rev 1992, 72:165-229.
109. Janusonis S., Anderson G.M., Shifrovich I., Rakic P. Ontogeny of brain and blood serotonin levels in 5-HT receptor knockout mice: potential relevance to the neurobiology of autism. J Neurochem 2006, 99:1019-1031.
110. Jitsuki S., Takemoto K., Kawasaki T., Tada H., Takahashi A., Becamel C., Sano A., Yuzaki M., Zukin R.S., Ziff E.B., Kessels H.W., Takahashi T. Serotonin mediates cross-modal reorganization of cortical circuits. Neuron 2011, 69:780-792.
111. Kane M.J., Angoa-Perez M., Briggs D.I., Sykes C.E., Francescutti D.M., Rosenberg D.R., Kuhn D.M. Mice genetically depleted of brain serotonin display social impairments, communication deficits and repetitive behaviors: possible relevance to autism. PLoS One 2012, 7:e48975.
112. Kanner L. Autistic disturbances of affective contact. Nerv Child 1943, 2:217-250.
113. Kepser L.J., Homberg J.R. The neurodevelopmental effects of serotonin: a behavioural perspective. Behav Brain Res 2015, 277:3-13.
114. Kerr T.M., Muller C.L., Miah M., Jetter C.S., Pfeiffer R., Shah C., Baganz N., Anderson G.M., Crawley J.N., Sutcliffe J.S., Blakely R.D., Veenstra-Vanderweele J. Genetic background modulates phenotypes of serotonin transporter Ala56 knock-in mice. Mol Autism 2013, 4:35.
115. Kim H., Toyofuku Y., Lynn F.C., Chak E., Uchida T., Mizukami H., Fujitani Y., Kawamori R., Miyatsuka T., Kosaka Y., Yang K., Honig G., van der Hart M., Kishimoto N., Wang J., Yagihashi S., Tecott L.H., Watada H., German M.S. Serotonin regulates pancreatic beta cell mass during pregnancy. Nat Med 2010, 16:804-808.
116. King B.H., Hollander E., Sikich L., McCracken J.T., Scahill L., Bregman J.D., Donnelly C.L., Anagnostou E., Dukes K., Sullivan L., Hirtz D., Wagner A., Ritz L. Lack of efficacy of citalopram in children with autism spectrum disorders and high levels of repetitive behavior: citalopram ineffective in children with autism. Arch Gen Psychiatry 2009, 66:583-590.
117. King B.H., Dukes K., Donnelly C.L., Sikich L., McCracken J.T., Scahill L., Hollander E., Bregman J.D., Anagnostou E., Robinson F., Sullivan L., Hirtz D. Baseline factors predicting placebo response to treatment in children and adolescents with autism spectrum disorders: a multisite randomized clinical trial. JAMA Pediatr 2013, 167:1045-1052.
118. Kishore S., Stamm S. The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C. Science 2006, 311:230-232.
119. Kistner-Griffin E., Brune C.W., Davis L.K., Sutcliffe J.S., Cox N.J., Cook E.H. Parent-of-origin effects of the serotonin transporter gene associated with autism. Am J Med Genet B 2011, 156:139-144.
120. Kolevzon A., Newcorn J.H., Kryzak L., Chaplin W., Watner D., Hollander E., Smith C.J., Cook E.H., Silverman J.M. Relationship between whole blood serotonin and repetitive behaviors in autism. Psychiatry Res 2010, 175:274-276.
121. Korade Z., Folkes O.M., Harrison F.E. Behavioral and serotonergic response changes in the Dhcr7-HET mouse model of Smith-Lemli-Opitz syndrome. Pharmacol Biochem Behav 2013.
122. Kuperman S., Beeghly J.H., Burns T.L., Tsai L.Y. Serotonin relationships of autistic probands and their first-degree relatives. J Am Acad Child Psychiatry 1985, 24:186-190.
123. Kuteykin-Teplyakov K., Maldonado R. Looking for prosocial genes: ITRAQ analysis of proteins involved in MDMA-induced sociability in mice. Eur Neuropsychopharmacol 2014, 24:1773-1783.
124. Langridge A.T., Glasson E.J., Nassar N., Jacoby P., Pennell C., Hagan R., Bourke J., Leonard H., Stanley F.J. Maternal conditions and perinatal characteristics associated with autism spectrum disorder and intellectual disability. PLoS One 2013, 8:e50963.
125. Leboyer M., Philippe A., Bouvard M., Guilloud-Bataille M., Bondoux D., Tabuteau F., Feingold J., Mouren-Simeoni M., Launay J. Whole blood serotonin and plasma beta-endorphin in autistic probands and their first-degree relatives. Biol Psychiatry 1999, 45:158-163.
126. Lebrand C., Cases O., Adelbrecht C., Doye A., Alvarez C., El Mestikawy S., Seif I., Gaspar P. Transient uptake and storage of serotonin in developing thalamic neurons. Neuron 1996, 17:823-835.
127. Leventhal B.L., Cook E.H., Morford M., Ravitz A., Freedman D.X. Relationships of whole blood serotonin and plasma norepinephrine within families. J Autism Dev Disord 1990, 20:499-511.
128. Levitt P. Serotonin and the autisms: a red flag or a red herring?. Arch Gen Psychiatry 2011, 68:1093-1094.
129. Lidow M.S., Rakic P. Scheduling of monoaminergic neurotransmitter receptor expression in the primate neocortex during postnatal development. Cereb Cortex 1992, 2:401-416.
130. Lovenberg W., Jequier E., Sjoerdsma A. Tryptophan hydroxylation: measurement in pineal gland, brainstem, and carcinoid tumor. Science 1967, 155:217-219.
131. Madden A.M., Zup S.L. Effects of developmental hyperserotonemia on juvenile play behavior, oxytocin and serotonin receptor expression in the hypothalamus are age and sex dependent. Physiol Behav 2014, 128:260-269.
132. Makkonen I., Riikonen R., Kokki H., Airaksinen M.M., Kuikka J.T. Serotonin and dopamine transporter binding in children with autism determined by SPECT. Dev Med Child Neurol 2008, 50:593-597.
133. Margolis K.G., Stevanovic K., Li Z., Yang Q.M., Oravecz T., Zambrowicz B., Jhaver K.G., Diacou A., Gershon M.D. Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine. Gut 2014, 63:928-937.
134. Marler S, Ferguson BJ, Lee EB, Peters B, Williams KC, McDonnell E, Macklin EA, Levitt P, Gillespie CH, Anderson GM, Margolis KG, Beversdorf DQ, Veenstra-VanderWeele J, Whole blood serotonin levels and gastrointestinal symptoms in autism spectrum disorder. J Autism Dev Disord, in press, PubMed ID: 26527110.
135. Martin M.M., Liu Y., Wang Z. Developmental exposure to a serotonin agonist produces subsequent behavioral and neurochemical changes in the adult male prairie vole. Physiol Behav 2012, 105:529-535.
136. McBride P.A., Anderson G.M., Hertzig M.E., Sweeney J.A., Kream J., Cohen D.J., Mann J.J. Serotonergic responsivity in male young adults with autistic disorder. Arch Gen Psychiatry 1989, 46:205-212.
137. McBride P.A., Anderson G.M., Hertzig M.E., Snow M.E., Thompson S.M., Khait V.D., Shapiro T., Cohen D.J. Effects of diagnosis, race, and puberty on platelet serotonin levels in autism and mental retardation. J Am Acad Child Adolesc Psychiatry 1998, 37:767-776.
138. McCauley J.L., Olson L.M., Dowd M., Amin T., Steele A., Blakely R.D., Folstein S.E., Haines J.L., Sutcliffe J.S. Linkage and association analysis at the serotonin transporter (SLC6A4) locus in a rigid-compulsive subset of autism. Am J Med Genet B 2004, 127B:104-112.
139. McCracken J.T., McGough J., Shah B., Cronin P., Hong D., Aman M.G., Arnold L.E., Lindsay R., Nash P., Hollway J., McDougle C.J., Posey D., Swiezy N., Kohn A., Scahill L., Martin A., Koenig K., Volkmar F., Carroll D., Lancor A., Tierney E., Ghuman J., Gonzalez N.M., Grados M., Vitiello B., Ritz L., Davies M., Robinson J., McMahon D. Risperidone in children with autism and serious behavioral problems. N Engl J Med 2002, 347:314-321.
140. McDougle C.J., Naylor S.T., Goodman W.K., Volkmar F.R., Cohen D.J., Price L.H. Acute tryptophan depletion in autistic disorder: a controlled case study. Biol Psychiatry 1993, 33:547-550.
141. McDougle C., Naylor S., Cohen D., Aghajanian G., Heninger G., Price L. Effects of tryptophan depletion in drug-free adults with autistic disorder. Arch Gen Psychiatry 1996, 53:993-1000.
142. McDougle C.J., Scahill L., Aman M.G., McCracken J.T., Tierney E., Davies M., Arnold L.E., Posey D.J., Martin A., Ghuman J.K., Shah B., Chuang S.Z., Swiezy N.B., Gonzalez N.M., Hollway J., Koenig K., McGough J.J., Ritz L., Vitiello B. Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacology. Am J Psychiatry 2005, 162:1142-1148.
143. McNamara I.M., Borella A.W., Bialowas L.A., Whitaker-Azmitia P.M. Further studies in the developmental hyperserotonemia model (DHS) of autism: social, behavioral and peptide changes. Brain Res 2008, 1189:203-214.
144. Mei H., Cuccaro M.L., Martin E.R. Multifactor dimensionality reduction-phenomics: a novel method to capture genetic heterogeneity with use of phenotypic variables. Am J Hum Genet 2007, 81:1251-1261.
145. Meltzer H.Y., Arora R.C. Genetic control of serotonin uptake in blood platelets: a twin study. Psychiatry Res 1988, 24:263-269.
146. Millan M.J., Marin P., Bockaert J., Mannoury la Cour C. Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions. Trends Pharmacol Sci 2008, 29:454-464.
147. Miller M., Bales K.L., Taylor S.L., Yoon J., Hostetler C.M., Carter C.S., Solomon M. Oxytocin and vasopressin in children and adolescents with autism spectrum disorders: sex differences and associations with symptoms. Autism Res 2013, 6:91-102.
148. Miller V.M., Zhu Y., Bucher C., McGinnis W., Ryan L.K., Siegel A., Zalcman S. Gestational flu exposure induces changes in neurochemicals, affiliative hormones and brainstem inflammation, in addition to autism-like behaviors in mice. Brain Behav Immun 2013, 33:153-163.
149. Minderaa R., Anderson G., Volkmar F., Akkerhuis G., Cohen D. Noradrenergic and adrenergic functioning in autism. Biol Psychiatry 1994, 36:237-241.
150. Miyazaki K., Narita N., Narita M. Maternal administration of thalidomide or valproic acid causes abnormal serotonergic neurons in the offspring: implication for pathogenesis of autism. Int J Dev Neurosci 2005, 23:287-297.
151. Modahl C., Green L., Fein D., Morris M., Waterhouse L., Feinstein C., Levin H. Plasma oxytocin levels in autistic children. Biol Psychiatry 1998, 43:270-277.
152. Montag C., Fiebach C.J., Kirsch P., Reuter M. Interaction of 5-HTTLPR and a variation on the oxytocin receptor gene influences negative emotionality. Biol Psychiatry 2011, 69:601-603.
153. Mosienko V., Beis D., Alenina N., Wohr M. Reduced isolation-induced pup ultrasonic communication in mouse pups lacking brain serotonin. Mol Autism 2015, 6:13.
154. Mottolese R., Redoute J., Costes N., Le Bars D., Sirigu A. Switching brain serotonin with oxytocin. Proc Natl Acad Sci USA 2014, 111:8637-8642.
155. Moy S.S., Nadler J.J., Young N.B., Nonneman R.J., Grossman A.W., Murphy D.L., D'Ercole A.J., Crawley J.N., Magnuson T.R., Lauder J.M. Social approach in genetically-engineered mouse lines relevant to autism. Genes Brain Behav 2008.
156. Mulder E.J., Anderson G.M., Kema I.P., de Bildt A., van Lang N.D., den Boer J.A., Minderaa R.B. Platelet serotonin levels in pervasive developmental disorders and mental retardation: diagnostic group differences, within-group distribution, and behavioral correlates. J Am Acad Child Adolesc Psychiatry 2004, 43:491-499.
157. Mulder E.J., Anderson G.M., Kemperman R.F., Oosterloo-Duinkerken A., Minderaa R.B., Kema I.P. Urinary excretion of 5-hydroxyindoleacetic acid, serotonin and 6-sulphatoxymelatonin in normoserotonemic and hyperserotonemic autistic individuals. Neuropsychobiology 2010, 61:27-32.
158. Murphy D.L., Lesch K.P. Targeting the murine serotonin transporter: insights into human neurobiology. Nat Rev Neurosci 2008, 9:85-96.
159. Murphy D.G., Daly E., Schmitz N., Toal F., Murphy K., Curran S., Erlandsson K., Eersels J., Kerwin R., Ell P., Travis M. Cortical serotonin 5-HT2A receptor binding and social communication in adults with Asperger's syndrome: an in vivo SPECT study. Am J Psychiatry 2006, 163:934-936.
160. Nakamura K., Sekine Y., Ouchi Y., Tsujii M., Yoshikawa E., Futatsubashi M., Tsuchiya K.J., Sugihara G., Iwata Y., Suzuki K., Matsuzaki H., Suda S., Sugiyama T., Takei N., Mori N. Brain serotonin and dopamine transporter bindings in adults with high-functioning autism. Arch Gen Psychiatry 2010, 67:59-68.
161. Nakatani J., Tamada K., Hatanaka F., Ise S., Ohta H., Inoue K., Tomonaga S., Watanabe Y., Chung Y.J., Banerjee R., Iwamoto K., Kato T., Okazawa M., Yamauchi K., Tanda K., Takao K., Miyakawa T., Bradley A., Takumi T. Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. Cell 2009, 137:1235-1246.
162. Neumeyer A.M., Gates A., Ferrone C., Lee H., Misra M. Bone density in peripubertal boys with autism spectrum disorders. J Autism Dev Disord 2013, 43:1623-1629.
163. Nyffeler J., Walitza S., Bobrowski E., Gundelfinger R., Grunblatt E. Association study in siblings and case-controls of serotonin- and oxytocin-related genes with high functioning autism. J Mol Psychiatry 2014, 2:1.
164. Oblak A., Gibbs T.T., Blatt G.J. Reduced serotonin receptor subtypes in a limbic and a neocortical region in autism. Autism Res 2013, 6:571-583.
165. O'Hearn E., Molliver M.E. Organization of raphe-cortical projections in rat: a quantitative retrograde study. Brain Res Bull 1984, 13:709-726.
166. Ohkawara T., Katsuyama T., Ida-Eto M., Narita N., Narita M. Maternal viral infection during pregnancy impairs development of fetal serotonergic neurons. Brain Dev 2015, 37:88-93.
167. Olivier B., Mos J., van Oorschot R., Hen R. Serotonin receptors and animal models of aggressive behavior. Pharmacopsychiatry 1995, 28(Suppl 2):80-90.
168. Ozaki N., Goldman D., Kaye W.H., Plotnicov K., Greenberg B.D., Lappalainen J., Rudnick G., Murphy D.L. Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype. Mol Psychiatry 2003, 8:933-936.
169. Pagan C., Delorme R., Callebert J., Goubran-Botros H., Amsellem F., Drouot X., Boudebesse C., Le Dudal K., Ngo-Nguyen N., Laouamri H., Gillberg C., Leboyer M., Bourgeron T., Launay J.M. The serotonin-N-acetylserotonin-melatonin pathway as a biomarker for autism spectrum disorders. Transl Psychiatry 2014, 4:e479.
170. Pagani J.H., Williams Avram S.K., Cui Z., Song J., Mezey E., Senerth J.M., Baumann M.H., Young W.S. Raphe serotonin neuron-specific oxytocin receptor knockout reduces aggression without affecting anxiety-like behavior in male mice only. Genes Brain Behav 2015, 14:167-176.
171. Page D.T., Kuti O.J., Prestia C., Sur M. Haploinsufficiency for Pten and serotonin transporter cooperatively influences brain size and social behavior. Proc Natl Acad Sci USA 2009, 106:1989-1994.
172. Panksepp J.B., Lahvis G.P. Social reward among juvenile mice. Genes Brain Behav 2007, 6:661-671.
173. Parker K.J., Garner J.P., Libove R.A., Hyde S.A., Hornbeak K.B., Carson D.S., Liao C.P., Phillips J.M., Hallmayer J.F., Hardan A.Y. Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder. Proc Natl Acad Sci USA 2014, 111:12258-12263.
174. Partington M.W., Tu J.B., Wong C.Y. Blood serotonin levels in severe mental retardation. Dev Med Child Neurol 1973, 15:616-627.
175. Patrick R.P., Ames B.N. Vitamin D hormone regulates serotonin synthesis. Part 1: relevance for autism. FASEB J 2014, 28:2398-2413.
176. Perry B.D., Cook E.H., Leventhal B.L., Wainwright M.S., Freedman D.X. Platelet 5-HT2 serotonin receptor binding sites in autistic children and their first-degree relatives. Biol Psychiatry 1991, 30:121-130.
177. Persico A.M., Altamura C., Calia E., Puglisi-Allegra S., Ventura R., Lucchese F., Keller F. Serotonin depletion and barrel cortex development: impact of growth impairment vs. serotonin effects on thalamocortical endings. Cereb Cortex 2000, 10:181-191.
178. Persico A.M., Mengual E., Moessner R., Hall S.F., Revay R.S., Sora I., Arellano J., DeFelipe J., Gimenez-Amaya J.M., Conciatori M., Marino R., Baldi A., Cabib S., Pascucci T., Uhl G.R., Murphy D.L., Lesch K.P., Keller F. Barrel pattern formation requires serotonin uptake by thalamocortical afferents, and not vesicular monoamine release. J Neurosci 2001, 21:6862-6873.
179. Piven J., Tsai G., Nehme E., Coyle J.T., Folstein S.E. Platelet serotonin, a possible marker for familial autism. J Autism Dev Disord 1991, 21:51-59.
180. Prasad H.C., Steiner J.A., Sutcliffe J.S., Blakely R.D. Enhanced activity of human serotonin transporter variants associated with autism. Philos Trans R Soc Lond B Biol Sci 2009, 364:163-173.
181. Preti A., Melis M., Siddi S., Vellante M., Doneddu G., Fadda R. Oxytocin and autism: a systematic review of randomized controlled trials. J Child Adolesc Psychopharmacol 2014, 24:54-68.
182. Proulx E., Young E.J., Osborne L.R., Lambe E.K. Enhanced prefrontal serotonin 5-HT(1A) currents in a mouse model of Williams-Beuren syndrome with low innate anxiety. J Neurodev Disord 2010, 2:99-108.
183. Qian Y., Melikian H.E., Rye D.B., Levey A.I., Blakely R.D. Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies. J Neurosci 1995, 15:1261-1274.
184. Rai D., Lee B.K., Dalman C., Golding J., Lewis G., Magnusson C. Parental depression, maternal antidepressant use during pregnancy, and risk of autism spectrum disorders: population based case-control study. BMJ 2013, 346:f2059.
185. Raznahan A., Pugliese L., Barker G.J., Daly E., Powell J., Bolton P.F., Murphy D.G. Serotonin transporter genotype and neuroanatomy in autism spectrum disorders. Psychiatr Genet 2009, 19:147-150.
186. Rebello T.J., Yu Q., Goodfellow N.M., Caffrey Cagliostro M.K., Teissier A., Morelli E., Demireva E.Y., Chemiakine A., Rosoklija G.B., Dwork A.J., Lambe E.K., Gingrich J.A., Ansorge M.S. Postnatal day 2 to 11 constitutes a 5-HT-sensitive period impacting adult mPFC function. J Neurosci 2014, 34:12379-12393.
187. Reiss A.L., Feinstein C., Rosenbaum K.N., Borengasser-Caruso M.A., Goldsmith B.M. Autism associated with Williams syndrome. J Pediatr 1985, 106:247-249.
188. Riccio O., Potter G., Walzer C., Vallet P., Szabo G., Vutskits L., Kiss J.Z., Dayer A.G. Excess of serotonin affects embryonic interneuron migration through activation of the serotonin receptor 6. Mol Psychiatry 2009, 14:280-290.
189. Robinson E.B., Samocha K.E., Kosmicki J.A., McGrath L., Neale B.M., Perlis R.H., Daly M.J. Autism spectrum disorder severity reflects the average contribution of de novo and familial influences. Proc Natl Acad Sci USA 2014, 111:15161-15165.
190. Sacco R., Curatolo P., Manzi B., Militerni R., Bravaccio C., Frolli A., Lenti C., Saccani M., Elia M., Reichelt K.L., Pascucci T., Puglisi-Allegra S., Persico A.M. Principal pathogenetic components and biological endophenotypes in autism spectrum disorders. Autism Res 2010, 3:237-252.
191. Sakurai T., Reichert J., Hoffman E.J., Cai G., Jones H.B., Faham M., Buxbaum J.D. A large-scale screen for coding variants in SERT/SLC6A4 in autism spectrum disorders. Autism Res 2008, 1:251-257.
192. Salichon N., Gaspar P., Upton A.L., Picaud S., Hanoun N., Hamon M., De Maeyer E., Murphy D.L., Mossner R., Lesch K.P., Hen R., Seif I. Excessive activation of serotonin (5-HT) 1B receptors disrupts the formation of sensory maps in monoamine oxidase a and 5-ht transporter knock-out mice. J Neurosci 2001, 21:884-896.
193. Sanders S.J., He X., Willsey A.J., Ercan-Sencicek A.G., Samocha K.E., Cicek A.E., Murtha M.T., Bal V.H., Bishop S.L., Dong S., Goldberg A.P., Jinlu C., Keaney J.F., Klei L., Mandell J.D., Moreno-De-Luca D., Poultney C.S., Robinson E.B., Smith L., Solli-Nowlan T., Su M.Y., Teran N.A., Walker M.F., Werling D.M., Beaudet A.L., Cantor R.M., Fombonne E., Geschwind D.H., Grice D.E., Lord C., Lowe J.K., Mane S.M., Martin D.M., Morrow E.M., Talkowski M.E., Sutcliffe J.S., Walsh C.A., Yu T.W., Ledbetter D.H., Martin C.L., Cook E.H., Buxbaum J.D., Daly M.J., Devlin B., Roeder K., State M.W. Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci. Neuron 2015, 87:1215-1233. Autism Sequencing C.
194. 1B receptor. Science 1994, 265:1875-1878.
195. Schain R.J., Freedman D.X. Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children. J Pediatr 1961, 58:315-320.
196. Schauder K.B., Muller C.L., Veenstra-VanderWeele J., Cascio C.J. Genetic variation in serotonin transporter modulates tactile hyperresponsiveness in ASD. Res Autism Spectr Disord 2015, 10:93-100.
197. 14C] labeled tracer. J Cereb Blood Flow Metab 2000, 20:244-252.
198. Simpson K.L., Weaver K.J., de Villers-Sidani E., Lu J.Y., Cai Z., Pang Y., Rodriguez-Porcel F., Paul I.A., Merzenich M., Lin R.C. Perinatal antidepressant exposure alters cortical network function in rodents. Proc Natl Acad Sci USA 2011, 108:18465-18470.
199. Skuse D.H., Lori A., Cubells J.F., Lee I., Conneely K.N., Puura K., Lehtimaki T., Binder E.B., Young L.J. Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills. Proc Natl Acad Sci USA 2014, 111:1987-1992.
200. Smit-Rigter L.A., Wadman W.J., van Hooft J.A. Impaired social behavior in 5-HT(3A) receptor knockout mice. Front Behav Neurosci 2010, 4:169.
201. Spivak B., Golubchik P., Mozes T., Vered Y., Nechmad A., Weizman A., Strous R.D. Low platelet-poor plasma levels of serotonin in adult autistic patients. Neuropsychobiology 2004, 50:157-160.
202. Stevenson R.A., Siemann J.K., Schneider B.C., Eberly H.E., Woynaroski T.G., Camarata S.M., Wallace M.T. Multisensory temporal integration in autism spectrum disorders. J Neurosci 2014, 34:691-697.
203. Stone J.L., Merriman B., Cantor R.M., Yonan A.L., Gilliam T.C., Geschwind D.H., Nelson S.F. Evidence for sex-specific risk alleles in autism spectrum disorder. Am J Hum Genet 2004, 75:1117-1123.
204. Suri D., Teixeira C., Cagliostro M.C., Mahadevia D., Ansorge M.S. Monoamine-sensitive developmental periods impacting adult emotional and cognitive behaviors. Neuropsychopharmacology 2014.
205. Sutcliffe J.S., Delahanty R.J., Prasad H.C., McCauley J.L., Han Q., Jiang L., Li C., Folstein S.E., Blakely R.D. Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. Am J Hum Genet 2005, 77:265-279.
206. Thanseem I., Anitha A., Nakamura K., Suda S., Iwata K., Matsuzaki H., Ohtsubo M., Ueki T., Katayama T., Iwata Y., Suzuki K., Minoshima S., Mori N. Elevated transcription factor specificity protein 1 in autistic brains alters the expression of autism candidate genes. Biol Psychiatry 2012, 71:410-418.
207. Thompson M.R., Callaghan P.D., Hunt G.E., Cornish J.L., McGregor I.S. A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy"). Neuroscience 2007, 146:509-514.
208. Tordjman S., Anderson G.M., Cohen D., Kermarrec S., Carlier M., Touitou Y., Saugier-Veber P., Lagneaux C., Chevreuil C., Verloes A. Presence of autism, hyperserotonemia, and severe expressive language impairment in Williams-Beuren syndrome. Mol Autism 2013, 4:29.
209. Tsujino N., Nakatani Y., Seki Y., Nakasato A., Nakamura M., Sugawara M., Arita H. Abnormality of circadian rhythm accompanied by an increase in frontal cortex serotonin in animal model of autism. Neurosci Res 2007, 57:289-295.
210. van Kleef E.S., Gaspar P., Bonnin A. Insights into the complex influence of 5-HT signaling on thalamocortical axonal system development. Eur J Neurosci 2012, 35:1563-1572.
211. Vaswani M., Linda F.K., Ramesh S. Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review. Prog Neuropsychopharmacol Biol Psychiatry 2003, 27:85-102.
212. Veenstra-VanderWeele J., Muller C.L., Iwamoto H., Sauer J.E., Owens W.A., Shah C.R., Cohen J., Mannangatti P., Jessen T., Thompson B.J., Ye R., Kerr T.M., Carneiro A.M., Crawley J.N., Sanders-Bush E., McMahon D.G., Ramamoorthy S., Daws L.C., Sutcliffe J.S., Blakely R.D. Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior. Proc Natl Acad Sci USA 2012, 109:5469-5474.
213. Waage-Baudet H., Lauder J.M., Dehart D.B., Kluckman K., Hiller S., Tint G.S., Sulik K.K. Abnormal serotonergic development in a mouse model for the Smith-Lemli-Opitz syndrome: implications for autism. Int J Dev Neurosci 2003, 21:451-459.
214. Walther D.J., Peter J.U., Bashammakh S., Hortnagl H., Voits M., Fink H., Bader M. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 2003, 299:76.
215. Wassink T.H., Hazlett H.C., Epping E.A., Arndt S., Dager S.R., Schellenberg G.D., Dawson G., Piven J. Cerebral cortical gray matter overgrowth and functional variation of the serotonin transporter gene in autism. Arch Gen Psychiatry 2007, 64:709-717.
216. Weiss L.A., Veenstra-VanderWeele J., Abney M., Newman D.L., Kim S.-J., Dytch H., McPeek M.S., Cheng S., Cook E.H., Ober C. Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin. Eur J Hum Genet Adv Online Publ 2004.
217. Weiss L.A., Veenstra-Vanderweele J., Newman D.L., Kim S.J., Dytch H., McPeek M.S., Cheng S., Ober C., Cook E.H., Abney M. Genome-wide association study identifies ITGB3 as a QTL for whole blood serotonin. Eur J Hum Genet 2004, 12:949-954.
218. Weiss L.A., Abney M., Cook E.H., Ober C. Sex-specific genetic architecture of whole blood serotonin levels. Am J Hum Genet 2005, 76:33-41.
219. Weiss L.A., Ober C., Cook E.H. ITGB3 shows genetic and expression interaction with SLC6A4. Hum Genet 2006, 120:93-100.
220. Welker C. Microelectrode delineation of fine grain somatotopic organization of (SmI) cerebral neocortex in albino rat. Brain Res 1971, 26:259-275.
221. Whyte A., Jessen T., Varney S., Carneiro A.M. Serotonin transporter and integrin beta 3 genes interact to modulate serotonin uptake in mouse brain. Neurochem Int 2014, 73:122-126.
222. Wiggins J.L., Peltier S.J., Bedoyan J.K., Carrasco M., Welsh R.C., Martin D.M., Lord C., Monk C.S. The impact of serotonin transporter genotype on default network connectivity in children and adolescents with autism spectrum disorders. Neuroimage Clin 2012, 2:17-24.
223. Wiggins J.L., Swartz J.R., Martin D.M., Lord C., Monk C.S. Serotonin transporter genotype impacts amygdala habituation in youth with autism spectrum disorders. Soc Cogn Affect Neurosci 2014, 9:832-838.
224. Winter C., Reutiman T.J., Folsom T.D., Sohr R., Wolf R.J., Juckel G., Fatemi S.H. Dopamine and serotonin levels following prenatal viral infection in mouse-implications for psychiatric disorders such as schizophrenia and autism. Eur Neuropsychopharmacol 2008, 18:712-716.
225. Worbe Y., Palminteri S., Savulich G., Daw N.D., Fernandez-Egea E., Robbins T.W., Voon V. Valence-dependent influence of serotonin depletion on model-based choice strategy. Mol Psychiatry 2015.
226. Yadav V.K., Ryu J.H., Suda N., Tanaka K.F., Gingrich J.A., Schutz G., Glorieux F.H., Chiang C.Y., Zajac J.D., Insogna K.L., Mann J.J., Hen R., Ducy P., Karsenty G. Lrp5 controls bone formation by inhibiting serotonin synthesis in the duodenum. Cell 2008, 135:825-837.
227. Ye R., Carneiro A.M., Airey D., Sanders-Bush E., Williams R.W., Lu L., Wang J., Zhang B., Blakely R.D. Evaluation of heritable determinants of blood and brain serotonin homeostasis using recombinant inbred mice. Genes Brain Behav 2014, 13:247-260.
228. Yonan A.L., Alarcon M., Cheng R., Magnusson P.K., Spence S.J., Palmer A.A., Grunn A., Juo S.H., Terwilliger J.D., Liu J., Cantor R.M., Geschwind D.H., Gilliam T.C. A genomewide screen of 345 families for autism-susceptibility loci. Am J Hum Genet 2003, 73:886-897.
229. Yoshida M., Takayanagi Y., Inoue K., Kimura T., Young L.J., Onaka T., Nishimori K. Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. J Neurosci 2009, 29:2259-2271.
230. Young E.J., Lipina T., Tam E., Mandel A., Clapcote S.J., Bechard A.R., Chambers J., Mount H.T., Fletcher P.J., Roder J.C., Osborne L.R. Reduced fear and aggression and altered serotonin metabolism in Gtf2ird1-targeted mice. Genes Brain Behav 2008, 7:224-234.
231. Zerbo O., Iosif A.M., Walker C., Ozonoff S., Hansen R.L., Hertz-Picciotto I. Is maternal influenza or fever during pregnancy associated with autism or developmental delays? Results from the CHARGE (CHildhood Autism Risks from Genetics and Environment) study. J Autism Dev Disord 2013, 43:25-33.
232. Zerbo O., Qian Y., Yoshida C., Grether J.K., Van de Water J., Croen L.A. Maternal infection during pregnancy and autism spectrum disorders. J Autism Dev Disord 2013.
233. Zhang W.Q., Smolik C.M., Barba-Escobedo P.A., Gamez M., Sanchez J.J., Javors M.A., Daws L.C., Gould G.G. Acute dietary tryptophan manipulation differentially alters social behavior, brain serotonin and plasma corticosterone in three inbred mouse strains. Neuropharmacology 2015, 90:1-8.
234. Zheng J.J., Li S.J., Zhang X.D., Miao W.Y., Zhang D., Yao H., Yu X. Oxytocin mediates early experience-dependent cross-modal plasticity in the sensory cortices. Nat Neurosci 2014, 17:391-399.